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  1. Book ; Online ; E-Book: Immunopharmacology and inflammation

    Riccardi, Carlo / Levi-Schaffer, Francesca / Tiligada, Ekaterini

    2018  

    Author's details Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada editors
    Language English
    Size 1 Online-Ressource (viii, 331 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019754596
    ISBN 978-3-319-77658-3 ; 9783319776576 ; 3-319-77658-4 ; 3319776576
    DOI 10.1007/978-3-319-77658-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial to the special issue on the challenge of histamine and histamine receptor pharmacology and therapeutics in the 21st century.

    Tiligada, Ekaterini

    Pharmacological research

    2016  Volume 114, Page(s) 74

    Language English
    Publishing date 2016-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2016.10.009
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  3. Article ; Online: Challenges in the development and exploitation of new therapeutic options targeting the histaminergic system.

    Chazot, Paul L / Tiligada, Ekaterini

    British journal of pharmacology

    2020  Volume 177, Issue 3, Page(s) 467–468

    Abstract: Linked articles: This article is part of a themed section on New Uses for 21st Century Antihistamines. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc. ...

    Abstract Linked articles: This article is part of a themed section on New Uses for 21st Century Antihistamines. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.3/issuetoc.
    Language English
    Publishing date 2020-01-28
    Publishing country England
    Document type Editorial
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14947
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  4. Article ; Online: Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS).

    Obara, Ilona / Fernandes, João Paulo S / Tiligada, Ekaterini

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2022  Volume 71, Issue 7-8, Page(s) 995–998

    Abstract: In the light of cancellation of the 50th Annual Meeting of the European Histamine Research Society (EHRS) due to continuing challenges and restrictions imposed by the coronavirus disease 2019 (COVID-19) outbreak, the EHRS Council decided to organize a ... ...

    Abstract In the light of cancellation of the 50th Annual Meeting of the European Histamine Research Society (EHRS) due to continuing challenges and restrictions imposed by the coronavirus disease 2019 (COVID-19) outbreak, the EHRS Council decided to organize a series of online events spread in 2021 to allow dissemination of histamine research progress and advancement among the Society members and beyond. This report summarizes the outcomes of the EHRS Council initiative that comprised the organization of four webinars, each focusing on a highly relevant histamine research scientific area. These included insights into novel therapeutic targets related to the histaminergic system in the eye, histamine intolerance, and the role of histamine and the histaminergic system in the regulation of the nervous system, as well as an update on studies leading to the development of novel methods for histamine detection. The outcome of this series of virtual events conformed that histamine research continued to develop despite the pandemic, and we witnessed stimulating advancements in 2021. Importantly, the EHRS Council brought histaminologists together in this unprecedented time.
    MeSH term(s) COVID-19 ; Histamine ; Humans ; Pandemics
    Chemical Substances Histamine (820484N8I3)
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-022-01589-9
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  5. Article ; Online: "Novel insights into the roles of mast cells and basophils": Joint Webinar of the Japanese and the European Histamine Research Societies (JHRS/EHRS).

    Tiligada, Ekaterini / Gibbs, Bernhard F / Tanaka, Satoshi

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2022  Volume 71, Issue 7-8, Page(s) 991–993

    Abstract: The joint webinar of the Japanese (JHRS) and the European (EHRS) Histamine Research Society focusing on "Novel insights into the roles of mast cells and basophils" was organized in hybrid format on January 7, 2022 during the 23rd meeting of the JHRS held ...

    Abstract The joint webinar of the Japanese (JHRS) and the European (EHRS) Histamine Research Society focusing on "Novel insights into the roles of mast cells and basophils" was organized in hybrid format on January 7, 2022 during the 23rd meeting of the JHRS held in Kyoto, Japan. Tissue mast cells and circulating basophils are the primary sources of histamine, and they are considered to be pivotal components shaping inflammatory and immune-related processes. The webinar comprised four lectures delivered by experts in the field from Japan and the European Mast Cell and Basophil Research Network (EMBRN) that exposed novel insights into the contribution of basophils and mast cells in inflammatory and (auto)immune diseases, including allergies, asthma, and urticaria. Several targets were also highlighted in terms of developing novel and improved treatments for these pathologies.
    MeSH term(s) Basophils ; Histamine ; Histamine Release ; Japan ; Mast Cells
    Chemical Substances Histamine (820484N8I3)
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-022-01575-1
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  6. Article ; Online: Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases.

    Tiligada, Ekaterini / Gafarov, Daria / Zaimi, Maria / Vitte, Joana / Levi-Schaffer, Francesca

    Annual review of pharmacology and toxicology

    2023  Volume 64, Page(s) 481–506

    Abstract: The exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The ... ...

    Abstract The exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeutic monoclonal antibodies against cytokines, alarmins, and their receptors, as well as small-molecule modifiers of signal transduction mainly mediated by Janus kinases and Bruton's tyrosine kinases. However, the first-line therapeutic options have yet to switch from symptomatic to disease-modifying interventions. Here we present an overview of available drugs in the context of our current understanding of allergy pathophysiology, identify potential therapeutic targets, and conclude by providing a selection of candidate immunopharmacological molecules under investigation for potential future use in allergic diseases.
    MeSH term(s) Humans ; Hypersensitivity/drug therapy ; Antibodies, Monoclonal ; Cytokines ; Inflammation ; Signal Transduction
    Chemical Substances Antibodies, Monoclonal ; Cytokines
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051623-091038
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  7. Article ; Online: Histamine pharmacology: from Sir Henry Dale to the 21st century.

    Tiligada, Ekaterini / Ennis, Madeleine

    British journal of pharmacology

    2018  Volume 177, Issue 3, Page(s) 469–489

    Abstract: Histamine has been one of the most studied substances in medicine, playing a major role in diverse (patho)physiological processes. It elicits its multifaceted modulatory functions by activating four types of GPCRs, designated as ... ...

    Abstract Histamine has been one of the most studied substances in medicine, playing a major role in diverse (patho)physiological processes. It elicits its multifaceted modulatory functions by activating four types of GPCRs, designated as H
    MeSH term(s) Histamine ; Histamine Antagonists/pharmacology ; Receptors, Histamine
    Chemical Substances Histamine Antagonists ; Receptors, Histamine ; Histamine (820484N8I3)
    Language English
    Publishing date 2018-12-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14524
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  8. Article ; Online: Editorial: is histamine the missing link in chronic inflammation?

    Tiligada, Ekaterini

    Journal of leukocyte biology

    2012  Volume 92, Issue 1, Page(s) 4–6

    MeSH term(s) Animals ; Antigen-Presenting Cells/drug effects ; Antigen-Presenting Cells/metabolism ; Histamine/pharmacology ; Histamine Agonists/pharmacology ; Humans ; Interleukins/metabolism ; Receptors, Histamine/physiology
    Chemical Substances Histamine Agonists ; Il27 protein, mouse ; Interleukins ; MYDGF protein, human ; Receptors, Histamine ; Histamine (820484N8I3)
    Language English
    Publishing date 2012-06-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.0212093
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    Zs.A 603: Show issues Location:
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  9. Article ; Online: Mast cells contribute to the resolution of allergic inflammation by releasing resolvin D1.

    Puzzovio, Pier Giorgio / Pahima, Hadas / George, Tresa / Mankuta, David / Eliashar, Ron / Tiligada, Ekaterini / Levy, Bruce D / Levi-Schaffer, Francesca

    Pharmacological research

    2023  Volume 189, Page(s) 106691

    Abstract: Background: Mast cells are initiators and main effectors of allergic inflammation, together with eosinophils, with whom they can interact in a physical and soluble cross-talk with marked pro-inflammatory features, the Allergic Effector Unit. The pro- ... ...

    Abstract Background: Mast cells are initiators and main effectors of allergic inflammation, together with eosinophils, with whom they can interact in a physical and soluble cross-talk with marked pro-inflammatory features, the Allergic Effector Unit. The pro-resolution role of mast cells, alone or in co-culture with eosinophils, has not been characterized yet.
    Objectives: We aimed to investigate select pro-resolution pathways in mast cells in vitro and in vivo in allergic inflammation.
    Methods: In vitro, we employed human and murine mast cells and analyzed release of resolvin D1 and expression of 15-lipoxygenase after IgE-mediated activation. We performed co-culture of IgE-activated mast cells with peripheral blood eosinophils and investigated 15-lipoxygenase expression and Resolvin D1 release. In vivo, we performed Ovalbumin/Alum and Ovalbumin/S. aureus enterotoxin B allergic peritonitis model in Wild Type mice following a MC "overshoot" protocol.
    Results: We found that IgE-activated mast cells release significant amounts of resolvin D1 30 min after activation, while 15-lipoxygenase expression remained unchanged. Resolvin D1 release was found to be decreased in IgE-activated mast cells co-cultured with peripheral blood eosinophils for 30 min In vivo, mast cell-overshoot mice exhibited a trend of reduced inflammation, together with increased peritoneal resolvin D1 release.
    Conclusions: Mast cells can actively contribute to resolution of allergic inflammation by releasing resolvin D1.
    MeSH term(s) Mice ; Humans ; Animals ; Mast Cells/metabolism ; Ovalbumin/metabolism ; Staphylococcus aureus/metabolism ; Arachidonate 15-Lipoxygenase/metabolism ; Inflammation/metabolism ; Immunoglobulin E
    Chemical Substances Ovalbumin (9006-59-1) ; resolvin D1 ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33) ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106691
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  10. Article ; Online: L-Thyroxine induces thermotolerance in yeast.

    Papamichael, Konstantinos / Delitheos, Basil / Mourouzis, Iordanis / Pantos, Constantinos / Tiligada, Ekaterini

    Cell stress & chaperones

    2019  Volume 24, Issue 2, Page(s) 469–473

    Abstract: The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of L-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was ... ...

    Abstract The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of L-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 °C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H
    MeSH term(s) Cell Survival ; HSP90 Heat-Shock Proteins/metabolism ; Proton-Translocating ATPases/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/physiology ; Saccharomyces cerevisiae Proteins/metabolism ; Thermotolerance ; Thyroxine/pharmacology
    Chemical Substances HSP82 protein, S cerevisiae ; HSP90 Heat-Shock Proteins ; Saccharomyces cerevisiae Proteins ; Proton-Translocating ATPases (EC 3.6.3.14) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2019-02-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-019-00978-0
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