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  1. Article ; Online: The neurotoxin "Lip Flip": A case series and discussion.

    Harview, Christina L / Tan, Kendra W / Dhinsa, Harpinder K / Harms, Jessica L

    Journal of cosmetic dermatology

    2021  Volume 20, Issue 11, Page(s) 3716–3718

    MeSH term(s) Humans ; Lip ; Neurotoxins
    Chemical Substances Neurotoxins
    Language English
    Publishing date 2021-10-03
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14505
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6539: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Making a difference: APIC chapters introducing public health graduate students to the infection prevention profession.

    Harms, Katelyn / McKinley, Linda / Meller, Megan / Grindle, Tina

    American journal of infection control

    2023  Volume 52, Issue 4, Page(s) 493–494

    Abstract: Health care workforce recruitment into the field of infection prevention and control (IPC) is imperative to address attrition and maintain safe patient care. Association for Professionals in Infection Control (APIC) Badger Chapter in Wisconsin ... ...

    Abstract Health care workforce recruitment into the field of infection prevention and control (IPC) is imperative to address attrition and maintain safe patient care. Association for Professionals in Infection Control (APIC) Badger Chapter in Wisconsin strategically aligned with their state's academic master of public health program to introduce students to the IP profession and offered scholarships to Wisconsin's annual infection prevention and control conference. Four scholarships were awarded from 2021 to 2022. Student feedback of the experience was positive and resulted in 2 participants becoming employed IPs.
    MeSH term(s) Humans ; Public Health ; Infection Control/methods ; Health Personnel ; Wisconsin ; Students
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.10.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1773: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Conference proceedings: INPP4A-Related Genetic and Phenotypic Spectrum and Functional Relevance of Subcellular Targeting of INPP4A Isoforms

    Hecher, L. / Harms, F. L. / Lisfeld, J. / Alawi, M. / Denecke, J. / Kutsche, K.

    Neuropediatrics

    2023  Volume 54, Issue S 01

    Event/congress Scientific Abstracts for the German Neuropediatric Society Congress 2023, Dortmund, Germany, 2023-11-16
    Language English
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0043-1777173
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 728: Show issues Location:
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  4. Article ; Online: The Case for a Primary Surgical Approach.

    Harms, Kelly L / Bichakjian, Christopher K

    International journal of radiation oncology, biology, physics

    2018  Volume 100, Issue 1, Page(s) 15–16

    MeSH term(s) Carcinoma, Merkel Cell/surgery ; Humans ; Skin Neoplasms/surgery
    Language English
    Publishing date 2018--01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.08.031
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
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  5. Article ; Online: Hierarchies of affectedness after disasters.

    Brady, Kate / Gibbs, Lisa / Harms, Louise

    Health & place

    2021  Volume 72, Page(s) 102687

    Abstract: Disasters result in a range of impacts that significantly disrupt the health and wellbeing of those affected. After disasters, a hierarchy of affectedness may be explicitly or implicitly developed, where those affected are compared to each other, and to ... ...

    Abstract Disasters result in a range of impacts that significantly disrupt the health and wellbeing of those affected. After disasters, a hierarchy of affectedness may be explicitly or implicitly developed, where those affected are compared to each other, and to people affected by disasters in other locations. When an individual's sense of place is so significantly disrupted, these hierarchies are critical to improving the understanding of recovery trajectories, including mental health and well-being outcomes. These hierarchies have practical implications that influence the health outcomes of those affected, including eligibility for disaster aid, support services, and the way that people affected by disasters relate to others in their community. This paper expands the 'hierarchy of affectedness' concept coined by Andersen (2013) using findings from a qualitative study in Australia and New Zealand. Using a letter writing research method, twenty people who had been impacted by a range of disasters in different locations described what they considered helpful and unhelpful in the recovery. One emergent finding in this study was that hierarchies of affectedness are negotiated between impacted individuals, others affected in the same community, and outsiders. These hierarchies served as a helpful sense-making tool for some people impacted by disasters, while causing considerable secondary stress for others. Based on these findings, we offer an expansion to Andersen's existing model of hierarchies of affectedness in post-disaster settings.
    MeSH term(s) Australia ; Data Collection ; Disasters ; Humans ; Mental Health ; New Zealand
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1262540-1
    ISSN 1873-2054 ; 1353-8292
    ISSN (online) 1873-2054
    ISSN 1353-8292
    DOI 10.1016/j.healthplace.2021.102687
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4333: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: INPP4A-related genetic and phenotypic spectrum and functional relevance of subcellular targeting of INPP4A isoforms.

    Hecher, Laura / Harms, Frederike L / Lisfeld, Jasmin / Alawi, Malik / Denecke, Jonas / Kutsche, Kerstin

    Neurogenetics

    2023  Volume 24, Issue 2, Page(s) 79–93

    Abstract: Type I inositol polyphosphate-4-phosphatase (INPP4A) belongs to the group of phosphoinositide phosphatases controlling proliferation, apoptosis, and endosome function by hydrolyzing phosphatidylinositol 3,4-bisphosphate. INPP4A produces multiple ... ...

    Abstract Type I inositol polyphosphate-4-phosphatase (INPP4A) belongs to the group of phosphoinositide phosphatases controlling proliferation, apoptosis, and endosome function by hydrolyzing phosphatidylinositol 3,4-bisphosphate. INPP4A produces multiple transcripts encoding shorter and longer INPP4A isoforms with hydrophilic or hydrophobic C-terminus. Biallelic INPP4A truncating variants cause a spectrum of neurodevelopmental disorders ranging from moderate intellectual disability to postnatal microcephaly with developmental and epileptic encephalopathy and (ponto)cerebellar hypoplasia. We report a girl with the novel homozygous INPP4A variant NM_001134224.2:c.2840del/p.(Gly947Glufs*12) (isoform d). She presented with postnatal microcephaly, global developmental delay, visual impairment, myoclonic seizures, and pontocerebellar hypoplasia and died at the age of 27 months. The level of mutant INPP4A mRNAs in proband-derived leukocytes was comparable to controls suggesting production of C-terminally altered INPP4A isoforms. We transiently expressed eGFP-tagged INPP4A isoform a (NM_004027.3) wildtype and p.(Gly908Glufs*12) mutant [p.(Gly947Glufs*12) according to NM_001134224.2] as well as INPP4A isoform b (NM_001566.2) wildtype and p.(Asp915Alafs*2) mutant, previously reported in family members with moderate intellectual disability, in HeLa cells and determined their subcellular distributions. While INPP4A isoform a was preferentially found in perinuclear clusters co-localizing with the GTPase Rab5, isoform b showed a net-like distribution, possibly localizing near and/or on microtubules. Quantification of intracellular localization patterns of the two INPP4A mutants revealed significant differences compared with the respective wildtype and similarity with each other. Our data suggests an important non-redundant function of INPP4A isoforms with hydrophobic or hydrophilic C-terminus in the brain.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Cerebellum ; HeLa Cells ; Intellectual Disability/genetics ; Microcephaly/genetics ; Phosphoric Monoester Hydrolases/genetics ; Phosphoric Monoester Hydrolases/metabolism
    Chemical Substances Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66)
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339887-8
    ISSN 1364-6753 ; 1364-6745
    ISSN (online) 1364-6753
    ISSN 1364-6745
    DOI 10.1007/s10048-023-00709-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A deep intronic variant in DNM1 in a patient with developmental and epileptic encephalopathy creates a splice acceptor site and affects only transcript variants including exon 10a.

    Harms, Frederike L / Weiss, Deike / Lisfeld, Jasmin / Alawi, Malik / Kutsche, Kerstin

    Neurogenetics

    2023  Volume 24, Issue 3, Page(s) 171–180

    Abstract: DNM1 developmental and epileptic encephalopathy (DEE) is characterized by severe to profound intellectual disability, hypotonia, movement disorder, and refractory epilepsy, typically presenting with infantile spasms. Most of the affected individuals had ... ...

    Abstract DNM1 developmental and epileptic encephalopathy (DEE) is characterized by severe to profound intellectual disability, hypotonia, movement disorder, and refractory epilepsy, typically presenting with infantile spasms. Most of the affected individuals had de novo missense variants in DNM1. DNM1 undergoes alternative splicing that results in expression of six different transcript variants. One alternatively spliced region affects the tandemly arranged exons 10a and 10b, producing isoforms DNM1A and DNM1B, respectively. Pathogenic variants in the DNM1 coding region affect all transcript variants. Recently, a de novo DNM1 NM_001288739.1:c.1197-8G > A variant located in intron 9 has been reported in several unrelated individuals with DEE that causes in-frame insertion of two amino acids and leads to disease through a dominant-negative mechanism. We report on a patient with DEE and a de novo DNM1 variant NM_001288739.2:c.1197-46C > G in intron 9, upstream of exon 10a. By RT-PCR and Sanger sequencing using fibroblast-derived cDNA of the patient, we identified aberrantly spliced DNM1 mRNAs with exon 9 spliced to the last 45 nucleotides of intron 9 followed by exon 10a (NM_001288739.2:r.1196_1197ins[1197-1_1197-45]). The encoded DNM1A mutant is predicted to contain 15 novel amino acids between Ile398 and Arg399 [NP_001275668.1:p.(Ile398_Arg399ins15)] and likely functions in a dominant-negative manner, similar to other DNM1 mutants. Our data confirm the importance of the DNM1 isoform A for normal human brain function that is underscored by previously reported predominant expression of DMN1A transcripts in pediatric brain, functional differences of the mouse Dnm1a and Dnm1b isoforms, and the Dnm1 fitful mouse, an epilepsy mouse model.
    MeSH term(s) Animals ; Child ; Humans ; Mice ; Exons/genetics ; Mutation ; Protein Isoforms/genetics ; RNA Splice Sites/genetics ; Spasms, Infantile/genetics
    Chemical Substances Protein Isoforms ; RNA Splice Sites
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339887-8
    ISSN 1364-6753 ; 1364-6745
    ISSN (online) 1364-6753
    ISSN 1364-6745
    DOI 10.1007/s10048-023-00716-w
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    Zs.A 5295: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Foregut Development and Metamorphosis in a Pyramidellid Gastropod: Modularity and Constraint within a Complex Life Cycle.

    Harms, K S / Hesketh, A V / Page, L R

    The Biological bulletin

    2019  Volume 237, Issue 3, Page(s) 254–269

    Abstract: Pyramidellids are tiny ectoparasitic gastropods with highly derived feeding structures for piercing and sucking. We attempted to resolve homology controversies about unique pyramidellid feeding structures by examining foregut development through larval ... ...

    Abstract Pyramidellids are tiny ectoparasitic gastropods with highly derived feeding structures for piercing and sucking. We attempted to resolve homology controversies about unique pyramidellid feeding structures by examining foregut development through larval and metamorphic stages, using sections for light and electron microscopy. We anticipated that, like many marine invertebrate larvae, post-metamorphic structures would differentiate extensively in late larvae to speed metamorphic transition. Previous studies of gastropods suggested that development of juvenile feeding structures in larvae was facilitated by foregut subdivision into dorsal and ventral developmental modules, and spatial uncoupling of these modules may have facilitated adaptive radiation in neogastropods. Observations of
    MeSH term(s) Animals ; Gastropoda ; Larva ; Life Cycle Stages ; Metamorphosis, Biological ; Morphogenesis
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1268-3
    ISSN 1939-8697 ; 0006-3185 ; 0148-9488
    ISSN (online) 1939-8697
    ISSN 0006-3185 ; 0148-9488
    DOI 10.1086/705357
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    In stock of ZB MED Bonn / Germany

    Z 49/62: Show issues

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  9. Article ; Online: Spectrum of Hemodynamic Responses in the First 60 Seconds after Active Standing Up: Importance of Time Course of Blood Pressure Changes and Definitions.

    Wieling, Wouter / van Twist, Daan J L / van Wijnen, Veera K / Harms, Mark P M

    Journal of the American Medical Directors Association

    2021  Volume 22, Issue 11, Page(s) 2401–2403

    MeSH term(s) Blood Pressure ; Hemodynamics ; Humans ; Hypotension, Orthostatic
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2021.03.035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5971: Show issues Location:
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  10. Article ; Online: Application of Ion Chromatography for the Reliable Quantification of Ammonium in Electrochemical Ammonia Synthesis Experiments: A Practical Guide.

    Bragulla, Sebastian C H / Lorenz, Julian / Harms, Corinna / Wark, Michael / Friedrich, K Andreas

    ChemSusChem

    2023  Volume 16, Issue 13, Page(s) e202202211

    Abstract: ... reliable, achieving a limit of quantification (LOQ) of 6 μg l ...

    Abstract Assessing novel electrocatalysts for the electrochemical ammonia synthesis (EAS) requires reliable quantitative trace analysis of electrochemically produced ammonia to infer activity and selectivity. This study concerns the development of an ion chromatography (IC) method for quantitative trace analysis of ammonium in 0.1 M sulfuric acid electrolyte, which is applied to EAS gas-diffusion electrode (GDE) experiments with commercial chromium nitride as electrocatalyst. The developed IC method is highly sensitive, versatile, and reliable, achieving a limit of quantification (LOQ) of 6 μg l
    MeSH term(s) Ammonia ; Ammonium Compounds ; Chromatography/methods ; Sulfuric Acids
    Chemical Substances Ammonia (7664-41-7) ; sulfuric acid (O40UQP6WCF) ; Ammonium Compounds ; Sulfuric Acids
    Language English
    Publishing date 2023-05-05
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202202211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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