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Article ; Online: Transition metals-doped g-C

Kalidasan, Kavya / Mallapur, Srinivas / Munirathnam, K / Nagarajaiah, H / Reddy, M B Madhusudana / Kakarla, Raghava Reddy / Raghu, Anjanapura V

Chemosphere

2024 Volume 352, Page(s) 141354

Abstract: Graphitic carbon nitride (g-C ...

Abstract	Graphitic carbon nitride (g-C
MeSH term(s)	Catalysis ; Light ; Nanostructures ; Semiconductors ; Wastewater
Chemical Substances	Wastewater
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141354
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Article ; Online: Questionnaires or Serum Immunoglobulin G Testing in the Diagnosis of Hypersensitivity Pneumonitis among Patients with Interstitial Lung Disease.

Jenkins, Alex R / Chua, Abigail / Chami, Hassan / Diaz-Mendoza, Javier / Duggal, Abhijit / Knight, Shandra / Patolia, Setu / Tamae-Kakazu, Maximiliano / Raghu, Ganesh / Wilson, Kevin C

Annals of the American Thoracic Society

2020 Volume 18, Issue 1, Page(s) 130–147

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Alveolitis, Extrinsic Allergic/blood ; Bronchial Provocation Tests ; Humans ; Immunoglobulin G/blood ; Lung Diseases, Interstitial/blood ; Observational Studies as Topic ; Randomized Controlled Trials as Topic ; Surveys and Questionnaires
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2020-09-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202005-419OC
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Article ; Online: Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in

Balakrishnan, Sruthi S / Basu, Urbashi / Shinde, Dhananjay / Thakur, Rajan / Jaiswal, Manish / Raghu, Padinjat

Journal of cell science

2018 Volume 131, Issue 15

Abstract: The activation of phospholipase C (PLC) is a conserved mechanism of receptor-activated cell signaling at the plasma membrane. PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5) ... ...

Abstract	The activation of phospholipase C (PLC) is a conserved mechanism of receptor-activated cell signaling at the plasma membrane. PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P
MeSH term(s)	Animals ; Cell Membrane/metabolism ; Drosophila ; Drosophila Proteins/metabolism ; Endoplasmic Reticulum/metabolism ; Female ; Male ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphatidylinositol Phosphates/metabolism ; Phosphatidylinositols/metabolism ; Signal Transduction ; Type C Phospholipases/metabolism
Chemical Substances	Drosophila Proteins ; Phosphatidylinositol 4,5-Diphosphate ; Phosphatidylinositol Phosphates ; Phosphatidylinositols ; phosphatidylinositol 4-phosphate ; Type C Phospholipases (EC 3.1.4.-)
Language	English
Publishing date	2018-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.217257
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Article ; Online: Rare-variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associations of orphan G protein-coupled receptors.

Dershem, Ridge / Metpally, Raghu P R / Jeffreys, Kirk / Krishnamurthy, Sarathbabu / Smelser, Diane T / Hershfinkel, Michal / Carey, David J / Robishaw, Janet D / Breitwieser, Gerda E

The Journal of biological chemistry

2019 Volume 294, Issue 48, Page(s) 18109–18121

Abstract: The pace of deorphanization of G protein-coupled receptors (GPCRs) has slowed, and new approaches ...

Abstract	The pace of deorphanization of G protein-coupled receptors (GPCRs) has slowed, and new approaches are required. Small molecule targeting of orphan GPCRs can potentially be of clinical benefit even if the endogenous receptor ligand has not been identified. Many GPCRs lack common variants that lead to reproducible genome-wide disease associations, and rare-variant approaches have emerged as a viable alternative to identify disease associations for such genes. Therefore, our goal was to prioritize orphan GPCRs by determining their associations with human diseases in a large clinical population. We used sequence kernel association tests to assess the disease associations of 85 orphan or understudied GPCRs in an unselected cohort of 51,289 individuals. Using rare loss-of-function variants, missense variants predicted to be pathogenic or likely pathogenic, and a subset of rare synonymous variants that cause large changes in local codon bias as independent data sets, we found strong, phenome-wide disease associations shared by two or more variant categories for 39% of the GPCRs. To validate the bioinformatics and sequence kernel association test analyses, we functionally characterized rare missense and synonymous variants of GPR39, a family A GPCR, revealing altered expression or Zn
MeSH term(s)	Genome-Wide Association Study ; Humans ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/genetics ; Silent Mutation
Chemical Substances	GPR39 protein, human ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2019-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.009253
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Article: A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women.

Vinod, Cingeetham / Jyothy, Akka / Vijay Kumar, Malladi / Raman, Ramaiyer Raghu / Nallari, Pratibha / Venkateshwari, Ananthapur

Iranian journal of cancer prevention

2015 Volume 8, Issue 4, Page(s) e3434

Abstract: ... evolution and tumorigenesis.: Objectives: Evaluating the role of IL10 (-1082A/G) gene promoter ... 1082A/G polymorphism is significantly associated with breast cancer (AA vs. AG: χ(2) = 14.46, P = 0 ...

Abstract	Background: Evading the immune destruction and angiogenesis has been the two hallmarks of cancer. Interleukin-10 (IL-10) is a cytokine with immune suppressing (pro-tumorigenic) and anti-angiogenic (anti-tumorigenic) properties, thus making the role of IL-10 in tumorigenesis enigmatic. Previous studies have suggested a critical role of IL10 altered expression in complex process of tumor-microenvironment, co-evolution and tumorigenesis. Objectives: Evaluating the role of IL10 (-1082A/G) gene promoter polymorphism in breast cancer patients from South India. Patients and methods: A case-control study was conducted with a total of 285 individuals, these include 125 histologically confirmed breast cancer patients and 160 age and sex matched controls. Genotypes were determined by allele-specific polymerase chain reaction (AS-PCR), followed by agarose gel electrophoresis. Statistical analysis was done to test the significance of results obtained. Results: Statistical analysis revealed that AA genotype of the Il-10 -1082A/G polymorphism is significantly associated with breast cancer (AA vs. AG: χ(2) = 14.46, P = 0.0001432, OR = 2.854, 95% CI = 1.68 - 4.849). Up on stratifying subjects based on cancer stage, age at onset, menopausal status, AA genotype has associated with all the sub groups, except for post-menopausal women. There was no significant association which was observed with respected to hormonal status (ER, PR) and Her2/neu status. Conclusions: The present study suggests that IL-10 AA genotype as a risk factor in the etiology of breast cancer in the South Indian population.
Language	English
Publishing date	2015-08-24
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2577885-7
ISSN	2008-2401 ; 2008-2398
ISSN (online)	2008-2401
ISSN	2008-2398
DOI	10.17795/ijcp-3434
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Article ; Online: A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors.

Chakrabarti, Purbani / Kolay, Sourav / Yadav, Shweta / Kumari, Kamalesh / Nair, Amit / Trivedi, Deepti / Raghu, Padinjat

PLoS genetics

2015 Volume 11, Issue 1, Page(s) e1004948

Abstract: ... the mechanism by which they are generated is unclear. In Drosophila photoreceptors, the hydrolysis of PIP2 by G ...

Abstract	Multiple PIP2 dependent molecular processes including receptor activated phospholipase C activity occur at the neuronal plasma membranes, yet levels of this lipid at the plasma membrane are remarkably stable. Although the existence of unique pools of PIP2 supporting these events has been proposed, the mechanism by which they are generated is unclear. In Drosophila photoreceptors, the hydrolysis of PIP2 by G-protein coupled phospholipase C activity is essential for sensory transduction of photons. We identify dPIP5K as an enzyme essential for PIP2 re-synthesis in photoreceptors. Loss of dPIP5K causes profound defects in the electrical response to light and light-induced PIP2 dynamics at the photoreceptor membrane. Overexpression of dPIP5K was able to accelerate the rate of PIP2 synthesis following light induced PIP2 depletion. Other PIP2 dependent processes such as endocytosis and cytoskeletal function were unaffected in photoreceptors lacking dPIP5K function. These results provide evidence for the existence of a unique dPIP5K dependent pool of PIP2 required for normal Drosophila phototransduction. Our results define the existence of multiple pools of PIP2 in photoreceptors generated by distinct lipid kinases and supporting specific molecular processes at neuronal membranes.
MeSH term(s)	Animals ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Cytoskeleton/genetics ; Cytoskeleton/metabolism ; Drosophila ; Drosophila melanogaster ; Light Signal Transduction/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Ocular Physiological Phenomena/genetics ; Phosphatidylinositol 4,5-Diphosphate/genetics ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphoinositide Phospholipase C/genetics ; Phosphoinositide Phospholipase C/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Photoreceptor Cells/metabolism ; Retina/metabolism ; Retina/physiology ; Signal Transduction/genetics
Chemical Substances	Membrane Proteins ; Phosphatidylinositol 4,5-Diphosphate ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; 1-phosphatidylinositol-4-phosphate 5-kinase (EC 2.7.1.68) ; Phosphoinositide Phospholipase C (EC 3.1.4.11)
Language	English
Publishing date	2015-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1004948
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Article ; Online: RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction.

Yadav, Shweta / Garner, Kathryn / Georgiev, Plamen / Li, Michelle / Gomez-Espinosa, Evelyn / Panda, Aniruddha / Mathre, Swarna / Okkenhaug, Hanneke / Cockcroft, Shamshad / Raghu, Padinjat

Journal of cell science

2015 Volume 128, Issue 17, Page(s) 3330–3344

Abstract: ... lipid intermediates during G-protein-coupled PtdIns(4,5)P2 turnover. ...

Abstract	Many membrane receptors activate phospholipase C (PLC) during signalling, triggering changes in the levels of several plasma membrane lipids including phosphatidylinositol (PtdIns), phosphatidic acid (PtdOH) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. It is widely believed that exchange of lipids between the plasma membrane and endoplasmic reticulum (ER) is required to restore lipid homeostasis during PLC signalling, yet the mechanism remains unresolved. RDGBα (hereafter RDGB) is a multi-domain protein with a PtdIns transfer protein (PITP) domain (RDGB-PITPd). We find that, in vitro, the RDGB-PITPd binds and transfers both PtdOH and PtdIns. In Drosophila photoreceptors, which experience high rates of PLC activity, RDGB function is essential for phototransduction. We show that binding of PtdIns to RDGB-PITPd is essential for normal phototransduction; however, this property is insufficient to explain the in vivo function because another Drosophila PITP (encoded by vib) that also binds PtdIns cannot rescue the phenotypes of RDGB deletion. In RDGB mutants, PtdIns(4,5)P2 resynthesis at the plasma membrane following PLC activation is delayed and PtdOH levels elevate. Thus RDGB couples the turnover of both PtdIns and PtdOH, key lipid intermediates during G-protein-coupled PtdIns(4,5)P2 turnover.
MeSH term(s)	Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Light Signal Transduction/physiology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phosphatidic Acids/genetics ; Phosphatidic Acids/metabolism ; Phosphatidylinositol 4,5-Diphosphate/genetics ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Type C Phospholipases/genetics ; Type C Phospholipases/metabolism
Chemical Substances	Drosophila Proteins ; Eye Proteins ; Membrane Proteins ; Phosphatidic Acids ; Phosphatidylinositol 4,5-Diphosphate ; rdgB protein, Drosophila (139135-48-1) ; Type C Phospholipases (EC 3.1.4.-)
Language	English
Publishing date	2015-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.173476
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Book ; Online ; E-Book: Lung transplantation

Raghu, Ganesh / Carbone, Roberto G.

evolving knowledge and new horizons

2018

Author's details	Ganesh Raghu, Roberto G. Carbone editors
Keywords	Medicine ; Cardiology ; Respiratory organs/Diseases ; Thoracic surgery
Subject code	616.2
Language	English
Size	1 Online-Ressource (xviii, 371 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019793175
ISBN	978-3-319-91184-7 ; 9783319911823 ; 3-319-91184-8 ; 3319911821
DOI	10.1007/978-3-319-91184-7
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women

Cingeetham Vinod / Akka Jyothy / Malladi Vijay kumar / Ramaiyer Raghu Raman / Pratibha Nallari / Ananthapur Venkateshwari

Iranian Journal of Cancer Prevention, Vol 8, Iss

2015 Volume 4

Abstract: ... evolution and tumorigenesis. Objectives: Evaluating the role of IL10 (-1082A/G) gene promoter polymorphism ... of results obtained. Results: Statistical analysis revealed that AA genotype of the Il-10 -1082A/G ...

Abstract	Background: Evading the immune destruction and angiogenesis has been the two hallmarks of cancer. Interleukin-10 (IL-10) is a cytokine with immune suppressing (pro-tumorigenic) and anti-angiogenic (anti-tumorigenic) properties, thus making the role of IL-10 in tumorigenesis enigmatic. Previous studies have suggested a critical role of IL10 altered expression in complex process of tumor-microenvironment, co-evolution and tumorigenesis. Objectives: Evaluating the role of IL10 (-1082A/G) gene promoter polymorphism in breast cancer patients from South India. Patients and Methods: A case-control study was conducted with a total of 285 individuals, these include 125 histologically confirmed breast cancer patients and 160 age and sex matched controls. Genotypes were determined by allele-specific polymerase chain reaction (AS-PCR), followed by agarose gel electrophoresis. Statistical analysis was done to test the significance of results obtained. Results: Statistical analysis revealed that AA genotype of the Il-10 -1082A/G polymorphism is significantly associated with breast cancer (AA vs. AG: χ2 = 14.46, P = 0.0001432, OR = 2.854, 95% CI = 1.68 - 4.849). Up on stratifying subjects based on cancer stage, age at onset, menopausal status, AA genotype has associated with all the sub groups, except for post-menopausal women. There was no significant association which was observed with respected to hormonal status (ER, PR) and Her2/neu status. Conclusions: The present study suggests that IL-10 AA genotype as a risk factor in the etiology of breast cancer in the South Indian population.
Keywords	Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	616 ; 610
Publishing date	2015-08-01T00:00:00Z
Publisher	Shahid Beheshti University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Trial of a Phosphodiesterase 4 Inhibitor for Idiopathic Pulmonary Fibrosis.

Raghu, Ganesh

The New England journal of medicine

2022 Volume 387, Issue 8, Page(s) 761

MeSH term(s)	Cyclic Nucleotide Phosphodiesterases, Type 4 ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Phosphodiesterase 4 Inhibitors/therapeutic use
Chemical Substances	Phosphodiesterase 4 Inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2209529
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