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  1. Article ; Online: A Rare Pulmonary Metastasis of Uveal Melanoma Diagnosed Through Endobronchial Endosonography and Fine Needle Aspiration: A Case Report.

    Cardenal, Borja Domingo / Serra-Mitjà, Pere

    Archivos de bronconeumologia

    2024  Volume 60, Issue 5, Page(s) 298–299

    MeSH term(s) Humans ; Uveal Neoplasms/pathology ; Uveal Neoplasms/diagnostic imaging ; Uveal Neoplasms/secondary ; Lung Neoplasms/secondary ; Lung Neoplasms/pathology ; Lung Neoplasms/diagnostic imaging ; Melanoma/secondary ; Melanoma/diagnostic imaging ; Biopsy, Fine-Needle ; Male ; Bronchoscopy ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Endosonography ; Middle Aged ; Female ; Aged
    Language Spanish
    Publishing date 2024-02-01
    Publishing country Spain
    Document type Case Reports ; Letter ; Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2655: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Pulmonary Infections in People Living with HIV.

    Franquet, Tomás / Domingo, Pere

    Radiologic clinics of North America

    2022  Volume 60, Issue 3, Page(s) 507–520

    Abstract: Despite the development of combination antiretroviral therapy (cART) infections continue to cause significant morbidity and mortality among people living with HIV (PLWH). Pulmonary infections with Streptococcus pneumoniae, Haemophilus influenza, and ... ...

    Abstract Despite the development of combination antiretroviral therapy (cART) infections continue to cause significant morbidity and mortality among people living with HIV (PLWH). Pulmonary infections with Streptococcus pneumoniae, Haemophilus influenza, and Staphylococcus aureus remain common. One-third of PLWH worldwide are infected with tuberculosis and the infection manifests at any stage of HIV infection. Fungal infection is usually confined to PLWH unaware of their HIV infection until immunosuppression is advanced or those choosing to discontinue cART. The importance of viral infections has diminished since wide availability of cART; however, mortality from COVID-19 in PLWH may remain greater than in the non-HIV population.
    MeSH term(s) COVID-19 ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215712-3
    ISSN 1557-8275 ; 0033-8389
    ISSN (online) 1557-8275
    ISSN 0033-8389
    DOI 10.1016/j.rcl.2022.01.008
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  3. Article ; Online: Alpha variant SARS-CoV-2 infection

    Pere Domingo / Natividad de Benito

    EBioMedicine, Vol 74, Iss , Pp 103703- (2021)

    How it all starts

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Alpha variant SARS-CoV-2 infection: How it all starts.

    Domingo, Pere / de Benito, Natividad

    EBioMedicine

    2021  Volume 74, Page(s) 103703

    MeSH term(s) Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Basic Reproduction Number ; COVID-19/immunology ; France ; Humans ; Immunoglobulin A/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Retrospective Studies ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Viral Load ; Virus Shedding
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G
    Language English
    Publishing date 2021-11-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection.

    Moga, Esther / Lynton-Pons, Elionor / Domingo, Pere

    Frontiers in immunology

    2022  Volume 13, Page(s) 904686

    Abstract: Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current global pandemic, it is time to analyze the evolution of the immune protection that infection and vaccination provide. Cellular immunity plays an important role in ... ...

    Abstract Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current global pandemic, it is time to analyze the evolution of the immune protection that infection and vaccination provide. Cellular immunity plays an important role in limiting disease severity and the resolution of infection. The early appearance, breadth and magnitude of SARS-CoV-2 specific T cell response has been correlated with disease severity and it has been thought that T cell responses may be sufficient to clear infection with minimal disease in COVID-19 patients with X-linked or autosomal recessive agammaglobulinemia. However, our knowledge of the phenotypic and functional diversity of CD8+ cytotoxic lymphocytes, CD4+ T helper cells, mucosal-associated invariant T (MAIT) cells and CD4+ T follicular helper (Tfh), which play a critical role in infection control as well as long-term protection, is still evolving. It has been described how CD8+ cytotoxic lymphocytes interrupt viral replication by secreting antiviral cytokines (IFN-γ and TNF-α) and directly killing infected cells, negatively correlating with stages of disease progression. In addition, CD4+ T helper cells have been reported to be key pieces, leading, coordinating and ultimately regulating antiviral immunity. For instance, in some more severe COVID-19 cases a dysregulated CD4+ T cell signature may contribute to the greater production of pro-inflammatory cytokines responsible for pathogenic inflammation. Here we discuss how cellular immunity is the axis around which the rest of the immune system components revolve, since it orchestrates and leads antiviral response by regulating the inflammatory cascade and, as a consequence, the innate immune system, as well as promoting a correct humoral response through CD4+ Tfh cells. This review also analyses the critical role of cellular immunity in modulating the development of high-affinity neutralizing antibodies and germinal center B cell differentiation in memory and long-lived antibody secreting cells. Finally, since there is currently a high percentage of vaccinated population and, in some cases, vaccine booster doses are even being administered in certain countries, we have also summarized newer approaches to long-lasting protective immunity and the cross-protection of cellular immune response against SARS-CoV-2.
    MeSH term(s) Antiviral Agents ; COVID-19 ; Cytokines ; Humans ; Immunity, Cellular ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Cytokines
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.904686
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  6. Article: Facing the SARS-CoV-2 (COVID-19) outbreak with IL-6R antagonists.

    Corominas, Hèctor / Castellví, Ivan / Domingo, Pere / Casademont, Jordi

    European journal of rheumatology

    2020  Volume 7, Issue Suppl 2, Page(s) S107–S109

    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.20061
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  7. Article: Acute Bacterial Meningitis in Healthy Adult Patients: A Prospective Cohort Study.

    Pomar, Virginia / Benito, Natividad / Duch, Pol / Colomé, Marc / Rivera, Alba / Domingo, Pere

    Journal of clinical medicine

    2023  Volume 12, Issue 11

    Abstract: Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in ... ...

    Abstract Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in patients without comorbidities.
    Patients and methods: Single-center, prospective observational cohort study of 328 adults with BM hospitalized in a tertiary university hospital in Barcelona (Spain). We compared the features of infections diagnosed in 1982-2000 and 2001-2019. The main outcome measure was in-hospital mortality.
    Results: The median age of the patients increased from 37 to 45 years. Meningococcal meningitis significantly diminished (56% versus 31%,
    Conclusions: Adult patients without underlying comorbidities that developed BM in recent years were older and more likely to have pneumococcal or listerial infections and systemic complications. In-hospital death was less likely in the second period, after adjusting for risk factors of mortality.
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12113624
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  8. Article ; Online: Acute Bacterial Meningitis in Healthy Adult Patients

    Virginia Pomar / Natividad Benito / Pol Duch / Marc Colomé / Alba Rivera / Pere Domingo

    Journal of Clinical Medicine, Vol 12, Iss 3624, p

    A Prospective Cohort Study

    2023  Volume 3624

    Abstract: Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in ... ...

    Abstract Spontaneous bacterial meningitis (BM) is more common among patients with underlying conditions, but its characteristics in previously healthy patients are not well described. We analyzed the time trends of BM in terms of characteristics, and outcomes in patients without comorbidities. Patients and methods: Single-center, prospective observational cohort study of 328 adults with BM hospitalized in a tertiary university hospital in Barcelona (Spain). We compared the features of infections diagnosed in 1982–2000 and 2001–2019. The main outcome measure was in-hospital mortality. Results: The median age of the patients increased from 37 to 45 years. Meningococcal meningitis significantly diminished (56% versus 31%, p < 0.000) whereas listerial meningitis increased (1.2% versus 8%, p = 0.004). Systemic complications were more common in the second period, although mortality did not vary significantly between periods (10.4% versus 9.2%). However, after adjusting for relevant variables, infection in the second period was associated with lower risk death. Conclusions: Adult patients without underlying comorbidities that developed BM in recent years were older and more likely to have pneumococcal or listerial infections and systemic complications. In-hospital death was less likely in the second period, after adjusting for risk factors of mortality.
    Keywords spontaneous meningitis ; bacterial meningitis ; cerebrospinal fluid analysis ; healthy patient ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Facing the SARS-CoV-2 (COVID-19) outbreak with IL-6R antagonists

    Hèctor Corominas / Ivan Castellví / Pere Domingo / Jordi Casademont

    European Journal of Rheumatology, Vol 7, Iss -2, Pp S107-S

    2020  Volume 109

    Keywords Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher AVES Yayincilik
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Atazanavir dose reduction: one size does not fit all.

    Domingo, Pere / Vidal, Francesc

    The lancet. HIV

    2016  Volume 3, Issue 8, Page(s) e334–e335

    Language English
    Publishing date 2016-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(16)30018-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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