Article ; Online: Protocatechualdehyde-ferric iron tricomplex embedded gelatin hydrogel with adhesive, antioxidant and photothermal antibacterial capacities for infected wound healing promotion.
International journal of biological macromolecules
2023 Volume 242, Issue Pt 4, Page(s) 125029
Abstract: Because of the indiscriminate use of antibiotics and the increasing threat of drug-resist bacteria, there is an urgent need to develop novel antibacterial strategies to combat infected wounds. In this work, stable tricomplex molecules (PA@Fe) assembled ... ...
Abstract | Because of the indiscriminate use of antibiotics and the increasing threat of drug-resist bacteria, there is an urgent need to develop novel antibacterial strategies to combat infected wounds. In this work, stable tricomplex molecules (PA@Fe) assembled by protocatechualdehyde (PA) and ferric iron (Fe) were successfully synthesized and then embedded in the gelatin matrix to obtain a series of Gel-PA@Fe hydrogels. The embedded PA@Fe served as a crosslinker to improve the mechanical, adhesive and antioxidant properties of hydrogels through coordination bonds (catechol-Fe) and dynamic Schiff base bonds, meanwhile acting as a photothermal agent to convert near-infrared (NIR) light into heat to kill bacteria effectively. Importantly, in vivo evaluation through an infected full-thickness skin wound mice model revealed that Gel-PA@Fe hydrogel developed collagen deposition, and accelerated reconstruction of wound closure, indicating great potential of Gel-PA@Fe hydrogel in promoting the healing process of infected full-thickness wounds. |
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MeSH term(s) | Animals ; Mice ; Gelatin ; Hydrogels/pharmacology ; Antioxidants/pharmacology ; Wound Healing ; Catechols/pharmacology ; Anti-Bacterial Agents/pharmacology ; Wound Infection/drug therapy ; Iron |
Chemical Substances | Gelatin (9000-70-8) ; Hydrogels ; protocatechualdehyde (4PVP2HCH4T) ; Antioxidants ; Catechols ; Anti-Bacterial Agents ; Iron (E1UOL152H7) |
Language | English |
Publishing date | 2023-05-25 |
Publishing country | Netherlands |
Document type | Journal Article |
ZDB-ID | 282732-3 |
ISSN | 1879-0003 ; 0141-8130 |
ISSN (online) | 1879-0003 |
ISSN | 0141-8130 |
DOI | 10.1016/j.ijbiomac.2023.125029 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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