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  1. Book: Research methods in community medicine

    Abramson, Joseph H. / Abramson, Zvi H.

    surveys, epidemiological research, programme evaluation, clinical trials

    2008  

    Author's details J. H. Abramson ; Z. H. Abramson
    Keywords Research / methods ; Community Medicine ; Clinical Trials as Topic ; Epidemiologic Methods ; Program Evaluation
    Language English
    Size VI, 414 S. : Ill.
    Edition 6. ed.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015372746
    ISBN 978-0-470-98661-5 ; 0-470-98661-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2008 A 2084 order for loan Magazin

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  2. Article ; Online: Re: Thibault et al.: Drug-induced uveitis related to checkpoint inhibitors and MAP-kinase inhibitors (Ophthalmology. 2024;131:249-251).

    Francis, Jasmine H / Canestraro, Julia / Abramson, David H

    Ophthalmology

    2024  

    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Letter
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 533: Show issues

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  3. Article ; Online: Circulating Tumor DNA Posttreatment Measurements and Clinical Correlates in Retinoblastoma.

    Abramson, David H / Robbins, Melissa A / Gobin, Y Pierre / Dunkel, Ira J / Francis, Jasmine H

    JAMA ophthalmology

    2024  Volume 142, Issue 3, Page(s) 257–261

    Abstract: Importance: Plasma measurements of RB1 circulating tumor DNA (ctDNA) after completion of treatment may be associated with the development of metastases in patients with retinoblastoma.: Objective: To determine if the absence of previously detectable ... ...

    Abstract Importance: Plasma measurements of RB1 circulating tumor DNA (ctDNA) after completion of treatment may be associated with the development of metastases in patients with retinoblastoma.
    Objective: To determine if the absence of previously detectable plasma ctDNA is associated with metastasis-free survival in patients with a minimum of 1 year follow-up after treatment of retinoblastoma.
    Design, setting, and participants: This cohort study was conducted from June 2019 to September 2023. Patients with retinoblastoma who had measurable ctDNA levels at diagnosis and had repeated ctDNA measurements after ocular treatment (enucleation or intra-arterial chemotherapy) with a minimum of 1 year of follow-up (mean [SD], 28.2 [10.3] months) were included in the study. Patients were recruited from a single-center, tertiary cancer hospital.
    Exposure: Memorial Sloan Kettering's New York State-approved gene test, which interrogates 129 known cancer genes (called ACCESS), was performed on plasma samples before and after ocular treatments. All exons of the RB1 gene are included in the test and listed as ctDNA in this article.
    Main outcomes and measures: Plasma ctDNA level before treatment, after completion of ocular treatment, and development or absence of metastases.
    Results: A total of 24 patients (mean [SD] age, 20.7 [17.1] months; 15 female [62.5%]) were included in the study. None of the 23 patients who had a measurable ctDNA level and then no detectable ctDNA level after completion of ocular treatment developed metastases with a minimum of 1 year of follow-up. One patient had persistent measurable ctDNA after initial treatment and developed metastases.
    Conclusion and relevance: Patients with retinoblastoma who had a measurable ctDNA level at diagnosis did not develop metastases if the plasma ctDNA level became unrecordable after ocular treatment; 1 patient who had persistent measurable ctDNA after treatment did develop metastasis.
    MeSH term(s) Humans ; Female ; Young Adult ; Adult ; Retinoblastoma/diagnosis ; Retinoblastoma/drug therapy ; Retinoblastoma/genetics ; Circulating Tumor DNA/genetics ; Circulating Tumor DNA/therapeutic use ; Cohort Studies ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/drug therapy ; Retinal Neoplasms/genetics ; Biomarkers, Tumor/genetics
    Chemical Substances Circulating Tumor DNA ; Biomarkers, Tumor
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2023.6516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Magnetic Resonance Imaging of Metastatic Retinoblastoma.

    Abramson, David H / Dunkel, Ira J / Francis, Jasmine H

    Journal of pediatric ophthalmology and strabismus

    2022  Volume 60, Issue 2, Page(s) 152

    MeSH term(s) Humans ; Infant ; Retinoblastoma/diagnosis ; Retinal Neoplasms/diagnosis ; Magnetic Resonance Imaging
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800921-1
    ISSN 1938-2405 ; 0191-3913
    ISSN (online) 1938-2405
    ISSN 0191-3913
    DOI 10.3928/01913913-20220623-02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 333: Show issues Location:
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  5. Article ; Online: Clearance of plasma cell free DNA in metastatic uveal melanoma with radiographic response to immune checkpoint inhibitors.

    Francis, Jasmine H / Barker, Christopher A / Canestraro, Julia / Abramson, David H / Shoushtari, Alexander N

    American journal of ophthalmology case reports

    2024  Volume 34, Page(s) 102021

    Abstract: Purpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment.: Observations: A 33-year-old man was diagnosed with metastatic uveal ... ...

    Abstract Purpose: To report a case of metastatic uveal melanoma treated with immune checkpoint inhibition in which serial circulating tumor DNA (ctDNA) was assessed throughout treatment.
    Observations: A 33-year-old man was diagnosed with metastatic uveal melanoma and initially had progression of disease following hepatic embolization and nivolumab/ipilimumab. At the time, plasma ctDNA
    Conclusions and importance: Clearance of cell free DNA in metastatic uveal melanoma may be associated with radiographic response to immune checkpoint inhibitors.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Case Reports
    ISSN 2451-9936
    ISSN (online) 2451-9936
    DOI 10.1016/j.ajoc.2024.102021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advancements in super-selective catheterization and drug selection for intra-arterial chemotherapy for retinoblastoma: a 15-year evolution.

    Kocharian, Gary / Gobin, Y Pierre / Kharas, Natasha / Knopman, Jared / Francis, Jasmine H / Abramson, David H

    Journal of neurointerventional surgery

    2024  Volume 16, Issue 4, Page(s) 398–404

    Abstract: Background: Retinoblastoma (Rb) is the most common primary ocular malignancy of childhood. Left untreated, it is 100% fatal and carries a substantial risk of impaired vision and removal of one or both eyes. Intra-arterial chemotherapy (IAC) has become a ...

    Abstract Background: Retinoblastoma (Rb) is the most common primary ocular malignancy of childhood. Left untreated, it is 100% fatal and carries a substantial risk of impaired vision and removal of one or both eyes. Intra-arterial chemotherapy (IAC) has become a pillar in the treatment paradigm for Rb that allows for better eye salvage and vision preservation without compromising survival. We describe the evolution of our technique over 15 years.
    Methods: A retrospective chart review was conducted of 571 patients (697 eyes) and 2391 successful IAC sessions over 15 years. This cohort was separated into three 5-year periods (P1, P2, P3) to assess trends in IAC catheterization technique, complications, and drug delivery.
    Results: From a total of 2402 attempted IAC sessions, there were 2391 successful IAC deliveries, consistent with a 99.5% success rate. The rate of successful super-selective catheterizations over the three periods ranged from 80% in P1 to 84.9% in P2 and 89.2% in P3. Catheterization-related complication rates were 0.7% in P1, 1.1% in P2, and 0.6% in P3. Chemotherapeutics used included combinations of melphalan, topotecan and carboplatin. The rate of patients receiving triple therapy among all groups was 128 (21%) in P1, 487 (41.9%) in P2, and 413 (66.7%) in P3.
    Conclusions: The overall rate of successful catheterization and IAC started high and has improved over 15 years, and catheterization-related complications are rare. There has been a significant trend towards triple chemotherapy over time.
    MeSH term(s) Humans ; Infant ; Retinoblastoma/drug therapy ; Retinal Neoplasms/drug therapy ; Pharmaceutical Preparations ; Retrospective Studies ; Treatment Outcome ; Follow-Up Studies ; Infusions, Intra-Arterial/adverse effects ; Melphalan ; Catheterization
    Chemical Substances Pharmaceutical Preparations ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2023-020109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6845: Show issues Location:
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  7. Book: Survey methods in community medicine

    Abramson, Joseph H. / Abramson, Zvi H.

    epidemiological research, programme evaluation, clinical trials

    1999  

    Author's details J. H. Abramson ; Z. H. Abramson
    Language English
    Size VIII, 419 S. : graph. Darst.
    Edition 5. ed.
    Publisher Churchill-Livingstone
    Publishing place Edinburgh u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT010497214
    ISBN 0-443-06163-7 ; 978-0-443-06163-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 3383 order for loan Magazin

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  8. Article ; Online: Plasma Circulating Tumor DNA to Assist in the Diagnose of Unknown Primary Malignancy Underlying Choroidal Metastases.

    Francis, Jasmine H / Levine, Sara / Canestraro, Julia / Eng, Juliana / Abramson, David H

    Retinal cases & brief reports

    2023  

    Abstract: Purpose: Management of suspected choroidal metastases requires diagnostic imaging and an invasive, sometimes intraocular, biopsy to determine the primary malignancy. This multistep process takes time which may impact morbidity and mortality.: Methods!# ...

    Abstract Purpose: Management of suspected choroidal metastases requires diagnostic imaging and an invasive, sometimes intraocular, biopsy to determine the primary malignancy. This multistep process takes time which may impact morbidity and mortality.
    Methods: Retrospective review of one case.
    Results: A 56-year-old woman presented with bilateral amelanotic choroidal masses suspicious for metastases of unknown origin. Plasma circulating tumor DNA revealed EGFR, PTEN, SMAD4, a profile consistent with non-small cell lung cancer. Subsequent radiographic imaging and scapular biopsy revealed lung adenocarcinoma and genetic profile concordant with the liquid biopsy. Patient was started on EGFR-inhibitor, Osimertinib1, with measurable systemic and ocular response.
    Conclusion: Plasma circulating tumor DNA revealed the genetic profile of the primary malignancy underlying choroidal metastases of unknown origin; aiding in the prompt diagnosis and detecting the driver mutation which guided management with targeted therapy.
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lung function changes in children exposed to mine fire smoke in infancy.

    Hemstock, Emily J / Foong, Rachel E / Hall, Graham L / Wheeler, Amanda J / Dharmage, Shyamali C / Dalton, Marita / Williamson, Grant J / Gao, Caroline / Abramson, Michael J / Johnston, Fay H / Zosky, Graeme R

    Respirology (Carlton, Vic.)

    2024  Volume 29, Issue 4, Page(s) 295–303

    Abstract: Background and objective: Chronic, low-intensity air pollution exposure has been consistently associated with reduced lung function throughout childhood. However, there is limited research regarding the implications of acute, high-intensity air ... ...

    Abstract Background and objective: Chronic, low-intensity air pollution exposure has been consistently associated with reduced lung function throughout childhood. However, there is limited research regarding the implications of acute, high-intensity air pollution exposure. We aimed to determine whether there were any associations between early life exposure to such an episode and lung growth trajectories.
    Methods: We conducted a prospective cohort study of children who lived in the vicinity of the Hazelwood coalmine fire. Lung function was measured using respiratory oscillometry. Z-scores were calculated for resistance (R
    Results: There were no associations between mine fire-related PM
    Conclusion: There was a moderate improvement in lung stiffness of children exposed to PM
    MeSH term(s) Child ; Humans ; Smoke/adverse effects ; Air Pollutants/analysis ; Prospective Studies ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Lung ; Environmental Exposure/adverse effects
    Chemical Substances Smoke ; Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2024-01-14
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mitogen-Activated Pathway Kinase Inhibitor-Associated Retinopathy: Do Features Differ with Upstream versus Downstream Inhibition?

    Francis, Jasmine H / Foulsham, William / Canestraro, Julia / Harding, James J / Diamond, Eli L / Drilon, Alexander / Abramson, David H

    Ocular oncology and pathology

    2023  Volume 9, Issue 1-2, Page(s) 25–31

    Abstract: Introduction: Many cancers have derangement of the mitogen-activated pathway kinase (MAPK), making this pathway blockade a therapeutic target. However, inhibitors of MAPK can result in adverse effects including retinopathy. This study compares clinical ... ...

    Abstract Introduction: Many cancers have derangement of the mitogen-activated pathway kinase (MAPK), making this pathway blockade a therapeutic target. However, inhibitors of MAPK can result in adverse effects including retinopathy. This study compares clinical and morphological characteristics of serous retinal disturbances in patients taking agents with variable inhibition of MAPK: either direct interference of mitogen-activated protein kinase kinase (MEK) or extracellular signal-regulated kinase (ERK) inhibitors or with indirect inhibition via interference with FGFR signaling.
    Methods: This retrospective observational study of prospectively collected pooled data is from a single tertiary oncology referral center. Of 339 patients receiving MAPK inhibitors (171, 107, and 61 on FGFR, MEK, and ERK inhibitors, respectively) for treatment of metastatic cancer, this study included 128 eyes of 65 patients with evidence of retinopathy confirmed by optical coherence tomography (OCT). The main outcome was characteristics of treatment-emergent choroid/retinal OCT abnormalities as compared to baseline OCT.
    Results: In all patients on one of three drug classes (FGFRi, MEKi, ERKi), the retinopathy manifested as subretinal fluid foci that were bilateral, fovea involving, and reversible without intervention. There were notable differences between the three classes of drugs: the proportion of patients with retinopathy, number of fluid foci per eye, proportion of eyes with intraretinal edema, and the proportion of symptomatic patients was least for the upstream target (FGFR inhibitors) and greatest for the downstream targets (MEK or ERK inhibitors).
    Conclusion: This study shows MAPK pathway inhibitors may cause subretinal fluid foci with unique clinical and morphological characteristics depending on the target (FGFR, MEK, or ERK) implicated. Retinopathy is more common, more symptomatic, and more severe (more fluid foci, more expansive fluid configurations) the further downstream the MAPK pathway is inhibited.
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000529127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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