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  1. Article ; Online: Aromaticity in P

    Attia, Amr A A / Muñoz-Castro, Alvaro / Lupan, Alexandru / King, R Bruce

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 13, Page(s) 9364–9372

    Abstract: The currently unknown phosphorus allotrope P ...

    Abstract The currently unknown phosphorus allotrope P
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp00147d
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  2. Article ; Online: The genetic landscape of origins of replication in P. falciparum.

    Castellano, Casilda Muñoz / Lacroix, Laurent / Mathis, Emilie / Prorok, Paulina / Hennion, Magali / Lopez-Rubio, Jose-Juan / Méchali, Marcel / Gomes, Ana Rita

    Nucleic acids research

    2024  Volume 52, Issue 2, Page(s) 660–676

    Abstract: ... drawn with the canonic eukaryote model, the distribution of ORIs in P. falciparum is likely shaped ...

    Abstract Various origin mapping approaches have enabled genome-wide identification of origins of replication (ORI) in model organisms, but only a few studies have focused on divergent organisms. By employing three complementary approaches we provide a high-resolution map of ORIs in Plasmodium falciparum, the deadliest human malaria parasite. We profiled the distribution of origin of recognition complex (ORC) binding sites by ChIP-seq of two PfORC subunits and mapped active ORIs using NFS and SNS-seq. We show that ORIs lack sequence specificity but are not randomly distributed, and group in clusters. Licensing is biased towards regions of higher GC content and associated with G-quadruplex forming sequences (G4FS). While strong transcription likely enhances firing, active origins are depleted from transcription start sites. Instead, most accumulate in transcriptionally active gene bodies. Single molecule analysis of nanopore reads containing multiple initiation events, which could have only come from individual nuclei, showed a relationship between the replication fork pace and the distance to the nearest origin. While some similarities were drawn with the canonic eukaryote model, the distribution of ORIs in P. falciparum is likely shaped by unique genomic features such as extreme AT-richness-a product of evolutionary pressure imposed by the parasitic lifestyle.
    MeSH term(s) Humans ; Binding Sites ; Chromosome Mapping ; DNA Replication ; Genomics ; Plasmodium falciparum/genetics ; Replication Origin/genetics ; Transcription, Genetic
    Language English
    Publishing date 2024-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad1103
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Usefulness of P

    Fernández Álvarez, Ramón / Escosura Muñoz, Covadonga de la / Cuadrado, Gemma Rubinos / Urrutia, Marta Iscar / Álvarez, Inés Ruiz / López, María José Vázquez / Carvajal, Claudia Madrid / Jerez, Francisco Rodríguez

    Respiratory care

    2022  

    Abstract: ... OHS) are changed when there is air trapping and auto-PEEP, which increase respiratory effort. P ... pressure was applied in their treatment. P: Results: A total of 88 subjects were analyzed: 56% were ... had air trapping, with an initial P: Conclusions: COPD and air trapping were associated ...

    Abstract Background: The ventilatory mechanics of patients with COPD and obesity-hypoventilation syndrome (OHS) are changed when there is air trapping and auto-PEEP, which increase respiratory effort. P
    Methods: With a prospective design, subjects with COPD and OHS were studied in whom positive airway pressure was applied in their treatment. P
    Results: A total of 88 subjects were analyzed: 56% were males, and the mean age of 65 ± 9 y old. Fifty-four (61%) had OHS, and 34 (39%) had COPD. Fifty (56%) had air trapping, with an initial P
    Conclusions: COPD and air trapping were associated with greater P
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.09023
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2285: Show issues Location:
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  4. Article: Substance P-Friend or Foe.

    Robinson, Prema / Rodriguez, Emma / Muñoz, Miguel

    Journal of clinical medicine

    2022  Volume 11, Issue 13

    Abstract: Substance P (SP), a neuropeptide and pain transmitter has multiple roles and is involved in various ...

    Abstract Substance P (SP), a neuropeptide and pain transmitter has multiple roles and is involved in various processes in the body [...].
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11133609
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  5. Article ; Online: Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency.

    Felzen, Antonia / van Wessel, Daan B E / Gonzales, Emmanuel / Thompson, Richard J / Jankowska, Irena / Shneider, Benjamin L / Sokal, Etienne / Grammatikopoulos, Tassos / Kadaristiana, Agustina / Jacquemin, Emmanuel / Spraul, Anne / Lipiński, Patryk / Czubkowski, Piotr / Rock, Nathalie / Shagrani, Mohammad / Broering, Dieter / Nicastro, Emanuele / Kelly, Deirdre / Nebbia, Gabriella /
    Arnell, Henrik / Fischler, Björn / Hulscher, Jan B F / Serranti, Daniele / Arikan, Cigdem / Polat, Esra / Debray, Dominique / Lacaille, Florence / Goncalves, Cristina / Hierro, Loreto / Muñoz Bartolo, Gema / Mozer-Glassberg, Yael / Azaz, Amer / Brecelj, Jernej / Dezsőfi, Antal / Calvo, Pier Luigi / Grabhorn, Enke / Hartleif, Steffen / van der Woerd, Wendy J / Kamath, Binita M / Wang, Jian-She / Li, Liting / Durmaz, Özlem / Kerkar, Nanda / Jørgensen, Marianne Hørby / Fischer, Ryan / Jimenez-Rivera, Carolina / Alam, Seema / Cananzi, Mara / Laverdure, Noemie / Ferreira, Cristina Targa / Guerrero, Felipe Ordoñez / Wang, Heng / Sency, Valerie / Kim, Kyung Mo / Chen, Huey-Ling / de Carvalho, Elisa / Fabre, Alexandre / Bernabeu, Jesus Quintero / Zellos, Aglaia / Alonso, Estella M / Sokol, Ronald J / Suchy, Frederick J / Loomes, Kathleen M / McKiernan, Patrick J / Rosenthal, Philip / Turmelle, Yumirle / Horslen, Simon / Schwarz, Kathleen / Bezerra, Jorge A / Wang, Kasper / Hansen, Bettina E / Verkade, Henkjan J

    JHEP reports : innovation in hepatology

    2022  Volume 5, Issue 2, Page(s) 100626

    Abstract: ... liver transplantation in childhood. In contrast to two predicted protein truncating mutations (PPTMs), homozygous p ... D482G or p.E297G mutations are associated with relatively mild phenotypes, responsive to surgical ... genotype of one p.D482G or p.E297G mutation and one PPTM has remained unclear. We aimed to assess ...

    Abstract Background & aims: Bile salt export pump (BSEP) deficiency frequently necessitates liver transplantation in childhood. In contrast to two predicted protein truncating mutations (PPTMs), homozygous p.D482G or p.E297G mutations are associated with relatively mild phenotypes, responsive to surgical interruption of the enterohepatic circulation (siEHC). The phenotype of patients with a compound heterozygous genotype of one p.D482G or p.E297G mutation and one PPTM has remained unclear. We aimed to assess their genotype-phenotype relationship.
    Methods: From the NAPPED database, we selected patients with homozygous p.D482G or p.E297G mutations (BSEP1/1; n = 31), with one p.D482G or p.E297G, and one PPTM (BSEP1/3; n = 30), and with two PPTMs (BSEP3/3; n = 77). We compared clinical presentation, native liver survival (NLS), and the effect of siEHC on NLS.
    Results: The groups had a similar median age at presentation (0.7-1.3 years). Overall NLS at age 10 years was 21% in BSEP1/3
    Conclusions: Individuals with BSEP deficiency with one p.E297G or p.D482G mutation and one PPTM have a similarly severe disease course and low responsiveness to siEHC as those with two PPTMs. This identifies a considerable subgroup of patients who are unlikely to benefit from interruption of the enterohepatic circulation by either surgical or ileal bile acid transporter inhibitor treatment.
    Impact and implications: This manuscript defines the clinical features and prognosis of individuals with BSEP deficiency involving the combination of one relatively mild and one very severe BSEP deficiency mutation. Until now, it had always been assumed that the mild mutation would be enough to ensure a relatively good prognosis. However, our manuscript shows that the prognosis of these patients is just as poor as that of patients with two severe mutations. They do not respond to biliary diversion surgery and will likely not respond to the new IBAT (ileal bile acid transporter) inhibitors, which have recently been approved for use in BSEP deficiency.
    Language English
    Publishing date 2022-11-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2022.100626
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  6. Article ; Online: First importations of SARS-CoV-2 P.1 and P.2 variants from Brazil to Spain and early community transmission.

    Sola Campoy, Pedro J / Buenestado-Serrano, Sergio / Pérez-Lago, Laura / Rodriguez-Grande, Cristina / Catalán, Pilar / Andrés-Zayas, Cristina / Alcalá, Luis / Losada, Carmen / Rico-Luna, Carla / Muñoz, Patricia / García de Viedma, Darío

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 5, Page(s) 262–265

    Abstract: ... South Africa (B.1.351) and Brazil (P.1). Among them, the most scarce information has been obtained from the P.1 ... SARS-CoV-2 P.1 and P.2 variants exported from Brazil to Spain. The case infected with the P.1 variant ... who had only stayed in Rio de Janeiro, required hospitalisation. The two P.2 cases remained asymptomatic ...

    Abstract Introduction: SARS-CoV-2variants of concern (VOC) have been described in the UK (B.1.1.7), South Africa (B.1.351) and Brazil (P.1). Among them, the most scarce information has been obtained from the P.1 variant and more data on its global presence and about its spreading dynamics are needed.
    Methods: Whole genome sequencing was performed prospectively on travellers arriving from Brazil and on a random selection of SARS-CoV-2 positive cases from our population.
    Results: In this study we report the first SARS-CoV-2 P.1 and P.2 variants exported from Brazil to Spain. The case infected with the P.1 variant, who had only stayed in Rio de Janeiro, required hospitalisation. The two P.2 cases remained asymptomatic. A wider distribution for P.1 variant beyond the Brazilian Amazonia should be considered. The exportation of the P.2 variant, carrying the E484K mutation, deserves attention. One month after the first description of P.1 and P.2 importations from Brazil to Madrid, these variants were identified circulating in the community, in cases without a travel history, and involved in household transmissions CONCLUSION: Whole genome sequencing of SARS-CoV-2 positive travellers arriving from Brazil allowed us to identify the first importations of P.1 and P.2 variants to Spain and their early community transmission.
    MeSH term(s) Brazil/epidemiology ; COVID-19/epidemiology ; Humans ; SARS-CoV-2/genetics ; Spain/epidemiology
    Language English
    Publishing date 2022-05-14
    Publishing country Spain
    Document type Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2021.05.015
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  7. Article ; Online: Experimental Evidence for an Attractive p-ϕ Interaction.

    Acharya, S / Adamová, D / Adler, A / Adolfsson, J / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akbar, Z / Akindinov, A / Al-Turany, M / Alam, S N / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R /
    Ali, B / Ali, Y / Alici, A / Alizadehvandchali, N / Alkin, A / Alme, J / Alt, T / Altenkamper, L / Altsybeev, I / Anaam, M N / Andrei, C / Andreou, D / Andronic, A / Angeletti, M / Anguelov, V / Antinori, F / Antonioli, P / Anuj, C / Apadula, N / Aphecetche, L / Appelshäuser, H / Arcelli, S / Arnaldi, R / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Aziz, S / Azmi, M D / Badalà, A / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Bala, R / Balbino, A / Baldisseri, A / Balis, B / Ball, M / Banerjee, D / Barbera, R / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Bartels, C / Barth, K / Bartsch, E / Baruffaldi, F / Bastid, N / Basu, S / Batigne, G / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Belyaev, V / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Berenyi, D / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / Bhasin, A / Bhat, I R / Bhat, M A / Bhattacharjee, B / Bhattacharya, P / Bianchi, L / Bianchi, N / Bielčík, J / Bielčíková, J / Biernat, J / Bilandzic, A / Biro, G / Biswas, S / Blair, J T / Blau, D / Blidaru, M B / Blume, C / Boca, G / Bock, F / Bogdanov, A / Boi, S / Bok, J / Boldizsár, L / Bolozdynya, A / Bombara, M / Bond, P M / Bonomi, G / Borel, H / Borissov, A / Bossi, H / Botta, E / Bratrud, L / Braun-Munzinger, P / Bregant, M / Broz, M / Bruno, G E / Buckland, M D / Budnikov, D / Buesching, H / Bufalino, S / Bugnon, O / Buhler, P / Buthelezi, Z / Butt, J B / Bysiak, S A / Caffarri, D / Cai, M / Caines, H / Caliva, A / Calvo Villar, E / Camacho, J M M / Camacho, R S / Camerini, P / Canedo, F D M / Carnesecchi, F / Caron, R / Castillo Castellanos, J / Casula, E A R / Catalano, F / Ceballos Sanchez, C / Chakraborty, P / Chandra, S / Chapeland, S / Chartier, M / Chattopadhyay, S / Chauvin, A / Chavez, T G / Cheshkov, C / Cheynis, B / Chibante Barroso, V / Chinellato, D D / Chizzali, E S / Cho, S / Chochula, P / Christakoglou, P / Christensen, C H / Christiansen, P / Chujo, T / Cicalo, C / Cifarelli, L / Cindolo, F / Ciupek, M R / Clai, G / Cleymans, J / Colamaria, F / Colburn, J S / Colella, D / Collu, A / Colocci, M / Concas, M / Conesa Balbastre, G / Conesa Del Valle, Z / Contin, G / Contreras, J G / Coquet, M L / Cormier, T M / Cortese, P / Cosentino, M R / Costa, F / Costanza, S / Crochet, P / Cuautle, E / Cui, P / Cunqueiro, L / Dainese, A / Damas, F P A / Danisch, M C / Danu, A / Das, I / Das, P / Das, S / Dash, S / De, S / De Caro, A / de Cataldo, G / De Cilladi, L / de Cuveland, J / De Falco, A / De Gruttola, D / De Marco, N / De Martin, C / De Pasquale, S / Deb, S / Degenhardt, H F / Deja, K R / Del Grande, R / Dello Stritto, L / Delsanto, S / Deng, W / Dhankher, P / Di Bari, D / Di Mauro, A / Diaz, R A / Dietel, T / Ding, Y / Divià, R / Dixit, D U / Djuvsland, Ø / Dmitrieva, U / Do, J / Dobrin, A / Dönigus, B / Dordic, O / Dubey, A K / Dubla, A / Dudi, S / Dukhishyam, M / Dupieux, P / Dzalaiova, N / Eder, T M / Ehlers, R J / Eikeland, V N / Eisenhut, F / Elia, D / Erazmus, B / Ercolessi, F / Erhardt, F / Erokhin, A / Ersdal, M R / Espagnon, B / Eulisse, G / Evans, D / Evdokimov, S / Fabbietti, L / Faggin, M / Faivre, J / Fan, F / Fantoni, A / Fasel, M / Fecchio, P / Feliciello, A / Feofilov, G / Fernández Téllez, A / Ferrero, A / Ferretti, A / Feuillard, V J G / Figiel, J / Filchagin, S / Finogeev, D / Fionda, F M / Fiorenza, G / Flor, F / Flores, A N / Foertsch, S / Foka, P / Fokin, S / Fragiacomo, E / Frajna, E / Fuchs, U / Funicello, N / Furget, C / Furs, A / Gaardhøje, J J / Gagliardi, M / Gago, A M / Gal, A / Galvan, C D / Ganoti, P / Garabatos, C / Garcia, J R A / Garcia-Solis, E / Garg, K / Gargiulo, C / Garibli, A / Garner, K / Gasik, P / Gauger, E F / Gautam, A / Gay Ducati, M B / Germain, M / Ghosh, J / Ghosh, P / Ghosh, S K / Giacalone, M / Gianotti, P / Giubellino, P / Giubilato, P / Glaenzer, A M C / Glässel, P / Goh, D J Q / Gonzalez, V / González-Trueba, L H / Gorbunov, S / Gorgon, M / Görlich, L / Gotovac, S / Grabski, V / Graczykowski, L K / Greiner, L / Grelli, A / Grigoras, C / Grigoriev, V / Grigoryan, A / Grigoryan, S / Groettvik, O S / Grosa, F / Grosse-Oetringhaus, J F / Grosso, R / Guardiano, G G / Guernane, R / Guilbaud, M / Gulbrandsen, K / Gunji, T / Gupta, A / Gupta, R / Guzman, I B / Guzman, S P / Gyulai, L / Habib, M K / Hadjidakis, C / Halimoglu, G / Hamagaki, H / Hamar, G / Hamid, M / Hannigan, R / Haque, M R / Harlenderova, A / Harris, J W / Harton, A / Hasenbichler, J A / Hassan, H / Hatzifotiadou, D / Hauer, P / Havener, L B / Hayashi, S / Heckel, S T / Hellbär, E / Helstrup, H / Herman, T / Hernandez, E G / Herrera Corral, G / Herrmann, F / Hetland, K F / Hillemanns, H / Hills, C / Hippolyte, B / Hofman, B / Hohlweger, B / Honermann, J / Hong, G H / Horak, D / Hornung, S / Horzyk, A / Hosokawa, R / Hristov, P / Huang, C / Hughes, C / Huhn, P / Humanic, T J / Hushnud, H / Husova, L A / Hutson, A / Hutter, D / Iddon, J P / Ilkaev, R / Ilyas, H / Inaba, M / Innocenti, G M / Ippolitov, M / Isakov, A / Islam, M S / Ivanov, M / Ivanov, V / Izucheev, V / Jablonski, M / Jacak, B / Jacazio, N / Jacobs, P M / Jadlovska, S / Jadlovsky, J / Jaelani, S / Jahnke, C / Jakubowska, M J / Janik, M A / Janson, T / Jercic, M / Jevons, O / Jonas, F / Jones, P G / Jowett, J M / Jung, J / Jung, M / Junique, A / Jusko, A / Kaewjai, J / Kalinak, P / Kalweit, A / Kaplin, V / Kar, S / Karasu Uysal, A / Karatovic, D / Karavichev, O / Karavicheva, T / Karczmarczyk, P / Karpechev, E / Kazantsev, A / Kebschull, U / Keidel, R / Keijdener, D L D / Keil, M / Ketzer, B / Khabanova, Z / Khan, A M / Khan, S / Khanzadeev, A / Kharlov, Y / Khatun, A / Khuntia, A / Kileng, B / Kim, B / Kim, D / Kim, D J / Kim, E J / Kim, J / Kim, J S / Kim, M / Kim, S / Kim, T / Kirsch, S / Kisel, I / Kiselev, S / Kisiel, A / Kitowski, J P / Klay, J L / Klein, J / Klein, S / Klein-Bösing, C / Kleiner, M / Klemenz, T / Kluge, A / Knospe, A G / Kobdaj, C / Köhler, M K / Kollegger, T / Kondratyev, A / Kondratyeva, N / Kondratyuk, E / Konig, J / Konigstorfer, S A / Konopka, P J / Kornakov, G / Koryciak, S D / Koska, L / Kotliarov, A / Kovalenko, O / Kovalenko, V / Kowalski, M / Králik, I / Kravčáková, A / Kreis, L / Krivda, M / Krizek, F / Krizkova Gajdosova, K / Kroesen, M / Krüger, M / Kryshen, E / Krzewicki, M / Kučera, V / Kuhn, C / Kuijer, P G / Kumaoka, T / Kumar, D / Kumar, L / Kumar, N / Kundu, S / Kurashvili, P / Kurepin, A / Kurepin, A B / Kuryakin, A / Kushpil, S / Kvapil, J / Kweon, M J / Kwon, J Y / Kwon, Y / La Pointe, S L / La Rocca, P / Lai, Y S / Lakrathok, A / Lamanna, M / Langoy, R / Lapidus, K / Larionov, P / Laudi, E / Lautner, L / Lavicka, R / Lazareva, T / Lea, R / Lee, J / Lehrbach, J / Lemmon, R C / León Monzón, I / Lesser, E D / Lettrich, M / Lévai, P / Li, X / Li, X L / Lien, J / Lietava, R / Lim, B / Lim, S H / Lindenstruth, V / Lindner, A / Lippmann, C / Liu, A / Liu, J / Lofnes, I M / Loginov, V / Loizides, C / Loncar, P / Lopez, J A / Lopez, X / López Torres, E / Luhder, J R / Lunardon, M / Luparello, G / Ma, Y G / Maevskaya, A / Mager, M / Mahmoud, T / Maire, A / Malaev, M / Malik, Q W / Malinina, L / Mal'Kevich, D / Mallick, N / Malzacher, P / Mandaglio, G / Manko, V / Manso, F / Manzari, V / Mao, Y / Mareš, J / Margagliotti, G V / Margotti, A / Marín, A / Markert, C / Marquard, M / Martin, N A / Martinengo, P / Martinez, J L / Martínez, M I / Martínez García, G / Masciocchi, S / Masera, M / Masoni, A / Massacrier, L / Mastroserio, A / Mathis, A M / Matonoha, O / Matuoka, P F T / Matyja, A / Mayer, C / Mazuecos, A L / Mazzaschi, F / Mazzilli, M / Mazzoni, M A / Mdhluli, J E / Mechler, A F / Meddi, F / Melikyan, Y / Menchaca-Rocha, A / Meninno, E / Menon, A S / Meres, M / Mhlanga, S / Miake, Y / Micheletti, L / Migliorin, L C / Mihaylov, D L / Mikhaylov, K / Mishra, A N / Miśkowiec, D / Modak, A / Mohanty, A P / Mohanty, B / Mohisin Khan, 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    Physical review letters

    2021  Volume 127, Issue 17, Page(s) 172301

    Abstract: ... a proton and a ϕ meson. The result is obtained from two-particle correlations of combined p-ϕ⊕ p[over ¯]-ϕ ... The spin-averaged scattering length and effective range of the p-ϕ interaction are extracted from the fully ... role for the p-ϕ interaction. These data demonstrate that the interaction is dominated by elastic p-ϕ ...

    Abstract This Letter presents the first experimental evidence of the attractive strong interaction between a proton and a ϕ meson. The result is obtained from two-particle correlations of combined p-ϕ⊕ p[over ¯]-ϕ pairs measured in high-multiplicity pp collisions at sqrt[s]=13  TeV by the ALICE Collaboration. The spin-averaged scattering length and effective range of the p-ϕ interaction are extracted from the fully corrected correlation function employing the Lednický-Lyuboshits approach. In particular, the imaginary part of the scattering length vanishes within uncertainties, indicating that inelastic processes do not play a prominent role for the p-ϕ interaction. These data demonstrate that the interaction is dominated by elastic p-ϕ scattering. Furthermore, an analysis employing phenomenological Gaussian- and Yukawa-type potentials is conducted. Under the assumption of the latter, the N-ϕ coupling constant is found to be g_{N-ϕ}=0.14±0.03(stat)±0.02(syst). This work provides valuable experimental input to accomplish a self-consistent description of the N-ϕ interaction, which is particularly relevant for the more fundamental studies on partial restoration of chiral symmetry in nuclear medium.
    Language English
    Publishing date 2021-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.172301
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  8. Article ; Online: Predictors of length of stay for simple gastroschisis: analysis of ACS NSQIP-P database.

    Bajinting, Adam / Sutthatarn, Pattamon / Osei, Hector / Abraham, Armando Salim Munoz / Villalona, Gustavo A

    Pediatric surgery international

    2022  Volume 38, Issue 10, Page(s) 1371–1376

    Abstract: ... the NSQIP-Pediatric Database.: Methods: The NSQIP-P Participant Use Data File was queried to identify ... of patients had LOS ≤ 30 days. Patients with LOS ≤ 30 were younger at repair (median age 1 day vs. 3 days, p ... 0.0001), had higher birth weight (median 2.5 kg vs. 2.4 kg, p = 0.0001), and were less premature (37 ...

    Abstract Purpose: We aimed to assess predictors of length of stay for simple gastroschisis utilizing the NSQIP-Pediatric Database.
    Methods: The NSQIP-P Participant Use Data File was queried to identify patients with simple gastroschisis. We defined short length of stay (LOS) as patients discharged home ≤ 30 days from birth. We compared patients with short LOS versus prolonged LOS > 30 days. Predictors and outcomes were evaluated.
    Results: There were 888 patients with simple gastroschisis identified. Half of patients had LOS ≤ 30 days. Patients with LOS ≤ 30 were younger at repair (median age 1 day vs. 3 days, p = 0.0001), had higher birth weight (median 2.5 kg vs. 2.4 kg, p = 0.0001), and were less premature (37 week vs. 36 weeks, p = 0.0001). However, only gestational age and weight at birth were significant predictors of LOS on multivariate analysis (p = 0.0001). Prolonged LOS patients had more instances of ventilation, oxygen supplementation, sepsis (n = 2/446 or 0.4% vs. n = 9/442 or 2%, p = 0.003), bleeding/transfusion (n = 7/446 or 1.6% vs. n = 43/442 or 9.7%, p = 0.0001), line infections (n = 1/446 or 0.2% vs. n = 12/442, p = 0.001), and reoperations (n = 9/446 or 2% vs. n = 26/442 or 5.9%, p = 0.003).
    Conclusion: Prematurity and birth weight are significant predictors of length of stay in simple gastroschisis patients. Prenatal counseling should continue to be one of the main factors to improve the outcomes for patients with gastroschisis. Type of study Retrospective cohort study. Level of evidence Level IV.
    MeSH term(s) Birth Weight ; Child ; Female ; Gastroschisis/surgery ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Length of Stay ; Postoperative Complications/epidemiology ; Pregnancy ; Retrospective Studies
    Language English
    Publishing date 2022-07-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-022-05189-w
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  9. Article ; Online: FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells.

    Muñoz, Juan Pablo / Sànchez-Fernàndez-de-Landa, Paula / Diarte-Añazco, Elena María Goretti / Zorzano, Antonio / Blanco-Vaca, Francisco / Julve, Josep

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: ... understood. Here, we demonstrate that nanomolar concentrations of the phosphorylated form of FTY720 (FTY720-P ... production rate in AC16 human cardiomyocyte cells. Additionally, FTY720-P increases the number ... a transcription factor that promotes mitochondrial function. Notably, the effect of FTY720-P on mitochondrial function ...

    Abstract FTY720 is an FDA-approved sphingosine derivative drug for the treatment of multiple sclerosis. This compound blocks lymphocyte egress from lymphoid organs and autoimmunity through sphingosine 1-phosphate (S1P) receptor blockage. Drug repurposing of FTY720 has revealed improvements in glucose metabolism and metabolic diseases. Studies also demonstrate that preconditioning with this compound preserves the ATP levels during cardiac ischemia in rats. The molecular mechanisms by which FTY720 promotes metabolism are not well understood. Here, we demonstrate that nanomolar concentrations of the phosphorylated form of FTY720 (FTY720-P), the active ligand of S1P receptor (S1PR), activates mitochondrial respiration and the mitochondrial ATP production rate in AC16 human cardiomyocyte cells. Additionally, FTY720-P increases the number of mitochondrial nucleoids, promotes mitochondrial morphology alterations, and induces activation of STAT3, a transcription factor that promotes mitochondrial function. Notably, the effect of FTY720-P on mitochondrial function was suppressed in the presence of a STAT3 inhibitor. In summary, our results suggest that FTY720 promotes the activation of mitochondrial function, in part, through a STAT3 action.
    MeSH term(s) Rats ; Humans ; Animals ; Sphingosine ; Fingolimod Hydrochloride/pharmacology ; Propylene Glycols/pharmacology ; Ligands ; Receptors, Lysosphingolipid/metabolism ; Sphingosine-1-Phosphate Receptors/metabolism ; Mitochondria/metabolism ; Adenosine Triphosphate ; Immunosuppressive Agents/pharmacology ; STAT3 Transcription Factor/metabolism
    Chemical Substances FTY 720P ; Sphingosine (NGZ37HRE42) ; Fingolimod Hydrochloride (G926EC510T) ; Propylene Glycols ; Ligands ; Receptors, Lysosphingolipid ; Sphingosine-1-Phosphate Receptors ; Adenosine Triphosphate (8L70Q75FXE) ; Immunosuppressive Agents ; STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087374
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  10. Article ; Online: First importations of SARS-CoV-2 P.1 and P.2 variants from Brazil to Spain and early community transmission.

    Sola Campoy, Pedro J / Buenestado-Serrano, Sergio / Pérez-Lago, Laura / Rodriguez-Grande, Cristina / Catalán, Pilar / Andrés-Zayas, Cristina / Alcalá, Luis / Losada, Carmen / Rico-Luna, Carla / Muñoz, Patricia / García de Viedma, Darío

    Enfermedades infecciosas y microbiologia clinica

    2021  Volume 40, Issue 5, Page(s) 262–265

    Abstract: ... South Africa (B.1.351) and Brazil (P.1). Among them, the most scarce information has been obtained from the P.1 ... SARS-CoV-2 P.1 and P.2 variants exported from Brazil to Spain. The case infected with the P.1 variant ... who had only stayed in Rio de Janeiro, required hospitalisation. The two P.2 cases remained asymptomatic ...

    Abstract Introduction: SARS-CoV-2variants of concern (VOC) have been described in the UK (B.1.1.7), South Africa (B.1.351) and Brazil (P.1). Among them, the most scarce information has been obtained from the P.1 variant and more data on its global presence and about its spreading dynamics are needed.
    Methods: Whole genome sequencing was performed prospectively on travellers arriving from Brazil and on a random selection of SARS-CoV-2 positive cases from our population.
    Results: In this study we report the first SARS-CoV-2 P.1 and P.2 variants exported from Brazil to Spain. The case infected with the P.1 variant, who had only stayed in Rio de Janeiro, required hospitalisation. The two P.2 cases remained asymptomatic. A wider distribution for P.1 variant beyond the Brazilian Amazonia should be considered. The exportation of the P.2 variant, carrying the E484K mutation, deserves attention. One month after the first description of P.1 and P.2 importations from Brazil to Madrid, these variants were identified circulating in the community, in cases without a travel history, and involved in household transmissions.
    Conclusion: Whole genome sequencing of SARS-CoV-2 positive travellers arriving from Brazil allowed us to identify the first importations of P.1 and P.2 variants to Spain and their early community transmission.
    Language English
    Publishing date 2021-06-03
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2021.05.008
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