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  1. Article ; Online: Filling an Important Knowledge Gap: The DOAC Score.

    Ezekowitz, Michael D / Kamareddine, Mohammed

    Circulation

    2023  Volume 148, Issue 12, Page(s) 947–949

    MeSH term(s) Humans ; Atrial Fibrillation ; Factor Xa Inhibitors ; Patients
    Chemical Substances Factor Xa Inhibitors
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.066316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  2. Article ; Online: Left Ventricular Thrombi: Uncommon But Clinically Important.

    Ezekowitz, Michael D / Kurz, Daniel / Kent, Anthony

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 14, Page(s) 1686–1688

    MeSH term(s) Fibrinolytic Agents/therapeutic use ; Heart Diseases/diagnostic imaging ; Heart Diseases/drug therapy ; Humans ; Thrombosis/diagnostic imaging ; Thrombosis/drug therapy
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  3. Article ; Online: The impact of IMPACT-AF.

    Ezekowitz, Michael D / Kent, Anthony P

    Lancet (London, England)

    2017  Volume 390, Issue 10104, Page(s) 1717–1718

    MeSH term(s) Anticoagulants ; Atrial Fibrillation/surgery ; Catheter Ablation ; Humans ; Treatment Outcome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2017-08-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(17)32248-1
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    Zs.MG 94: Show issues

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  4. Book: Anticoagulants, antiplatelet therapy and cardiovascular disease

    Ezekowitz, Michael D.

    (Cardiology clinics ; 12,3)

    1994  

    Author's details Michael D. Ezekowitz, guest ed
    Series title Cardiology clinics ; 12,3
    Collection
    Keywords Platelet Aggregation Inhibitors / therapeutic use ; Anticoagulants / therapeutic use ; Thrombosis / prevention & control ; Thrombosis / drug therapy
    Language English
    Size VII S., S. 399 - 541 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006372979
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 853 -12,3- verfügbar in Königswinter Königswinter

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  5. Book: Systemic cardiac embolism

    Ezekowitz, Michael D.

    (Fundamental and clinical cardiology ; 18)

    1994  

    Author's details ed. by Michael D. Ezekowitz
    Series title Fundamental and clinical cardiology ; 18
    Collection
    Keywords Blood Coagulation / physiology ; Thrombolytic Therapy / methods ; Thromboembolism / diagnosis ; Thromboembolism / therapy ; Cardiovascular Diseases / etiology ; Cardiovascular System / physiopathology ; Koronararterie ; Embolie
    Subject Herzkranzgefäß ; Koronargefäß ; Kranzarterie
    Language English
    Size XIX, 393 S. : Ill., graph. Darst.
    Edition 1. print.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006319975
    ISBN 0-8247-9151-7 ; 978-0-8247-9151-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 2695 order for loan Magazin

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  6. Article ; Online: Estimating Vitamin K Antagonist Anticoagulation Benefit in People With Atrial Fibrillation Accounting for Competing Risks: Evidence From 12 Randomized Trials.

    Shah, Sachin J / van Walraven, Carl / Jeon, Sun Young / Boscardin, John / Hobbs, F D Richard / Connolly, Stuart J / Ezekowitz, Michael D / Covinsky, Kenneth E / Fang, Margaret C / Singer, Daniel E

    Circulation. Cardiovascular quality and outcomes

    2024  Volume 17, Issue 4, Page(s) e010269

    Abstract: Background: Patients with atrial fibrillation have a high mortality rate that is only partially attributable to vascular outcomes. The competing risk of death may affect the expected anticoagulant benefit. We determined if competing risks materially ... ...

    Abstract Background: Patients with atrial fibrillation have a high mortality rate that is only partially attributable to vascular outcomes. The competing risk of death may affect the expected anticoagulant benefit. We determined if competing risks materially affect the guideline-endorsed estimate of anticoagulant benefit.
    Methods: We conducted a secondary analysis of 12 randomized controlled trials that randomized patients with atrial fibrillation to vitamin K antagonists (VKAs) or either placebo or antiplatelets. For each participant, we estimated the absolute risk reduction (ARR) of VKAs to prevent stroke or systemic embolism using 2 methods-first using a guideline-endorsed model (CHA
    Results: A total of 7933 participants (median age, 73 years, 36% women) had a median life expectancy of 8 years (interquartile range, 6-12), determined by comorbidity-adjusted life tables and 43% were randomized to VKAs. The CHA
    Conclusions: VKA anticoagulants were exceptionally effective at reducing stroke risk. However, VKA benefits were misestimated with CHA
    MeSH term(s) Humans ; Female ; Aged ; Male ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/complications ; Randomized Controlled Trials as Topic ; Anticoagulants/adverse effects ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/prevention & control ; Fibrinolytic Agents/therapeutic use ; Vitamin K ; Risk Assessment ; Risk Factors
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6744: Show issues Location:
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  7. Article ; Online: Adding rigor to stroke risk prediction in atrial fibrillation.

    Singer, Daniel E / Ezekowitz, Michael D

    Journal of the American College of Cardiology

    2015  Volume 65, Issue 3, Page(s) 233–235

    MeSH term(s) Atrial Fibrillation/epidemiology ; Brain Ischemia/epidemiology ; Female ; Humans ; Male ; Risk Assessment ; Stroke/epidemiology
    Language English
    Publishing date 2015-01-27
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2014.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1846: Show issues Location:
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  8. Article ; Online: Integration of longitudinal and circumferential strain predicts volumetric change across the cardiac cycle and differentiates patients along the heart failure continuum.

    Samuel, T Jake / Oneglia, Andrew P / Cipher, Daisha J / Ezekowitz, Justin A / Dyck, Jason R B / Anderson, Todd / Howlett, Jonathan G / Paterson, D Ian / Thompson, Richard B / Nelson, Michael D

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2023  Volume 25, Issue 1, Page(s) 55

    Abstract: Background: Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes throughout the cardiac cycle. We sought to explore this strain-volume ... ...

    Abstract Background: Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes throughout the cardiac cycle. We sought to explore this strain-volume relationship in more detail, by mathematically integrating circumferential and longitudinal strain and strain rate to predict LV volume and volumetric rates of change.
    Methods: Cardiac magnetic resonance (CMR) imaging from 229 participants from the Alberta HEART Study (46 healthy controls, 77 individuals at risk for developing heart failure [HF], 70 patients with diagnosed HF with preserved ejection fraction [HFpEF], and 36 patients with diagnosed HF with reduced ejection fraction [HFrEF]) were evaluated. LV volume was assessed by the method of disks and strain/strain rate were assessed by CMR feature tracking.
    Results: Integrating endocardial circumferential and longitudinal strain provided a close approximation of LV ejection fraction (EF
    Conclusions: The data herein establish the theoretical framework for integrating discrete strain components into volumetric measurements across the cardiac cycle, and highlight the potential benefit of this approach for differentiating patients along the heart failure continuum.
    MeSH term(s) Humans ; Heart Failure ; Stroke Volume ; Predictive Value of Tests ; Heart ; Ventricular Function, Left
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-023-00969-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Patients With Atrial Fibrillation: Switching Emphasis From Stroke Prevention to Stroke and Hemorrhage Prevention.

    Ezekowitz, Michael D / Chandhok, Sheetal / Arce, Javier E

    JACC. Clinical electrophysiology

    2017  Volume 3, Issue 12, Page(s) 1377–1379

    MeSH term(s) Anticoagulants ; Atrial Fibrillation ; Hemorrhage ; Humans ; Stroke
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2017-11-06
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2017.06.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prognostic Impact of Repeated NT-proBNP Measurements in Patients With Heart Failure With Reduced Ejection Fraction.

    Fuery, Michael A / Leifer, Eric S / Samsky, Marc D / Sen, Sounok / O'Connor, Christopher M / Fiuzat, Mona / Ezekowitz, Justin / Piña, Ileana / Whellan, David / Mark, Daniel / Felker, G Michael / Desai, Nihar R / Januzzi, James L / Ahmad, Tariq

    JACC. Heart failure

    2023  Volume 12, Issue 3, Page(s) 479–487

    Abstract: Background: Although clinical studies have demonstrated the association between a single N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement and clinical outcomes in chronic heart failure, the biomarker is frequently measured serially in ... ...

    Abstract Background: Although clinical studies have demonstrated the association between a single N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement and clinical outcomes in chronic heart failure, the biomarker is frequently measured serially in clinical practice.
    Objectives: The aim of this study was to determine the added prognostic value of repeated NT-proBNP measurements compared with single measurements alone for chronic heart failure patients.
    Methods: In the GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study, 894 study participants with chronic heart failure with reduced ejection fraction were enrolled at 45 outpatient sites in the United States and Canada. Repeated NT-proBNP levels were measured over a 2-year study period. Associations between repeated NT-proBNP measurements and trial endpoints were assessed using a joint longitudinal and survival model.
    Results: After adjustment for baseline covariates, each doubling of the baseline NT-proBNP level was associated with a HR of 1.17 (95% CI: 1.08-1.28; P = 0.0003) for the primary trial endpoint of cardiovascular death or heart failure hospitalization. Serial measurements increased the adjusted HR for the primary trial endpoint to 1.66 (95% CI: 1.50-1.84; P < 0.0001), and a similar increased risk was observed across secondary trial endpoints. In joint modeling, an increase in NT-proBNP occurred weeks before the onset of adjudicated events.
    Conclusions: Repeated NT-proBNP measurements are a strong predictor of outcomes in heart failure with reduced ejection fraction with an increase in concentration occurring well before event onset. These results may support routine NT-proBNP monitoring to assist in clinical decision making. (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure [GUIDE-IT]; NCT01685840).
    MeSH term(s) Humans ; Prognosis ; Heart Failure/therapy ; Stroke Volume ; Natriuretic Peptide, Brain/therapeutic use ; Peptide Fragments ; Biomarkers ; Chronic Disease
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments ; Biomarkers
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.11.007
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