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  1. Book ; Online: Geochemistry of ODP Hole 108-658C sediments, supplementary data to: Cole, Jennifer M; Goldstein, Steven L; deMenocal, Peter B; Hemming, Sidney R; Grousset, Francis E (2009): Contrasting compositions of Saharan dust in the eastern Atlantic Ocean during the last deglaciation and African Humid Period. Earth and Planetary Science Letters, 278(3-4), 257-266

    Cole, Jennifer M / Goldstein, Steven L / Grousset, Francis E / Hemming, Sidney R / deMenocal, Peter B

    2009  

    Abstract: During the African Humid Period (AHP), much of the modern hyperarid Saharan desert was vegetated and covered with numerous lakes. In marine sediments off northwestern Africa, the AHP is represented by markedly reduced siliciclastic sediment flux between ~ ...

    Abstract During the African Humid Period (AHP), much of the modern hyperarid Saharan desert was vegetated and covered with numerous lakes. In marine sediments off northwestern Africa, the AHP is represented by markedly reduced siliciclastic sediment flux between ~ 12.3 and 5.5 ka. Changes in the origin of this terrigenous sediment fraction can be constrained by sediment chemistry and radiogenic isotope tracers. At Ocean Drilling Program (ODP) Site 658, Hole C (20°44.95'N, 18°34.85'W, 2263 mbsl), the neodymium (Nd) isotope composition of terrigenous detritus shows little variability throughout the last 25 kyr, indicating that the contributing geological terranes have not changed appreciably since the last glacial period. In contrast, there were large and abrupt changes in strontium (Sr) isotope ratios and chemical compositions associated with the AHP, during which 87Sr/86Sr ratios were markedly less radiogenic, and sediments show higher chemical indices of alteration. We show that sediment geochemical changes during the AHP cannot be attributed to changes in the source terranes, physical sorting, or intensity of chemical weathering. The low 87Sr/86Sr and high Sr concentrations of AHP-age samples also conflict with the interpretation of increased fine-grained, fluvially derived sediments. We propose that the most significant compositional changes at ODP 658C are due to the addition of an aluminosilicate component that has a highly altered major element signature but is enriched in soluble elements like Sr and magnesium (Mg) compared to aluminum (Al) and has low 87Sr/86Sr relative to local terrigenous source areas. We interpret these characteristics to reflect authigenic sediment supply from extensive North African paleolake basins that were prevalent during the AHP.
    Language English
    Dates of publication 2009-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.epsl.2008.12.011
    DOI 10.1594/PANGAEA.785479
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: Evaluation of Author Instructions for Inclusive Language Guidance in Highly Cited English Language Medical Journals.

    Stark, Jennifer E / Cole, Jennifer

    Journal of general internal medicine

    2023  Volume 39, Issue 2, Page(s) 272–276

    Abstract: Background: Diversity, equity, and inclusion (DEI) are at the core of publication ethics, and language around DEI has been shown to affect patient outcomes. Inclusive language is an important piece of effective communication and is one way to ... ...

    Abstract Background: Diversity, equity, and inclusion (DEI) are at the core of publication ethics, and language around DEI has been shown to affect patient outcomes. Inclusive language is an important piece of effective communication and is one way to demonstrate and foster a welcoming, respectful, and accessible environment. Non-inclusive terminology in research may represent implicit bias, which is not typically corrected through introspection; thus, a systematic approach is needed in scientific writing. The prevalence of inclusive language guidance in leading medical journals is currently unknown.
    Objective: Investigators assess the prevalence and quality of inclusive language guidelines in author instructions in highly cited English language medical journals.
    Design: A cross-sectional review of author instructions from a convenience sample of 100 highly cited medical journals was completed in January 2023.
    Subjects: Each journal's author instructions were reviewed for presence of inclusive language guidelines for manuscript submissions.
    Main measures: Guidelines that included specific examples of inclusive language were defined as "strong." Author instructions were also reviewed for the Sex and Gender Equity in Research (SAGER) checklist, and each journal's publisher and impact factor (IF) were recorded.
    Key results: The 100 journals reviewed had an IF range of 3.0-202.7 with a median IF = 19.5 (IQR 11.95, 38.68), and 28 unique publishers were represented. Inclusive language guidance was provided in 23% of medical journals reviewed. Of those, 20 (86.9%) provided strong guidance. Seven journals also recommended use of the SAGER checklist.
    Conclusion: Significant gaps still exist in ensuring use of inclusive language in medical journals.
    MeSH term(s) Humans ; Publishing ; Cross-Sectional Studies ; Periodicals as Topic ; Checklist ; Language
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-023-08390-2
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  3. Article ; Online: Deinduction of P-glycoprotein resulting in delayed viral response during hepatitis C treatment.

    Stark, Jennifer E / Cole, Jennifer L

    Journal of clinical pharmacy and therapeutics

    2021  Volume 46, Issue 5, Page(s) 1465–1468

    Abstract: What is known and objective: Drug-drug interactions can involve inhibition or induction of cell membrane transporters. Deinduction occurs after an inducing agent is stopped.: Case summary: This case describes suspected P-glycoprotein (P-gp) ... ...

    Abstract What is known and objective: Drug-drug interactions can involve inhibition or induction of cell membrane transporters. Deinduction occurs after an inducing agent is stopped.
    Case summary: This case describes suspected P-glycoprotein (P-gp) deinduction by carbamazepine resulting in a slow viral response during treatment of chronic hepatitis C virus (HCV) infection. Evidence of deinduction occurred beyond clearance of carbamazepine and resulted in extension of HCV treatment.
    What is new: The understanding of the role P-gp transport plays in drug elimination is relatively new and evidence of P-gp deinduction is variable.
    Conclusion: Clinicians should consider deinduction when starting and stopping medications involving strong inducers of P-gp transport proteins.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/drug effects ; Anti-Retroviral Agents/administration & dosage ; Anti-Retroviral Agents/therapeutic use ; Carbamates/administration & dosage ; Carbamates/therapeutic use ; Carbamazepine/pharmacology ; Cell Membrane/drug effects ; Drug Combinations ; Drug Interactions ; Hepatitis C, Chronic/drug therapy ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; Male ; Middle Aged ; Ribavirin/administration & dosage ; Ribavirin/therapeutic use ; Sofosbuvir/administration & dosage ; Sofosbuvir/therapeutic use
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Anti-Retroviral Agents ; Carbamates ; Drug Combinations ; Heterocyclic Compounds, 4 or More Rings ; sofosbuvir-velpatasvir drug combination ; Carbamazepine (33CM23913M) ; Ribavirin (49717AWG6K) ; Sofosbuvir (WJ6CA3ZU8B)
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.13374
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  4. Article ; Online: A multifaceted stewardship intervention helps curb steroid overprescribing in hospitalized patients with acute exacerbations of COPD.

    Cole, Jennifer L / Smith, Sarah E

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2021  Volume 79, Issue 8, Page(s) 643–650

    Abstract: Purpose: Corticosteroid overprescribing is well documented in real-world practice. There is currently no evidence to guide best practices for steroid stewardship. The aim of this study was to assess the effects of a 3-part stewardship intervention ... ...

    Abstract Purpose: Corticosteroid overprescribing is well documented in real-world practice. There is currently no evidence to guide best practices for steroid stewardship. The aim of this study was to assess the effects of a 3-part stewardship intervention strategy on inpatient steroid prescribing in patients with acute exacerbations of COPD (AECOPD).
    Summary: Investigators implemented a 3-part stewardship initiative consisting of (1) an anonymous survey for providers on steroid prescribing in a simplified case of AECOPD, (2) face-to-face education and review of survey results, and (3) prospective audit and feedback from a clinical pharmacist. This was a quasi-experimental before-and-after study evaluating hospitalized adults diagnosed with AECOPD in two 12-month study periods before (April 2019-March 2020) and after (May 2020-April 2021) implementation. The primary outcome was mean inpatient steroid dosing. Secondary outcomes were duration of therapy, length of stay (LOS), 30-day readmissions, 30-day mortality, and incidence of hyperglycemia. Per power analysis, there were 27 patients per cohort. The interventions resulted in a significant reduction in prednisone equivalents during hospitalization: 118 mg vs 53 mg (P = 0.0003). This decrease was similar in ICU (160 mg vs 61 mg, P = 0.008) and non-ICU (102 mg vs 49 mg, P = 0.004) locations. There was no significant difference in duration of therapy (8 days vs 7 days, P = 0.44), length of stay (3.3 days vs 3.9 days, P = 0.21), 30-day mortality (4% vs 7%, P = 0.55), 30-day readmissions (15% vs 7%, P = 0.39), or rate of hyperglycemia (48% vs 44%, P = 0.78).
    Conclusion: A multifaceted stewardship intervention significantly reduced steroid dosing in hospitalized AECOPD patients. This reduction was not associated with known deleterious effects.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Humans ; Inappropriate Prescribing ; Prednisone ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Retrospective Studies
    Chemical Substances Adrenal Cortex Hormones ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxab468
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  5. Article ; Online: Impact of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RA) on Food Content During Esophagogastroduodenoscopy (EGD).

    Stark, Jennifer E / Cole, Jennifer L / Ghazarian, Rachel N / Klass, Marian J

    The Annals of pharmacotherapy

    2021  Volume 56, Issue 8, Page(s) 922–926

    Abstract: Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) have delayed gastric emptying properties; however, the impact on esophagogastroduodenoscopy (EGD) visualization is unknown.: Objective: This study examines the impact of GLP-1RA use on ... ...

    Abstract Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) have delayed gastric emptying properties; however, the impact on esophagogastroduodenoscopy (EGD) visualization is unknown.
    Objective: This study examines the impact of GLP-1RA use on EGD visualization and gastric content retention.
    Methods: This was a retrospective cohort study with matched controls. The primary endpoint was the odds of retained food documented during EGD. Secondary endpoints included incidence of lavage and need for repeat EGD due to poor visualization and were compared using Fisher exact test. Analyses were performed in R Studio.
    Results: There were 59 patients in the cohort prescribed a GLP-1RA with 118 matched controls. Food retention was documented with 4 patients (6.8%) in the GLP-1RA cohort versus 2 patients (1.7%) in the control group (odds ratio [OR] 4.22 [95% CI 0.87-20.34]). No difference was observed in the need for lavage during EGD or in the need for repeat EGD attributed to poor visualization.
    Conclusion and relevance: This study addresses a previously uninvestigated question in clinical practice. GLP-1RA did not significantly increase odds of retained food on EGD. Although a numerical difference was observed, it did not reach statistical difference. No cases required repeat EGD due to poor visualization, and no change to EGD pre-procedure instructions were warranted at the study facility.
    MeSH term(s) Diabetes Mellitus, Type 2 ; Endoscopy, Digestive System ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Hypoglycemic Agents ; Retrospective Studies
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280211055804
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  6. Article ; Online: Successful treatment of chronic hepatitis C virus infection in a patient receiving daily peritoneal dialysis.

    Stark, Jennifer E / Cole, Jennifer

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2018  Volume 74, Issue 19, Page(s) 1541–1544

    Abstract: Purpose: Successful use of a 4-drug oral fixed-dose combination therapy to treat chronic hepatitis C in a patient receiving peritoneal dialysis (PD) is reported.: Summary: New highly effective treatments for chronic hepatitis C virus (HCV) infection ... ...

    Abstract Purpose: Successful use of a 4-drug oral fixed-dose combination therapy to treat chronic hepatitis C in a patient receiving peritoneal dialysis (PD) is reported.
    Summary: New highly effective treatments for chronic hepatitis C virus (HCV) infection are now available, but safety and efficacy data on the use of anti-HCV therapies in patients with renal failure, particularly those requiring PD, remain limited. A 73-year-old black man with chronic HCV genotype 1a infection and stage 5 chronic renal disease requiring daily automated PD was referred for HCV treatment prior to renal transplantation. HCV treatment was initiated with paritaprevir-ritonavir-ombitasvir- dasabuvir, or "PrOD" (a combination tablet containing paritaprevir 75 mg, ritonavir 50 mg, and ombitasvir 12.5 mg to be taken once daily and a dasabuvir sodium 250-mg tablet to be taken twice daily), in conjunction with ribavirin 200 mg once daily. After a 12-week course of PrOD therapy, during which ribavirin therapy was tapered and then discontinued at week 10 and subcutaneous epoetin alfa was administered for anemia control from weeks 4 to 12, the patient's HCV viral load was undetectable; a sustained virologic response at 12 weeks (SVR12) was noted.
    Conclusion: A patient with end-stage renal disease requiring PD was treated successfully for HCV genotype 1a infection with PrOD fixed-dose combination therapy plus ribavirin therapy. The patient achieved an SVR12 despite withdrawal of ribavirin at treatment week 10, with minimal adverse effects reported.
    MeSH term(s) Aged ; Anilides/administration & dosage ; Antiviral Agents/administration & dosage ; Carbamates/administration & dosage ; Drug Administration Schedule ; Drug Combinations ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/therapy ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Macrocyclic Compounds/administration & dosage ; Male ; Peritoneal Dialysis ; Ritonavir/administration & dosage ; Sulfonamides/administration & dosage ; Treatment Outcome ; Uracil/administration & dosage ; Uracil/analogs & derivatives
    Chemical Substances Anilides ; Antiviral Agents ; Carbamates ; Drug Combinations ; Macrocyclic Compounds ; Sulfonamides ; ombitasvir (2302768XJ8) ; Uracil (56HH86ZVCT) ; dasabuvir (DE54EQW8T1) ; Ritonavir (O3J8G9O825) ; paritaprevir (OU2YM37K86)
    Language English
    Publishing date 2018-01-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.2146/ajhp160729
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  7. Article ; Online: Provider and Nursing Perceptions and Practices: Gap Analysis for ICU Delirium Protocol Implementation.

    Cole, Jennifer L / Stark, Jennifer E

    Journal of intensive care medicine

    2016  Volume 31, Issue 7, Page(s) 493

    MeSH term(s) Attitude of Health Personnel ; Clinical Protocols ; Critical Care/methods ; Delirium/nursing ; Delirium/therapy ; Guideline Adherence ; Humans ; Intensive Care Units ; Nursing Methodology Research ; Nursing Staff, Hospital ; Practice Guidelines as Topic ; Surveys and Questionnaires
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066616654466
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  8. Article: Older adults recover more marginal knowledge and use feedback more effectively than younger adults: evidence using "I don't know" vs. "I don't remember" for general knowledge questions.

    Umanath, Sharda / Barrett, Talia E / Kim, Stacy / Walsh, Cole A / Coane, Jennifer H

    Frontiers in psychology

    2023  Volume 14, Page(s) 1145278

    Abstract: Through three experiments, we examined older and younger adults' metacognitive ability to distinguish between what is not stored in the knowledge base versus merely inaccessible. Difficult materials were selected to test this ability when retrieval ... ...

    Abstract Through three experiments, we examined older and younger adults' metacognitive ability to distinguish between what is not stored in the knowledge base versus merely inaccessible. Difficult materials were selected to test this ability when retrieval failures were very frequent. Of particular interest was the influence of feedback (and lack thereof) in potential new learning and recovery of marginal knowledge across age groups. Participants answered short-answer general knowledge questions, responding "I do not know" (DK) or "I do not remember" (DR) when retrieval failed. After DKs, performance on a subsequent multiple-choice (Exp. 1) and short-answer test following correct-answer feedback (Exp. 2) was lower than after DRs, supporting self-reported
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1145278
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  9. Article ; Online: Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Cytotoxicity in Anaplastic Thyroid Cancer in Female Mice.

    Davidson, Cole D / Tomczak, Jennifer A / Amiel, Eyal / Carr, Frances E

    Endocrinology

    2022  Volume 163, Issue 12

    Abstract: Anaplastic thyroid cancer (ATC) is one of the most lethal solid tumors, yet there are no effective, long-lasting treatments for ATC patients. Most tumors, including tumors of the endocrine system, exhibit an increased consumption of glucose to fuel ... ...

    Abstract Anaplastic thyroid cancer (ATC) is one of the most lethal solid tumors, yet there are no effective, long-lasting treatments for ATC patients. Most tumors, including tumors of the endocrine system, exhibit an increased consumption of glucose to fuel cancer progression, and some cancers meet this high glucose requirement by metabolizing glycogen. Our goal was to determine whether ATC cells metabolize glycogen and if this could be exploited for treatment. We detected glycogen synthase and glycogen phosphorylase (PYG) isoforms in normal thyroid and thyroid cancer cell lines and patient-derived biopsy samples. Inhibition of PYG using CP-91,149 induced apoptosis in ATC cells but not normal thyroid cells. CP-91,149 decreased NADPH levels and induced reactive oxygen species accumulation. CP-91,149 severely blunted ATC tumor growth in vivo. Our work establishes glycogen metabolism as a novel metabolic process in thyroid cells, which presents a unique, oncogenic target that could offer an improved clinical outcome.
    MeSH term(s) Female ; Mice ; Animals ; Thyroid Carcinoma, Anaplastic/drug therapy ; Reactive Oxygen Species ; Cell Line, Tumor ; Thyroid Neoplasms/pathology ; Apoptosis ; Glucose/pharmacology ; Glycogen ; Cell Proliferation
    Chemical Substances Reactive Oxygen Species ; Glucose (IY9XDZ35W2) ; Glycogen (9005-79-2)
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac169
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  10. Article ; Online: Implementation of a novel learning experience in scientific writing, publishing, and peer review into a first year pharmacy practice residency.

    Stark, Jennifer E / Cole, Jennifer L / Barnes, Lisa M / Chapman, Amanda / Costner, Marcus

    Journal of the American Pharmacists Association : JAPhA

    2021  Volume 62, Issue 3, Page(s) 840–844

    Abstract: Background: Pharmacists with competency in writing, publishing, and peer review are essential to continue advancing the pharmacy profession, but structured training of these skills may vary.: Objective: The authors set out to implement and assess the ...

    Abstract Background: Pharmacists with competency in writing, publishing, and peer review are essential to continue advancing the pharmacy profession, but structured training of these skills may vary.
    Objective: The authors set out to implement and assess the impact of a structured learning experience into a postgraduate year 1 pharmacy residency training program that provides tangible experience in the processes of scientific writing, publishing, and peer reviewing.
    Methods: A quarterly pharmacy newsletter process was augmented to include an editorial board that consisted of residency trained pharmacists with varying levels of experience in scientific writing, publishing, and peer reviewing. The process was designed to provide a structured writing learning experience, to reinforce important concepts and terminology, and to simulate the process of submitting a manuscript to a peer-reviewed publication. Impact of the learning experience on quality of article submissions was assessed by comparing first quarter and last quarter writing submission scores for residents between 2017 and 2020.
    Results: A statistically significant difference was observed in both raw scores (27 vs. 42.5 points out of 50 points possible, P < 0.05) and the proportion of pass or fail when comparing writing submission scores from the first quarter of the learning experience to submission scores from the last quarter (25% passing rate vs. 83% passing rate, P = 0.007).
    Conclusion: This novel learning experience was successfully integrated into a quarterly pharmacy newsletter and resulted in improved writing scores. This structured writing learning experience can be readily integrated into pharmacy residency training programs, and it provides hands-on training in scientific writing, publishing, and peer review for both residents and preceptors.
    MeSH term(s) Humans ; Internship and Residency ; Peer Review ; Pharmacy ; Pharmacy Residencies/methods ; Publishing ; Writing
    Language English
    Publishing date 2021-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2021.11.014
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