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Article ; Online: Impact of bariatric surgery, lifestyle change, and pharmacotherapy on fertility in men with obesity: a systematic review protocol.

Peel, Andrew / Mathews, Nicola / Vincent, Andrew D / Jesudason, David / Wittert, Gary / McPherson, Nicole O

JBI evidence synthesis

2024

Abstract: Objective: This review will determine whether various health interventions designed to reduce weight (lifestyle change, bariatric surgery, pharmacotherapy) in men with obesity are associated with improved fertility markers. The review will also ... ...

Abstract	Objective: This review will determine whether various health interventions designed to reduce weight (lifestyle change, bariatric surgery, pharmacotherapy) in men with obesity are associated with improved fertility markers. The review will also establish whether the degree of weight loss achieved through these methods is associated with improvement. Background: Current preconception guidelines provide limited information for men with obesity. Small studies implementing lifestyle changes in men are associated with improvement in sperm quality, whereas bariatric surgery has not been associated with improvements in sperm quality. Determining the benefit of different interventions and the relationship to weight lost is necessary to optimize male fertility. Inclusion criteria: The population will be men < 50 years who are either overweight (BMI > 25 kg/m2) or obese (BMI > 30 kg/m2). The exposure of interest will be an intervention undertaken to improve health or reduce weight, categorized as lifestyle change, bariatric surgery, or pharmacotherapy. Outcomes will include time to conception, fecundity rate, assisted reproduction outcomes, and semen quality measures. Secondary analysis will determine whether degree of weight loss achieved is associated with degree of improvement. Methods: This review will follow the JBI methodology for systematic reviews of etiology and risk. Databases to be searched will include PubMed, Embase (Ovid), Cochrane Central Register of Controlled Trials, Web of Science, and Scopus. Articles not translated into English will be excluded. Methodological quality will be assessed using the JBI critical appraisal tools. Data will be extracted using a standardized tool developed by the reviewers. Statistical meta-analysis will be performed where possible to synthesize outcomes of similar methods. Review registration number: PROSPERO CRD 42022349665.
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBIES-23-00195
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Article ; Online: Association of alcohol and bone mineral density dependent on type of alcohol consumed.

Peel, Andrew / Jesudason, David / Martin, Sean / Wittert, Gary

Journal of bone and mineral metabolism

2023 Volume 41, Issue 5, Page(s) 702–713

Abstract: Introduction: Osteoporosis prevalence will increase in coming decades, with significant financial and economic implications. Whilst alcohol excess has significant detrimental impacts on bone mineral density (BMD), knowledge of low-volume consumption is ... ...

Abstract	Introduction: Osteoporosis prevalence will increase in coming decades, with significant financial and economic implications. Whilst alcohol excess has significant detrimental impacts on bone mineral density (BMD), knowledge of low-volume consumption is inconsistent. Type of alcohol may mediate impact on BMD and warrants further investigation. Materials and methods: Participants were drawn from the Florey Adelaide Male Aging Study, a cohort of community dwelling men from Adelaide, Australia (n = 1195). The final cohort (n = 693) provided information regarding alcohol consumption and undertook BMD scan at wave one (2002-2005) and wave two (2007-2010). Cross-sectional and longitudinal multivariable regression was performed for whole-body and spine BMD. To assess change in exposure over time, change in BMD was compared to change in covariates between waves. Results: Cross-sectionally, whole-body BMD was positively associated with obesity (p < 0.001), exercise (p = 0.009), prior smoking (p = 0.001), oestrogen concentration (p = 0.001), rheumatoid arthritis (p = 0.013) and grip strength (p < 0.001). No association was identified with volume of differing types of alcohol consumed. Spinal BMD was inversely associated with low-strength beer consumption (p = 0.003). The volume of alcohol consumed at Wave 1 did not predict change in whole-body or spinal BMD; however, increases in full-strength beer consumption between waves were associated with reduced spinal BMD (p = 0.031). Conclusion: When consumed at quantities in the usual social range, alcohol was not associated with whole-body BMD. However, low-strength beer consumption was inversely related to spinal BMD.
MeSH term(s)	Humans ; Male ; Bone Density ; Cross-Sectional Studies ; Risk Factors ; Osteoporosis/epidemiology ; Alcohol Drinking/adverse effects ; Ethanol ; Absorptiometry, Photon
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-07-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1295123-7
ISSN	1435-5604 ; 0914-8779
ISSN (online)	1435-5604
ISSN	0914-8779
DOI	10.1007/s00774-023-01450-x
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Article: A chiral phosphazane reagent strategy for the determination of enantiomeric excess of amines.

Peel, Andrew J / Terzopoulos, Alexandros / Jethwa, Rajesh B / Choudhury, Dipanjana / Niu, Hao-Che / Bond, Andrew D / Slaughter, Jonathan / Wright, Dominic S

Chemical science

2022 Volume 13, Issue 18, Page(s) 5398–5412

Abstract: Methods for measuring enantiomeric excess ( ...

Abstract	Methods for measuring enantiomeric excess (
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc01692c
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Article ; Online: Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors.

Clark, Erik / Peel, Andrew D

Development (Cambridge, England)

2018

Abstract: Long-germ insects, such as the fruit ... ...

Abstract	Long-germ insects, such as the fruit fly
Language	English
Publishing date	2018-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.155580
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Article ; Online: Arthropod segmentation.

Clark, Erik / Peel, Andrew D / Akam, Michael

Development (Cambridge, England)

2019 Volume 146, Issue 18

Abstract: There is now compelling evidence that many arthropods pattern their segments using a clock-and-wavefront mechanism, analogous to that operating during vertebrate somitogenesis. In this Review, we discuss how the arthropod segmentation clock generates a ... ...

Abstract	There is now compelling evidence that many arthropods pattern their segments using a clock-and-wavefront mechanism, analogous to that operating during vertebrate somitogenesis. In this Review, we discuss how the arthropod segmentation clock generates a repeating sequence of pair-rule gene expression, and how this is converted into a segment-polarity pattern by 'timing factor' wavefronts associated with axial extension. We argue that the gene regulatory network that patterns segments may be relatively conserved, although the timing of segmentation varies widely, and double-segment periodicity appears to have evolved at least twice. Finally, we describe how the repeated evolution of a simultaneous (
MeSH term(s)	Animals ; Arthropods/embryology ; Biological Evolution ; Body Patterning/genetics ; Signal Transduction
Language	English
Publishing date	2019-09-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.170480
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Article ; Online: Uncovering the Hidden Landscape of Tris(4-pyridyl) Ligands: Topological Complexity Derived from the Bridgehead.

Waters, Jessica E / Berger, Georg / Peel, Andrew J / García-Rodríguez, Raúl / Bond, Andrew D / Wright, Dominic S

Chemistry (Weinheim an der Bergstrasse, Germany)

2021 Volume 27, Issue 47, Page(s) 12036–12040

Abstract: Supramolecular main group chemistry is a developing field which parallels the conventional domain of metallo-organic chemistry. Little explored building blocks in this area are main group metal-based ligands which have the appropriate donor symmetry to ... ...

Abstract	Supramolecular main group chemistry is a developing field which parallels the conventional domain of metallo-organic chemistry. Little explored building blocks in this area are main group metal-based ligands which have the appropriate donor symmetry to build desired molecular or extended arrangements. Tris(pyridyl) main group ligands (E(py)
Language	English
Publishing date	2021-06-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202101291
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Article ; Online: Implementation Strategies Addressing Stakeholder-Perceived Barriers and Enablers to the Establishment of a Beta-Lactam Antibiotic Therapeutic Drug Monitoring Program: A Qualitative Analysis.

Pai Mangalore, Rekha / Udy, Andrew Alexander / Peel, Trisha Nicole / Peleg, Anton Yariv / Ayton, Darshini

Therapeutic drug monitoring

2023

Abstract: Background: Therapeutic drug monitoring (TDM) of beta-lactam antibiotics (beta-lactams) is increasingly recommended for optimizing antibiotic exposure in intensive care patients with sepsis. However, limited data are available on the implementation of ... ...

Abstract	Background: Therapeutic drug monitoring (TDM) of beta-lactam antibiotics (beta-lactams) is increasingly recommended for optimizing antibiotic exposure in intensive care patients with sepsis. However, limited data are available on the implementation of beta-lactam TDM in complex health care settings. Theory-based approaches were used to systematically explore barriers and enablers perceived by key stakeholders in the implementation of beta-lactam TDM in the intensive care unit. Methods: In this qualitative descriptive study, the authors interviewed key stakeholders (n = 40): infectious disease physicians, intensive care unit physicians, pharmacists, clinical leaders, scientists, and nurses. The data were thematically analyzed and coded using the theoretical domains framework, and the codes and themes were mapped to the relevant domains of the capability, opportunity, and motivation behavior-change wheel model. Results: Barriers included a lack of knowledge, experience, evidence, and confidence, which led to concerns about capability, lack of resources, and harm in straying from standard practice. Access to education and guidelines, on-site assays with short turnaround times, communication among teams, and workflow integration were identified as enablers. A focus on patient care, trust in colleagues, and endorsement by hospital leaders were strong motivators. Pharmacist and nursing stakeholder groups emerged as key targets in the implementation of strategies. Conclusions: Using theory-based approaches, the authors identified the key barriers and enablers to establishing beta-lactam TDM. These data were used to identify strategies, policies, and key target groups for the implementation of interventions.
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	424443-6
ISSN	1536-3694 ; 0163-4356
ISSN (online)	1536-3694
ISSN	0163-4356
DOI	10.1097/FTD.0000000000001162
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Article ; Online: Ruxolitinib Cream Has Dual Efficacy on Pruritus and Inflammation in Experimental Dermatitis.

Scuron, Monika D / Fay, Brittany L / Connell, Andrew J / Peel, Michael T / Smith, Paul A

Frontiers in immunology

2021 Volume 11, Page(s) 620098

Abstract: The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs ...

Abstract	The goal of this study was to elucidate the anti-pruritic and anti-inflammatory efficacy of ruxolitinib cream in experimentally-induced dermatitis. Atopic dermatitis (AD), the most common chronic relapsing inflammatory skin disease, significantly impairs patients' quality of life, with pruritus being a common complaint. The sensation of itch results from the interplay between epidermal barrier dysfunction, upregulated immune signaling and the activation of the central nervous system. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a central role in pro-inflammatory cytokine signaling in AD. Ruxolitinib cream is a potent and selective JAK1/2 inhibitor currently undergoing clinical evaluation in adults with mild-to-moderate AD (NCT03745638, NCT03920852 and NCT03745651). The efficacy of ruxolitinib cream was tested in murine models of acute and chronic dermatitis and was also characterized in an
MeSH term(s)	Administration, Cutaneous ; Animals ; Betamethasone/administration & dosage ; Betamethasone/therapeutic use ; Clobetasol/administration & dosage ; Clobetasol/therapeutic use ; Cytokines/biosynthesis ; Cytokines/genetics ; Cytokines/toxicity ; Dermatitis/drug therapy ; Disease Models, Animal ; Drug Eruptions/drug therapy ; Drug Eruptions/immunology ; Drug Evaluation, Preclinical ; Female ; Fluorescein-5-isothiocyanate/toxicity ; Grooming/drug effects ; Humans ; In Vitro Techniques ; Interleukin-33/genetics ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/therapeutic use ; Lymphocyte Subsets/drug effects ; Lymphocyte Subsets/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Ointments ; Organ Culture Techniques ; Pruritus/drug therapy ; Pyrazoles/administration & dosage ; Pyrazoles/therapeutic use ; Random Allocation ; Signal Transduction/drug effects ; Skin/drug effects ; Specific Pathogen-Free Organisms ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology ; Transcriptome
Chemical Substances	Cytokines ; Il33 protein, mouse ; Interleukin-33 ; Janus Kinase Inhibitors ; Ointments ; Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Betamethasone (9842X06Q6M) ; Clobetasol (ADN79D536H) ; thymic stromal lymphopoietin (GT0IL38SP4) ; Fluorescein-5-isothiocyanate (I223NX31W9)
Language	English
Publishing date	2021-02-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.620098
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Article ; Online: Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology.

Peel, Andrew D

Journal of biology

2009 Volume 8, Issue 12, Page(s) 106

Abstract: A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased, 'forward genetics' approach to the study of ...

Abstract	A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased, 'forward genetics' approach to the study of genetic mechanisms operating in Tribolium.
MeSH term(s)	Animals ; Arthropods/genetics ; Chromosome Mapping ; Coleoptera/genetics ; Gene Expression Profiling ; Genetic Speciation ; Genome, Insect ; Larva/genetics ; Oligonucleotide Array Sequence Analysis ; Phylogeny ; Research ; Tribolium/classification ; Tribolium/genetics
Language	English
Publishing date	2009-12-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2082214-5
ISSN	1475-4924 ; 1475-4924
ISSN (online)	1475-4924
ISSN	1475-4924
DOI	10.1186/jbiol208
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Article: The evolution of developmental gene networks: lessons from comparative studies on holometabolous insects.

Peel, Andrew D

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2008 Volume 363, Issue 1496, Page(s) 1539–1547

Abstract: Recent comparative studies have revealed significant differences in the developmental gene networks operating in three holometabolous insects: the beetle Tribolium castaneum, the parasitic wasp Nasonia vitripennis and the fruitfly Drosophila melanogaster. ...

Abstract	Recent comparative studies have revealed significant differences in the developmental gene networks operating in three holometabolous insects: the beetle Tribolium castaneum, the parasitic wasp Nasonia vitripennis and the fruitfly Drosophila melanogaster. I discuss these differences in relation to divergent and convergent changes in cellular embryology. I speculate on how segmentation gene networks have evolved to operate in divergent embryological contexts, and highlight the role that co-option might have played in this process. I argue that insects represent an important example of how diversification in life-history strategies between lineages can lead to divergence in the genetic and cellular mechanisms controlling the development of homologous adult structures.
MeSH term(s)	Animals ; Biological Evolution ; Body Patterning/genetics ; Drosophila melanogaster/embryology ; Drosophila melanogaster/genetics ; Female ; Gene Expression Regulation, Developmental ; Genes, Insect ; Insecta/classification ; Insecta/embryology ; Insecta/genetics ; Ovum/growth & development ; Phylogeny ; Tribolium/embryology ; Tribolium/genetics ; Wasps/embryology ; Wasps/genetics
Language	English
Publishing date	2008-04-27
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	208382-6
ISSN	1471-2970 ; 0962-8436 ; 0080-4622 ; 0264-3839
ISSN (online)	1471-2970
ISSN	0962-8436 ; 0080-4622 ; 0264-3839
DOI	10.1098/rstb.2007.2244
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