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Article ; Online: The friendly use of chloroquine in the COVID-19 disease: a warning for the G6PD-deficient males and for the unaware carriers of pathogenic alterations of the G6PD gene.

Capoluongo, Ettore D / Amato, Felice / Castaldo, Giuseppe

Clinical chemistry and laboratory medicine

2020 Volume 58, Issue 7, Page(s) 1162–1164

MeSH term(s)	Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; Chloroquine/adverse effects ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Female ; Glucosephosphate Dehydrogenase/drug effects ; Glucosephosphate Dehydrogenase/genetics ; Glucosephosphate Dehydrogenase Deficiency/drug therapy ; Heterozygote ; Humans ; Male ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
Chemical Substances	Chloroquine (886U3H6UFF) ; Glucosephosphate Dehydrogenase (EC 1.1.1.49)
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0442
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Article: The friendly use of chloroquine in the COVID-19 disease: a warning for the G6PD-deficient males and for the unaware carriers of pathogenic alterations of the G6PD gene

Capoluongo, Ettore D / Amato, Felice / Castaldo, Giuseppe

Clin Chem Lab Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #116812
Database	COVID19

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Article ; Online: The friendly use of chloroquine in the COVID-19 disease

Capoluongo, Ettore D. / Amato, Felice / Castaldo, Giuseppe

Clinical Chemistry and Laboratory Medicine (CCLM)

a warning for the G6PD-deficient males and for the unaware carriers of pathogenic alterations of the G6PD gene

2020 Volume 58, Issue 7, Page(s) 1162–1164

Keywords	Clinical Biochemistry ; Biochemistry, medical ; General Medicine ; covid19
Publisher	Walter de Gruyter GmbH
Publishing country	de
Document type	Article ; Online
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0442
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homologous Recombination Deficiency (HRD) Scoring, by Means of Two Different Shallow Whole-Genome Sequencing Pipelines (sWGS), in Ovarian Cancer Patients: A Comparison with Myriad MyChoice Assay.

Scaglione, Giovanni L / Pignata, Sandro / Pettinato, Angela / Paolillo, Carmela / Califano, Daniela / Scandurra, Giuseppa / Lombardo, Valentina / Di Gaudio, Francesca / Pecorino, Basilio / Mereu, Liliana / Scollo, Paolo / Capoluongo, Ettore D

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: High-grade serous ovarian cancer (HGSOC) patients carrying ... ...

Abstract	High-grade serous ovarian cancer (HGSOC) patients carrying the
MeSH term(s)	Humans ; Female ; BRCA1 Protein/genetics ; Mutation ; BRCA2 Protein/genetics ; Retrospective Studies ; Homologous Recombination ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics
Chemical Substances	BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242317095
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Article ; Online: Results from an IFCC global survey on laboratory practices for the analysis of circulating tumor DNA.

Linder, Mark W / Huggett, Jim F / Baluchova, Katarina / Capoluongo, Ettore D / Payne, Deborah A / Salinas, Aldo Vacaflores / Haselmann, Verena / Ashavaid, Tester / Pan, Shiyang / Ahmad-Nejad, Parviz

Clinica chimica acta; international journal of clinical chemistry

2023 Volume 547, Page(s) 117398

Abstract: Background: The clinical validity of ctDNA analysis as a diagnostic, prognostic and predictive biomarker has been demonstrated in many studies. The rapid spread of tests for the analysis of ctDNA raises questions regarding their standardization and ... ...

Abstract	Background: The clinical validity of ctDNA analysis as a diagnostic, prognostic and predictive biomarker has been demonstrated in many studies. The rapid spread of tests for the analysis of ctDNA raises questions regarding their standardization and quality assurance. The aim of this study was to provide a global overview of the test methods, laboratory procedures and quality assessment practices using ctDNA diagnostics. Methods: The Molecular Diagnostics Committee of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC C-MD) conducted a survey among international laboratories performing ctDNA analysis. Questions on analytical techniques, test parameters, quality assurance and the reporting of findings were included. Results: A total of 58 laboratories participated in the survey. The majority of the participating laboratories (87.7 %) performed testing for patient care. Most laboratories conducted their assays for lung cancer (71.9 %), followed by colorectal (52.6 %) and breast (40.4 %) cancer, and 55.4 % of the labs used ctDNA analysis for follow-up/monitoring of treatment-resistant alterations. The most frequent gene analysed was EGFR (75.8 %), followed by KRAS (65.5 %) and BRAF (56.9 %). Participation in external quality assessment programs was reported by only 45.6 % of laboratories. Conclusions: The survey indicates that molecular diagnostic methods for the analysis of ctDNA are not standardized across countries and laboratories. Furthermore, it reveals a number of differences regarding sample preparation, processing and reporting test results. Our findings indicate that ctDNA testing is being conducted without sufficient attention to analytical performance between laboratories and highlights the need for standarisation of ctDNA analysis and reporting in patient care.
MeSH term(s)	Humans ; Circulating Tumor DNA ; Laboratories ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Reference Standards ; Prognosis ; Mutation ; Biomarkers, Tumor/genetics
Chemical Substances	Circulating Tumor DNA ; Biomarkers, Tumor
Language	English
Publishing date	2023-05-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2023.117398
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Article ; Online: ISO 15189 is a sufficient instrument to guarantee high-quality manufacture of laboratory developed tests for in-house-use conform requirements of the European

Vanstapel, Florent J L A / Orth, Matthias / Streichert, Thomas / Capoluongo, Ettore D / Oosterhuis, Wytze P / Çubukçu, Hikmet Can / Bernabeu-Andreu, Francisco A / Thelen, Marc / Jacobs, Leo H J / Linko, Solveig / Bhattoa, Harjit Pal / Bossuyt, Patrick M M / Meško Brguljan, Pika / Boursier, Guilaine / Cobbaert, Christa M / Neumaier, Michael

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 4, Page(s) 608–626

Abstract: ... The ... ...

Abstract	The EU
MeSH term(s)	Humans ; Reagent Kits, Diagnostic/standards ; European Union ; Clinical Laboratory Services/legislation & jurisprudence
Chemical Substances	Reagent Kits, Diagnostic
Language	English
Publishing date	2023-01-31
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2023-0045
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Article: Aligning Cancer Research Priorities in Europe with Recommendations for Conquering Cancer: A Comprehensive Analysis.

Horgan, Denis / Bulcke, Marc Van den / Malapelle, Umberto / Normanno, Nicola / Capoluongo, Ettore D / Prelaj, Arsela / Rizzari, Carmelo / Stathopoulou, Aliki / Singh, Jaya / Kozaric, Marta / Dube, France / Ottaviano, Manuel / Boccia, Stefania / Pravettoni, Gabriella / Cattaneo, Ivana / Malats, Núria / Buettner, Reinhard / Lekadir, Karim / de Lorenzo, Francesco /

Blanc, Patricia / Alix-Panabieres, Catherine / Badreh, Sara / Hofman, Paul / Solary, Eric / De Maria, Ruggero

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 2

Abstract: Improvements in cancer care require a new degree of collaboration beyond the purely medical sphere, extending deeply into the world of other stakeholders-preeminently patients but also the other stakeholders in the hardware and software of care. Cancer ... ...

Abstract	Improvements in cancer care require a new degree of collaboration beyond the purely medical sphere, extending deeply into the world of other stakeholders-preeminently patients but also the other stakeholders in the hardware and software of care. Cancer remains a global health challenge, necessitating collaborative efforts to understand, prevent, and treat this complex disease. To achieve this goal, a comprehensive analysis was conducted, aligning the prioritization of cancer research measures in 13 European countries with 13 key recommendations for conquering cancer in the region. The study utilized a survey involving both patients and citizens, alongside data from IQVIA, a global healthcare data provider, to assess the availability and access to single-biomarker tests in multiple European countries. The results revealed a focused approach toward understanding, preventing, and treating cancer, with each country emphasizing specific research measures tailored to its strengths and healthcare objectives. This analysis highlights the intricate relationship between research priorities, access to biomarker tests, and financial support. Timely access to tests and increased availability positively influence research areas such as cancer prevention, early detection, ageing, and data utilization. The alignment of these country-specific measures with 13 recommendations for conquering cancer in Europe underscores the importance of tailored strategies for understanding, preventing, and treating cancer.
Language	English
Publishing date	2024-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12020259
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Article ; Online: Demographic Analysis of Cancer Research Priorities and Treatment Correlations.

Horgan, Denis / Van den Bulcke, Marc / Malapelle, Umberto / Normanno, Nicola / Capoluongo, Ettore D / Prelaj, Arsela / Rizzari, Carmelo / Stathopoulou, Aliki / Singh, Jaya / Kozaric, Marta / Dube, France / Ottaviano, Manuel / Boccia, Stefania / Pravettoni, Gabriella / Cattaneo, Ivana / Malats, Núria / Buettner, Reinhard / Lekadir, Karim / de Lorenzo, Francesco /

Alix-Panabieres, Catherine / Badreh, Sara / Solary, Eric / De Maria, Ruggero / Hofman, Paul

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 4, Page(s) 1839–1864

Abstract: Understanding the diversity in cancer research priorities and the correlations among different treatment modalities is essential to address the evolving landscape of oncology. This study, conducted in collaboration with the European Cancer Patient ... ...

Abstract	Understanding the diversity in cancer research priorities and the correlations among different treatment modalities is essential to address the evolving landscape of oncology. This study, conducted in collaboration with the European Cancer Patient Coalition (ECPC) and Childhood Cancer International-Europe (CCI-E) as part of the "UNCAN.eu" initiative, analyzed data from a comprehensive survey to explore the complex interplay of demographics, time since cancer diagnosis, and types of treatments received. Demographic analysis revealed intriguing trends, highlighting the importance of tailoring cancer research efforts to specific age groups and genders. Individuals aged 45-69 exhibited highly aligned research priorities, emphasizing the need to address the unique concerns of middle-aged and older populations. In contrast, patients over 70 years demonstrated a divergence in research priorities, underscoring the importance of recognising the distinct needs of older individuals in cancer research. The analysis of correlations among different types of cancer treatments underscored the multidisciplinary approach to cancer care, with surgery, radiotherapy, chemotherapy, precision therapy, and biological therapies playing integral roles. These findings support the need for personalized and combined treatment strategies to achieve optimal outcomes. In conclusion, this study provides valuable insights into the complexity of cancer research priorities and treatment correlations in a European context. It emphasizes the importance of a multifaceted, patient-centred approach to cancer research and treatment, highlighting the need for ongoing support, adaptation, and collaboration to address the ever-changing landscape of oncology.
MeSH term(s)	Humans ; Neoplasms/therapy ; Male ; Aged ; Middle Aged ; Female ; Biomedical Research ; Adult ; Demography ; Research ; Europe
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31040139
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Article ; Online: The gaps between the new EU legislation on

Horgan, Denis / Plebani, Mario / Orth, Matthias / Macintyre, Elizabeth / Jackson, Stan / Lal, Jonathan A / Dube, France / Kozaric, Marta / Tumiene, Birute / Salgado, Roberto / Schalken, Jack A / Capoluongo, Ettore D / Carnielli, Marta

Clinical chemistry and laboratory medicine

2022 Volume 61, Issue 2, Page(s) 224–233

Abstract: The background to this debate is now well-known: an EU policy decision to tighten controls on the devices and diagnostics sector led to the adoption of a regulation in 2017 with a schedule for implementation over coming years - a timetable extended still ...

Abstract	The background to this debate is now well-known: an EU policy decision to tighten controls on the devices and diagnostics sector led to the adoption of a regulation in 2017 with a schedule for implementation over coming years - a timetable extended still further by last-minute legislation in early 2022, to provide the sector and regulators with more time to adapt to the changes. Discussions among experts organised in April by the European Alliance for Personalized Medicine (EAPM) exposed continuing challenges that cannot be fully resolved by the recent deferral of implementation deadlines. One salient problem is that there is little awareness of the
MeSH term(s)	Humans ; Europe ; Precision Medicine
Language	English
Publishing date	2022-11-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-1051
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Article ; Online: Homologous Recombination Deficiency (HRD) Scoring, by Means of Two Different Shallow Whole-Genome Sequencing Pipelines (sWGS), in Ovarian Cancer Patients

Giovanni L. Scaglione / Sandro Pignata / Angela Pettinato / Carmela Paolillo / Daniela Califano / Giuseppa Scandurra / Valentina Lombardo / Francesca Di Gaudio / Basilio Pecorino / Liliana Mereu / Paolo Scollo / Ettore D. Capoluongo

International Journal of Molecular Sciences, Vol 24, Iss 23, p

A Comparison with Myriad MyChoice Assay

2023 Volume 17095

Abstract: High-grade serous ovarian cancer (HGSOC) patients carrying the BRCA1/2 mutation or deficient in the homologous recombination repair system (HRD) generally benefit from treatment with PARP inhibitors. Some international recommendations suggest that BRCA1/ ... ...

Abstract	High-grade serous ovarian cancer (HGSOC) patients carrying the BRCA1/2 mutation or deficient in the homologous recombination repair system (HRD) generally benefit from treatment with PARP inhibitors. Some international recommendations suggest that BRCA1/2 genetic testing should be offered for all newly diagnosed epithelial ovarian cancer, along with HRD assessment. Academic tests (ATs) are continuously under development, in order to break down the barriers patients encounter in accessing HRD testing. Two different methods for shallow whole-genome sequencing (sWGS) were compared to the reference assay, Myriad. All these three assays were performed on 20 retrospective HGSOC samples. Moreover, HRD results were correlated with the progression-free survival rate (PFS). Both sWGS chemistries showed good correlation with each other and a complete agreement, even when compared to the Myriad score. Our academic HRD assay categorized patients as HRD-Deficient, HRM-Mild and HRN-Negative. These three groups were matched with PFS, providing interesting findings in terms of HRD scoring and months of survival. Both our sWGS assays and the Myriad test correlated with the patient’s response to treatments. Finally, our AT confirms its capability of determining HRD status, with the advantage of being faster, cheaper, and easier to carry out. Our results showed a prognostic value for the HRD score.
Keywords	academic HRD ; sWGS ; PFS ; HGSOC ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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