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  1. Article: Which is the top player for the cardiovascular safety? ibrutinib vs. obinutuzumab in CLL.

    Mascolo, Annamaria / Di Napoli, Raffaella / Balzano, Nunzia / D'Alessio, Elena / Izzo, Imma / Rossi, Francesco / Paolisso, Giuseppe / Capuano, Annalisa / Sportiello, Liberata

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1229304

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1229304
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  2. Article ; Online: COSMIC-312: mounting immunotherapy enigmas for hepatocellular carcinoma.

    Cabibbo, Giuseppe / Celsa, Ciro / D'Alessio, Antonio / Fulgenzi, Claudia A M / Pinato, David J

    The Lancet. Oncology

    2022  Volume 23, Issue 10, Page(s) e441

    MeSH term(s) Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/therapy ; Humans ; Immunologic Factors ; Immunotherapy/adverse effects ; Liver Neoplasms/genetics ; Liver Neoplasms/therapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2022-09-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00497-1
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  3. Article: Training in Vascular Microsurgery: The Ex Vivo Biological Model on Domestic Turkey Leg (

    La Torre, Francesca / Manfellotto, Vincenzo / Mazzarella, Vincenzo / Sorbino, Luigi / D'Alessio, Matteo / Petroccione, Carlo / Nicoletti, Maria Maddalena / Ferraro, Giuseppe Andrea / Pieretti, Gorizio

    Plastic and reconstructive surgery. Global open

    2024  Volume 12, Issue 4, Page(s) e5733

    Abstract: There are various models for practicing microsurgical anastomoses, from synthetic to ex vivo and in vivo biological ones. In this study, we present the domestic turkey ( ...

    Abstract There are various models for practicing microsurgical anastomoses, from synthetic to ex vivo and in vivo biological ones. In this study, we present the domestic turkey (
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005733
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  4. Article ; Online: Feature extraction and artificial neural networks for the on-the-fly classification of high-dimensional thermochemical spaces in adaptive-chemistry simulations – ERRATUM

    Giuseppe D’Alessio / Alberto Cuoci / Alessandro Parente

    Data-Centric Engineering, Vol

    2021  Volume 2

    Keywords Adaptive chemistry ; artificial neural networks ; feature extraction ; local principal component analysis ; ERRATUM ; Engineering (General). Civil engineering (General) ; TA1-2040
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
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  5. Article ; Online: Feature extraction and artificial neural networks for the on-the-fly classification of high-dimensional thermochemical spaces in adaptive-chemistry simulations

    Giuseppe D’Alessio / Alberto Cuoci / Alessandro Parente

    Data-Centric Engineering, Vol

    2021  Volume 2

    Abstract: The integration of Artificial Neural Networks (ANNs) and Feature Extraction (FE) in the context of the Sample- Partitioning Adaptive Reduced Chemistry approach was investigated in this work, to increase the on-the-fly classification accuracy for very ... ...

    Abstract The integration of Artificial Neural Networks (ANNs) and Feature Extraction (FE) in the context of the Sample- Partitioning Adaptive Reduced Chemistry approach was investigated in this work, to increase the on-the-fly classification accuracy for very large thermochemical states. The proposed methodology was firstly compared with an on-the-fly classifier based on the Principal Component Analysis reconstruction error, as well as with a standard ANN (s-ANN) classifier, operating on the full thermochemical space, for the adaptive simulation of a steady laminar flame fed with a nitrogen-diluted stream of n-heptane in air. The numerical simulations were carried out with a kinetic mechanism accounting for 172 species and 6,067 reactions, which includes the chemistry of Polycyclic Aromatic Hydrocarbons (PAHs) up to C $ {}_{20} $ . Among all the aforementioned classifiers, the one exploiting the combination of an FE step with ANN proved to be more efficient for the classification of high-dimensional spaces, leading to a higher speed-up factor and a higher accuracy of the adaptive simulation in the description of the PAH and soot-precursor chemistry. Finally, the investigation of the classifier’s performances was also extended to flames with different boundary conditions with respect to the training one, obtained imposing a higher Reynolds number or time-dependent sinusoidal perturbations. Satisfying results were observed on all the test flames.
    Keywords Adaptive chemistry ; artificial neural networks ; feature extraction ; local principal component analysis ; laminar flames ; Engineering (General). Civil engineering (General) ; TA1-2040
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
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  6. Article: Squamous Carcinoma of the Oral Cavity in Patient with Fanconi Anemia: A Challenging Reconstruction with Double-barrel Free Fibula Flap Case Report.

    Gargiulo, Maurizio / Petroccione, Carlo / Razzano, Sergio / La Torre, Francesca / Manfellotto, Vincenzo / D'Aniello, Giuseppe / Barbieri, Gerarda / d'Alessio, Matteo / Nicoletti, Giovanni Francesco / Ferraro, Giuseppe Andrea

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 11, Page(s) e5414

    Abstract: Fanconi anemia (FA) is a very rare form of aplastic anemia. Patients with FA have a higher risk of developing solid tumors such as head and neck squamous cell carcinoma, higher risk of local recurrence, and impaired resistance to chemotherapy and ... ...

    Abstract Fanconi anemia (FA) is a very rare form of aplastic anemia. Patients with FA have a higher risk of developing solid tumors such as head and neck squamous cell carcinoma, higher risk of local recurrence, and impaired resistance to chemotherapy and radiotherapy treatments than the normal population. In this article, we describe the challenging clinical case of a patient with FA who underwent surgery for the removal of a large squamous cell carcinoma in the oral cavity. Mandibular reconstruction was performed using a biaxial double-barrel fibular flap, with excellent functional aesthetic outcomes.
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005414
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  7. Article ; Online: The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.

    Caiazza, Carmen / Brusco, Teresa / D'Alessio, Federica / D'Agostino, Massimo / Avagliano, Angelica / Arcucci, Alessandro / Ambrosino, Concetta / Fiume, Giuseppe / Mallardo, Massimo

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen ... ...

    Abstract STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be involved in a broader range of immune processes. Here, we assessed its role in the antigen presentation by generating a STING KO macrophage cell line. In the absence of STING, we observed an impaired OVA-derived SIINFEKL peptide presentation together with a decreased level of MHC-I complex on the plasma membrane, likely due to a decreased mRNA expression of β2 m light chain as no relevant alterations of the peptide-loading complex (TAPs) were found. Moreover, JAK-STAT signaling resulted in impaired STING KO cells following OVA and LPS treatments, suggesting a dampened activation of immune response. Our data revealed a new molecular role of STING in immune mechanisms that could elucidate its role in the pathogenesis of autoimmune disorders and cancer.
    MeSH term(s) Animals ; Mice ; Antigen Presentation ; Macrophages/metabolism ; Signal Transduction ; Immunity, Innate ; Histocompatibility Antigens ; Membrane Proteins/metabolism
    Chemical Substances Histocompatibility Antigens ; Membrane Proteins
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214232
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  8. Article: Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms.

    D'Alessio, Federico / Lione, Lucia / Salvatori, Erika / Bucci, Federica / Muzi, Alessia / Roscilli, Giuseppe / Compagnone, Mirco / Pinto, Eleonora / Battistuzzi, Gianfranco / Conforti, Antonella / Aurisicchio, Luigi / Palombo, Fabio

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we ... ...

    Abstract DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunological response induced by a plasmid DNA vaccine delivered using electroporation. As a model, we used COVID-eVax, a plasmid DNA-based vaccine that targets the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Increased nicked DNA was produced by using either an accelerated stability protocol or a lyophilization protocol. Surprisingly, the immune response induced in vivo was only minimally affected by the percentage of open circular DNA. This result suggests that plasmid DNA vaccines, such as COVID-eVax that have recently completed a phase I clinical trial, retain their efficacy upon storage at higher temperatures, and this feature may facilitate their use in low-/middle-income countries.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030678
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  9. Article ; Online: Conversion factors for effective dose and organ doses with the air Kerma area product in hysterosalpingography.

    D'Alessio, Andrea / Cannillo, Barbara / Guzzardi, Giuseppe / Cernigliaro, Massimiliano / Carriero, Alessandro / Brambilla, Marco

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2020  Volume 81, Page(s) 40–46

    Abstract: Histerosalpingography (HSG) remains the dominant diagnostic tool for investigation of infertility in women. Conversion factors used to estimate effective (E) and organ doses ( ... ...

    Abstract Histerosalpingography (HSG) remains the dominant diagnostic tool for investigation of infertility in women. Conversion factors used to estimate effective (E) and organ doses (H
    MeSH term(s) Female ; Fluoroscopy ; Humans ; Hysterosalpingography ; Monte Carlo Method ; Radiation Dosage ; Radiography
    Language English
    Publishing date 2020-12-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2020.11.032
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    Zs.B 2941: Show issues Location:
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  10. Article ; Online: Evaluation of operator eye exposure and eye protective devices in interventional radiology: Results on clinical staff and phantom.

    D'Alessio, Andrea / Matheoud, Roberta / Cannillo, Barbara / Guzzardi, Giuseppe / Galbani, Francesca / Galbiati, Andrea / Spinetta, Marco / Stanca, Carmelo / Tettoni, Serena Maria / Carriero, Alessandro / Brambilla, Marco

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2023  Volume 110, Page(s) 102603

    Abstract: Purpose: To assess occupational eye lens dose based on clinical monitoring of interventional radiologists and to assess personal protective eyewear (PPE) efficacy through measurements with anthropomorphic phantom.: Methods: Two positions of the ... ...

    Abstract Purpose: To assess occupational eye lens dose based on clinical monitoring of interventional radiologists and to assess personal protective eyewear (PPE) efficacy through measurements with anthropomorphic phantom.
    Methods: Two positions of the operator with respect to X-ray beam were simulated with phantom. Dose reduction factor (DRF) of four PPE was assessed, as well as correlation between eye lens and whole-body doses. Brain dose was also assessed. Five radiologists were monitored for one-year clinical procedures. All subjects were equipped with whole-body dosimeter placed over lead apron at the chest level and eye lens dosimeter placed over the left side of the PPE. Kerma-Area Product (KAP) of procedures performed during the monitoring period was recorded. The correlation of eye lens dose with whole-body dose and KAP was assessed.
    Results: DRF was 4.3/2.4 for wraparound glasses, 4.8/1.9 for fitover glasses, 9.1/6.8 for full-face visor in radial/femoral geometries. DRF of half-face visor depended on how it is worn (range 1.0-4.9). Statistically significant correlation between dose value over the PPE and chest dose was observed, while there was no correlation between eye lens dose and chest dose. The results on clinical staff showed statistically significant correlation between dose values over the PPE and KAP.
    Conclusions: All PPE showed significant DRF in all configurations, provided they were worn correctly. Single DRF value is not applicable to all clinical situations. KAP is a valuable tool for determining appropriate radiation protection measures.
    MeSH term(s) Humans ; Radiology, Interventional/methods ; Radiation Dosage ; Eye Protective Devices ; Radiation Protection/methods ; Lens, Crystalline ; Occupational Exposure/prevention & control ; Occupational Exposure/analysis ; Radiation Exposure/prevention & control
    Language English
    Publishing date 2023-05-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2023.102603
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