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  1. Article ; Online: Intrinsic and synaptic contributions to repetitive spiking in dentate granule cells.

    Shu, Wen-Chi / Jackson, Meyer B

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  

    Abstract: Repetitive firing of granule cells (GCs) in the dentate gyrus facilitates synaptic transmission to the CA3 region. This facilitation can gate and amplify the flow information through the hippocampus. High frequency bursts in the dentate gyrus are linked ... ...

    Abstract Repetitive firing of granule cells (GCs) in the dentate gyrus facilitates synaptic transmission to the CA3 region. This facilitation can gate and amplify the flow information through the hippocampus. High frequency bursts in the dentate gyrus are linked to behavior and plasticity, but GCs do not readily burst. Under normal conditions, a single shock to the perforant path in a hippocampal slice typically drives a GC to fire a single spike, and only occasionally more than one spike is seen. Repetitive spiking in GCs is not robust and the mechanisms are poorly understood. Here, we used a hybrid genetically-encoded voltage sensor to image voltage changes evoked by cortical inputs in many mature GCs simultaneously in hippocampal slices from male and female mice. This enabled us to study relatively infrequent double and triple spikes. We found GCs are relatively homogeneous and their double spiking behavior is cell autonomous. Blockade of GABA
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0716-23.2024
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  2. Article ; Online: Hebbian and non-Hebbian timing-dependent plasticity in the hippocampal CA3 region.

    Jackson, Meyer B

    Hippocampus

    2020  Volume 30, Issue 12, Page(s) 1241–1256

    Abstract: The timing between synaptic inputs has been proposed to play a role in the induction of plastic changes that enable neural circuits to store information. In the case of spike timing-dependent plasticity (STDP), this relates to the interval between a ... ...

    Abstract The timing between synaptic inputs has been proposed to play a role in the induction of plastic changes that enable neural circuits to store information. In the case of spike timing-dependent plasticity (STDP), this relates to the interval between a synaptic input and a postsynaptic spike, thus providing a conceptual link to the Hebb learning rule. Experiments have documented STDP in many synapses and brain regions, and computational models have tested its utility in many neural network functions. However, questions remain about whether timing plays a role in plasticity during natural activity, and whether it can function in information storage. The present study used imaging with voltage sensitive dye to investigate the effectiveness of input timing in the plasticity of responses in the CA3 region of hippocampal slices. Plasticity was induced by sequential dual-site stimulation at 10 ms intervals of either synaptic inputs and cell bodies (synaptic-somatic induction) or of two sets of synaptic inputs (synaptic-synaptic induction). Both protocols potentiated responses, with greater potentiation of responses to the first stimulation of the sequence than the second. Neither of these protocols induced depression. Synaptic-somatic stimulation was much more effective than synaptic-synaptic stimulation in evoking somatic action potentials, but both protocols potentiated responses equally well. This suggests that sequential dual-site stimulation can potentiate equally well with very different degrees of somatic action potential firing. With synaptic-somatic induction, potentiation was focused at the sites of stimulation. In contrast, with synaptic-synaptic induction, the distribution of potentiation varied greatly. Changes in the spatial distribution of responses indicated that sequential dual-site stimulation functions poorly in the storage of activity patterns. These results suggest that in the hippocampal CA3 region, timed sequential activation of two inputs is less effective than theta bursts, both in the induction of LTP and in the storage of information.
    MeSH term(s) Action Potentials/physiology ; Animals ; CA3 Region, Hippocampal/physiology ; Electric Stimulation/methods ; Long-Term Potentiation/physiology ; Male ; Neuronal Plasticity/physiology ; Organ Culture Techniques ; Rats ; Synapses/physiology ; Time Factors
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1074352-2
    ISSN 1098-1063 ; 1050-9631
    ISSN (online) 1098-1063
    ISSN 1050-9631
    DOI 10.1002/hipo.23252
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    Zs.A 3227: Show issues Location:
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  3. Article ; Online: Synaptophysin transmembrane domain III controls fusion pore dynamics in Ca

    Hsiao, Yu-Tien / Jackson, Meyer B

    Biophysical journal

    2022  Volume 122, Issue 11, Page(s) 1962–1973

    Abstract: Synaptophysin (syp) is a major protein of secretory vesicles with four transmembrane domains (TMDs) and a large cytoplasmic C-terminus. Syp has been shown to regulate exocytosis, vesicle cycling, and synaptic plasticity through its C-terminus. However, ... ...

    Abstract Synaptophysin (syp) is a major protein of secretory vesicles with four transmembrane domains (TMDs) and a large cytoplasmic C-terminus. Syp has been shown to regulate exocytosis, vesicle cycling, and synaptic plasticity through its C-terminus. However, the roles of its TMDs remain unclear. The TMDs of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are thought to line initial fusion pores, and structural work together with sequence analysis suggest that TMD III of syp may play a similar role. To test this hypothesis, we performed tryptophan scanning experiments of TMD III in chromaffin cells and used amperometry to evaluate fusion pores. In contrast to SNARE TMDs, tryptophan substitutions in syp TMD III had no effect on the flux through initial fusion pores. However, a number of these mutants increased the fraction of kiss-and-run events and decreased the initial fusion pore lifetime. These results indicate that TMD III stabilizes the initial fusion pore and controls the initial choice between kiss and run and full fusion. Late-stage fusion pores were not impacted by TMD III mutations. These results indicate that syp TMD III does not line the initial fusion pore. However, its impact on pore dynamics suggests that it interacts with a SNARE protein implicated as a part of the fusion pore that forms at the onset of exocytosis.
    MeSH term(s) Synaptophysin ; Tryptophan ; Membrane Fusion/physiology ; Exocytosis/physiology ; SNARE Proteins/metabolism
    Chemical Substances Synaptophysin ; Tryptophan (8DUH1N11BX) ; SNARE Proteins
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2022.09.029
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  4. Article ; Online: Editors' Note.

    Jackson, Meyer B / Dyson, Jane

    Biophysical journal

    2020  Volume 119, Issue 7, Page(s) E1

    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2020.08.033
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  5. Article ; Online: Chemistry in a vesicle.

    Jackson, Meyer B

    The Journal of general physiology

    2017  Volume 149, Issue 10, Page(s) 893–896

    MeSH term(s) Biological Transport ; Membrane Fusion
    Language English
    Publishing date 2017-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201711894
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  6. Article ; Online: Comparing confocal and two-photon Ca

    Cheng, Jinbo / McMahon, Shane M / Piston, David W / Jackson, Meyer B

    Biophysical reports

    2023  Volume 3, Issue 2, Page(s) 100109

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2667-0747
    ISSN (online) 2667-0747
    DOI 10.1016/j.bpr.2023.100109
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  7. Article: Inter and Intralaminar Excitation of Parvalbumin Interneurons in Mouse Barrel Cortex.

    Scheuer, Kate S / Jansson, Anna M / Zhao, Xinyu / Jackson, Meyer B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Parvalbumin (PV) interneurons are inhibitory fast-spiking cells with essential roles in directing the flow of information through cortical circuits. These neurons set the balance between excitation and inhibition, control rhythmic activity, and have been ...

    Abstract Parvalbumin (PV) interneurons are inhibitory fast-spiking cells with essential roles in directing the flow of information through cortical circuits. These neurons set the balance between excitation and inhibition, control rhythmic activity, and have been linked to disorders including autism spectrum and schizophrenia. PV interneurons differ between cortical layers in their morphology, circuitry, and function, but how their electrophysiological properties vary has received little attention. Here we investigate responses of PV interneurons in different layers of primary somatosensory barrel cortex (BC) to different excitatory inputs. With the genetically-encoded hybrid voltage sensor, hVOS, we recorded voltage changes simultaneously in many L2/3 and L4 PV interneurons to stimulation in either L2/3 or L4. Decay-times were consistent across L2/3 and L4. Amplitude, half-width, and rise-time were greater for PV interneurons residing in L2/3 compared to L4. Stimulation in L2/3 elicited responses in both L2/3 and L4 with longer latency compared to stimulation in L4. These differences in latency between layers could influence their windows for temporal integration. Thus PV interneurons in different cortical layers of BC show differences in response properties with potential roles in cortical computations.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.02.543448
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  8. Article ; Online: Velocity of conduction between columns and layers in barrel cortex reported by parvalbumin interneurons.

    Scheuer, Katherine S / Judge, John M / Zhao, Xinyu / Jackson, Meyer B

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Volume 33, Issue 17, Page(s) 9917–9926

    Abstract: Inhibitory interneurons expressing parvalbumin (PV) play critical roles throughout the brain. Their rapid spiking enables them to control circuit dynamics on a millisecond time scale, and the timing of their activation by different excitatory pathways is ...

    Abstract Inhibitory interneurons expressing parvalbumin (PV) play critical roles throughout the brain. Their rapid spiking enables them to control circuit dynamics on a millisecond time scale, and the timing of their activation by different excitatory pathways is critical to these functions. We used a genetically encoded hybrid voltage sensor to image PV interneuron voltage changes with sub-millisecond precision in primary somatosensory barrel cortex (BC) of adult mice. Electrical stimulation evoked depolarizations with a latency that increased with distance from the stimulating electrode, allowing us to determine conduction velocity. Spread of responses between cortical layers yielded an interlaminar conduction velocity and spread within layers yielded intralaminar conduction velocities in different layers. Velocities ranged from 74 to 473 μm/ms depending on trajectory; interlaminar conduction was 71% faster than intralaminar conduction. Thus, computations within columns are more rapid than between columns. The BC integrates thalamic and intracortical input for functions such as texture discrimination and sensory tuning. Timing differences between intra- and interlaminar PV interneuron activation could impact these functions. Imaging of voltage in PV interneurons reveals differences in signaling dynamics within cortical circuitry. This approach offers a unique opportunity to investigate conduction in populations of axons based on their targeting specificity.
    MeSH term(s) Mice ; Animals ; Parvalbumins/metabolism ; Interneurons/physiology ; Axons/physiology ; Electric Stimulation ; Brain/metabolism ; Somatosensory Cortex/physiology
    Chemical Substances Parvalbumins
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad254
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    Zs.A 3235: Show issues Location:
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  9. Article ; Online: The Hydrophobic Effect in Solute Partitioning and Interfacial Tension.

    Jackson, Meyer B

    Scientific reports

    2016  Volume 6, Page(s) 19265

    Abstract: Studies of the partitioning of hydrophobic solutes between water and nonpolar solvents provide estimates for the energy cost of creating hydrophobic-water contacts. This energy is a factor of three lower than the work of adhesion derived from interfacial ...

    Abstract Studies of the partitioning of hydrophobic solutes between water and nonpolar solvents provide estimates for the energy cost of creating hydrophobic-water contacts. This energy is a factor of three lower than the work of adhesion derived from interfacial tension measurements. This discrepancy noted by Tanford in 1979 is widely viewed as a serious challenge to our understanding of hydrophobic interactions. However, the interfacial energy of a water-alkane interface depends on chain length. A simple analysis of published data shows that the loss of rotational freedom of an alkane chain at an interface accounts quantitatively for the length-dependent contribution to interfacial tension, leaving a length-independent contribution very close to the free energy of transfer per unit of solvent accessible surface area. This analysis thus clarifies the discrepancy between the thermodynamic and interfacial tension measurements of hydrophobic interaction energy. Alkanes do not loose rotational freedom when transferred between two different liquid phases but they do at an interface. This reconciles the difference between microscopic and macroscopic measurements. Like the partitioning free energy, the work of adhesion also has a large entropy and small enthalpy at 20 (o)C.
    MeSH term(s) Hydrophobic and Hydrophilic Interactions ; Solutions/chemistry ; Surface Tension
    Chemical Substances Solutions
    Language English
    Publishing date 2016-01-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep19265
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  10. Article ; Online: Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells.

    Chang, Che-Wei / Hsiao, Yu-Tien / Jackson, Meyer B

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2021  Volume 41, Issue 16, Page(s) 3563–3578

    Abstract: Synaptophysin (syp) is a major integral membrane protein of secretory vesicles. Previous work has demonstrated functions for syp in synaptic vesicle cycling, endocytosis, and synaptic plasticity, but the role of syp in the process of membrane fusion ... ...

    Abstract Synaptophysin (syp) is a major integral membrane protein of secretory vesicles. Previous work has demonstrated functions for syp in synaptic vesicle cycling, endocytosis, and synaptic plasticity, but the role of syp in the process of membrane fusion during Ca
    MeSH term(s) Animals ; Animals, Newborn ; Catecholamines/metabolism ; Chromaffin Cells/physiology ; Dynamins/metabolism ; Dynamins/physiology ; Electrophysiological Phenomena ; Exocytosis/genetics ; Exocytosis/physiology ; Female ; Membrane Fusion ; Mice ; Mice, Knockout ; Pregnancy ; Primary Cell Culture ; Synaptic Vesicles/metabolism ; Synaptic Vesicles/physiology ; Synaptogyrins/genetics ; Synaptogyrins/physiology ; Synaptophysin/genetics ; Synaptophysin/physiology
    Chemical Substances Catecholamines ; Synaptogyrins ; Synaptophysin ; Syp protein, mouse ; Dynamins (EC 3.6.5.5)
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2833-20.2021
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