LIVIVO - Search results -

Search results

Result 1 - 10 of total 67

Search options

Article: The president's perspective: perseverance and bridging the gap in the world of medicine.

Chung, Maurice K

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2013 Volume 16, Issue 4, Page(s) 509–510

MeSH term(s)	Clinical Medicine/trends ; Female ; Global Health ; Gynecology/trends ; Humans ; International Cooperation ; Obstetrics/trends ; Societies, Medical
Language	English
Publishing date	2013-04-11
Publishing country	United States
Document type	Address
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
DOI	10.4293/108680812X13517013316915
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

San Gil, Rebecca / Pascovici, Dana / Venturato, Juliana / Brown-Wright, Heledd / Mehta, Prachi / Madrid San Martin, Lidia / Wu, Jemma / Luan, Wei / Chui, Yi Kit / Bademosi, Adekunle T / Swaminathan, Shilpa / Naidoo, Serey / Berning, Britt A / Wright, Amanda L / Keating, Sean S / Curtis, Maurice A / Faull, Richard L M / Lee, John D / Ngo, Shyuan T /

Lee, Albert / Morsch, Marco / Chung, Roger S / Scotter, Emma / Lisowski, Leszek / Mirzaei, Mehdi / Walker, Adam K

Nature communications

2024 Volume 15, Issue 1, Page(s) 1508

Abstract: Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic ... ...

Abstract	Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD, and developed a complementary open-access webtool, TDP-map ( https://shiny.rcc.uq.edu.au/TDP-map/ ). We identified distinct protein subsets enriched for diverse biological pathways with temporal alterations in protein abundance, including increases in protein folding factors prior to disease onset. This included increased levels of DnaJ homolog subfamily B member 5, DNAJB5, which also co-localized with TDP-43 pathology in diseased human motor cortex. DNAJB5 over-expression decreased TDP-43 aggregation in cell and cortical neuron cultures, and knockout of Dnajb5 exacerbated motor impairments caused by AAV-mediated cytoplasmic TDP-43 expression in mice. Together, these findings reveal molecular mechanisms at distinct stages of ALS and FTLD progression and suggest that protein folding factors could be protective in neurodegenerative diseases.
MeSH term(s)	Animals ; Humans ; Mice ; Amyotrophic Lateral Sclerosis/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Frontotemporal Dementia/metabolism ; Frontotemporal Lobar Degeneration/metabolism ; Neurons/metabolism ; Proteomics ; TDP-43 Proteinopathies/metabolism ; Protein Aggregates
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human ; Tardbp protein, mouse ; Protein Aggregates
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45646-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer

Niu, J / Maurice-Dror, C / Lee, D H / Kim, D-W / Nagrial, A / Voskoboynik, M / Chung, H C / Mileham, K / Vaishampayan, U / Rasco, D / Golan, T / Bauer, T M / Jimeno, A / Chung, V / Chartash, E / Lala, M / Chen, Q / Healy, J A / Ahn, M-J

Annals of oncology : official journal of the European Society for Medical Oncology

2021 Volume 33, Issue 2, Page(s) 169–180

Abstract: Background: In this first-in-human phase 1 study (NCT02964013; MK-7684-001), we investigated the safety and efficacy of the anti-TIGIT (T cell immunoglobulin and ITIM domain) antibody vibostolimab as monotherapy or in combination with pembrolizumab.: ... ...

Abstract	Background: In this first-in-human phase 1 study (NCT02964013; MK-7684-001), we investigated the safety and efficacy of the anti-TIGIT (T cell immunoglobulin and ITIM domain) antibody vibostolimab as monotherapy or in combination with pembrolizumab. Patients and methods: Part A enrolled patients with advanced solid tumors, and part B enrolled patients with non-small-cell lung cancer (NSCLC). Patients received vibostolimab 2.1-700 mg alone or with pembrolizumab 200 mg in part A and vibostolimab 200 mg alone or with pembrolizumab 200 mg in part B. Primary endpoints were safety and tolerability. Secondary endpoints included pharmacokinetics and objective response rate (ORR) per RECIST v1.1. Results: Part A enrolled 76 patients (monotherapy, 34; combination therapy, 42). No dose-limiting toxicities were reported. Across doses, 56% of patients receiving monotherapy and 62% receiving combination therapy had treatment-related adverse events (TRAEs); grade 3-4 TRAEs occurred in 9% and 17% of patients, respectively. The most common TRAEs were fatigue (15%) and pruritus (15%) with monotherapy and pruritus (17%) and rash (14%) with combination therapy. Confirmed ORR was 0% with monotherapy and 7% with combination therapy. In part B, 39 patients had anti-PD-1 (programmed cell death protein 1)/PD-L1 (programmed death-ligand 1)-naive NSCLC (all received combination therapy), and 67 had anti-PD-1/PD-L1-refractory NSCLC (monotherapy, 34; combination therapy, 33). In patients with anti-PD-1/PD-L1-naive NSCLC: 85% had TRAEs-the most common were pruritus (38%) and hypoalbuminemia (31%); confirmed ORR was 26%, with responses occurring in both PD-L1-positive and PD-L1-negative tumors. In patients with anti-PD-1/PD-L1-refractory NSCLC: 56% receiving monotherapy and 70% receiving combination therapy had TRAEs-the most common were rash and fatigue (21% each) with monotherapy and pruritus (36%) and fatigue (24%) with combination therapy; confirmed ORR was 3% with monotherapy and 3% with combination therapy. Conclusions: Vibostolimab plus pembrolizumab was well tolerated and demonstrated antitumor activity in patients with advanced solid tumors, including patients with advanced NSCLC.
MeSH term(s)	Antibodies, Monoclonal, Humanized/adverse effects ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/pathology ; Response Evaluation Criteria in Solid Tumors
Chemical Substances	Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2021.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2862: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Interstitial cystitis in persistent posthysterectomy chronic pelvic pain.

Chung, Maurice K

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2004 Volume 8, Issue 4, Page(s) 329–333

Abstract: Objectives: Hysterectomies may be performed unnecessarily in women with chronic pelvic pain if the diagnosis of interstitial cystitis is not considered. The objectives of this study were to investigate the prevalence of interstitial cystitis in patients ...

Abstract	Objectives: Hysterectomies may be performed unnecessarily in women with chronic pelvic pain if the diagnosis of interstitial cystitis is not considered. The objectives of this study were to investigate the prevalence of interstitial cystitis in patients with posthysterectomy chronic pelvic pain and to evaluate the efficacy of various therapies for interstitial cystitis. Methods: A study was performed of 111 patients with chronic pelvic pain whose pain persisted after hysterectomy. Patients were screened with the Pelvic Pain and Urgency/Frequency symptom scale, and underwent Potassium Sensitivity Testing. Patients were treated with dietary changes alone or in combination with cystoscopic hydrodistention or oral pentosan polysulfate, or both of these, for 3 to 6 months. Results: Of the 111 patients enrolled, 79% (n=88) were diagnosed with bladder dysfunction consistent with interstitial cystitis. For patients treated with dietary modification alone (n=33), the mean score on the Pelvic Pain and Urgency/Frequency questionnaire improved 15.4%, from 13.18 at baseline to 11.15 at follow-up. For patients treated with pentosan polysulfate or cystoscopic hydrodistention, or both, plus diet changes (n=78), Pelvic Pain and Urgency/Frequency scores improved 34.2%, from 15.01 to 9.87. Conclusion: In this study, nonsurgical treatment for interstitial cystitis resulted in a marked improvement in symptoms that had not improved with surgery. Without determining the origin of bladder pain, gynecologists should not proceed to hysterectomy in patients with chronic pelvic pain.
MeSH term(s)	Chronic Disease ; Cystitis, Interstitial/complications ; Cystitis, Interstitial/diagnosis ; Cystitis, Interstitial/epidemiology ; Cystitis, Interstitial/therapy ; Diagnostic Errors ; Female ; Humans ; Hysterectomy ; Pelvic Pain/etiology ; Pelvic Pain/surgery ; Postoperative Complications ; Prevalence ; Unnecessary Procedures
Language	English
Publishing date	2004-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: inPhocus: Current State and Challenges of Phage Research in Singapore.

Verma, Navin Kumar / Tan, Si Jia / Chen, John / Chen, Hanrong / Ismail, Muhammad Hafiz / Rice, Scott A / Bifani, Pablo / Hariharan, Sukumar / Paul, Vivek Daniel / Sriram, Bharathi / Dam, Linh Chi / Chan, Chia Ching / Ho, Peiying / Goh, Boon Chong / Chung, Shimin Jasmine / Goh, Kenneth Choon Meng / Thong, Shu Hua / Kwa, Andrea Lay-Hoon / Ostrowski, Adam /

Aung, Thet Tun / Razali, Halimah / Low, Shermaine W Y / Bhattacharyya, Mani Shankar / Gautam, Hemant K / Lakshminarayanan, Rajamani / Sicheritz-Pontén, Thomas / Clokie, Martha R J / Moreira, Wilfried / van Steensel, Maurice Adrianus Monique

PHAGE (New Rochelle, N.Y.)

2022 Volume 3, Issue 1, Page(s) 6–11

Abstract: Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang ... ...

Abstract	Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2986345-4
ISSN	2641-6549 ; 2641-6530
ISSN (online)	2641-6549
ISSN	2641-6530
DOI	10.1089/phage.2022.29028.nkv
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Early identification of interstitial cystitis may avoid unnecessary hysterectomy.

Chung, Maurice K / Jarnagin, Barry

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2009 Volume 13, Issue 3, Page(s) 350–357

Abstract: Background: Interstitial cystitis is a clinical syndrome characterized by symptoms of pelvic pain, urinary urgency and frequency, and nocturia. It can be difficult to accurately identify interstitial cystitis because the symptoms overlap many other ... ...

Abstract	Background: Interstitial cystitis is a clinical syndrome characterized by symptoms of pelvic pain, urinary urgency and frequency, and nocturia. It can be difficult to accurately identify interstitial cystitis because the symptoms overlap many other common gynecologic and urologic conditions. Patients with undiagnosed interstitial cystitis may undergo unnecessary procedures, including hysterectomy. Methods: A PubMed literature search for articles dating back to 1990 was conducted on the topics of interstitial cystitis and hysterectomy. Further references were identified by cross-referencing the bibliographies in articles of interest. Results: The literature review found that hysterectomy is performed more often in patients with undiagnosed interstitial cystitis than in patients with a confirmed diagnosis. Interstitial cystitis often coexists with conditions like endometriosis, for which hysterectomy is indicated. Many patients subsequently diagnosed with interstitial cystitis continue to experience persistent pelvic pain despite having had a hysterectomy for chronic pelvic pain. Careful history and physical examination can identify the majority of interstitial cystitis cases. Conclusion: Interstitial cystitis should be considered prior to hysterectomy in women who present with pelvic pain or who experience pelvic pain after a hysterectomy. If interstitial cystitis is diagnosed, appropriate therapy may eliminate the need for hysterectomy.
MeSH term(s)	Cystitis, Interstitial/diagnosis ; Cystitis, Interstitial/drug therapy ; Cystitis, Interstitial/surgery ; Diagnosis, Differential ; Female ; Humans ; Hysterectomy/statistics & numerical data ; Unnecessary Procedures
Language	English
Publishing date	2009-10-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The overlap of interstitial cystitis/painful bladder syndrome and overactive bladder.

Chung, Maurice K / Butrick, Charles W / Chung, Cherie W

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2010 Volume 14, Issue 1, Page(s) 83–90

Abstract: Objective: We evaluated the prevalence of positive potassium sensitivity and cystoscopy with hydrodistention findings in patients with overactive bladder.: Method: This was a prospective cohort study of 98 patients who presented with overactive ... ...

Abstract	Objective: We evaluated the prevalence of positive potassium sensitivity and cystoscopy with hydrodistention findings in patients with overactive bladder. Method: This was a prospective cohort study of 98 patients who presented with overactive bladder symptoms. The diagnosis of overactive bladder is established by the presence of irritable voiding symptoms. All patients completed a PUF questionnaire and underwent potassium sensitivity testing. Eighty patients underwent urodynamic testing, and 42 patients underwent cystoscopic hydrodistention while under general anesthesia. Results: The Potassium Sensitivity Test was positive in 59 (60.2%) of the 98 patients, 37 (56%) of wet overactive bladder patients, and 22 (68.8%) of dry overactive bladder patients. Their mean PUF score was 7. Thirty-three (78.5%) of the patients who underwent cystoscopic hydrodistention had glomerulations consistent with NIH criteria for interstitial cystitis, and 26 of these patients tested positive for potassium sensitivity. Fifty-one (63.8%) of the patients who underwent urodynamics tested positive for potassium sensitivity. Conclusion: Many patients with symptoms of overactive bladder with little or no pain have cystoscopic evidence of interstitial cystitis and a positive Potassium Sensitivity Test. Therapies directed toward the uroepithelial dysfunction and neural upregulation associated with interstitial cystitis/painful bladder syndrome may be an important adjunct for patients who have failed or have had a partial response to anticholinergic therapy and behavior modification.
MeSH term(s)	Adolescent ; Adult ; Cystitis, Interstitial/diagnosis ; Cystitis, Interstitial/epidemiology ; Cystitis, Interstitial/physiopathology ; Cystoscopy ; Female ; Humans ; Male ; Middle Aged ; Urinary Bladder, Overactive/diagnosis ; Urinary Bladder, Overactive/epidemiology ; Urinary Bladder, Overactive/physiopathology ; Urinary Incontinence/epidemiology ; Urinary Incontinence/physiopathology ; Urodynamics ; Young Adult
Language	English
Publishing date	2010-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
DOI	10.4293/108680810X12674612014743
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparison of laparoscopic Burch and tension-free vaginal tape in treating stress urinary incontinence in obese patients.

Chung, Maurice K / Chung, Rosemary P

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2002 Volume 6, Issue 1, Page(s) 17–21

Abstract: Objective: To compare the efficacy and safety of the tension-free vaginal tape (TVT) and laparoscopic Burch procedures in treating genuine stress urinary incontinence in obese patients.: Methods: This was a retrospective evaluation of 91 consecutive ... ...

Abstract	Objective: To compare the efficacy and safety of the tension-free vaginal tape (TVT) and laparoscopic Burch procedures in treating genuine stress urinary incontinence in obese patients. Methods: This was a retrospective evaluation of 91 consecutive cases of TVT alone or TVT combined with other procedures from April 1999 through March 2000 and 51 consecutive cases of the laparoscopic Burch procedure from January 1998 through February 1999. All procedures were performed in a private practice and community hospitals in the midwest. One hundred forty-two women (ages 34 to 79) with stress urinary incontinence documented by clinical examination and preoperative cystometric and urodynamic evaluation were included in the study. They were also divided into 5 groups based on their body mass index (BMI): NL (normal-BMI < 25), OW (overweight-BMI 25 to 29), OBI (obesity I-BMI 30 to 34), OBII (obesity II-BMI 35 to 39), OBIII (obesity III-BMI > 40). In the TVT group, 66% were obese (OBI-21, OBII-17. OBIII-22) versus 36% in the laparoscopic Burch (OBI-13, OBII-5) group. Results: All TVT patients remain cured or symptoms improved in their genuine stress urinary incontinence, which favorably compares with the laparoscopic Burch procedure after 1 year. Operating time for the TVT portion ranged from 18 to 40 minutes. The laparoscopic Burch procedure in general took over 1 hour. No bladder, bowel, or vascular injuries have occurred in the TVT group. Superficial suprapubic ecchymoses have occurred in the TVT group occasionally but required no intervention. The average length of stay was 1 day; TVT-only patients usually were released on the same day. Ninety percent of patients were voiding normally by postoperative day 7. Most of the patients with continued urinary retention had had combined procedures. Conclusions: This preliminary study indicates that TVT is a safer, more effective, and easier minimally invasive surgery for genuine stress urinary incontinence regardless of the patients' BMI and favorably compares with the laparoscopic Burch procedure, which requires advanced surgical skills.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Laparoscopy ; Middle Aged ; Obesity/complications ; Postoperative Complications ; Prostheses and Implants ; Retrospective Studies ; Urinary Incontinence, Stress/complications ; Urinary Incontinence, Stress/surgery ; Urologic Surgical Procedures/instrumentation ; Urologic Surgical Procedures/methods ; Vagina
Language	English
Publishing date	2002-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Controversies in orthopaedic oncology.

Jeys, Lee M / Thorkildsen, Joachim / Kurisunkal, Vineet / Puri, Ajay / Ruggieri, Pietro / Houdek, Matthew T / Boyle, Richard A / Ebeid, Walid / Botello, Eduardo / Morris, Guy V / Laitinen, Minna K / Abudu, Adesegun / Ae, Keisuke / Agarwal, Manish / Ajit Singh, Vivek / Akiyama, Toru / Albergo, Jose I / Alexander, John / Alpan, Bugra /

Aoude, Ahmed / Asavamongkolkul, Apichat / Aston, William / Baad-Hansen, Thomas / Balach, Tessa / Benevenia, Joseph / Bergh, Peter / Bernthal, Nicholas / Binitie, Odion / Boffano, Michele / Bramer, Jos / Branford White, Harriet / Brennan, Bernadette / Cabrolier, Jorge / Calvo Haro, Jose A / Campanacci, Domenico A / Cardoso, Rodrigo / Carey Smith, Richard / Casales Fresnga, Nicolas / Casanova, Jose M / Ceballos, Oscar / Chan, Chung M / Chung, Yang-Guk / Clara-Altamirano, Miguel A / Cribb, Gillian / Dadia, Solomon / Dammerer, Dietmar / de Vaal, Marieke / Delgado Obando, Javier / Deo, Shaneel / Di Bella, Claudia / Donati, Davide M / Endo, Makoto / Eralp, Levent / Erol, Bulent / Evans, Scott / Eward, Will / Fiorenza, Fabrice / Freitas, Joao / Funovics, Philipp T / Galli Serra, Marcos / Ghert, Michelle / Ghosh, Kanishka / Gomez Mier, Luis C / Gomez Vallejo, Jesus / Griffin, Anthony / Gulia, Ashish / Guzman, Maurice / Hardes, Jendrik / Healey, John / Hernandez, Adriana / Hesla, Asle / Hongsaprabhas, Chindanai / Hornicek, Francis / Hosking, Keith / Iwata, Shintaro / Jagiello, Jake / Johnson, Luke / Johnston, Andy / Joo, Min Wook / Jutte, Paul / Kapanci, Bilal / Khan, Zeeshan / Kobayashi, Hiroshi / Kollender, Yehuda / Koob, Sebastian / Kotrych, Daniel / Le Nail, Louis-Romee / Legosz, Pawel / Lehner, Burkhard / Leithner, Andreas / Lewis, Valerae / Lin, Peng / Linares, Francisco / Lozano Calderon, Santiago / Mahendra, Ashish / Mahyudin, Ferdiansyah / Mascard, Eric / Mattei, Jean-Camille / McCullough, Louise / Medellin Rincon, Manuel R / Morgan-Jones, Rhidian / Moriel Garcesco, Diego J / Mottard, Sophie / Nakayama, Robert / Narhari, Prashant / O'Toole, Gary / Vania, Oliveira / Olivier, André / Omar, Mohamed / Ortiz-Cruz, Eduardo / Ozger, Harzem / Ozkan, Korhan / Palmerini, Emanuela / Papagelopoulos, Panayiotis / Parry, Michael / Patton, Sam / Petersen, Michael M / Powell, Gerard / Puhaindran, Mark / Raja, Anand / Rajasekaran, Raja B / Repsa, Lauris / Ropars, Mickael / Sambri, Andrea / Schubert, Thomas / Shehadeh, Ahmad / Siegel, Geoffrey / Sommerville, Scott / Spiguel, Andre / Stevenson, Jonathan / Sys, Gwen / Temple, Thomas / Traub, Frank / Tsuchiya, Hiroyuki / Valencia, Juan / Van de Sande, Michel / Vaz, Gualter / Velez Villa, Roberto / Vyrva, Oleg / Wafa, Hazem / Wan Faisham Numan, Wan I / Wang, Edward / Warnock, David / Werier, Joel / Wong, Kwok-Chuen / Norio, Yamamoto / Zhaoming, Ye / Zainul Abidin, Suraya / Zamora, Tomas / Zumarraga, Juan P / Abou-Nouar, Ghaith / Gebert, Carsten / Randall, R L

The bone & joint journal

2024 Volume 106-B, Issue 5, Page(s) 425–429

Abstract: Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and ... ...

Abstract	Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions. In parallel, periprosthetic joint infection (PJI) in oncological reconstructions poses unique challenges due to factors such as adjuvant treatments, large exposures, and the complexity of surgery. The meeting debated two-stage revisions, antibiotic prophylaxis, managing acute PJI in patients undergoing chemotherapy, and defining the best strategies for wound management and allograft reconstruction. The objectives of the meeting extended beyond resolving immediate controversies. It sought to foster global collaboration among specialists attending the meeting, and to encourage future research projects to address unsolved dilemmas. By highlighting areas of disagreement and promoting collaborative research endeavours, this initiative aims to enhance treatment standards and potentially improve outcomes for patients globally. This paper sets out some of the controversies and questions that were debated in the meeting.
MeSH term(s)	Humans ; Bone Neoplasms/therapy ; Bone Neoplasms/surgery ; Chondrosarcoma/therapy ; Prosthesis-Related Infections/therapy ; Prosthesis-Related Infections/etiology ; Reoperation ; Antibiotic Prophylaxis ; Orthopedics ; Medical Oncology
Language	English
Publishing date	2024-05-01
Publishing country	England
Document type	Journal Article ; Review ; Consensus Development Conference
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.106B5.BJJ-2023-1381
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6989: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Interstitial cystitis and endometriosis in patients with chronic pelvic pain: The "Evil Twins" syndrome.

Chung, Maurice K / Chung, Rosemary P / Gordon, David

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2004 Volume 9, Issue 1, Page(s) 25–29

Abstract: Objective: To determine the prevalence of interstitial cystitis and endometriosis in patients with chronic pelvic pain.: Methods: A prospective analysis was conducted in 178 women with CPP who presented with bladder base/anterior vaginal wall and/or ... ...

Abstract	Objective: To determine the prevalence of interstitial cystitis and endometriosis in patients with chronic pelvic pain. Methods: A prospective analysis was conducted in 178 women with CPP who presented with bladder base/anterior vaginal wall and/or uterine tenderness, with or without irritative voiding symptoms. The Potassium Sensitivity Test was used to assess bladder epithelial dysfunction. Patients were evaluated with concurrent laparoscopy and cystoscopy with hydrodistention. Results: Laparoscopic findings among the 178 patients with chronic pelvic pain supported a diagnosis of endometriosis in 134 (75%) patients, and cystoscopy confirmed a diagnosis of interstitial cystitis in 159 (89%) patients. Both interstitial cystitis and endometriosis were diagnosed in 115 patients (65%). The Potassium Sensitivity Test was positive in 146 (82%) patients, with 140 (96%) of these patients diagnosed with interstitial cystitis and 105 (72%) with endometriosis. Conclusions: Results of this prospective study show that interstitial cystitis and endometriosis may frequently coexist in patients with chronic pelvic pain. A positive Potassium Sensitivity Test accurately predicted the presence of interstitial cystitis in 96% of these patients with chronic pelvic pain, as confirmed by cystoscopic hydrodistention. It is necessary to consider the diagnosis of endometriosis and interstitial cystitis concurrently in the evaluation of patients with chronic pelvic pain to avoid unnecessary delay in identifying either condition.
MeSH term(s)	Adolescent ; Adult ; Chronic Disease ; Cystitis, Interstitial/complications ; Cystitis, Interstitial/epidemiology ; Decision Trees ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/epidemiology ; Female ; Humans ; Laparoscopy ; Middle Aged ; Pelvic Pain/etiology ; Potassium ; Prevalence ; Prospective Studies ; Urinary Bladder Diseases/complications ; Urinary Bladder Diseases/diagnosis ; Urinary Bladder Diseases/epidemiology
Chemical Substances	Potassium (RWP5GA015D)
Language	English
Publishing date	2004-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 310: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito