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Article ; Online: Albuminuria improves R

Piscitelli, Pamela / D'Errico, Maria Maddalena / Vigna, Carlo / Marchese, Nicola / Lamacchia, Olga / Fontana, Andrea / Copetti, Massimiliano / Pontremoli, Roberto / Mirijello, Antonio / De Cosmo, Salvatore A

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 33, Issue 8, Page(s) 1591–1598

Abstract: ... increase of Alb-R: Conclusions: The addition of albuminuria to R ...

Abstract	Background and aims: The CHA Methods and results: Prospective, monocentric, observational study, evaluating a subset of 737 subjects consecutively undergoing to coronary angiography at Coronary Unit of Scientific Institute "Casa Sollievo della Sofferenza" from June 2016 to December 2018. The presence of albuminuria was significantly associated with all-cause mortality (p < 0.0001). Any one-point increase of Alb-R Conclusions: The addition of albuminuria to R
MeSH term(s)	Humans ; Risk Factors ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/complications ; Prospective Studies ; Albuminuria/diagnosis ; Atrial Fibrillation/epidemiology ; Heart Disease Risk Factors ; Risk Assessment ; Stroke/epidemiology
Language	English
Publishing date	2023-05-13
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.05.014
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Article ; Online: Measurement of the Ratios of Branching Fractions R(D^{*}) and R(D^{0}).

Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Adlarson, P / Afsharnia, H / Agapopoulou, C / Aidala, C A / Ajaltouni, Z / Akar, S / Akiba, K / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A /

Aliouche, Z / Alvarez Cartelle, P / Amalric, R / Amato, S / Amey, J L / Amhis, Y / An, L / Anderlini, L / Andersson, M / Andreianov, A / Andreotti, M / Andreou, D / Ao, D / Archilli, F / Artamonov, A / Artuso, M / Aslanides, E / Atzeni, M / Audurier, B / Bachiller Perea, I B / Bachmann, S / Bachmayer, M / Back, J J / Bailly-Reyre, A / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista de Souza Leite, J / Barbetti, M / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Beck, A / Becker, M / Bedeschi, F / Bediaga, I B / Beiter, A / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Benane, G / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Bernet Andres, S / Berninghoff, D / Bernstein, H C / Bertella, C / Bertolin, A / Betancourt, C / Betti, F / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bian, L / Bieker, M S / Biesuz, N V / Billoir, P / Biolchini, A / Birch, M / Bishop, F C R / Bitadze, A / Bizzeti, A / Blago, M P / Blake, T / Blanc, F / Blank, J E / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bolognani, C S / Bolzonella, R / Bondar, N / Borgato, F / Borghi, S / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodzicka, J / Brossa Gonzalo, A / Brown, J / Brundu, D / Buonaura, A / Buonincontri, L / Burke, A T / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Cali, S / Calvi, M / Calvo Gomez, M / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Cardinale, R / Cardini, A / Carniti, P / Carus, L / Casais Vidal, A / Caspary, R / Casse, G / Cattaneo, M / Cavallero, G / Cavallini, V / Celani, S / Cerasoli, J / Cervenkov, D / Chadwick, A J / Chahrour, I / Chapman, M G / Charles, M / Charpentier, Ph / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, A / Chernyshenko, S / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Cifra, P / Ciullo, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Congedo, L / Contu, A / Cooke, N / Corredoira, I / Corti, G / Couturier, B / Craik, D C / Cruz Torres, M / Currie, R / Da Silva, C L / Dadabaev, S / Dai, L / Dai, X / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Daniel, J / Danilina, A / d'Argent, P / Davies, J E / Davis, A / De Aguiar Francisco, O / de Boer, J / De Bruyn, K / De Capua, S / De Cian, M / De Freitas Carneiro Da Graca, U / De Lucia, E / De Miranda, J M / De Paula, L / De Serio, M / De Simone, D / De Simone, P / De Vellis, F / de Vries, J A / Dean, C T / Debernardis, F / Decamp, D / Dedu, V / Del Buono, L / Delaney, B / Dembinski, H-P / Denysenko, V / Deschamps, O / Dettori, F / Dey, B / Di Nezza, P / Diachkov, I / Didenko, S / Dieste Maronas, L / Ding, S / Dobishuk, V / Dolmatov, A / Dong, C / Donohoe, A M / Dordei, F / Dos Reis, A C / Douglas, L / Downes, A G / Duda, P / Dudek, M W / Dufour, L / Duk, V / Durante, P / Duras, M M / Durham, J M / Dutta, D / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eirea Orro, C / Eisenhardt, S / Ejopu, E / Ek-In, S / Eklund, L / Elashri, M E / Ellbracht, J / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Fabiano, F / Falcao, L N / Fan, Y / Fang, B / Fantini, L / Faria, M / Farry, S / Fazzini, D / Felkowski, L F / Feo, M / Fernandez Gomez, M / Fernez, A D / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzgerald, D S / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Foulds-Holt, 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/ Jost, B / Jurik, N / Juszczak, I / Kandybei, S / Kang, Y / Karacson, M / Karpenkov, D / Karpov, M / Kautz, J W / Keizer, F / Keller, D M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kholodenko, S / Khreich, G / Kirn, T / Kirsebom, V S / Kitouni, O / Klaver, S / Kleijne, N / Klimaszewski, K / Kmiec, M R / Koliiev, S / Kolk, L / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kozachuk, A / Kravchenko, P / Kravchuk, L / Krawczyk, R D / Kreps, M / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kubat, J / Kubis, S / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kulikova, E K / Kupsc, A / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Landesa Gomez, C / Lane, J J / Lane, R / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Lazzaroni, M / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Lenisa, P / Leroy, O / Lesiak, T / Leverington, B / Li, 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/ Materok, M / Matev, R / Mathad, A / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Mauricio, J / Mazurek, M / McCann, M / Mcconnell, L / McGrath, T H / McHugh, N T / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meier, G / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Miao, D / Mikhasenko, M / Milanes, D A / Millard, E / Milovanovic, M / Minard, M-N / Minotti, A / Miralles, T / Mitchell, S E / Mitreska, B / Mitzel, D S / Mödden, A / Mohammed, R A / Moise, R D / Mokhnenko, S / Mombächer, T / Monk, M / Monroy, I A / Monteil, S / Morello, G / Morello, M J / Morgenthaler, M P / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muhammad, E / Muheim, F / Mulder, M / Müller, K / Murphy, C H / Murray, D / Murta, R / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Neustroev, P / Newcombe, R / Nicolini, J / Nicotra, D / Niel, E M / Nieswand, S / Nikitin, N / 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Zhou, X / Zhou, Y / Zhovkovska, V / Zhu, X / Zhu, Z / Zhukov, V / Zou, Q / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2023 Volume 131, Issue 11, Page(s) 111802

Abstract: The ratios of branching fractions R(D^{*})≡B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}μ^ ... ν[over ¯]_{μ}) and R(D^{0})≡B(B^{-}→D^{0}τ^{-}ν[over ¯]_{τ})/B(B^{-}→D^{0}μ^{-}ν[over ¯]_{μ}) are ... is identified in the decay mode τ^{-}→μ^{-}ν_{τ}ν[over ¯]_{μ}. The measured values are R(D^{*})=0 ...

Abstract	The ratios of branching fractions R(D^{})≡B(B[over ¯]→D^{}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{}μ^{-}ν[over ¯]_{μ}) and R(D^{0})≡B(B^{-}→D^{0}τ^{-}ν[over ¯]_{τ})/B(B^{-}→D^{0}μ^{-}ν[over ¯]_{μ}) are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb^{-1} of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode τ^{-}→μ^{-}ν_{τ}ν[over ¯]_{μ}. The measured values are R(D^{})=0.281±0.018±0.024 and R(D^{0})=0.441±0.060±0.066, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is ρ=-0.43. The results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the standard model.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.111802
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Article ; Online: Unaltered R-R interval variability and bradycardia in cyclists as compared with non-athletes.

Molina, Guilherme E / Porto, Luiz Guilherme G / Fontana, Keila E / Junqueira, Luiz F

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

2013 Volume 23, Issue 3, Page(s) 141–148

Abstract: ... controls were evaluated for time- and frequency-domain heart rate variability based on a 5-min ECG R-R ...

Abstract	Purpose: To test whether elite mountain bikers display a cardiac autonomic modulation pattern that is distinctive from that of active non-athletes. Background: The relationship between autonomic adaptation and bradycardia during physical exercise, including high-performance sports such as the mountain biking, remains to be elucidated. Methods: Twelve elite mountain bikers and 11 matched non-athletes controls were evaluated for time- and frequency-domain heart rate variability based on a 5-min ECG R-R intervals series obtained in both the supine and the orthostatic positions. Oxygen uptake and pulse rate were obtained at ventilatory thresholds and peak effort during an incremental cardiopulmonary exercise test. Significance of differences between medians (25th, 75th percentiles) from the two groups was evaluated by the Mann-Whitney test at p ≤ 0.05. Results: Athletes had lower heart rate [50 (47, 59) versus 63 (60, 69) bpm; p = 0.0004] and higher cardiopulmonary performance than controls [70.9 (64.6, 74.4) versus 47.7 (41.0, 51.9) mL (kg min)(-1); p = 0.01]. No statistical difference was found in heart rate variability in the group of athletes (p = 0.17-0.97), except for trend toward having lower coefficient of variation and low-frequency absolute power indices both in supine position (p = 0.06). Conclusions: Bradycardia and higher oxygen uptake were found in association with unaltered cardiac autonomic modulation in elite mountain bikers athletes in supine and orthostatic positions, compared to active non-athletes. This bradycardia was not dependent on distinctive resting autonomic modulation. Intrinsic adaptation of sinus node and/or a peculiar state of autonomic adaptation to this exercise can be possible mechanisms.
MeSH term(s)	Adaptation, Physiological/physiology ; Adult ; Athletes ; Autonomic Nervous System/physiology ; Bicycling ; Bradycardia ; Exercise Test ; Female ; Heart Rate/physiology ; Humans ; Male
Language	English
Publishing date	2013-05-09
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1080007-4
ISSN	1619-1560 ; 0959-9851
ISSN (online)	1619-1560
ISSN	0959-9851
DOI	10.1007/s10286-013-0196-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laparoscopic repair for perforated peptic ulcers with U-CLIP(R).

Guglielminotti, Piero / Bini, Roberto / Fontana, Diego / Leli, Renzo

World journal of emergency surgery : WJES

2009 Volume 4, Page(s) 28

Abstract: ... Medtronic U-Clip(R).: Methods: From January 2008 to June 2008 we performed laparoscopic repair ... of perforated peptic ulcers using Medtronic U-Clip(R) in 10 consecutive patients (6 men and 4 women, from 20 ... recognized, perforation was sutured using U-Clip(R) in a full-thickness manner.: Results and discussion ...

Abstract	Background: The literature established that, in patients without Boey's risk factors, laparoscopic repair of perforated peptic ulcers, compared to open repair, is associated to lower wound infection rate, less analgesic use, reduction in post operative pain, shorter hospital stay. Some of the main drawbacks are length of operative time and laparoscopic surgeon's experience in intracorporeal knotting.We, for first, report our preliminary experience of perforated peptic ulcers' laparoscopic repair using Medtronic U-Clip(R). Methods: From January 2008 to June 2008 we performed laparoscopic repair of perforated peptic ulcers using Medtronic U-Clip(R) in 10 consecutive patients (6 men and 4 women, from 20 to 65 years-old of age). All the patients presented with iuxtapyloric perforated peptic ulcer, not greater than 10 mm, without signs of sepsis, free from major illnesses. The mini-invasive procedure was performed both by skilled and non-skilled laparoscopic surgeons under experts' surveillance. After it was recognized, perforation was sutured using U-Clip(R) in a full-thickness manner. Results and discussion: We reported no surgical complications in the peri-operative period. The clinical outcome and time needed to perform the intervention didn't change between skilled and non-skilled surgeons. The follow-up at 30 days was good. Conclusion: In our experience, the anastomotic device U-Clip(R) simplifies laparoscopic repair of perforated peptic ulcer, avoiding the need to perform knots and making the procedure safe and easier.
Language	English
Publishing date	2009-07-29
Publishing country	England
Document type	Journal Article
ISSN	1749-7922
ISSN (online)	1749-7922
DOI	10.1186/1749-7922-4-28
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuroprotective Effects of the Glutamate Transporter Activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153) following Traumatic Brain Injury in the Adult Rat.

Fontana, Andréia Cristina / Fox, Douglas P / Zoubroulis, Argie / Mortensen, Ole Valente / Raghupathi, Ramesh

Journal of neurotrauma

2015 Volume 33, Issue 11, Page(s) 1073–1083

Abstract: ... not altered by the injury. Administration of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153 ...

Abstract	Traumatic brain injury (TBI) in humans and in animals leads to an acute and sustained increase in tissue glutamate concentrations within the brain, triggering glutamate-mediated excitotoxicity. Excitatory amino acid transporters (EAATs) are responsible for maintaining extracellular central nervous system glutamate concentrations below neurotoxic levels. Our results demonstrate that as early as 5 min and up to 2 h following brain trauma in brain-injured rats, the activity (Vmax) of EAAT2 in the cortex and the hippocampus was significantly decreased, compared with sham-injured animals. The affinity for glutamate (KM) and the expression of glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST) were not altered by the injury. Administration of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), a GLT-1 activator, beginning immediately after injury and continuing for 24 h, significantly decreased neurodegeneration, loss of microtubule-associated protein 2 and NeuN (+) immunoreactivities, and attenuated calpain activation in both the cortex and the hippocampus at 24 h after the injury; the reduction in neurodegeneration remained evident up to 14 days post-injury. In synaptosomal uptake assays, MS-153 up-regulated GLT-1 activity in the naïve rat brain but did not reverse the reduced activity of GLT-1 in traumatically-injured brains. This study demonstrates that administration of MS-153 in the acute post-traumatic period provides acute and long-term neuroprotection for TBI and suggests that the neuroprotective effects of MS-153 are related to mechanisms other than GLT-1 activation, such as the inhibition of voltage-gated calcium channels.
MeSH term(s)	Animals ; Brain Injuries, Traumatic/drug therapy ; Disease Models, Animal ; Excitatory Amino Acid Transporter 1/drug effects ; Excitatory Amino Acid Transporter 1/metabolism ; Excitatory Amino Acid Transporter 2/drug effects ; Excitatory Amino Acid Transporter 2/metabolism ; Male ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/pharmacology ; Nicotinic Acids/administration & dosage ; Nicotinic Acids/pharmacology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	5-methyl-1-nicotinoyl-2-pyrazoline ; Excitatory Amino Acid Transporter 1 ; Excitatory Amino Acid Transporter 2 ; Neuroprotective Agents ; Nicotinic Acids ; Slc1a3 protein, rat
Language	English
Publishing date	2015-09-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2015.4079
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Article: Sectors and the additionality effects of R&D tax credits

Bodas Freitas, Isabel Maria / Castellacci, Fulvio / Fontana, Roberto / Malerba, Franco / Vezzulli, Andrea

Research policy : policy, management and economic studies of science, technology and innovation Vol. 46, No. 1 , p. 57-72

a cross-country microeconometric analysis

2017 Volume 46, Issue 1, Page(s) 57–72

Author's details	Isabel Bodas Freitas, Fulvio Castellacci, Roberto Fontana, Franco Malerba, Andrea Vezzulli
Keywords	R&D policy ; R&D tax credits ; Input additionality ; Output additionality ; Pavitt taxonomy ; Market concentration
Language	English
Publisher	Elsevier
Publishing place	Amsterdam [u.a.]
Document type	Article
ZDB-ID	121149-3 ; 1491698-8
ISSN	1873-7625 ; 0048-7333
ISSN (online)	1873-7625
ISSN	0048-7333
Database	ECONomics Information System

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Article ; Online: (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities.

Cacciatore, Ivana / Baldassarre, Leonardo / Fornasari, Erika / Cornacchia, Catia / Di Stefano, Antonio / Sozio, Piera / Cerasa, Laura Serafina / Fontana, Antonella / Fulle, Stefania / Di Filippo, Ester Sara / La Rovere, Rita Maria Laura / Pinnen, Francesco

ChemMedChem

2012 Volume 7, Issue 11, Page(s) 2021–2029

Abstract: The (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug (LA-GPE, 1) was synthesized ...

Abstract	The (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug (LA-GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant and neuroprotective properties for the treatment of neurodegenerative diseases. Physicochemical properties, chemical and enzymatic stabilities were evaluated, along with the capacity of LA-GPE to penetrate the blood-brain barrier (BBB) according to an in vitro parallel artificial membrane permeability assay for the BBB. We also investigated the potential effectiveness of LA-GPE against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) and H2O2 on the human neuroblastoma cell line SH-SY5Y by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. Our results show that codrug 1 is stable at both pH 1.3 and 7.4, exhibits good lipophilicity (log P=1.51) and a pH-dependent permeability profile. Furthermore, LA-GPE was demonstrated to be significantly neuroprotective and to act as an antioxidant against H2O2- and 6-OHDA-induced neurotoxicity in SH-SY5Y cells.
MeSH term(s)	Antioxidants/chemistry ; Antioxidants/pharmacokinetics ; Antioxidants/pharmacology ; Blood-Brain Barrier/metabolism ; Cell Line, Tumor ; Humans ; Hydrogen Peroxide/metabolism ; Neuroblastoma/drug therapy ; Neuroblastoma/metabolism ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacokinetics ; Neuroprotective Agents/pharmacology ; Oligopeptides/chemistry ; Oligopeptides/pharmacokinetics ; Oligopeptides/pharmacology ; Oxidative Stress/drug effects ; Thioctic Acid/analogs & derivatives ; Thioctic Acid/pharmacokinetics ; Thioctic Acid/pharmacology
Chemical Substances	Antioxidants ; Neuroprotective Agents ; Oligopeptides ; glycyl-prolyl-glutamic acid (32302-76-4) ; Thioctic Acid (73Y7P0K73Y) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2012-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.201200320
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Book ; Thesis: Prävention, Detektion und Behandlung postinterventioneller Komplikationen nach Versorgung interkranieller Aneurysmen

Fontana, Johann

2016

Institution	Ruhr-Universität Bochum
Author's details	von Dr. med. Johann Fontana aus Bad Dürkheim
Language	German
Size	190 Seiten, Illustrationen
Publishing place	Bochum
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Habilitationsschrift, Ruhr-Universität Bochum, 2017
HBZ-ID	HT019455729
Database	Catalogue ZB MED Medicine, Health

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Article: Factors affecting university-industry R&D projects: The importance of searching, screening and signalling

Fontana, Roberto / Geuna, Aldo / Matt, Mireille

Research policy : a journal devoted to research policy, research management and planning Vol. 35, No. 2 , p. 309-323

2006 Volume 35, Issue 2, Page(s) 309–323

Author's details	Roberto Fontana, Aldo Geuna, Mireille Matt
Keywords	Forschungskooperation ; Theorie ; EU-Staaten
Language	English
Publisher	Elsevier
Publishing place	Amsterdam [u.a.]
Document type	Article
ZDB-ID	121149-3
Database	ECONomics Information System

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Article ; Online: Disorder and circadian periodicity in within-day variability of sinusal R-R intervals in myocardial infarcted patients

Cugini, P / Bernardini, F / Cammarota, C / Cedrone, L / Cipriani, D / Coda, S / Curione, M / Danese, C / De Francesco, GP / De Rosa, R / Fontana, S / Pellegrino, AM / Proietti, E

Journal of Clinical and Basic Cardiology

2000 Volume 3, Issue 1, Page(s) 53–58

Abstract: ... Each one of the CHS and PIP underwent a Holter electrocardiogram. The sinusal R-R intervals (SRRI ...

Abstract	The present study investigates whether the disorder in nonlinear variability of human heart rate shows a periodic pattern along the 24-h scale in postinfarct patients (PIP). The aim is to detect whether there are chronoalterations between disorder and periodicity in heart rate variability (HRV) that can contribute to explaining the postinfarct risk of sudden cardiac death. The study was performed in 7 asymptomatic PIP, who have had an acute myocardial infarction, complicated by ventricular arrhythmias, three months prior to the research. The control group was constituted by 10 clinically healthy subjects (CHS). Each one of the CHS and PIP underwent a Holter electrocardiogram. The sinusal R-R intervals (SRRI) of each dynamic Holter monitoring were detected and partitioned in units of one hour to cover the 24-h span. The hourly-qualified values of the SRRI were analyzed in their disorder using the Information Entropy (E) method. The hourly-qualified mean values of both the SRRI and E were, further, analyzed for their eventual circadian rhythm (CR), via the Cosinor method. A clear nychtohemeral variability was found in the hourly-qualified mean values of both the SRRI and E. This variability during the day was found to have a significant CR. However, the oscillatory extent for the E CR was found to be less pronounced in PIP as compared to CHS. In addition, the oscillatory acrophase of the E CR was found to be shifted to the night in PIP as compared to CHS. The lack of the matutinal increase of disorder in HRV may be speculatively regarded as a mechanism for explaining why the PIP are more exposed to the risk of sudden cardiac death in the morning hours. J Clin Basic Cardiol 2000; 3: 53-8.
MeSH term(s)	Chaos, Chronobiologie, Entropie, Herzfrequenz, Holter, nichtlineare Dynamik, Chaos, chronobiology, entropy, heart rate, Holter monitoring, nonlinear dynamics
Publishing date	20030729
Document type	Article ; Online
ZDB-ID	2019374-9
ISSN	1680-9386 ; 1561-2775
ISSN (online)	1680-9386
ISSN	1561-2775
Database	Krause and Pachernegg publications database

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