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Article ; Online: Retraction notice to "Corrigendum to 'LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway'" [Biomed. Pharmacother. 111 (2019) 1508-1508].

Zhang, Butian / Yu, Lili / Han, Ning / Hu, Zhenzhen / Wang, Shuang / Ding, Lei / Jiang, Jinlan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116327

Language	English
Publishing date	2024-03-05
Publishing country	France
Document type	Journal Article ; Retraction of Publication
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116327
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Article ; Online: Retraction notice to "LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway" [Biomed. Pharmacother. 107 (2018) 270-282].

Zhang, Butian / Yu, Lili / Han, Ning / Hu, Zhenzhen / Wang, Shuang / Ding, Lei / Jiang, Jinlan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116325

Language	English
Publishing date	2024-03-04
Publishing country	France
Document type	Journal Article ; Retraction of Publication
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116325
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Ud II Zs.198: Show issues

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Article ; Online: Retraction notice to "Corrigendum to LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway" [Biomed. Pharmacother. 133 (2020) 110893].

Zhang, Butian / Yu, Lili / Han, Ning / Hu, Zhenzhen / Wang, Shuang / Ding, Lei / Jiang, Jinlan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116326

Language	English
Publishing date	2024-03-04
Publishing country	France
Document type	Journal Article ; Retraction of Publication
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ud II Zs.198: Show issues

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Article ; Online: Enhancer RNA: What we know and what we can achieve.

Han, Zhenzhen / Li, Wei

Cell proliferation

2022 Volume 55, Issue 4, Page(s) e13202

Abstract: Enhancers are important cis-acting elements that can regulate gene transcription and cell fate alongside promoters. In fact, many human cancers and diseases are associated with the malfunction of enhancers. Recent studies have shown that enhancers can ... ...

Abstract	Enhancers are important cis-acting elements that can regulate gene transcription and cell fate alongside promoters. In fact, many human cancers and diseases are associated with the malfunction of enhancers. Recent studies have shown that enhancers can produce enhancer RNAs (eRNAs) by RNA polymerase II. In this review, we discuss eRNA production, characteristics, functions and mechanics. eRNAs can determine chromatin accessibility, histone modification and gene expression by constructing a 'chromatin loop', thereby bringing enhancers to their target gene. eRNA can also be involved in the phase separation with enhancers and other proteins. eRNAs are abundant, and importantly, tissue-specific in tumours, various diseases and stem cells; thus, eRNAs can be a potential target for disease diagnosis and treatment. As eRNA is produced from the active transcription of enhancers and is involved in the regulation of cell fate, its manipulation will influence cell function, and therefore, it can be a new target for biological therapy.
MeSH term(s)	Chromatin/genetics ; Enhancer Elements, Genetic/genetics ; Gene Expression Regulation ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Promoter Regions, Genetic/genetics ; RNA/genetics ; Transcription, Genetic/genetics
Chemical Substances	Chromatin ; RNA (63231-63-0)
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13202
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Zs.A 532: Show issues

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Article ; Online: Clinicopathologic Features and Frozen Diagnostic Pitfalls of Bronchiolar Adenoma/Ciliated Muconodular Papillary Tumors (BA/CMPTs).

Ding, Bowen / Shang, Zhanxian / Xiang, Zhenzhen / Han, Yuchen

The American journal of surgical pathology

2023 Volume 47, Issue 4, Page(s) 431–439

Abstract: To describe the histologic features of bronchiolar adenoma/ciliated muconodular papillary tumors (BA/CMPTs) and analyze the pitfalls in diagnosis from frozen sections. A total of 208 frozen and permanent sections of BA/CMPTs from Shanghai Chest Hospital ... ...

Abstract	To describe the histologic features of bronchiolar adenoma/ciliated muconodular papillary tumors (BA/CMPTs) and analyze the pitfalls in diagnosis from frozen sections. A total of 208 frozen and permanent sections of BA/CMPTs from Shanghai Chest Hospital from July 2018 to July 2021 were retrospectively analyzed. The median age of BA/CMPT patients was 65 years (15 to 79 y), and women accounted for 61.62% (122/198). The median size of BA/CMPTs was 0.6 cm (range 0.2 to 2 cm), of which 88.94% were small (≤1 cm, 185/208). In terms of location, the right lower lobe accounted for 44.23% (92/208), and the left lower lobe accounted for 33.65% (70/208). In 10 patients with 2 independent BA/CMPTs, 5 lesions were located in the left lower lobe and 4 in the right lower lobe. A total of 86.06% of the CT images of BA/CMPT showed solid/subsolid nodules (179/208). Among 208 tumors, 68.75% were distal type (143/208), and 31.25% were proximal type (65/208). The qualitative error rate of frozen sections was 21.33% (32/150), of which the distal type accounted for 75% (24/32); most of them were misdiagnosed as invasive adenocarcinoma during frozen diagnosis. The frozen diagnosis of BA/CMPTs might result in misdiagnosis as invasive adenocarcinoma. A careful search for characteristics of BA/CMPT, such as bilayer epithelial cells with basal cells and a lack of cellular atypia and invasive growth patterns, may be helpful for frozen diagnosis.
MeSH term(s)	Retrospective Studies ; Humans ; Male ; Female ; Adolescent ; Adult ; Middle Aged ; Aged ; Adenocarcinoma, Bronchiolo-Alveolar/pathology ; Lung Neoplasms/pathology
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/PAS.0000000000002016
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Zs.A 1356: Show issues

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Article ; Online: Optimal rehabilitation strategies for early postacute stroke recovery: An ongoing inquiry.

Tong, Yanna / Ding, Yuchuan / Han, Zhenzhen / Duan, Honglian / Geng, Xiaokun

Brain circulation

2023 Volume 9, Issue 4, Page(s) 201–204

Abstract: Early rehabilitation is crucial in reducing stroke-related disability, but the optimal training model remains unclear. We conducted a trial comparing different initiation timings and intensities of mobilization strategies after stroke. Results showed ... ...

Abstract	Early rehabilitation is crucial in reducing stroke-related disability, but the optimal training model remains unclear. We conducted a trial comparing different initiation timings and intensities of mobilization strategies after stroke. Results showed that early intensive mobilization had favorable outcomes at 3 months post-stroke, while very early intensive mobilization had poorer chances of favorable outcomes. Our investigation into brain injury mechanisms induced by very early exercise within 24 hours of stroke onset aligned with guidelines advising against high-dose very early mobilization. Additionally, we are studying the effects of various exercise intensities and frequencies on early stroke rehabilitation. Integrated rehabilitation models, such as combining remote ischemic conditioning (RIC) with exercise (RICE), hold promise. Our study found RICE to be safe and feasible for early rehabilitation of acute ischemic stroke patients, and further research is underway to determine its efficacy in a larger sample size. Despite extensive research, identifying the most effective early recovery strategies remains a complex challenge, necessitating ongoing work in the field of early rehabilitation after stroke.
Language	English
Publishing date	2023-11-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2950273-1
ISSN	2455-4626 ; 2394-8108
ISSN (online)	2455-4626
ISSN	2394-8108
DOI	10.4103/bc.bc_33_23
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Article ; Online: Application of CT functional imaging in the assessment of chemotherapy efficacy in lung cancer.

Hu, Lili / Pan, Yuanwei / Wang, Bo / Han, Zhenzhen / Gao, Jianbo

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–16

Abstract: In this research, we aim to investigate the feasibility of a one-stop CT energy spectrum perfusion imaging technique for chemotherapy efficacy assessment of lung cancer patients by obtaining both functional imaging parameters of energy spectrum and ... ...

Abstract	In this research, we aim to investigate the feasibility of a one-stop CT energy spectrum perfusion imaging technique for chemotherapy efficacy assessment of lung cancer patients by obtaining both functional imaging parameters of energy spectrum and perfusion in one scan. From November 2018 to February 2020, a group of 23 patients with pathologically confirmed lung cancer were chosen to undergo CT energy spectrum scans both before and after treatment. The post-treatment CT perfusion data was acquired one week after the second conventional chemotherapy session. Out of the 23 patients, 15 were in the chemotherapy effective group and the remaining 8 were in the ineffective group. The reason for this group was according to recist criteria. Arterial phase iodine concentration (icap) and intravenous phase iodine concentration (icpp) of the lesions were measured, and standardized iodine base values (nic) were calculated. The maximum diameter of the tumor before and after treatment was compared to the perfusion parameters and energy spectrum parameters before and after chemotherapy in the effective group and the invalid group was compared by two tests that p<0.05. The differences between the maximum diameter of the tumor before and after chemotherapy. 2 of the 15 patients in the effective group had liquefied necrotic areas in their lesions. One-stop ct energy-spectrum perfusion imaging can show the disease progression from a functional perspective and assess the efficacy early according to the changes in perfusion parameters and energy-spectrum parameters after lung cancer treatment.
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2193063
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Se 1012: Show issues

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Article ; Online: Rapid, Highly-Efficient and Selective Removal of Anionic and Cationic Dyes from Wastewater Using Hollow Polyelectrolyte Microcapsules.

Zhao, Zhiqi / Zhou, Hongbing / Han, Xu / Han, Lun / Xu, Zhenzhen / Wang, Peng

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 7

Abstract: Herein, poly (allylamine hydrochloride) (PAH)/ poly (styrene sulfonic acid) sodium salt (PSS) microcapsules of (PAH/PSS) ...

Abstract	Herein, poly (allylamine hydrochloride) (PAH)/ poly (styrene sulfonic acid) sodium salt (PSS) microcapsules of (PAH/PSS)
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28073010
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Article ; Online: The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice.

Duan, Zhenzhen / Shi, Lei / He, Zhen Ning Tony / Kuang, Chunxiang / Han, Tianxiong / Yang, Qing

American journal of Alzheimer's disease and other dementias

2024 Volume 38, Page(s) 15333175231214861

Abstract: Alzheimer's disease (AD) is an inflammatory associated disease, in which dysregulated kynurenine pathway (KP) plays a key role. Through KP, L-tryptophan is catabolized into neurotoxic and neuroprotective metabolites. The overactivation of indolamine 2,3- ... ...

Abstract	Alzheimer's disease (AD) is an inflammatory associated disease, in which dysregulated kynurenine pathway (KP) plays a key role. Through KP, L-tryptophan is catabolized into neurotoxic and neuroprotective metabolites. The overactivation of indolamine 2,3-dioxygenase1 (IDO1), the first rate-limiting enzyme of KP, and the abnormal accumulation of KP metabolites have been noted in AD, and blocking IDO1 has been suggested as a therapeutic strategy. However, the expression patterns of KP enzymes in AD, and whether these enzymes are related to AD pathogenesis, have not been fully studied. Herein, we examined the expression patterns of inflammatory cytokines, neurotrophic factors and KP enzymes, and the activity of IDO1 and IDO1 effector pathway AhR (aryl hydrocarbon receptor) in AD mice. We studied the effects of IDO1 inhibitors on Aβ-related neuroinflammation in rat primary neurons, mouse hippocampal neuronal cells, and APP/PS1 mice. The results further demonstrated the importance of IDO1-catalyzed KP in neuroinflammation in Alzheimer's disease.
MeSH term(s)	Mice ; Rats ; Animals ; Alzheimer Disease/drug therapy ; Neuroinflammatory Diseases ; Tryptophan/metabolism ; Kynurenine/metabolism ; Neurons/metabolism
Chemical Substances	Tryptophan (8DUH1N11BX) ; Kynurenine (343-65-7)
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/15333175231214861
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Zs.A 3299: Show issues

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Article: Garlic Origin Traceability and Identification Based on Fusion of Multi-Source Heterogeneous Spectral Information.

Han, Hao / Sha, Ruyi / Dai, Jing / Wang, Zhenzhen / Mao, Jianwei / Cai, Min

Foods (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: The chemical composition and nutritional content of garlic are greatly impacted by its production location, leading to distinct flavor profiles and functional properties among garlic varieties from diverse origins. Consequently, these variations ... ...

Abstract	The chemical composition and nutritional content of garlic are greatly impacted by its production location, leading to distinct flavor profiles and functional properties among garlic varieties from diverse origins. Consequently, these variations determine the preference and acceptance among diverse consumer groups. In this study, purple-skinned garlic samples were collected from five regions in China: Yunnan, Shandong, Henan, Anhui, and Jiangsu Provinces. Mid-infrared spectroscopy and ultraviolet spectroscopy were utilized to analyze the components of garlic cells. Three preprocessing methods, including Multiple Scattering Correction (MSC), Savitzky-Golay Smoothing (SG Smoothing), and Standard Normalized Variate (SNV), were applied to reduce the background noise of spectroscopy data. Following variable feature extraction by Genetic Algorithm (GA), a variety of machine learning algorithms, including XGboost, Support Vector Classification (SVC), Random Forest (RF), and Artificial Neural Network (ANN), were used according to the fusion of spectral data to obtain the best processing results. The results showed that the best-performing model for ultraviolet spectroscopy data was SNV-GA-ANN, with an accuracy of 99.73%. The best-performing model for mid-infrared spectroscopy data was SNV-GA-RF, with an accuracy of 97.34%. After the fusion of ultraviolet and mid-infrared spectroscopy data, the SNV-GA-SVC, SNV-GA-RF, SNV-GA-ANN, and SNV-GA-XGboost models achieved 100% accuracy in both training and test sets. Although there were some differences in the accuracy of the four models under different preprocessing methods, the fusion of ultraviolet and mid-infrared spectroscopy data yielded the best outcomes, with an accuracy of 100%. Overall, the combination of ultraviolet and mid-infrared spectroscopy data fusion and chemometrics established in this study provides a theoretical foundation for identifying the origin of garlic, as well as that of other agricultural products.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13071016
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