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Article ; Online: Reducing the burden of travel and environmental impact through decentralization of cancer care.

Fattore, Giovanni / Bobini, Michela / Meda, Francesca / Pongiglione, Benedetta / Baldino, Luca / Gandolfi, Stefano / Confalonieri, Licia / Proietto, Manuela / Vecchia, Stefano / Cavanna, Luigi

Health services management research

2024 , Page(s) 9514848241229564

Abstract: Life expectancy, quality of life and satisfaction of oncologic patients highly depend on access to adequate specialized services, that consider their conditions in a holistic way. The present study aims to evaluate the introduction of oncology services ... ...

Abstract	Life expectancy, quality of life and satisfaction of oncologic patients highly depend on access to adequate specialized services, that consider their conditions in a holistic way. The present study aims to evaluate the introduction of oncology services in an outpatient setting in a mountain village in Northern Italy. The initiative is evaluated using the three pillars of sustainability (social, economic and environmental) as dimensions that are often overlooked by healthcare policy makers. Using micro data on 18,625 interventions, we estimate the number of kilometers saved by patients (reduction of "travel burden" as indicator of social sustainability), the additional travel costs for the NHS (indicator of economic sustainability) and the implied reduction of CO
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	645114-7
ISSN	1758-1044 ; 0951-4848
ISSN (online)	1758-1044
ISSN	0951-4848
DOI	10.1177/09514848241229564
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Article: Nerves and hydrogen peroxide: how old enemies become new friends.

Meda, Francesca / Joliot, Alain / Vriz, Sophie

Neural regeneration research

2017 Volume 12, Issue 4, Page(s) 568–569

Language	English
Publishing date	2017-04-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.205088
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Article ; Online: A process-based approach to understanding and managing triggered seismicity.

Hager, Bradford H / Dieterich, James / Frohlich, Cliff / Juanes, Ruben / Mantica, Stefano / Shaw, John H / Bottazzi, Francesca / Caresani, Federica / Castineira, David / Cominelli, Alberto / Meda, Marco / Osculati, Lorenzo / Petroselli, Stefania / Plesch, Andreas

Nature

2021 Volume 595, Issue 7869, Page(s) 684–689

Abstract: There is growing concern about seismicity triggered by human activities, whereby small increases in stress bring tectonically loaded faults to failure. Examples of such activities include mining, impoundment of water, stimulation of geothermal fields, ... ...

Abstract	There is growing concern about seismicity triggered by human activities, whereby small increases in stress bring tectonically loaded faults to failure. Examples of such activities include mining, impoundment of water, stimulation of geothermal fields, extraction of hydrocarbons and water, and the injection of water, CO
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-03668-z
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration.

Rampon, Christine / Gauron, Carole / Meda, Francesca / Volovitch, Michel / Vriz, Sophie

Purinergic signalling

2014 Volume 10, Issue 4, Page(s) 595–602

Abstract: A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In ... ...

Abstract	A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In this context, we explore its possible mode of action in progenitor cell recruitment during adult regeneration in zebrafish. Here, we show that apoptosis inhibition impairs blastema formation and nerve growth, both of which can be restored by exogenous adenosine acting through its A2B receptor. Moreover, adenosine increases the number of progenitor cells. Purinergic signalling is therefore an early and essential event in the pathway from lesion to blastema formation and provides new targets for manipulating cell plasticity in the adult.
MeSH term(s)	Adenosine/metabolism ; Animal Fins/physiology ; Animals ; Apoptosis/physiology ; Neurogenesis/physiology ; Receptor, Adenosine A2B/metabolism ; Regeneration ; Stem Cells/metabolism ; Zebrafish
Chemical Substances	Receptor, Adenosine A2B ; Adenosine (K72T3FS567)
Language	English
Publishing date	2014-08-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2172143-9
ISSN	1573-9546 ; 1573-9538
ISSN (online)	1573-9546
ISSN	1573-9538
DOI	10.1007/s11302-014-9420-9
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Article ; Online: Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling.

Meda, Francesca / Gauron, Carole / Rampon, Christine / Teillon, Jérémie / Volovitch, Michel / Vriz, Sophie

Antioxidants & redox signaling

2016 Volume 24, Issue 6, Page(s) 299–311

Abstract: Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that ... ...

Abstract	Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H2O2 levels in mature tissue would be of great interest. Results: We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H2O2 levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H2O2 production in the wounded epidermis. Finally, we show that H2O2 and nerve growth are regulated via reciprocal action in adults. Innovation and conclusion: These data support a new paradigm for the regulation of tissue homeostasis: H2O2 attracts nerves and nerves control H2O2 levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Hedgehog Proteins/metabolism ; Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/pharmacology ; Oxidation-Reduction/drug effects ; Reactive Oxygen Species/metabolism ; Schwann Cells/drug effects ; Schwann Cells/metabolism ; Signal Transduction/drug effects ; Zebrafish
Chemical Substances	Hedgehog Proteins ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2016-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2015.6380
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Zs.A 5488: Show issues

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Article ; Online: Scrotal granulomatous aspergillosis in a dromedary camel (Camelus dromedarius).

Scaglione, Frine Eleonora / Peano, Andrea / Piga, Sara / Meda, Stefano / Bollo, Enrico / Cannizzo, Francesca Tiziana / Pasquetti, Mario / Jensen, Henrik Elvang

BMC veterinary research

2017 Volume 13, Issue 1, Page(s) 79

Abstract: Background: This report describes a case of primary subcutaneous aspergillosis in a 7-year-old neutered male dromedary camel (Camelus dromedarius).: Case presentation: The animal developed a large nodular lesion in the right scrotum two years after ... ...

Abstract	Background: This report describes a case of primary subcutaneous aspergillosis in a 7-year-old neutered male dromedary camel (Camelus dromedarius). Case presentation: The animal developed a large nodular lesion in the right scrotum two years after surgical intervention for neutering. The mass had a firm consistency and was painful at palpation. Histopathology revealed dermal granulomatous inflammation with a necrotic centre, surrounded by plasma cells, macrophages, neutrophils, and sparse fungal hyphae characterised by parallel cell walls, distinct septa, and dichotomous branching. Fungal culture was not performed, but a panel of mono- and polyclonal antibodies specific for different fungal genera identified the hyphae as Aspergillus sp. Conclusions: The occurrence of subcutaneous lesions is a rare manifestation of aspergillosis in animals, and this appears to be the first case reported in the dromedary camel.
MeSH term(s)	Animals ; Animals, Zoo ; Aspergillosis/diagnosis ; Aspergillosis/microbiology ; Aspergillosis/veterinary ; Camelus ; Granuloma/diagnosis ; Granuloma/microbiology ; Granuloma/veterinary ; Male ; Scrotum/microbiology ; Scrotum/pathology ; Subcutaneous Tissue/pathology
Language	English
Publishing date	2017-03-29
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-017-1001-z
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Article ; Online: The epigenetics of autoimmunity.

Meda, Francesca / Folci, Marco / Baccarelli, Andrea / Selmi, Carlo

Cellular & molecular immunology

2011 Volume 8, Issue 3, Page(s) 226–236

Abstract: The etiology of autoimmune diseases remains largely unknown. Concordance rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of patients. These lines ... ...

Abstract	The etiology of autoimmune diseases remains largely unknown. Concordance rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of patients. These lines of evidence strongly support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt autoimmunity. Alterations in the post-translational modification of histones and DNA methylation are the two major epigenetic mechanisms that may potentially cause a breakdown of immune tolerance and the perpetuation of autoimmune diseases. In recent years, several studies both in clinical settings and experimental models proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation. More specifically, data support the impact of epigenetic changes in systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, in some cases based on mechanistical observations. We herein discuss what we currently know and what we expect will come in the next future. Ultimately, epigenetic treatments already being used in oncology may soon prove beneficial also in autoimmune diseases.
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Autoimmunity/genetics ; DNA Methylation ; Epigenesis, Genetic/immunology ; Gene Expression Regulation/immunology ; Histones/immunology ; Humans ; Protein Processing, Post-Translational
Chemical Substances	Histones
Language	English
Publishing date	2011-01-31
Publishing country	China
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/cmi.2010.78
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Article ; Online: Nerves, H

Meda, Francesca / Rampon, Christine / Dupont, Edmond / Gauron, Carole / Mourton, Aurélien / Queguiner, Isabelle / Thauvin, Marion / Volovitch, Michel / Joliot, Alain / Vriz, Sophie

Seminars in cell & developmental biology

2017 Volume 80, Page(s) 65–73

Abstract: The tight control of reactive oxygen species (ROS) levels is required during regeneration. ... ...

Abstract	The tight control of reactive oxygen species (ROS) levels is required during regeneration. H
MeSH term(s)	Animals ; Hedgehog Proteins/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Nerve Net/metabolism ; Reactive Oxygen Species/metabolism ; Regeneration/physiology ; Signal Transduction/physiology
Chemical Substances	Hedgehog Proteins ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2017-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2017.08.015
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Article ; Online: Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing-Part 2.

Brufani, Mario / Rizzi, Nicoletta / Meda, Clara / Filocamo, Luigi / Ceccacci, Francesca / D'Aiuto, Virginia / Bartoli, Gabriele / Bella, Angela La / Migneco, Luisa M / Bettolo, Rinaldo Marini / Leonelli, Francesca / Ciana, Paolo / Maggi, Adriana

Scientific reports

2017 Volume 7, Issue 1, Page(s) 2510

Abstract: Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic molecules have undesired systemic effects, ... ...

Abstract	Estrogen deprivation is associated with delayed healing, while estrogen replacement therapy (ERT) accelerates acute wound healing and protects against development of chronic wounds. However, current estrogenic molecules have undesired systemic effects, thus the aim of our studies is to generate new molecules for topic administration that are devoid of systemic effects. Following a preliminary study, the new 17β-estradiol derivatives 1 were synthesized. The estrogenic activity of these novel compounds was evaluated in vitro using the cell line ERE-Luc B17 stably transfected with an ERE-Luc reporter. Among the 17β-estradiol derivatives synthesized, compounds 1e and 1f showed the highest transactivation potency and were therefore selected for the study of their systemic estrogenic activity. The study of these compounds in the ERE-Luc mouse model demonstrated that both compounds lack systemic effects when administered in the wound area. Furthermore, wound-healing experiments showed that 1e displays a significant regenerative and anti-inflammatory activity. It is therefore confirmed that this class of compounds are suitable for topical administration and have a clear beneficial effect on wound healing.
MeSH term(s)	Administration, Topical ; Animals ; Cells, Cultured ; Estradiol/administration & dosage ; Estradiol/analogs & derivatives ; Estradiol/chemical synthesis ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Replacement Therapy ; Estrogens/metabolism ; Estrone/metabolism ; Female ; Humans ; Mice ; Ovariectomy ; Skin/drug effects ; Skin/injuries ; Skin/pathology ; Wound Healing/drug effects ; Wound Healing/physiology
Chemical Substances	Estrogen Receptor alpha ; Estrogens ; Estrone (2DI9HA706A) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2017-05-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-02820-y
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Article ; Online: Serum autoantibodies for the diagnosis and management of autoimmune liver diseases.

Achenza, Maria I S / Meda, Francesca / Brunetta, Enrico / Selmi, Carlo

Expert review of gastroenterology & hepatology

2012 Volume 6, Issue 6, Page(s) 717–729

Abstract: The spectrum of autoimmune liver diseases (AILD) includes primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis. The immunological mechanisms triggering the initiation and perpetuation of AILD remains unknown, while ... ...

Abstract	The spectrum of autoimmune liver diseases (AILD) includes primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis. The immunological mechanisms triggering the initiation and perpetuation of AILD remains unknown, while autoantigens are now recognized in most cases, and are generally nontraditional in their widespread distribution. Sensitive and specific methods for the detection of serum autoantibodies in patients affected by AILD represent a challenge for researchers and clinicians who desire to obtain an early and certain diagnosis as well as markers of disease control. To this regard, the use and interpretation of serum autoantibodies in AILD may be seen as paradigmatic for the large gaps in our knowledge based on the lack of true population-based studies. The present review article will critically discuss the available evidence on the use of autoantibody findings in the diagnosis or management of autoimmune liver disease.
MeSH term(s)	Actins/immunology ; Adrenal Cortex Hormones/therapeutic use ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antinuclear/blood ; Autoantibodies/blood ; Autoantigens/immunology ; Biomarkers/blood ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/drug therapy ; Cholangitis, Sclerosing/immunology ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/immunology ; Humans ; Immunosuppressive Agents/therapeutic use ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/drug therapy ; Liver Cirrhosis, Biliary/immunology
Chemical Substances	Actins ; Adrenal Cortex Hormones ; Antibodies, Antineutrophil Cytoplasmic ; Antibodies, Antinuclear ; Autoantibodies ; Autoantigens ; Biomarkers ; Immunosuppressive Agents ; anti-liver kidney microsome antibody ; liver antigen LA-1
Language	English
Publishing date	2012-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1586/egh.12.58
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