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  1. Article ; Online: Cytokines 2022: 10th Annual Meeting of the International Cytokine & Interferon Society.

    Donnelly, Raymond P

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2023  Volume 43, Issue 2, Page(s) 55–58

    MeSH term(s) Interferons ; Cytokines
    Chemical Substances Interferons (9008-11-1) ; Cytokines
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.29050.rad
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Darren P. Baker, PhD A Pioneer in the Development of Pegylated Interferon-β for Clinical Use.

    Donnelly, Raymond P

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2023  Volume 43, Issue 3, Page(s) 105–107

    MeSH term(s) Interferon-beta ; Antiviral Agents ; Interferon-alpha ; Polyethylene Glycols ; Recombinant Proteins ; Ribavirin
    Chemical Substances Interferon-beta (77238-31-4) ; Antiviral Agents ; Interferon-alpha ; Polyethylene Glycols (3WJQ0SDW1A) ; Recombinant Proteins ; Ribavirin (49717AWG6K)
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2023.29051.editorial
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Howard A. Young: Always Willing to Lend a Helping Hand.

    Donnelly, Raymond P

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2022  

    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Letter
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.0085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Cytokine therapies

    Donnelly, Raymond P.

    novel approaches for clinical indications ; [manuscripts stemming from the Conference "Cytokine Therapies: Novel Approaches for Clinical Indications," held at the New York Academy of Sciences Conference Center on March 26 - 27, 2009]

    (Annals of the New York Academy of Sciences ; 1182)

    2009  

    Event/congress Conference Cytokine Therapies: Novel Approaches for Clinical Indications (2009, NewYorkNY)
    Author's details ed. by Raymond P. Donnelly
    Series title Annals of the New York Academy of Sciences ; 1182
    Collection
    Language English
    Size VI, 160 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016205812
    ISBN 978-1-57331-783-2 ; 1-57331-783-7
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: The Interferon-Lambda Family Celebrates 20 Years of Scientific Discovery.

    Donnelly, Raymond P / Prokunina-Olsson, Ludmila

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2023  Volume 43, Issue 9, Page(s) 359–362

    Abstract: It has now been 20 years since the original discovery of the interferon λ (IFN-λ) family (Kotenko et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina-Olsson et al., 2013). The IFN-λ family (type III IFNs) ...

    Abstract It has now been 20 years since the original discovery of the interferon λ (IFN-λ) family (Kotenko et al., 2003; Sheppard et al., 2003) and 10 years since the subsequent discovery of IFN-λ4 (Prokunina-Olsson et al., 2013). The IFN-λ family (type III IFNs) includes 4 members: IFN-λ1, 2, 3, and 4, and all 4 of these proteins signal through the same heterodimeric receptor complex: IFN-λR1 plus IL-10R2. Throughout the past 20 years, much has been learned about the IFN-λ family and the important role of these cytokines in antiviral responses against viruses such as hepatitis C virus, influenza A virus, and SARS-CoV-2. This special issue of the
    MeSH term(s) Humans ; Interferon Lambda ; COVID-19 ; SARS-CoV-2 ; Interferons ; Cytokines
    Chemical Substances Interferon Lambda ; Interferons (9008-11-1) ; Cytokines
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2023.0122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of the Antiviral Activity of Remdesivir, Chloroquine, and Interferon-β as Single or Dual Agents Against the Human Beta-Coronavirus OC43.

    Hickerson, Brady T / Sheikh, Faruk / Donnelly, Raymond P / Ilyushina, Natalia A

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2023  Volume 43, Issue 1, Page(s) 35–42

    Abstract: The human beta-coronavirus strain, OC43, provides a useful model for testing the antiviral activity of various agents. We compared the activity of several antiviral drugs against OC43, including remdesivir, chloroquine, interferon (IFN)-β, IFN-λ1, and ... ...

    Abstract The human beta-coronavirus strain, OC43, provides a useful model for testing the antiviral activity of various agents. We compared the activity of several antiviral drugs against OC43, including remdesivir, chloroquine, interferon (IFN)-β, IFN-λ1, and IFN-λ4, in two distinct cell types: human colorectal carcinoma cell line (HCT-8 cells) and normal human bronchial epithelial (NHBE) cells. We also tested whether these agents mediate additive, synergistic, or antagonistic activity against OC43 infection when used in combination. When used as single agents, remdesivir exhibited stronger antiviral activity than chloroquine, and IFN-β exhibited stronger activity than IFN-λ1 or IFN-λ4 against OC43 in both HCT-8 and NHBE cells. Anakinra (IL-1 inhibitor) and tocilizumab (IL-6 inhibitor) did not mediate any antiviral activity. The combination of IFN-β plus chloroquine or remdesivir resulted in higher synergy scores and higher expression of IFN-stimulated genes than did IFN-β alone. In contrast, the combination of remdesivir plus chloroquine resulted in an antagonistic interaction in NHBE cells. Our findings indicate that the combined use of IFN-β plus remdesivir or chloroquine induces maximal antiviral activity against human coronavirus strain OC43 in primary human respiratory epithelial cells. Furthermore, our experimental OC43 virus infection model provides an excellent method for evaluating the biological activity of antiviral drugs.
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Interferon-beta/pharmacology ; Interferon-beta/therapeutic use ; Coronavirus OC43, Human/genetics ; Coronavirus OC43, Human/metabolism ; Chloroquine/pharmacology ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Interferons/metabolism
    Chemical Substances Antiviral Agents ; Interferon-beta (77238-31-4) ; Chloroquine (886U3H6UFF) ; remdesivir (3QKI37EEHE) ; Interferons (9008-11-1)
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.0210
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  7. Article: Generation and characterization of interferon-beta-resistant H1N1 influenza A virus.

    Hickerson, Brady T / Adams, Simone E / Bovin, Nicolai V / Donnelly, Raymond P / Ilyushina, Natalia A

    Acta virologica

    2022  Volume 66, Issue 3, Page(s) 263–274

    Abstract: Interferons (IFNs) mediate innate antiviral activity against many types of viruses, including influenza viruses. In light of their potential use as anti-influenza agents, we examined whether resistance to these host antiviral proteins can develop. We ... ...

    Abstract Interferons (IFNs) mediate innate antiviral activity against many types of viruses, including influenza viruses. In light of their potential use as anti-influenza agents, we examined whether resistance to these host antiviral proteins can develop. We generated IFN-β-resistant variants of the A/California/04/09 (H1N1) virus by serial passage in a human airway epithelial cell line, Calu-3, under IFN-β selective pressure. The combination of specific mutations (i.e., L373I in PB1, K154E1, D222G1, I56V2, and V122I2 in HA, and M269I in NA) correlated with decreased ability of the virus to induce expression of IFN (IFNB1, IFNL1, and IFNL2/3) and IFN-stimulated genes (IFIT1, IFIT3, OAS1, IRF7, and MX1) by target respiratory epithelial cells. In addition, the IFN-induced mutations were associated with decreased HA binding affinity to α2,6 sialyl receptors, reduced NA enzyme catalytic activity, and decreased polymerase transcription activity. Our findings demonstrate that the mutations in the influenza HA, NA, and PB1 proteins induced by IFN-b selective pressure significantly increase viral ability to productively infect and replicate in host cells. Keywords: influenza A virus; interferon-β; lung epithelial cells; interferon response.
    MeSH term(s) Antiviral Agents/pharmacology ; Cytokines ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A virus ; Influenza, Human/genetics ; Interferon-beta/genetics ; Interferons/genetics ; Interferons/pharmacology ; Virus Replication
    Chemical Substances Antiviral Agents ; Cytokines ; Interferon-beta (77238-31-4) ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-08-26
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 210452-0
    ISSN 1336-2305 ; 0001-723X
    ISSN (online) 1336-2305
    ISSN 0001-723X
    DOI 10.4149/av_2022_311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility.

    Hickerson, Brady T / Petrovskaya, Svetlana N / Dickensheets, Harold / Donnelly, Raymond P / Ince, William L / Ilyushina, Natalia A

    Journal of virology

    2023  Volume 97, Issue 7, Page(s) e0015423

    Abstract: Baloxavir marboxil (baloxavir) is a recently FDA-approved influenza virus polymerase acidic (PA) endonuclease inhibitor. Several PA substitutions have been demonstrated to confer reduced susceptibility to baloxavir; however, their impacts on measurements ...

    Abstract Baloxavir marboxil (baloxavir) is a recently FDA-approved influenza virus polymerase acidic (PA) endonuclease inhibitor. Several PA substitutions have been demonstrated to confer reduced susceptibility to baloxavir; however, their impacts on measurements of antiviral drug susceptibility and replication capacity when present as a fraction of the viral population have not been established. We generated recombinant A/California/04/09 (H1N1)-like viruses (IAV) with PA I38L, I38T, or E199D substitutions and B/Victoria/504/2000-like virus (IBV) with PA I38T. These substitutions reduced baloxavir susceptibility by 15.3-, 72.3-, 5.4-, and 54.5-fold, respectively, when tested in normal human bronchial epithelial (NHBE) cells. We then assessed the replication kinetics, polymerase activity, and baloxavir susceptibility of the wild-type:mutant (WT:MUT) virus mixtures in NHBE cells. The percentage of MUT relative to WT virus necessary to detect reduced baloxavir susceptibility in phenotypic assays ranged from 10% (IBV I38T) to 92% (IAV E199D). While I38T did not alter IAV replication kinetics or polymerase activity, IAV PA I38L and E199D MUTs and the IBV PA I38T MUT exhibited reduced replication levels and significantly altered polymerase activity. Differences in replication were detectable when the MUTs comprised ≥90%, ≥90%, or ≥75% of the population, respectively. Droplet digital PCR (ddPCR) and next-generation sequencing (NGS) analyses showed that WT viruses generally outcompeted the respective MUTs after multiple replication cycles and serial passaging in NHBE cells when initial mixtures contained ≥50% of the WT viruses; however, we also identified potential compensatory substitutions (IAV PA D394N and IBV PA E329G) that emerged and appeared to improve the replication capacity of baloxavir-resistant virus in cell culture.
    MeSH term(s) Humans ; Amino Acid Substitution ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Resistance, Viral/genetics ; Endonucleases/genetics ; Influenza A Virus, H1N1 Subtype/drug effects ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Nucleotidyltransferases/genetics ; Thiepins/pharmacology ; Thiepins/therapeutic use ; Virus Replication/drug effects ; Virus Replication/genetics ; Mutation ; Cell Line
    Chemical Substances Antiviral Agents ; baloxavir (4G86Y4JT3F) ; Endonucleases (EC 3.1.-) ; Nucleotidyltransferases (EC 2.7.7.-) ; Thiepins
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00154-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Identification of a pharmacological approach to reduce ACE2 expression and development of an

    Endo, Yukinori / Hickerson, Brady T / Ilyushina, Natalia A / Mohan, Nishant / Peng, Hanjing / Takeda, Kazuyo / Donnelly, Raymond P / Wu, Wen Jin

    Journal of virus eradication

    2022  , Page(s) 100307

    Abstract: Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19. In this study we ... ...

    Abstract Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19. In this study we developed an
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2868549-0
    ISSN 2055-6659 ; 2055-6640
    ISSN (online) 2055-6659
    ISSN 2055-6640
    DOI 10.1016/j.jve.2022.100307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donors.

    Ilyushina, Natalia A / Dickensheets, Harold / Donnelly, Raymond P

    Virus research

    2019  Volume 264, Page(s) 1–7

    Abstract: ... cells (˜31-fold↑ in D1 cells versus D2 cells; P < 0.05). The levels of IFN-λ1 protein at individual time ... than in D2 NHBE cells (0.7-7.7-fold↑, P < 0.05). The relative levels of IFN-stimulated gene (ISG) expression ...

    Abstract Influenza is an acute respiratory disease that can cause local annual epidemics and worldwide pandemics of different morbidity and mortality. Our understanding of host factors that modulate the frequency and severity of influenza virus infections is less than complete. In this study, we examined the inter-individual variations in the innate immune responses to H1N1 and H3N2 influenza A viruses (IAV) using primary cultures of normal human bronchial epithelial (NHBE) cells derived from two different donors (D1 and D2). Although IAV replication kinetics were similar in cultures derived from these two donors, the levels of type III interferons (IFNs) were significantly higher in D1 cells compared to D2 cells (˜31-fold↑ in D1 cells versus D2 cells; P < 0.05). The levels of IFN-λ1 protein at individual time points as well as the total amounts of IFN-λ1 secreted over 72 h were also significantly higher in D1 than in D2 NHBE cells (0.7-7.7-fold↑, P < 0.05). The relative levels of IFN-stimulated gene (ISG) expression also differed significantly between D1 and D2 cells. Our data indicate that donor-specific differences can result in significant differences in IFN and ISG induction by human airway epithelium.
    MeSH term(s) Animals ; Bronchi/cytology ; Bronchi/virology ; Cells, Cultured ; Dogs ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression ; Humans ; Immunity, Innate ; Influenza A Virus, H1N1 Subtype/physiology ; Influenza A Virus, H3N2 Subtype/physiology ; Interferons/genetics ; Madin Darby Canine Kidney Cells ; Virus Replication
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2019-02-16
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2019.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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