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  1. Article ; Online: La transgression en temps de guerre. De l’Antiquité à nos jours, Nathalie Barrandon, Isabelle Pimouguet-Pédarros (dir.)

    Thierry Lucas

    Kentron, Vol 36, Pp 297-

    2022  Volume 303

    Keywords History (General) and history of Europe ; D ; Language and Literature ; P
    Language French
    Publishing date 2022-01-01T00:00:00Z
    Publisher Presses universitaires de Caen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book: Schnittstelle Kinder- und Jugendpsychiatrie

    Blaess, Isabelle / Zug, Lucas / Frey, Michael / Illy, Daniel

    ein Praxishandbuch für Lehrer*innen, Erzieher*innen und Fachkräfte der Jugendhilfe

    2023  

    Abstract: Psychische und psychosomatische Störungen frühzeitig erkennen - für Lehrer_innen, Erzieher_innen und Pädagog_innen nicht immer leicht. Das Buch möchte Sie für das Thema sensibilisieren und Sie dabei unterstützen, bestmöglich zu agieren. Es zeigt anhand ... ...

    Title variant Schnittstelle Kinderpsychiatrie und Jugendpsychiatrie
    Author's details Michael Frey, Daniel Illy (Hrsg.) ; mit Beiträgen von: Isabelle Blaess [und vielen weiteren] ; mit einem Geleitwort von: Lucas Zug, München
    Abstract Psychische und psychosomatische Störungen frühzeitig erkennen - für Lehrer_innen, Erzieher_innen und Pädagog_innen nicht immer leicht. Das Buch möchte Sie für das Thema sensibilisieren und Sie dabei unterstützen, bestmöglich zu agieren. Es zeigt anhand von praktischen Fallbeispielen welche Möglichkeiten aus pädagogischer, medizinischer und rechtlicher Sicht bestehen. In Schnittstelle Kinder- und Jugendpsychiatrie erfahren Sie den pädagogischen Umgang mit psychischen und psychosomatischen Störungsbildern bei Kindern und Jugendlichen Möglichkeiten der pädagogischen Förderung und schulische Strukturierungshilfen den Umgang mit Schulabsentismus (Schulangst und Schulphobie). Das Buch eignet sich für Weieterbildungsassistent_innen und Fachärzt_innen Kinder- und Jugendpsychiatrie Kinder- und Jugend-Psychotherapeut_innen Pädagog_innen (Lehrer_innen/Erzieher_innen) u.v.a.
    Keywords Entwicklungspsychologie ; Klinische Psychologie ; Medizin, allgemein ; Psychiatrie ; Psychische Störungen ; Psychotherapie ; Pädagogik ; Pädiatrie ; Lehrerinnen ; Erzieher ; ADHS ; Aggressivität ; Beratungslehrkräfte ; Cyber-Mobbing ; Entwicklungsstörungen ; Geschlechtsidentitätsstörungen ; Schulabsentismus ; Schulangst ; Schulpsychologen ; Kind ; Jugend ; Psychische Störung ; Schule ; Schulsozialarbeit ; Jugendhilfe ; Kinderpsychiatrie ; Jugendpsychiatrie
    Subject Seelische Störung ; Mental disorder ; Psychische Krankheit ; Seelische Krankheit ; Psychiatrische Krankheit ; Psychische Erkrankung ; Psychische Störungen ; Jugend ; Jugendalter ; Jugendlicher ; Teenager ; Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Kind ; Schule ; Schulwesen ; Schulform ; Schulart ; Schulsystem ; Schulen ; Behandlung ; Psychologische Behandlung ; Kinder- und Jugendhilfe ; Jugendfürsorge ; Jugendwohlfahrtspflege ; Öffentliche Jugendfürsorge
    Language German
    Size XV, 334 Seiten, Illustrationen, Diagramme, 24 cm x 17 cm
    Edition 1. Auflage
    Publisher Elsevier
    Publishing place München, Deutschland
    Publishing country Germany
    Document type Book
    HBZ-ID HT030021488
    ISBN 978-3-437-21307-6 ; 3-437-21307-5 ; 9783437051470 ; 3437051474
    Database Catalogue ZB MED Medicine, Health

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    2023 A 689 on loan 0 Vormerkungen

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  3. Article: Optimization of a Mass Trapping Method against the Striped Cucumber Beetle

    Tinslay, Jessee / Fournier, Marc / Couture, Isabelle / Lafontaine, Pierre J / Lefebvre, Maxime / Lucas, Eric

    Insects

    2022  Volume 13, Issue 5

    Abstract: The striped cucumber beetle (SCB) ...

    Abstract The striped cucumber beetle (SCB)
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13050465
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  4. Article ; Online: Human Induced Pluripotent Spheroids’ Growth Is Driven by Viscoelastic Properties and Macrostructure of 3D Hydrogel Environment

    Lucas Lemarié / Tanushri Dargar / Isabelle Grosjean / Vincent Gache / Edwin J. Courtial / Jérôme Sohier

    Bioengineering, Vol 10, Iss 12, p

    2023  Volume 1418

    Abstract: Stem cells, particularly human iPSCs, constitute a powerful tool for tissue engineering, notably through spheroid and organoid models. While the sensitivity of stem cells to the viscoelastic properties of their direct microenvironment is well-described, ... ...

    Abstract Stem cells, particularly human iPSCs, constitute a powerful tool for tissue engineering, notably through spheroid and organoid models. While the sensitivity of stem cells to the viscoelastic properties of their direct microenvironment is well-described, stem cell differentiation still relies on biochemical factors. Our aim is to investigate the role of the viscoelastic properties of hiPSC spheroids’ direct environment on their fate. To ensure that cell growth is driven only by mechanical interaction, bioprintable alginate–gelatin hydrogels with significantly different viscoelastic properties were utilized in differentiation factor-free culture medium. Alginate–gelatin hydrogels of varying concentrations were developed to provide 3D environments of significantly different mechanical properties, ranging from 1 to 100 kPa, while allowing printability. hiPSC spheroids from two different cell lines were prepared by aggregation (⌀ = 100 µm, n > 1 × 10 4 ), included and cultured in the different hydrogels for 14 days. While spheroids within dense hydrogels exhibited limited growth, irrespective of formulation, porous hydrogels prepared with a liquid–liquid emulsion method displayed significant variations of spheroid morphology and growth as a function of hydrogel mechanical properties. Transversal culture (adjacent spheroids-laden alginate–gelatin hydrogels) clearly confirmed the separate effect of each hydrogel environment on hiPSC spheroid behavior. This study is the first to demonstrate that a mechanically modulated microenvironment induces diverse hiPSC spheroid behavior without the influence of other factors. It allows one to envision the combination of multiple formulations to create a complex object, where the fate of hiPSCs will be independently controlled by their direct microenvironment.
    Keywords human iPSCs ; spheroids ; growth ; stem cells ; hydrogel ; viscoelastic properties ; Technology ; T ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article: Prevalence and molecular epidemiology of

    Perrin-Guyomard, Agnès / Houée, Paméla / Lucas, Pierrick / Felten, Arnaud / Le Devendec, Laetitia / Chauvin, Claire / Kempf, Isabelle

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1254122

    Abstract: Introduction: Within the 2007-2014 programme for the surveillance of antimicrobial resistance (AMR) in livestock in France, : Methods: Antimicrobial susceptibility of commensal : Results and discussion: In 2020, in France, the resistance ... ...

    Abstract Introduction: Within the 2007-2014 programme for the surveillance of antimicrobial resistance (AMR) in livestock in France,
    Methods: Antimicrobial susceptibility of commensal
    Results and discussion: In 2020, in France, the resistance prevalence to colistin in poultry production was 3% in turkeys and 1% in broilers, showing a significant highly positive correlation with a -68% decrease of poultry exposure to colistin since 2014. Only the
    Language English
    Publishing date 2023-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1254122
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  6. Article ; Online: Water-soluble polymers: Emerging contaminants detected, separated and quantified by a novel GPC/MALDI-TOF method.

    Tarring, Eve C / Durance, Isabelle / Harbottle, Michael J / Lucas, Robert / Read, Daniel S / Ward, Benjamin D

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 340, Issue Pt 1, Page(s) 122888

    Abstract: Water-soluble polymers (WSPs) are additives used as thickeners, stabilisers and flocculants in industry and in household products, including personal care products. Given their widespread use, it is likely WSPs enter the environment, particularly through ...

    Abstract Water-soluble polymers (WSPs) are additives used as thickeners, stabilisers and flocculants in industry and in household products, including personal care products. Given their widespread use, it is likely WSPs enter the environment, particularly through wastewaters. This is of concern as there is little ecotoxicological research on their fate and behaviour once in the environment, which means their risk to aquatic life is not understood. The lack of suitable analytical techniques to detect, characterise and quantify WSPs hinders research on the potential impact of these polymers. A novel method has been developed that identifies polymers within a sample and separates them using gel-permeation chromatography (GPC). This is coupled with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS), to quantify the polymer fractions using molecular weight information. This process has been carried out on a range of aqueous media. Polyethylene glycol (PEG) ingredients were successfully separated from non-polymeric material in a commercial shaving gel personal care product (PCP), before being quantified at 1.62 wt%. This method was applied to a spiked wastewater influent sample to demonstrate the extraction and separation of PEG from organic constituents such as dissolved organic matter (DOM). This highlighted the additional challenges of analysing WSPs in the environment, as factors such as sorption and biodegradation affected the total recovery of PEG, with an extraction efficiency of 53%. Overall, this method was applied for the extraction of PEG from a PCP with accurate quantification, before a proof-of-concept extraction from wastewater demonstrated the difficulties associated with WSP analysis in environmental samples. This method provides opportunities to use tandem GPC/MALDI-TOF MS to quantify WSPs in a broad array of environmental samples. Additional studies could include its application to wastewater or freshwater monitoring.
    MeSH term(s) Polymers/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Water ; Wastewater ; Polyethylene Glycols/chemistry ; Cosmetics
    Chemical Substances Polymers ; Water (059QF0KO0R) ; Wastewater ; Polyethylene Glycols (3WJQ0SDW1A) ; Cosmetics
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122888
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  7. Article ; Online: Impact of

    Mourand, Gwénaëlle / Paboeuf, Frédéric / Grippon, Pauline / Lucas, Pierrick / Bougeard, Stéphanie / Denamur, Erick / Kempf, Isabelle

    Veterinary and animal science

    2021  Volume 14, Page(s) 100217

    Abstract: We evaluated the impact of the administration of ... ...

    Abstract We evaluated the impact of the administration of two
    Language English
    Publishing date 2021-11-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2451-943X
    ISSN (online) 2451-943X
    DOI 10.1016/j.vas.2021.100217
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  8. Article: Human Induced Pluripotent Spheroids' Growth Is Driven by Viscoelastic Properties and Macrostructure of 3D Hydrogel Environment.

    Lemarié, Lucas / Dargar, Tanushri / Grosjean, Isabelle / Gache, Vincent / Courtial, Edwin J / Sohier, Jérôme

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 12

    Abstract: Stem cells, particularly human iPSCs, constitute a powerful tool for tissue engineering, notably through spheroid and organoid models. While the sensitivity of stem cells to the viscoelastic properties of their direct microenvironment is well-described, ... ...

    Abstract Stem cells, particularly human iPSCs, constitute a powerful tool for tissue engineering, notably through spheroid and organoid models. While the sensitivity of stem cells to the viscoelastic properties of their direct microenvironment is well-described, stem cell differentiation still relies on biochemical factors. Our aim is to investigate the role of the viscoelastic properties of hiPSC spheroids' direct environment on their fate. To ensure that cell growth is driven only by mechanical interaction, bioprintable alginate-gelatin hydrogels with significantly different viscoelastic properties were utilized in differentiation factor-free culture medium. Alginate-gelatin hydrogels of varying concentrations were developed to provide 3D environments of significantly different mechanical properties, ranging from 1 to 100 kPa, while allowing printability. hiPSC spheroids from two different cell lines were prepared by aggregation (⌀ = 100 µm, n > 1 × 10
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10121418
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  9. Article ; Online: Place de l’IRM pour explorer les pathologies anorectales.

    Haouari, Mohamed Amine / Touloupas, Caroline / Boulay-Coletta, Isabelle / Fathallah, Nadia / Spindler, Lucas / de Parades, Vincent / Zins, Marc

    La Revue du praticien

    2024  Volume 73, Issue 10, Page(s) 1113–1118

    Abstract: PLACE DE L'IRM POUR EXPLORER LES PATHOLOGIES ANORECTALES. L'imagerie par résonance magnétique (IRM) est l'un des examens d'imagerie les plus utiles à l'exploration des pathologies ano rectales. Elle est complémentaire de l'examen clinique et de l'endo ... ...

    Title translation The rôle of MRI in exploration anorectal pathologies.
    Abstract PLACE DE L'IRM POUR EXPLORER LES PATHOLOGIES ANORECTALES. L'imagerie par résonance magnétique (IRM) est l'un des examens d'imagerie les plus utiles à l'exploration des pathologies ano rectales. Elle est complémentaire de l'examen clinique et de l'endo scopie. Elle permet de fournir des données indispensables à une prise en charge optimale du patient par le proctologue, le chirurgien ou l'oncologue en fonction de la nature de l'atteinte anale ou rectale. Il est nécessaire de respecter les différentes indications de cet examen, qui ont été bien définies pour chaque pathologie par les différentes sociétés savantes. Le protocole de l'IRM varie en fonction de la zone explorée et de la pathologie suspectée. C'est pourquoi il est indispensable de fournir au radiologue les informations nécessaires telles que la suspicion diagnostique, les données cliniques, ainsi que les résultats des examens complémentaires déjà réalisés. Les indications les plus fréquentes de l'IRM en proctologie sont les tumeurs anales et rectales. L'IRM permet le bilan initial de l'extension locorégionale de la tumeur ainsi que le suivi oncologique précoce et tardif grâce à l'étude comparative des examens de surveillance par rapport au bilan initial. L'IRM est indispensable pour l'exploration des suppurations anopérinéales complexes, en particulier liées à la maladie de Crohn. Elle permet la réalisation du bilan lésionnel initial ainsi que le contrôle post-drainage. En cas de suspicion de maladie de Verneuil ou de sinus pilonidal infecté, l'IRM participe à l'orientation vers le diagnostic étiologique. La déféco-IRM est une variante particulière de l'IRM pelvienne et périnéale. Elle fait partie du bilan des dysfonctions du plancher pelvien, car elle permet l'étude du comportement des différents organes pelviens au cours des efforts de poussée et de défécation. Les fissures anales et les thromboses hémorroïdaires sont les causes les plus fréquentes de douleurs anales. Leur diagnostic est purement clinique. En cas d'examen proctologique normal, l'IRM sert à chercher une autre cause à ces douleurs.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Affect ; Awards and Prizes ; Suppuration
    Language French
    Publishing date 2024-01-31
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  10. Article ; Online: A Set of Screening Techniques for a Quick Overview of the Neutrophil Function.

    Souza Luz, Isabelle / Takaya, Raquel / Gonzaga Ribeiro, Daiane / Sales Silva, Natanael / Fontes, Lucas / Castro, Mariana S / Fontes, Wagner

    Journal of visualized experiments : JoVE

    2024  , Issue 204

    Abstract: Neutrophils are known as one of the first lines of defense in the innate immune response and can perform many particular cellular functions, such as chemotaxis, reverse migration, phagocytosis, degranulation of cytotoxic enzymes and metabolites, and ... ...

    Abstract Neutrophils are known as one of the first lines of defense in the innate immune response and can perform many particular cellular functions, such as chemotaxis, reverse migration, phagocytosis, degranulation of cytotoxic enzymes and metabolites, and release of DNA as neutrophil extracellular traps (NETs). Neutrophils not only have tightly regulated signaling themselves, but also participate in the regulation of other components of the immune system. As fresh neutrophils are terminally differentiated, short-lived, and highly variable among individuals, it is important to make the most of the collected samples. Researchers often need to perform screening assays to assess an overview of the many neutrophil functions that may be affected by specific conditions under evaluation. A set of tests following a single isolation process of normal density neutrophils was developed to address this need, seeking a balance between speed, comprehensiveness, cost, and accuracy. The results can be used to reason and guide in-depth follow-up studies. This procedure can be carried out in an average time of 4 h and includes the evaluation of cell viability, reactive oxygen species (ROS) production, real-time migration, and phagocytosis of yeast on glass slides, leaving enough cells for more detailed approaches like omics studies. Moreover, the procedure includes a way to easily observe a preliminary suggestion of NETs after fast panoptic staining observed by light microscopy, with a lack of specific markers, albeit enough to indicate if further efforts in that way would be worthwhile. The diversity of functions tested combines common points among tests, reducing the analysis time and expenses. The procedure was named NeutroFun Screen, and although having limitations, it balances the aforementioned factors. Furthermore, the aim of this work is not a definite test set, but rather a guideline that can easily be adjusted to each lab's resources and demands.
    MeSH term(s) Humans ; Neutrophils ; Extracellular Traps ; Phagocytosis ; Cytodiagnosis ; Immunity, Innate
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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