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Article: Changtai granule, a traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions.

Liu, Bin-Guo / Jia, Xin-Ming / Cao, Ying-Ying / Chen, Shang-Hong / Gao, Ping-Hui / Wang, Yan / Jiang, Yuan-Ying / Cao, Yong-Bin

Journal of ethnopharmacology

2008 Volume 115, Issue 1, Page(s) 1–8

Abstract: The study was aimed to investigate the effects and mechanism of action of Changtai granule (CT ...

Abstract	The study was aimed to investigate the effects and mechanism of action of Changtai granule (CT), a traditional compound Chinese medicinal formula, in rodent 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis. Rats with TNBS/ethanol-induced colitis were used. The colonic wet weight, myeloperoxidase (MPO) activity, macroscopic and histological colon injury was observed. Inflammation cytokines were determined by ELISA methods and semi-quantitative RT-PCR. When dosed orally once daily, CT markedly attenuated TNBS-induced colitis. CT significantly attenuated colonic wet weight, macroscopic and histological colon injury. CT decreased mucosal mRNA levels for several inflammatory mediators: inducible nitric oxide synthase, cyclooxygenase 2, and macrophage inflammatory protein 2. CT also decreased mucosal mRNA and protein levels of T effectors cytokines: tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). Systemic levels of these cytokines were also dramatically attenuated. CD3/CD28-mediated costimulation of T helper 1 effector cytokines release in lamina propria mononuclear cells (LPMC) was markedly inhibited by CT ex vivo and in vitro. Also CT prevented cytokines production by nuclear factor-kappaB (NF-kappaB). The potential anti-inflammatory and immunomodulatory effect of CT in TNBS colitis suggests that CT may be an effective treatment approach for inflammatory bowel disease.
MeSH term(s)	Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/immunology ; Enzyme-Linked Immunosorbent Assay ; Euphorbia/chemistry ; Haptens ; Inflammation/drug therapy ; Inflammation/etiology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Male ; Medicine, Chinese Traditional ; Phellodendron/chemistry ; Plant Preparations/pharmacology ; Polygonum/chemistry ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; Sanguisorba/chemistry ; Trinitrobenzenesulfonic Acid
Chemical Substances	Haptens ; Plant Preparations ; RNA, Messenger ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4)
Language	English
Publishing date	2008-01-04
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2007.08.045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Changtai granules, a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats.

Cao, Yong-Bing / Zhang, Jun-Dong / Diao, Ya-Ying / Yan, Lan / Wang, De-Jun / Jia, Xin-Ming / Gao, Ping-Hui / Cheng, Ming-He / Xu, Zheng / Wang, Yan / Jiang, Yuan-Ying

World journal of gastroenterology

2005 Volume 11, Issue 23, Page(s) 3539–3543

Abstract: Aim: To study the effects of Changtai granules (CTG), a traditional compound Chinese medicine ...

Abstract	Aim: To study the effects of Changtai granules (CTG), a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats. Methods: Healthy adult Sprague-Dawley (SD) rats of both sexes, weighing 250-300 g, were employed in the present study. The rat colitis models were induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) enemas at a concentration of 100 mg/kg in 50% ethanol. The experimental animals were randomly divided into dexamethasone (DX) treatment, CTG treatment, and model control groups, which were intracolicly treated daily with DX (0.2 mg/kg), CTG at doses of 2.9, 5.7 and 11.4 g crude drug/kg, and the equal amount of saline respectively from 6 h following induction of the colitis in rats inflicted with TNBS to the end of study. A normal control group of rats treated without TNBS but saline enema was also included in the study. After 3 wk of treatment, the animals were assessed for colonal inflammatory and ulcerative responses with respect to mortality, frequency of diarrhea, histology and myeloperoxidase activity (MPO). Results: The therapeutic effect of CTG on ulcerative colitis (UC) was better than DX. CTG effectively inhibited the activity of granulocytes, macrophages and monocytes in a dose-dependent manner. Also it reduced MPO and formation of inflammation in colonic mucosal tissue. Furthermore, administration of CTG significantly prevented body mass loss and death, and decreased frequency of diarrhea in UC rats, when compared with the model control group rats. Conclusion: CTG would prove to be an ideal drug for chronic UC, and is warranted to be studied further.
MeSH term(s)	Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/parasitology ; Diarrhea/etiology ; Inflammation ; Medicine, Chinese Traditional ; Rats ; Rats, Sprague-Dawley ; Trinitrobenzenesulfonic Acid/toxicity
Chemical Substances	Trinitrobenzenesulfonic Acid (8T3HQG2ZC4)
Language	English
Publishing date	2005-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v11.i23.3539
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Article: Changtai granule, a traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions

Liu, B.G / Jia, X.M / Cao, Y.Y / Chen, S.H / Gao, P.H / Wang, Y / Jiang, Y.Y / Cao, Y.B

Journal of ethnopharmacology. 2008 Jan. 4, v. 115, issue 1

2008

Abstract: The study was aimed to investigate the effects and mechanism of action of Changtai granule (CT ...

Abstract	The study was aimed to investigate the effects and mechanism of action of Changtai granule (CT), a traditional compound Chinese medicinal formula, in rodent 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis. Rats with TNBS/ethanol-induced colitis were used. The colonic wet weight, myeloperoxidase (MPO) activity, macroscopic and histological colon injury was observed. Inflammation cytokines were determined by ELISA methods and semi-quantitative RT-PCR. When dosed orally once daily, CT markedly attenuated TNBS-induced colitis. CT significantly attenuated colonic wet weight, macroscopic and histological colon injury. CT decreased mucosal mRNA levels for several inflammatory mediators: inducible nitric oxide synthase, cyclooxygenase 2, and macrophage inflammatory protein 2. CT also decreased mucosal mRNA and protein levels of T effectors cytokines: tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). Systemic levels of these cytokines were also dramatically attenuated. CD3/CD28-mediated costimulation of T helper 1 effector cytokines release in lamina propria mononuclear cells (LPMC) was markedly inhibited by CT ex vivo and in vitro. Also CT prevented cytokines production by nuclear factor-kappaB (NF-kappaB). The potential anti-inflammatory and immunomodulatory effect of CT in TNBS colitis suggests that CT may be an effective treatment approach for inflammatory bowel disease.
Keywords	Oriental traditional medicine ; colitis ; human diseases ; rats ; in vivo studies ; in vitro studies ; inflammation ; tissue weight ; intestinal mucosa ; messenger RNA ; nitric oxide synthase ; prostaglandin synthase ; tumor necrosis factor-alpha ; interleukin-2 ; interferons ; cytokines ; transcription factors ; immune response ; animal disease models ; colon ; oral administration ; surface antigens ; immunomodulators ; inflammatory bowel disease ; interferon-gamma
Language	English
Dates of publication	2008-0104
Size	p. 1-8.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2007.08.045
Database	NAL-Catalogue (AGRICOLA)

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Article: Treatment for Triple-Negative Breast Cancer: An Umbrella Review of Meta-Analyses.

Yin, Jianyun / Zhu, Changtai / Wang, Gaofeng / Gu, Jianwei

International journal of general medicine

2022 Volume 15, Page(s) 5901–5914

Abstract: Purpose: In recent years, many meta-analyses of triple-negative breast cancer (TNBC) treatment have been published; however, these studies still lack systematic summary. Therefore, the aim of this study is to summarize and evaluate the evidence level ... ...

Abstract	Purpose: In recent years, many meta-analyses of triple-negative breast cancer (TNBC) treatment have been published; however, these studies still lack systematic summary. Therefore, the aim of this study is to summarize and evaluate the evidence level and efficacy of treatment for TNBC. Materials and methods: Retrospective and prospective studies on treatment of TNBC were searched in the PubMed, Embase, and Cochrane Library databases. The literature search deadline was June 30, 2021. Two investigators independently screened the literature and extracted the data. In addition, the joint World Health Organization-United Nations Food and Agriculture Organization expert consultation was used to evaluate the validity of the evidence. Results: A total of 28 meta-analyses were included in this study. The treatment interventions for TNBC mainly included surgery, chemotherapy (CT), radiotherapy, molecular targeted therapy, immunotherapy, zoledronic acid, and gonadotropin-releasing hormone (GnRH) analog. Platinum improves the pathological complete response (PCR) rate of patients treated with neoadjuvant chemotherapy (NACT), the objective remission rate (ORR) and overall survival (OS) in patients with metastatic triple-negative breast cancer. Capecitabine improves disease-free survival (DFS) and OS in patients treated with adjuvant CT. Bevacizumab was added to NACT to improve the PCR rate in patients. Immunotherapy improves the PCR rate in patients treated with NACT. The improvement in PCR rate in patients with high Ki67 expression treated with neoadjuvant therapy is highly suggestive. Other interventions had suggestive or weak evidence. Conclusion: Among the strategies for treating TNBC, platinum, bevacizumab, and immunotherapy can lead to better PCR rates as part of a NACT regimen. Capecitabine as adjuvant CT and platinum in the treatment of metastatic TNBC can benefit patients' survival. However, the effectiveness of other interventions for TNBC is not yet clear. Further research is needed in the future to obtain more reliable clinical evidence.
Language	English
Publishing date	2022-06-30
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S370351
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Article ; Online: Association between serum albumin levels and disease severity in adult patients with dengue

Changtai Wang / Huiqin Yang / Jielan Xu / Jian Wang / Lingzhai Zhao / Wenxin Hong / Fuchun Zhang

Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 5, Pp 204-

A 7-year retrospective cohort study in mainland China

2023 Volume 212

Abstract: Objective: To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China. Methods: This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with ... ...

Abstract	Objective: To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China. Methods: This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in mainland China. Serum albumin levels were estimated and compared between patients with severe dengue and non-severe dengue. Additionally, the association between serum albumin levels and severe dengue was evaluated using a generalized linear model [relative risks (RR)]. Multivariate logistic regression analysis was performed to identify the potential predictors of severe dengue. Results: Overall, 1568 patients were included in this study. Of these patients, 34 (2.17%) developed severe dengue. The median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue (33 g/L vs. 37 g/L, P<0.001). After adjustment for age, sex, and comorbidities, hypoalbuminemia (RR 4.877, 95% CI 2.193-11.461, P<0.001) was found to be a predictor of severe dengue. Serum albumin levels (OR 1.303, 95% CI 1.161-1.462, P<0.001)] and age (OR 1.038, 95% CI 1.017-1.061, P<0.001) were significant risk factors for severe dengue. The area under the curve for serum albumin levels to distinguish severe dengue was 0.787. Conclusions: Lower serum albumin levels were significantly associated with disease severity in adult patients with dengue. Hypoalbuminemia on admission resulted in at least a four-fold increased risk of severe dengue.
Keywords	dengue ; severe dengue ; serum albumin ; hypoalbuminemia ; prediction ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	610 ; 616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anisotropic luminescence and third-order electric susceptibility of Mg-doped gallium oxide under the half-bandgap edge.

Zhang, Naiji / Kislyakov, Ivan M / Xia, Changtai / Qi, Hongji / Wang, Jun / Mohamed, H F

Optics express

2021 Volume 29, Issue 12, Page(s) 18587–18600

Abstract: Strong anisotropy of photoluminescence of a (100)-cut β- ... ...

Abstract	Strong anisotropy of photoluminescence of a (100)-cut β-Ga
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.427021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A case of COVID-19 with long duration of viral shedding.

Wang, Changtai / Xu, Mengyuan / Zhang, Zhenhua

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2020 Volume 54, Issue 1, Page(s) 152–153

MeSH term(s)	Antibodies, Viral/blood ; COVID-19/virology ; Female ; Humans ; Middle Aged ; Nasopharynx/virology ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Time Factors ; Virus Shedding
Chemical Substances	Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-23
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2020.05.008
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Article ; Online: Prevalence, Characteristics, and Outcomes Associated with Acute Kidney Injury among Adult Patients with Severe Dengue in Mainland China.

Wang, Changtai / Hong, Wenxin / Ou, Zhiyue / Yang, Huiqin / Zhao, Lingzhai / Zhang, Zhenhua / Zhang, Fuchun

The American journal of tropical medicine and hygiene

2023 Volume 109, Issue 2, Page(s) 404–412

Abstract: Acute kidney injury (AKI) can occur in adult patients with severe dengue (SD) and have serious clinical outcomes. This study aimed to determine the prevalence, characteristics, risk factors, and clinical outcomes of AKI in adult patients with SD; the ... ...

Abstract	Acute kidney injury (AKI) can occur in adult patients with severe dengue (SD) and have serious clinical outcomes. This study aimed to determine the prevalence, characteristics, risk factors, and clinical outcomes of AKI in adult patients with SD; the correlation of dengue virus (DENV) serological and virological profiles with AKI; and the clinical features of patients with severe AKI who received renal replacement treatment (RRT). This multicenter study was conducted in Guangdong Province, China, between January 2013 and November 2019. A total of 242 patients were evaluated, of which 85 (35.1%) developed AKI and 32 (13.2%) developed severe AKI (stage 3). Patients with AKI had a higher fatality rate (22.4% versus 5.7%; P < 0.001) and longer length of hospital stay (median: 13 versus 9 days; P < 0.001). Independent risk factors for AKI were hypertension (odds ratio [OR]: 2.03; 95% CI: 1.10-3.76), use of nephrotoxic drugs (OR: 1.90; 95% CI: 1.00-3.60), respiratory distress (OR: 4.15; 95% CI: 1.787-9.632), high international normalized ratio (INR) levels (OR: 6.44; 95% CI: 1.89-21.95), and hematuria (OR: 2.12; 95% CI: 1.14-3.95). There was no significant association between DENV serological and virological profiles and the presence or absence of AKI. Among patients with severe AKI, those who received RRT had a longer length of hospital stay and similar fatality rate. Hence, adult patients with SD should be closely monitored for the development of AKI to enable timely and appropriate therapy.
MeSH term(s)	Humans ; Adult ; Severe Dengue/complications ; Prevalence ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Kidney ; China/epidemiology ; Risk Factors ; Retrospective Studies ; Intensive Care Units
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0803
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Article: A case of COVID-19 with long duration of viral shedding

Wang, Changtai / Xu, Mengyuan / Zhang, Zhenhua

J. microbiol. immunol. infect

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #342739
Database	COVID19

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Article ; Online: The Universal Super Cation-Conductivity in Multiple-cation Mixed Chloride Solid-State Electrolytes.

Li, Xiaona / Xu, Yang / Zhao, Changtai / Wu, Duojie / Wang, Limin / Zheng, Matthew / Han, Xu / Zhang, Simeng / Yue, Junyi / Xiao, Biwei / Xiao, Wei / Wang, Ligen / Mei, Tao / Gu, Meng / Liang, Jianwen / Sun, Xueliang

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 48, Page(s) e202306433

Abstract: As exciting candidates for next-generation energy storage, all-solid-state lithium batteries (ASSLBs) are highly dependent on advanced solid-state electrolytes (SSEs). Here, using cost-effective ... ...

Abstract	As exciting candidates for next-generation energy storage, all-solid-state lithium batteries (ASSLBs) are highly dependent on advanced solid-state electrolytes (SSEs). Here, using cost-effective LaCl
Language	English
Publishing date	2023-10-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202306433
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