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Article: [Foreign Medicine "Angdi Moniu" in Qing Dynasty Court].

Wang, L / Xian, Y S / Zhang, Z L / Li, Y Y

Zhonghua yi shi za zhi (Beijing, China : 1980)

2024 Volume 54, Issue 1, Page(s) 23–28

Abstract: ... metal and appears frequently in the archives of the Qing Dynasty as a foreign medicine.It is stated ...

Abstract	There is a kind of historical relics called "Angdi moniu" in the Palace Museum, which looks like metal and appears frequently in the archives of the Qing Dynasty as a foreign medicine.It is stated that it can treat sores and pus in the
MeSH term(s)	Antimony ; Museums ; Internationality ; Medicine ; China ; Medicine, Chinese Traditional
Chemical Substances	Antimony (9IT35J3UV3)
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20230614-00057
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Article: Research on Nursing Intervention of Qing Dai Cream Walking Jar on Pruritic Discomfort in Patients with Common Psoriasis.

Chen, Hui / Zhang, Liping / Tang, Rui / Liu, Fang / Li, Xiaoping

Alternative therapies in health and medicine

2024

Abstract: Introduction: Qing Dai cream is a Chinese medicine that helps relieve the symptoms of psoriasis ... and comfortableness of Qing Dai cream walking jar as a nursing intervention for patients ... while the subjects in the observation group were joint Qing Dai cream walking jar on this basis. The quality of life ...

Abstract	Introduction: Qing Dai cream is a Chinese medicine that helps relieve the symptoms of psoriasis vulgaris. However, its mechanism hasn't been illustrated well. Objective: To evaluate the effectiveness and comfortableness of Qing Dai cream walking jar as a nursing intervention for patients with psoriasis vulgaris. Methods: Seventy-six patients with vulgar psoriasis admitted to our hospital from February 2020 to February 2021 who met the criteria according to the including and exclusion criteria were screened as this study's subjects. According to the randomized number and double-blind principle, all of them were separated into 2 groups, the subjects in the control group were provided with conventional care, while the subjects in the observation group were joint Qing Dai cream walking jar on this basis. The quality of life and the degree of skin lesions of the patients after the intervention were comprehensively evaluated compared and observed. Results: Compared to the control group, the psoriasis lesion area and severity index (PASI) score after the intervention was remarkably lower in the observation group (P < .05) while the symptom scores, itching degree, itching frequency, duration, lesion area, sleep condition, and self-conscious condition degrees were significantly lower in the observation group (P < .05). The observed group showed a significant effect, effective, and the overall effective rate of 57.89% (22/38), 36.84%, and 94.74% were all significantly more than those of the control group after intervention (P < .05). After the intervention, the scores of dermatological disease quality of life index (DLQI), the subjective symptoms, daily life, work and study, and interpersonal relationships in the observation group were all significantly lower than those in the control group, P < .05. In the intervention, the satisfaction, total satisfaction of 65.79% (25/38), and 97.37% were statistically significantly higher than that of the control group, P < .05. Conclusion: The Qing Dai cream walking jar is effective in improving patients' clinical symptoms, relieving their pruritus discomfort, and promoting the repair of skin lesions, to improve their quality of life and satisfaction.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.

Li, Tian / Mao, Na / Xie, Zihao / Wang, Jianing / Jin, Fuyu / Li, Yaqian / Liu, Shupeng / Cai, Wenchen / Gao, Xuemin / Wei, Zhongqiu / Yang, Fang / Xu, Hong / Liu, Heliang / Zhang, Haibo / Xu, Dingjie

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155616

Abstract: ... to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key ...

Abstract	Background: Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate. Objective: The study aims to elucidate the therapeutic role and mechanisms of the Yang-Yin-Qing-Fei Decoction (YYQFD) and its key component, paeoniflorin, in silicosis using a murine model. Methods: Silicotic mice were treated with YYQFD, pirfenidone (PFD), or paeoniflorin. RAW264.7 cells and mouse lung fibroblasts (MLF) were stimulated with silica, matrix metalloproteinase-12 (MMP-12), or TGF-β1, followed by treatment with paeoniflorin, PFD, or relevant inhibitors. YYQFD constituents were characterized using High-Performance Liquid Chromatography (HPLC). Lung fibrosis severity was assessed via histopathological examination, micro-CT imaging, lung functions, and Western blot analysis. Transcriptome sequencing and bioinformatics analysis were employed to delineate the gene expression profile and target genes modulated by YYQFD in silicosis. Results: Treatment with YYQFD ameliorated silica-induced lung fibrosis. Transcriptome sequencing identified MMP-12 as a potential common target of YYQFD and PFD. Additionally, a potential pro-inflammatory role of MMP-12, regulated by silica-induced TLR4 signaling pathways, was revealed. Paeoniflorin, one of the most distinctive compounds in YYQFD, attenuated silica-induced MMP-12 increase and its derived inflammatory factors in macrophages through a direct binding effect. Notably, paeoniflorin treatment exerted anti-fibrotic effects by inhibiting MMP-12-derived inflammatory factors and TGF-β1-induced myofibroblast differentiation in silica-exposed mice. Conclusions: This study underscores paeoniflorin as one of the most principal bioactive compounds in YYQFD, highlighting its capacity to attenuate lung inflammation driven by macrophage-derived MMP-12 and reduce lung fibrosis both in vivo and in vitro.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155616
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Article ; Online: Corrigendum to "Qing Chang Hua Shi granule ameliorate inflammation in experimental rats and cell model of ulcerative colitis through MEK/ERK signaling pathway" [Biomed. Pharmacother. 116 (2019) 108967].

Zhu, Lei / Dai, Lu-Ming / Shen, Hong / Gu, Pei-Qing / Zheng, Kai / Liu, Ya-Jun / Zhang, Lu / Cheng, Jia-Fei

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114854

Language	English
Publishing date	2023-05-12
Publishing country	France
Document type	Published Erratum
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114854
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Article: Toxicological evaluation of aqueous extract of the traditional Chinese formula Qing Hao Gan Cao.

Li, Yongchun / Zhang, Hui / Chen, Shanshan / Zhao, Liutao / Wu, Jie / Li, Pan / Wu, Guanlian / Wang, Qing / Wu, Chunli / Xu, Hongde

Toxicology research

2021 Volume 10, Issue 2, Page(s) 183–191

Abstract: Qing Hao Gan Cao ...

Abstract	Qing Hao Gan Cao
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2684701-2
ISSN	2045-4538 ; 2045-452X
ISSN (online)	2045-4538
ISSN	2045-452X
DOI	10.1093/toxres/tfaa103
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Article: [Overview on diagnosis and treatment of oral diseases in the Qing Royal Court].

Zhou, J / Zhang, J Q / Wang, J B / Wang, S L

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

2022 Volume 57, Issue 4, Page(s) 403–409

Abstract: ... diseases in royal court of the Qing Dynasty was over 200 years. The departmental system of medical care ... in the Qing Royal Court was inherited from former Ming Dynasty. Although the departments in the system changed ... involved various ranks in the court, showing that oral diseases were common in the Qing Royal Court ...

Abstract	The remained documents and archives show that the history of diagnosis and treatment of oral diseases in royal court of the Qing Dynasty was over 200 years. The departmental system of medical care in the Qing Royal Court was inherited from former Ming Dynasty. Although the departments in the system changed over reigns, the Department of Dentistry exist all the time. In a set of historical records of 38 medical cases opened to the public, the documented symptoms and diseases, in the sense of modern medical science, included periodontitis, oral mucosal diseases, dental caries, parotiditis, etc., and the patients involved various ranks in the court, showing that oral diseases were common in the Qing Royal Court. The royal doctors ranked variedly and the medication they used was diverse. Medical fuming or steaming and medical heating were some distinctive methods among the treatments. In 1600s, the western modern medical science started to be introduced into China. In the reign of Kangxi Emperor (1700s), many western doctors were employed by the royal court and they engaged in the treatment of oral diseases. The late Qing Dynasty appeared the second peak that western doctors came into China. In 1898, Dr. Jingrong Chen, a dentist who possessed knowledge of modern dentistry in Beijing city, set up a dental clinic in the royal court and gave treatment to patients in the royal members and high-ranking officials.
MeSH term(s)	Beijing ; China ; Dental Caries ; Humans ; Medicine, Chinese Traditional
Language	Chinese
Publishing date	2022-04-02
Publishing country	China
Document type	Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
DOI	10.3760/cma.j.cn112144-20220130-00039
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Zs.B 2507: Show issues

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Article ; Online: Important Explorations on Surface Corrosion of the Copper Coins Sourced from the Qing Dynasty.

Yin, Xue / Yang, Kang / Zhang, Honglei / Xiong, Bangying / Duan, Mengcheng / Wang, Minghao / Hao, Yongxing

Scanning

2022 Volume 2022, Page(s) 1647217

Abstract: ... sourced from the Qing Dynasty. In this study, micromorphology and the structural feature of the copper ...

Abstract	Surface corrosion is considered to be a main reason for the surface pattern damages of copper coin sourced from the Qing Dynasty. In this study, micromorphology and the structural feature of the copper coins were analyzed to determine their corrosion mechanisms. The results revealed that the etching rates successively reduced with decreasing corrosion thickness, possibly because of unique macrofeatures of the surface pattern. Variable phases, bonding morphologies, and three-/two-dimensional structures of Ql-TB (Qianlong-Tongbao) coins were visibly different at the microscale, which induced disproportional stresses and microscopic cracks, facilitating an unhindered entry of oxide and hydroxyl (OH
MeSH term(s)	Copper ; Corrosion ; Numismatics
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	391900-6
ISSN	1932-8745 ; 0161-0457
ISSN (online)	1932-8745
ISSN	0161-0457
DOI	10.1155/2022/1647217
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Article ; Online: Integrated pharmacokinetic properties and tissue distribution of multiple active constituents in Qing-Yi Recipe: A comparison between granules and decoction.

Ma, Shurong / Wei, Tianfu / Zhang, Biao / Zhang, Yunshu / Lai, Jinwen / Qu, Jialin / Liu, Jianjun / Yin, Peiyuan / Shang, Dong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 129, Page(s) 155645

Abstract: Background: Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used ... bioactive constituents of Qing-Yi Recipe in biological samples was developed using liquid chromatography ... of Qing-Yi Recipe and its major metabolites in rats were investigated using the post-listed granules ...

Abstract	Background: Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, the efficacy of which has been demonstrated in more than thirty clinical trials. However, the in-vivo pharmacodynamic material basis for this formula remains unclear. Methods: A sensitive and accurate method for quantifying twenty-two potential bioactive constituents of Qing-Yi Recipe in biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and this method was fully validated. Then, the integrated pharmacokinetic properties of Qing-Yi Recipe and its major metabolites in rats were investigated using the post-listed granules at both dosages. Subsequently, tissue distributions of those constituents in nine organs (especially the pancreas) were determined, and the overall parameters between the two formulations were compared. Results: Though the chemical profiles of the formulas varied across formulations, the overall exposure level was very similar, and baicalin, wogonoside, geniposide, rhein, costunolide, and paeoniflorin were the top six bioactive compounds in the circulation. All twenty-two natural products reached their first peak within 2 h, and several of them exhibited bimodal or multimodal patterns under the complicated transformation of metabolic enzymes, and the parameters of these products markedly changed compared with those of monomers. Diverse metabolites of emodin and baicalin/baicalein were detected in circulation and tissues, augmenting the in vivo forms of these compounds. Finally, the enrichment of tetrahydropalmatine and corydaline in the pancreas were observed and most compounds remained in the gastrointestinal system, providing a foundation basis for their potential regulatory effects on the gut microbiota as well as the intestinal functions. Conclusion: Herein, the pharmacokinetic properties and tissue distribution of multiple potential active constituents in Qing-Yi Recipe were investigated at two dosages, providing a pharmacodynamic material basis of Qing-Yi Recipe for the first time. This investigation is expected to provide a new perspective and reference for future studies on the physiological disposition and potential pharmacodynamic basis of traditional Chinese medicine to treat acute abdomen diseases.
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155645
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Article: SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment.

Zhang, Shuyan / Wu, Jiajun / Wang, Leilei / Mu, Lin / Xu, Xiaoyu / Li, Jiahui / Tang, Guoyi / Chen, Guang / Zhang, Cheng / Zhang, Yinjian / Feng, Yibin

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1366020

Abstract: ... visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been ...

Abstract	Objective: Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been identified as an efficient therapy for DR with retinal vascular dysfunction for decades and has been experimentally reported to ameliorate retinal conditions in diabetic mice. This study endeavors to explore the therapeutic potential of HF with key ingredients in DR and its underlying novel mechanisms. Methods: Co-expression gene modules and hub genes were calculated by weighted gene co-expression network analysis (WGCNA) based on transcriptome sequencing data from high-glucose-treated adult retinal pigment epithelial cell line-19 (ARPE-19). The chromatographic fingerprint of HF was established by ultra-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-Q-TOF-MS). The molecular affinity of the herbal compound was measured by molecular docking. Reactive oxygen species (ROS) was measured by a DCFDA/H2DCFDA assay. Apoptosis was detected using the TUNEL Assay Kit, while ELISA, Western blot, and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used for detecting the cytokine, protein, and mRNA expressions, respectively. Results: Key compounds in HF were identified as luteolin, paeoniflorin, and nobiletin. For WGCNA, ME-salmon ("protein deacetylation") was negatively correlated with ME-purple ("oxidative impairment") in high-glucose-treated ARPE-19. Luteolin has a high affinity for SIRT1 and P53, as indicated by molecular docking. Luteolin has a hypoglycemic effect on type I diabetic mice. Moreover, HF and luteolin suppress oxidative stress production (ROS and MDA), inflammatory factor expression (IL-6, TNF-α, IL1-β, and MCP-1), and apoptosis, as shown in the Conclusion: Using HF and its active compound luteolin as therapeutic agents offers a promising approach to diabetic retinopathy treatment. It primarily suppressed protein acetylation and oxidative stress via the SIRT1/P53 pathway in retinal pigment epithelial cells.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1366020
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Article ; Online: Qing-Re-Chu-shi decoction ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice through anti-inflammation and immunoregulatory mechanisms.

Meng, YuJiao / Liu, Yu / Guo, Jianning / Guo, Xiaoyao / Han, Xuyang / Zhang, Lu / Di, Tingting / Zhao, Jingxia / Wang, Yan / Li, Ping

Journal of ethnopharmacology

2024 Volume 323, Page(s) 117702

Abstract: Ethnopharmacological relevance: Qing-Re-Chu-Shi Decoction (QRCSD), a traditional Chinese herbal ...

Abstract	Ethnopharmacological relevance: Qing-Re-Chu-Shi Decoction (QRCSD), a traditional Chinese herbal formula, has been employed as a complementary and alternative therapy for inflammatory skin diseases. However, its active constituents and the mechanistic basis of its action on atopic dermatitis remain in adequately understood. Aim of the study: Atopic dermatitis (AD) is an allergic dermatitis marked by eczematous lesions and pruritus. The study aimed to elucidate the underlying effects of QRCSD on AD and to identify the components responsible for its therapeutic efficacy in a mouse model. Materials and methods: Network pharmacology and UPLC-mass analysis were used to anticipate the pharmacological mechanisms and to identify active components of QRCSD, respectively. A DNCB-induced AD-like model was established in NC/Nga mice. QRCSD or prednisolone (as a positive control) was administered via gavage every other day from day14 to day 21. Dermatitis severity score, scratching behavior, skin barrier function, spleen index, Th1/Th2 lymphocyte ratio, and serum IgE levels were evaluated. Protein arrays, including 40 inflammatory cytokines, were performed on skin lesions, followed by confirmation experiments of Western blotting in dorsal skin lesions. Results: The construction of a QRCSD-AD-Network and topological analysis firstly proposed potential targets of QRCSD acting on AD. Animal experiments demonstrated that oral administration of QRCSD ameliorated AD-like lesions, reduced epidermal thickness and mast cell count, decreased serum IgE levels, augmented tight junction protein (Claudin 1, Occludin) levels, and regulated the Th1/Th2 balance in the spleen, as well as spleen index. Elevated levels of interleukin (IL)-4, IL-5, IL-6, IL-17, and Eotaxin were revealed in AD-like skin lesions by protein arrays. Western blotting confirmed that the phosphorylation levels of ERK, P38, JNK, STAT3 and P65 were downregulated, and IL-6 expression was also reduced following QRCSD treatment. Conclusions: The study enhances the understanding of the anti-inflammatory and immunomodulatory effects of QRCSD, showcasing its significant protective role against atopic dermatitis. Treatment with QRCSD may be considered as a viable candidate for complementary and alternative therapy in managing atopic dermatitis.
MeSH term(s)	Mice ; Animals ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Dinitrochlorobenzene/toxicity ; Skin/pathology ; Interleukin-6/metabolism ; Cytokines/metabolism ; Anti-Inflammatory Agents/adverse effects ; Immunoglobulin E
Chemical Substances	Dinitrochlorobenzene ; Interleukin-6 ; Cytokines ; Anti-Inflammatory Agents ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-01-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117702
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