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  1. Article: Editorial: Micronutrients and critically ill patients.

    Lazzarin, Taline / Azevedo, Paula Schmidt / Cardoso, Barbara Rita / Suen, Vivian Marques Miguel / Minicucci, Marcos Ferreira

    Frontiers in medicine

    2024  Volume 10, Page(s) 1352808

    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1352808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial

    Taline Lazzarin / Paula Schmidt Azevedo / Barbara Rita Cardoso / Vivian Marques Miguel Suen / Marcos Ferreira Minicucci

    Frontiers in Medicine, Vol

    Micronutrients and critically ill patients

    2024  Volume 10

    Keywords micronutrients ; critically ill patients ; mortality ; vitamins ; electrolyte ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Role of sulfonylurea administration in sepsis and septic shock patients: A systematic review.

    Lazzarin, Taline / Ballarin, Raquel Simões / Pereira, Filipe Welson Leal / Azevedo, Paula Schmidt / Tanni, Suzana Erico / Minicucci, Marcos Ferreira

    Clinics (Sao Paulo, Brazil)

    2023  Volume 78, Page(s) 100197

    MeSH term(s) Humans ; Shock, Septic ; Sepsis ; Hospital Mortality
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Systematic Review ; Letter
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2023.100197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Plasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients: A Cohort Study.

    Pagnussatt Neto, Eugenio / Lopes da Costa, Paula Daniele / Gurgel, Sanderland J Tavares / Schmidt Azevedo, Paula / Modolo, Norma S Pinheiro / do Nascimento Junior, Paulo

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/ ... ...

    Abstract There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL
    Language English
    Publishing date 2023-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: FRAIL scale as a screening tool and a predictor of mortality in non-dialysis dependent patients.

    Rodrigues, Hellen Christina Neves / Sousa, Amanda Goulart de Oliveira / Preto, Vitória Rodrigues Morais / Ferro, Camila Moura Batista / Sugizaki, Clara Sandra de Araújo / Freitas, Ana Tereza Vaz de Souza / Minicucci, Marcos Ferreira / Azevedo, Paula Schmidt / Peixoto, Maria do Rosário Gondim / Costa, Nara Aline

    Journal of nephrology

    2024  

    Abstract: Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.: Methods: In this prospective cohort study, ...

    Abstract Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.
    Methods: In this prospective cohort study, non-dialysis dependent patients with chronic kidney disease (CKD) stages 3b-5 seen in the nephrology outpatient clinics of two university hospitals were included. The presence of frailty was evaluated by physical frailty phenotype measure and the FRAIL scale. Patients were evaluated for six months, and mortality was recorded. The Kappa test was used to evaluate the diagnostic properties between the methods, and logistic regression to test the association between frailty and mortality.
    Results: One hundred fifty-three patients were evaluated; average age was 65 (56-70) years, 50.9% were women, and the all-cause mortality rate was 2.6%. Forty-six patients were classified as living with frailty according to the physical frailty phenotype while 36 patients were rated frail by the FRAIL scale. In adults < 60 years of age, the FRAIL scale showed good accuracy (84.9%) and specificity (93.2%) but had low sensitivity (41.3%) and moderate agreement (Kappa = 0.41; p < 0.001) compared to the definition of the physical frailty phenotype. The adjusted logistic regression model showed that the patients with frailty assessed by the FRAIL scale had a greater chance of mortality than the non-frail patients (OR: 6.8; CI95%:1.477-31.513; p = 0.014).
    Conclusion: Physical frailty phenotype identifies more patients as having pre-frailty and frailty in non-dialysis dependent patients as compared to the FRAIL scale. However, the FRAIL scale is a simple bedside tool that can be useful for screening for frailty and whose results were associated with mortality.
    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01900-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of Outdoor Relative Humidity and Temperature on In-Hospital Cardiac Arrest Prognosis.

    Lazzarin, Taline / Fávero Junior, Edson Luiz / Delai, Caroline Casagrande / Pinheiro, Victor Rocha / Ballarin, Raquel Simões / Rischini, Felipe Antonio / Polegato, Bertha Furlan / Azevedo, Paula Schmidt / de Paiva, Sergio Alberto Rupp / Zornoff, Leonardo / da Cunha, Antônio Ribeiro / do Valle, Adriana Polachini / Minicucci, Marcos Ferreira

    Global heart

    2023  Volume 18, Issue 1, Page(s) 52

    MeSH term(s) Humans ; Temperature ; Humidity ; Heart Arrest ; Prognosis ; Hospitals ; Retrospective Studies
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.1266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Plasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients

    Eugenio Pagnussatt Neto / Paula Daniele Lopes da Costa / Sanderland J. Tavares Gurgel / Paula Schmidt Azevedo / Norma S. Pinheiro Modolo / Paulo do Nascimento Junior

    Diagnostics, Vol 13, Iss 976, p

    A Cohort Study

    2023  Volume 976

    Abstract: There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL −1 . This study aimed to assess whether there is an association between preoperative fibrinogen levels and perioperative blood-product ... ...

    Abstract There is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL −1 . This study aimed to assess whether there is an association between preoperative fibrinogen levels and perioperative blood-product transfusion up to 48 h after major orthopedic surgery. This cohort study included 195 patients who underwent primary or revision hip arthroplasty for nontraumatic etiologies. Plasma fibrinogen, blood count, coagulation tests, and platelet count were measured preoperatively. A plasma fibrinogen level of 200 mg/dL −1 was the cutoff value used to predict blood transfusion. The mean (SD) plasma fibrinogen level was 325 (83) mg/dL −1 . Only thirteen patients had levels < 200 mg/dL −1 , and only one of them received a blood transfusion, with an absolute risk of 7.69% (1/13; 95%CI: 1.37–33.31%). Preoperative plasma fibrinogen levels were not associated with the need for blood transfusion ( p = 0.745). The sensitivity and the positive predictive value of plasma fibrinogen < 200 mg/dL −1 as a predictor of blood transfusion were 4.17% (95%CI: 0.11–21.12%) and 7.69% (95%CI: 1.12–37.99%), respectively. Test accuracy was 82.05% (95%CI: 75.93–87.17%), but positive and negative likelihood ratios were poor. Therefore, preoperative plasma fibrinogen level in hip-arthroplasty patients was not associated with the need for blood-product transfusion.
    Keywords anesthesia ; blood transfusion ; blood-coagulation tests ; fibrinogen ; orthopedic surgeries ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Reduced mobility is associated with adverse outcomes after in-hospital cardiac arrest.

    Lazzarin, Taline / Fávero Junior, Edson Luiz / Rischini, Felipe Antonio / Azevedo, Paula Schmidt / Polegato, Bertha Furlan / Paiva, Sergio Alberto Rupp de / Zornoff, Leonardo / Minicucci, Marcos Ferreira

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 12, Page(s) e20230947

    Abstract: Objective: In-hospital cardiac arrest is a critical medical emergency. Knowledge of prognostic factors could assist in cardiopulmonary resuscitation decision-making. Frailty and functional status are emerging risk factors and may play a role in ... ...

    Abstract Objective: In-hospital cardiac arrest is a critical medical emergency. Knowledge of prognostic factors could assist in cardiopulmonary resuscitation decision-making. Frailty and functional status are emerging risk factors and may play a role in prognostication. The objective was to evaluate the association between reduced mobility and in-hospital cardiac arrest outcomes.
    Methods: This retrospective cohort study included patients over 18 years of age with in-hospital cardiac arrest in Botucatu, Brazil, from April 2018 to December 2021. Exclusion criteria were patients with a do-not-resuscitate order or patients with recurrent in-hospital cardiac arrest. Reduced mobility was defined as the need for a bed bath 48 h before in-hospital cardiac arrest. The outcomes of no return of spontaneous circulation and in-hospital mortality were evaluated.
    Results: A total of 387 patients were included in the analysis. The mean age was 65.4±14.8 years; 53.7% were males and 75.4% had reduced mobility. Among the evaluated outcomes, the no return of spontaneous circulation rate was 57.1%, and in-hospital mortality was 94.3%. In multivariate analysis, reduced mobility was associated with no return of spontaneous circulation when adjusted by age, gender, initial shockable rhythm, duration of cardiopulmonary resuscitation, and epinephrine administration. However, in multiple logistic regression, there was no association between reduced mobility and in-hospital mortality.
    Conclusion: In patients with in-hospital cardiac arrest, reduced mobility is associated with no return of spontaneous circulation. However, there is no relation to in-hospital mortality.
    MeSH term(s) Male ; Humans ; Adolescent ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Retrospective Studies ; Out-of-Hospital Cardiac Arrest ; Emergency Medical Services ; Cardiopulmonary Resuscitation ; Hospitals
    Language English
    Publishing date 2023-10-30
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20230947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Beans comsumption can contribute to the prevention of cardiovascular disease.

    Vieira, Nayane Maria / Peghinelli, Vinícius Vigliazzi / Monte, Marina Gaiato / Costa, Nara Aline / Pereira, Amanda Gomes / Seki, Marcos Mitsuo / Azevedo, Paula Schmidt / Polegato, Bertha Furlan / de Paiva, Sergio Alberto Rupp / Zornoff, Leonardo Antonio Mamede / Minicucci, Marcos Ferreira

    Clinical nutrition ESPEN

    2023  Volume 54, Page(s) 73–80

    Abstract: Cardiovascular diseases (CVD) are the major cause of global mortality, accounting for 31% of deaths worldwide. Healthy eating habits based on the consumption of bioactive molecules present in plant-based diets can contribute to the prevention of CVD. In ... ...

    Abstract Cardiovascular diseases (CVD) are the major cause of global mortality, accounting for 31% of deaths worldwide. Healthy eating habits based on the consumption of bioactive molecules present in plant-based diets can contribute to the prevention of CVD. In this context, the consumption of common beans (Phaseolus vulgaris L.) is relevant. There are several species of beans, all of which provide proteins, carbohydrates, dietary fiber, vitamins, minerals, and phenolic compounds. More recently, the complexity of phytochemical components has expanded, including the role of antinutritional factors in nutrient bioavailability and immune responses. Experimental and clinical studies have shown that the consumption of beans results in less food consumption, control of body weight, and improvement of metabolic biochemical parameters. Thus, the consumption of beans is associated with a decrease in CVD risk factors. To date, there have been no interventional studies assessing CVD outcomes, such as hospitalization, infarction, and mortality, in the context of bean consumption. Furthermore, studies on the effect of bean consumption on metabolomics and intestinal microbiota are lacking. The purpose of this review is to explore the nutritional properties of beans and discuss the main effects of the consumption of beans on cardiovascular health. In conclusion, eating habits based on the consumption of bioactive molecules present in beans can contribute to the prevention of cardiovascular disease. Furthermore, there is a large gap in the literature regarding the consumption of beans associated with clinical outcomes, such as hospitalization and mortality.
    MeSH term(s) Humans ; Cardiovascular Diseases/prevention & control ; Phaseolus/metabolism ; Minerals ; Nutritive Value ; Dietary Fiber
    Chemical Substances Minerals ; Dietary Fiber
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2023.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Higher urea-to-albumin ratio is associated with mortality risk in critically ill COVID-19 patients.

    Rodrigues, Hellen Christina Neves / Silva, Mikaelly Luiz / Mantovani, Milena Dos Santos / Silva, Juliana Medeiros da / Domingues, Marielle Fernanda Panelli / Tanni, Suzana Érico / Azevedo, Paula Schmidt / Minicucci, Marcos Ferreira / Buffarah, Marina Nogueira Berbel / Pereira, Amanda Gomes / Costa, Nara Aline

    Clinical nutrition ESPEN

    2023  Volume 56, Page(s) 9–12

    Abstract: Background: This study aimed to evaluate the ability of the urea-to-albumin ratio (UAR) to predict mortality in critically ill coronavirus disease 2019 (COVID-19) patients.: Methods: This retrospective study included adult patients admitted with ... ...

    Abstract Background: This study aimed to evaluate the ability of the urea-to-albumin ratio (UAR) to predict mortality in critically ill coronavirus disease 2019 (COVID-19) patients.
    Methods: This retrospective study included adult patients admitted with COVID-19 at two intensive care units (ICUs) at the University Hospital. Serum urea and albumin concentrations at ICU admission were used to calculate the UAR. All patients were followed up during hospitalization, and the ICU mortality rate was recorded.
    Results: Two hundred and eleven patients were evaluated. The mean age was 57.8 ± 15.5 years, and 54% were male. Approximately 84.4% of patients were considered to be at nutritional risk by the NRS 2002, and the median UAR was 18.3 (10.5-34.8). The length of stay in the ICU was 10 (6-16) days, 38.4% of the patients required dialysis, and 64.9% died. Age, male sex, need of hemodialysis, lactate level, and inflammatory parameters were associated with higher mortality. Patients non-survivors had a higher UAR (23.7 [13.6-41.8] vs. 10.9 [8.5-16.8]; p < 0.001). The cutoff point with the best performance of UAR in the ROC curve for predicting mortality was ≥12.17 (AUC: 0.7201; CI 95%: 0.656-0.784). Additionally, the risk of mortality was 2.00-fold in the group of patients with UAR ≥12.17 (HR: 2.00 CI: 1.274-3.149; p = 0.003) and remained significant after adjusted analyzes (models 1 and 2).
    Conclusion: Our data suggest that a UAR ≥12.17 increased the risk of mortality by 2.00-fold in critically ill COVID-19 patients.
    MeSH term(s) COVID-19/blood ; COVID-19/mortality ; Urea/blood ; Humans ; Retrospective Studies ; Male ; Female ; Middle Aged ; Intensive Care Units ; Serum Albumin, Human ; Prognosis
    Chemical Substances Urea (8W8T17847W) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2023.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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