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Article ; Online: On Target: Using Technology to Address Cognitive Control in Late-Life Depression.

Ajilore, Olusola

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2020 Volume 28, Issue 9, Page(s) 981–982

MeSH term(s)	Aged ; Biomedical Enhancement ; Biomedical Technology/methods ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy ; Depression/diagnosis ; Depression/psychology ; Depression/therapy ; Humans ; Psychological Techniques/trends
Language	English
Publishing date	2020-06-24
Publishing country	England
Document type	Editorial
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2020.06.016
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Article ; Online: A novel biomarker selection method using multimodal neuroimaging data.

Wang, Yue / Yen, Pei-Shan / Ajilore, Olusola A / Bhaumik, Dulal K

PloS one

2024 Volume 19, Issue 4, Page(s) e0289401

Abstract: Identifying biomarkers is essential to obtain the optimal therapeutic benefit while treating patients with late-life depression (LLD). We compare LLD patients with healthy controls (HC) using resting-state functional magnetic resonance and diffusion ... ...

Abstract	Identifying biomarkers is essential to obtain the optimal therapeutic benefit while treating patients with late-life depression (LLD). We compare LLD patients with healthy controls (HC) using resting-state functional magnetic resonance and diffusion tensor imaging data to identify neuroimaging biomarkers that may be potentially associated with the underlying pathophysiology of LLD. We implement a Bayesian multimodal local false discovery rate approach for functional connectivity, borrowing strength from structural connectivity to identify disrupted functional connectivity of LLD compared to HC. In the Bayesian framework, we develop an algorithm to control the overall false discovery rate of our findings. We compare our findings with the literature and show that our approach can better detect some regions never discovered before for LLD patients. The Hub of our discovery related to various neurobehavioral disorders can be used to develop behavioral interventions to treat LLD patients who do not respond to antidepressants.
MeSH term(s)	Humans ; Diffusion Tensor Imaging ; Bayes Theorem ; Neuroimaging ; Magnetic Resonance Imaging/methods ; Biomarkers ; Brain/pathology ; Depression
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289401
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Article: Cerebello-cortical functional connectivity may regulate reactive balance control in older adults with mild cognitive impairment.

Kannan, Lakshmi / Bhatt, Tanvi / Ajilore, Olusola

Frontiers in neurology

2023 Volume 14, Page(s) 1041434

Abstract: Background: Older adults with mild cognitive impairment (OAwMCI) experience a two-fold increased risk of falling compared to their cognitively intact counterparts. This increased risk could be attributed to impairments in balance control mechanisms ( ... ...

Abstract	Background: Older adults with mild cognitive impairment (OAwMCI) experience a two-fold increased risk of falling compared to their cognitively intact counterparts. This increased risk could be attributed to impairments in balance control mechanisms (both volitional and reactive), however, the exact neural substrates contributing to the balance impairments remain unclear. While changes in functional connectivity (FC) networks in volitional balance control tasks have been well highlighted, the relationship between these changes and reactive balance control has not been examined. Therefore, this study aims to explore the relationship between FC networks of the brain obtained during resting state fMRI (no visualization or active task performed) and behavioral measures on a reactive balance task in OAwMCI. Methods: Eleven OAwMCI (< 25/30 on MoCA, > 55 years) underwent fMRI and were exposed to slip-like perturbations on the Activestep treadmill. Postural stability, i.e., dynamic center of mass motion state (i.e., its position and velocity) was computed to determine reactive balance control performance. The relationship between reactive stability and FC networks was explored using the CONN software. Results: OAwMCI with greater FC in default mode network-cerebellum (r Conclusion: Older adults with mild cognitive impairment demonstrate significant associations between reactive balance control and cortico-subcortical regions involved in cognitive-motor control. Results indicate that the cerebellum and its communications with higher cortical centers could be potential substrates contributing to impaired reactive responses in OAwMCI.
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1041434
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Article: A Review on Smartphone Keystroke Dynamics as a Digital Biomarker for Understanding Neurocognitive Functioning.

Nguyen, Theresa M / Leow, Alex D / Ajilore, Olusola

Brain sciences

2023 Volume 13, Issue 6

Abstract: Can digital technologies provide a passive unobtrusive means to observe and study cognition outside of the laboratory? Previously, cognitive assessments and monitoring were conducted in a laboratory or clinical setting, allowing for a cross-sectional ... ...

Abstract	Can digital technologies provide a passive unobtrusive means to observe and study cognition outside of the laboratory? Previously, cognitive assessments and monitoring were conducted in a laboratory or clinical setting, allowing for a cross-sectional glimpse of cognitive states. In the last decade, researchers have been utilizing technological advances and devices to explore ways of assessing cognition in the real world. We propose that the virtual keyboard of smartphones, an increasingly ubiquitous digital device, can provide the ideal conduit for passive data collection to study cognition. Passive data collection occurs without the active engagement of a participant and allows for near-continuous, objective data collection. Most importantly, this data collection can occur in the real world, capturing authentic datapoints. This method of data collection and its analyses provide a more comprehensive and potentially more suitable insight into cognitive states, as intra-individual cognitive fluctuations over time have shown to be an early manifestation of cognitive decline. We review different ways passive data, centered around keystroke dynamics, collected from smartphones, have been used to assess and evaluate cognition. We also discuss gaps in the literature where future directions of utilizing passive data can continue to provide inferences into cognition and elaborate on the importance of digital data privacy and consent.
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13060959
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Article ; Online: Development of a Bayesian multimodal model to detect biomarkers in neuroimaging studies.

Bhaumik, Dulal K / Wang, Yue / Yen, Pei-Shan / Ajilore, Olusola A

Frontiers in neuroimaging

2023 Volume 2, Page(s) 1147508

Abstract: In this article, we developed a Bayesian multimodal model to detect biomarkers (or neuromarkers) using resting-state functional and structural data while comparing a late-life depression group with a healthy control group. Biomarker detection helps ... ...

Abstract	In this article, we developed a Bayesian multimodal model to detect biomarkers (or neuromarkers) using resting-state functional and structural data while comparing a late-life depression group with a healthy control group. Biomarker detection helps determine a target for treatment intervention to get the optimal therapeutic benefit for treatment-resistant patients. The borrowing strength of the structural connectivity has been quantified for functional activity while detecting the biomarker. In the biomarker searching process, thousands of hypotheses are generated and tested simultaneously using our novel method to control the false discovery rate for small samples. Several existing statistical approaches, frequently used in analyzing neuroimaging data have been investigated and compared via simulation with the proposed approach to show its excellent performance. Results are illustrated with a live data set generated in a late-life depression study. The role of detected biomarkers in terms of cognitive function has been explored.
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3123824-5
ISSN	2813-1193 ; 2813-1193
ISSN (online)	2813-1193
ISSN	2813-1193
DOI	10.3389/fnimg.2023.1147508
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Article ; Online: Network Analysis of Behavioral Activation/Inhibition Systems and Brain Volume in Individuals With and Without Major Depressive Disorder or Social Anxiety Disorder.

Liu, Qimin / Davey, Delaney / Jimmy, Jagan / Ajilore, Olusola / Klumpp, Heide

Biological psychiatry. Cognitive neuroscience and neuroimaging

2023

Abstract: Background: Social anxiety disorder (SAD) and major depressive disorder (MDD) are characterized by behavioral abnormalities in motivational systems, namely the behavioral inhibition system (BIS) and behavioral activation system (BAS). Limited studies ... ...

Abstract	Background: Social anxiety disorder (SAD) and major depressive disorder (MDD) are characterized by behavioral abnormalities in motivational systems, namely the behavioral inhibition system (BIS) and behavioral activation system (BAS). Limited studies indicate brain volume in regions that support emotion, learning/memory, reward, and cognitive functions relate to BIS/BAS. To increase understanding of BIS/BAS, the current study used a network approach. Methods: Patients with SAD (n = 59), patients with MDD (n = 64), and healthy control participants (n = 36) completed a BIS/BAS questionnaire and structural magnetic resonance imaging scans; volumetric regions of interest comprised cortical and limbic structures based on previous BIS/BAS studies. A Bayesian Gaussian graphical model was used for each diagnostic group, and groups were compared. Among network metrics, bridge centrality was of primary interest. Analysis of variance evaluated BIS/BAS behaviors between groups. Results: Bridge centrality showed hippocampus positively related to BAS, but not to BIS, in the MDD group; no findings were observed in the SAD or control groups. Yet, network density (i.e., overall strength of relationships between variables) and degree centrality (i.e., overall relationship between one variable to all other variables) showed that cortical (e.g., precuneus, medial orbitofrontal) and subcortical (e.g., amygdala, hippocampus) regions differed between diagnostic groups. Analysis of variance results showed BAS was lower in the MDD/SAD groups compared with the control group, while BIS was higher in the SAD group relative to the MDD group, which in turn was higher than the control group. Conclusions: Preliminary findings indicate that network-level aberrations may underlie motivational abnormalities in MDD and SAD. Evidence of BIS/BAS differences builds on previous work that points to shared and distinct motivational differences in internalizing psychopathologies.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2023.08.006
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Article ; Online: Association of balance control mechanisms with brain structural integrity in older adults with mild cognitive impairment.

Kannan, Lakshmi / Bhatt, Tanvi / Zhang, Aifeng / Ajilore, Olusola

Neuroscience letters

2022 Volume 783, Page(s) 136699

Abstract: Background: Older adults with mild cognitive impairment (OAwMCI) exhibit subtle balance control and gait deficits which are predominantly associated with structural brain pathologies such as impaired white matter integrity and reduced gray matter volume. ...

Abstract	Background: Older adults with mild cognitive impairment (OAwMCI) exhibit subtle balance control and gait deficits which are predominantly associated with structural brain pathologies such as impaired white matter integrity and reduced gray matter volume. However, the relationship between balance recovery mechanisms and neural substrates in OAwMCI remains unknown. This study thus aimed to explore the associations of volitional (self-initiated) and reactive balance (in response to an external perturbation) control with structural brain integrity. Methods: Ten OAwMCI (MoCA 18-25/30; greater than 55 years) were examined on the limits of stability test (volitional balance via Equitest), stance perturbation test (reactive balance via ActiveStep treadmill) and underwent magnetic resonance imaging. Forward movement (frequently performed functional activity of daily living) was quantified by maximum excursion (maximum ability to shift one's center of gravity toward the theoretical limit [MXE-%])and directional control (amount of movement exhibited towards the target proportional to the movement away from the target [DCL-%]) on the limits of stability test. Slip-like (prevalent type of accidental falls) perturbations were quantified by postural stability (shortest distance of the COM motion state, i.e., its position and velocity, to the theoretical boundary) on the ActiveStep treadmill. White matter integrity was quantified by fractional anisotropy (FA, movement of water molecules directionality) and gray matter volume measured in mm Results: For volitional balance control, reduced forward MXE was significantly (p < 0.05) associated with lower FA in left (R Conclusion: Our results indicate that structural brain integrity influences stability control in OAwMCI for both volitional and reactive balance tasks, which may share some common cortico-subcortical motor pathways and relay centers. Results also show that the integrity of descending pathways from cortical attentional centers could influence stability control for both tasks.
MeSH term(s)	Aged ; Anisotropy ; Brain ; Cognitive Dysfunction ; Gray Matter/pathology ; Humans ; White Matter/pathology
Language	English
Publishing date	2022-05-30
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2022.136699
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Zs.A 1166: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Beyond non-inferior: how telepsychiatry technologies can lead to superior care.

Zulueta, John / Ajilore, Olusola A

International review of psychiatry (Abingdon, England)

2020 Volume 33, Issue 4, Page(s) 366–371

Abstract: Telepsychiatry refers to the use of technology to support the remote provision of psychiatric services. Discussions of this technology have often focussed on the use of video conferencing in place of in-person visits and how such care is found to be non- ... ...

Abstract	Telepsychiatry refers to the use of technology to support the remote provision of psychiatric services. Discussions of this technology have often focussed on the use of video conferencing in place of in-person visits and how such care is found to be non-inferior to traditional care. New developments in the fields of remote-sensing and digital phenotyping have the potential to overcome the limitations inherent in remote visits as well as the limitations of current outpatient care models more generally. Such technologies may enable the collection of more relevant, objective clinical data which could lead to improved care quality and transformed care delivery models. The development and implementation of these new technologies raise important ethical questions.
MeSH term(s)	Delivery of Health Care ; Humans ; Psychiatry ; Technology ; Telemedicine ; Videoconferencing
Language	English
Publishing date	2020-11-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018090-4
ISSN	1369-1627 ; 0954-0261
ISSN (online)	1369-1627
ISSN	0954-0261
DOI	10.1080/09540261.2020.1835840
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Zs.A 2819: Show issues

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Article ; Online: The fire this time: The stress of racism, inflammation and COVID-19.

Ajilore, Olusola / Thames, April D

Brain, behavior, and immunity

2020 Volume 88, Page(s) 66–67

MeSH term(s)	African Americans ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/ethnology ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Gene Expression Regulation/immunology ; Health Status Disparities ; Healthcare Disparities/ethnology ; Humans ; Immunity, Innate/immunology ; Inflammation ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral/ethnology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Racism ; Renin-Angiotensin System ; SARS-CoV-2 ; Social Determinants of Health ; United States/epidemiology
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2020.06.003
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Exploring current smartphone-based cognitive assessments in schizophrenia and bipolar disorder.

Lane, Erlend / Joshi, Devayani / Guimond, Synthia / Moore, Raeanne / Ahmed, Anthony O / Ajilore, Olusola / Torous, John

Schizophrenia research. Cognition

2024 Volume 37, Page(s) 100309

Abstract: Schizophrenia and bipolar disorder are associated with cognitive deficits that contribute significantly to disability. However, traditional in-lab cognitive assessments are time-consuming and not optimized for remote administration. Recent advancements ... ...

Abstract	Schizophrenia and bipolar disorder are associated with cognitive deficits that contribute significantly to disability. However, traditional in-lab cognitive assessments are time-consuming and not optimized for remote administration. Recent advancements in smartphone technology enable momentary cognitive assessments in a real-world context. This brief report reviews recent research in momentary cognitive assessments in individuals with schizophrenia and bipolar disorder through reviewing mobile platforms and cognitive assessments studied. A total of 14 experimental articles were reviewed, focusing on cognitive domains including visual working memory, processing speed, executive function, verbal fluency, verbal memory, social cognition, and typing patterns. The review highlights the feasibility of remote cognitive assessment with smartphones, and provides a layout of domains studied in this context, but illustrates a low volume of current research, the need for additional studies, and the potential for innovations like digital phenotyping.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2800609-4
ISSN	2215-0013
ISSN	2215-0013
DOI	10.1016/j.scog.2024.100309
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