Result 1 - 10 of total 356
Great American liberals , p. 1-13
1971 , Page(s) 1–13
| Author's details | Buell G. Gallagher |
|---|---|
| Publisher | Books for Libraries Press |
| Publishing place | Freeport, New York |
| Document type | Article |
| Database | ECONomics Information System |
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2022
Abstract: What is the psychiatry of old age and why do we need it? -- Assessment of the elderly psychiatric patient -- Differential diagnosis - the 3 Ds -- The dementias -- Behavioural and psychological symptoms of dementia -- Delirium -- Mood disorders in late ... ...
| Author's details | David Ames (University of Melbourne), Damien Gallagher (University of Toronto), Samantha Loi (Royal Melbourne Hospital), Tom Russ (University of Edinburgh & NHS Lothian) |
|---|---|
| Abstract | What is the psychiatry of old age and why do we need it? -- Assessment of the elderly psychiatric patient -- Differential diagnosis - the 3 Ds -- The dementias -- Behavioural and psychological symptoms of dementia -- Delirium -- Mood disorders in late life -- Schizophrenia and related disorders in late life -- Neurotic and personality disorders -- Substance abuse and iatrogenesis in late life -- Services for older patients with psychiatric disorders -- The future of the psychiatry of old age. "Emeritus Professor of Psychiatry, University of Melbourne Academic Unit for Psychiatry of Old Age and National Ageing Research Institute, Parkville and consultant psychiatrist for Royal Melbourne, St George's and Epworth Camberwell Hospitals, all in Melbourne. David Ames is an experienced old age psychiatrist who has worked both clinically and academically in the field for 31 years. He has edited/written over 20 books, over 250 peer reviewed research papers and led the first edition of this book. is an old age psychiatrist in Sunnybrook Health Sciences Centre, Toronto, Canada and assistant professor with the University of Toronto. His clinical and research interests include the neurobiology of depression in later life and associated cognitive dysfunction. In his work he has explored modifiable risk factors for cognitive decline and is now engaged in interventional studies to improve treatment outcomes for older adults with behavioural and neurocognitive disorders in later life. Samantha Loi is an old age psychiatrist working at the Royal Melbourne Hospital, Australia in the Neuropsychiatry Unit since 2015. She is also a senior lecturer at the University of Melbourne Academic Unit for Psychiatry of Old Age and recently received her PhD qualification. She has extensive clinical experience and her research interests include carer well-being and the use of modern technology to improve quality of life of older adults. Intermediate Clinical Fellow at the Centre for Dementia Prevention and Alzheimer Scotland Dementia Research Centre, both at the University of Edinburgh, and an Honorary Consultant Psychiatrist for NHS Lothian"-- |
| Keywords | Mental Disorders ; Aged ; Geriatric Psychiatry / methods ; Geriatrie ; Psychiatrie |
| Subject | Seelenheilkunde ; Altersmedizin ; Altersheilkunde |
| Language | English |
| Size | xvi, 125 Seiten, Illustrationen |
| Edition | Second edition |
| Publisher | Cambridge University Press |
| Publishing place | Cambridge |
| Publishing country | Great Britain |
| Document type | Book |
| Note | "... revised second edition ... The new edition is updated to incorporate new developments in assessment, investigation, classification, treatment and care since the publication of the first edition, including the ICD-11 and DSM-5.". - Rückumschlag ; Includes bibliographical references and index |
| HBZ-ID | HT021401133 |
| ISBN | 978-1-108-40715-1 ; 9781108290173 ; 1-108-40715-3 ; 1108290175 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2022 A 821 | available for loan (reading room) | Lesesaal EG |
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2022 Volume 13, Issue 3, Page(s) e0044522
Abstract: To successfully infect, viruses must respond to cues that promote their genome delivery into host cells. These keys to virus entry frequently reside inside endocytic vesicles. In a recent mBio article, Poston et al. (D. Poston, Y. Weisblum, A. Hobbs, and ...
| Abstract | To successfully infect, viruses must respond to cues that promote their genome delivery into host cells. These keys to virus entry frequently reside inside endocytic vesicles. In a recent mBio article, Poston et al. (D. Poston, Y. Weisblum, A. Hobbs, and P. D. Bieniasz, mBio 13:e0300221, 2022, https://doi.org/10.1128/mbio.03002-21) identified and characterized protein complexes generating endocytic environments favorable for virus entry. These included retromer-associated vacuolar protein sorting 29 (VPS29) proteins. Without VPS29, endosomes lacked cathepsin activities, making them incapable of supporting those viruses in which endosomal proteolysis triggers entry. These protease-dependent viruses encompass several zoonotic filoviruses and coronaviruses, including recent SARS-CoV-2 variants of concern. The valuable findings of Poston et al. reveal retromer complexes as master keys for select endosomal virus entry processes and raise the possibility that threatening coronaviruses might be resisted through targeted inactivation of components controlling endosome structure and function. |
|---|---|
| MeSH term(s) | COVID-19 ; Endosomes/metabolism ; Humans ; SARS-CoV-2 ; Virus Internalization |
| Language | English |
| Publishing date | 2022-05-17 |
| Publishing country | United States |
| Document type | Journal Article ; Comment |
| ZDB-ID | 2557172-2 |
| ISSN | 2150-7511 ; 2161-2129 |
| ISSN (online) | 2150-7511 |
| ISSN | 2161-2129 |
| DOI | 10.1128/mbio.00445-22 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 66, Page(s) 103289
| MeSH term(s) | Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; SARS-CoV-2 |
|---|---|
| Chemical Substances | Antiviral Agents |
| Language | English |
| Publishing date | 2021-03-19 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Comment |
| ZDB-ID | 2851331-9 |
| ISSN | 2352-3964 |
| ISSN (online) | 2352-3964 |
| DOI | 10.1016/j.ebiom.2021.103289 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 7090: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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EBioMedicine, Vol 66, Iss , Pp 103289- (2021)
Expanding the antiviral arsenal
2021
| Keywords | Medicine ; R ; Medicine (General) ; R5-920 |
|---|---|
| Language | English |
| Publishing date | 2021-04-01T00:00:00Z |
| Publisher | Elsevier |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2020 Volume 105, Issue 10, Page(s) 2140–2141
| Language | English |
|---|---|
| Publishing date | 2020-09-10 |
| Publishing country | United States |
| Document type | Journal Article ; Comment |
| ZDB-ID | 208424-7 |
| ISSN | 1534-6080 ; 0041-1337 |
| ISSN (online) | 1534-6080 |
| ISSN | 0041-1337 |
| DOI | 10.1097/TP.0000000000003492 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 488: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 509: Show issues |
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2023 Volume 14, Issue 4, Page(s) e0017123
Abstract: Evolved SARS-CoV-2 variants of concern (VOCs) spread through human populations in succession. Major virus variations are in the entry-facilitating viral spike (S) proteins; Omicron VOCs have 29-40 S mutations relative to ancestral D614G viruses. The ... ...
| Abstract | Evolved SARS-CoV-2 variants of concern (VOCs) spread through human populations in succession. Major virus variations are in the entry-facilitating viral spike (S) proteins; Omicron VOCs have 29-40 S mutations relative to ancestral D614G viruses. The impacts of this Omicron divergence on S protein structure, antigenicity, cell entry pathways, and pathogenicity have been extensively evaluated, yet gaps remain in correlating specific alterations with S protein functions. In this study, we compared the functions of ancestral D614G and Omicron VOCs using cell-free assays that can reveal differences in several distinct steps of the S-directed virus entry process. Relative to ancestral D614G, Omicron BA.1 S proteins were hypersensitized to receptor activation, to conversion into intermediate conformational states, and to membrane fusion-activating proteases. We identified mutations conferring these changes in S protein character by evaluating domain-exchanged D614G/Omicron recombinants in the cell-free assays. Each of the three functional alterations was mapped to specific S protein domains, with the recombinants providing insights on inter-domain interactions that fine-tune S-directed virus entry. Our results provide a structure-function atlas of the S protein variations that may promote the transmissibility and infectivity of current and future SARS-CoV-2 VOCs. IMPORTANCE Continuous SARS-CoV-2 adaptations generate increasingly transmissible variants. These succeeding variants show ever-increasing evasion of suppressive antibodies and host factors, as well as increasing invasion of susceptible host cells. Here, we evaluated the adaptations enhancing invasion. We used reductionist cell-free assays to compare the entry steps of ancestral (D614G) and Omicron (BA.1) variants. Relative to D614G, Omicron entry was distinguished by heightened responsiveness to entry-facilitating receptors and proteases and by enhanced formation of intermediate states that execute virus-cell membrane fusion. We found that these Omicron-specific characteristics arose from mutations in specific S protein domains and subdomains. The results reveal the inter-domain networks controlling S protein dynamics and efficiencies of entry steps, and they offer insights on the evolution of SARS-CoV-2 variants that arise and ultimately dominate infections worldwide. |
|---|---|
| MeSH term(s) | Humans ; COVID-19 ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Virus Internalization ; Endopeptidases |
| Chemical Substances | spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Endopeptidases (EC 3.4.-) |
| Language | English |
| Publishing date | 2023-06-29 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2557172-2 |
| ISSN | 2150-7511 ; 2161-2129 |
| ISSN (online) | 2150-7511 |
| ISSN | 2161-2129 |
| DOI | 10.1128/mbio.00171-23 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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iScience
2023 Volume 26, Issue 10, Page(s) 107819
Abstract: Signal peptide peptidase-like 2a and b (SPPL2a/b) are aspartyl intramembrane proteases and cleave tail-anchored proteins as well as N-terminal fragments (NTFs) derived from type II-oriented transmembrane proteins. How these proteases recruit substrates ... ...
| Abstract | Signal peptide peptidase-like 2a and b (SPPL2a/b) are aspartyl intramembrane proteases and cleave tail-anchored proteins as well as N-terminal fragments (NTFs) derived from type II-oriented transmembrane proteins. How these proteases recruit substrates and cleavage is regulated, is still incompletely understood. We found that SPPL2a/b localize to detergent-resistant membrane (DRM) domains with the characteristics of tetraspanin-enriched microdomains (TEMs). Based on this, association with several tetraspanins was evaluated. We demonstrate that not only SPPL2a/b but also their substrates tumor necrosis factor (TNF) and CD74 associate with tetraspanins like CD9, CD81, and CD82 and/or TEMs and analyze the stability of these complexes in different detergents. CD9 and CD81 deficiency has protease- and substrate-selective effects on SPPL2a/b function. Our findings suggest that reciprocal interactions with tetraspanins may assist protease-substrate encounters of SPPL2a/b within the membrane. Beyond SPP/SPPL proteases, this supports previous concepts that tetraspanins facilitate membrane-embedded proteolytic processes. |
|---|---|
| Language | English |
| Publishing date | 2023-09-04 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2589-0042 |
| ISSN (online) | 2589-0042 |
| DOI | 10.1016/j.isci.2023.107819 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Volume 41, Issue 4, Page(s) 271–273
Abstract: As an atypical pneumonia began to appear in December 2019, Zhou et al. worked with remarkable speed to identify the associated virus, determine its relationship to animal viruses, and evaluate factors conferring infection susceptibility and resistance. ... ...
| Abstract | As an atypical pneumonia began to appear in December 2019, Zhou et al. worked with remarkable speed to identify the associated virus, determine its relationship to animal viruses, and evaluate factors conferring infection susceptibility and resistance. These foundational results are being advanced to control the current worldwide human coronavirus epidemic. |
|---|---|
| MeSH term(s) | Animals ; Betacoronavirus ; Chiroptera ; Coronavirus ; Disease Outbreaks ; Humans ; Pneumonia, Viral/epidemiology ; SARS Virus |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-03-12 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Comment |
| ZDB-ID | 2036831-8 |
| ISSN | 1471-4981 ; 1471-4906 |
| ISSN (online) | 1471-4981 |
| ISSN | 1471-4906 |
| DOI | 10.1016/j.it.2020.02.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1601: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MG 2: Show issues |
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practical knowledge, skills, and strategies
2006
| Author's details | Tom Christoffel and Susan Scavo Gallagher |
|---|---|
| Keywords | Wounds and Injuries / prevention & control ; Accident Prevention ; Wounds and injuries/Prevention ; Accidents/Prevention ; Personal injuries/Prevention |
| Subject code | 617.1 |
| Language | English |
| Size | XXX, 495 S., 24cm |
| Edition | 2. ed. |
| Publisher | Jones and Bartlett |
| Publishing place | Sudbury, Mass. u.a. |
| Publishing country | United States |
| Document type | Book |
| Note | Includes bibliographical references and index. - Formerly CIP |
| HBZ-ID | HT015351426 |
| ISBN | 0-7637-3392-X ; 978-0-7637-3392-6 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| 2008 A 465 | order for loan | Magazin |
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