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  1. Article: Surgical management of intramuscular hemangioma of left masseter muscle: A case report.

    Shah, Rishabh / Venkatesh, Rashmi / Badi, Kavita / Shah, Kreena

    National journal of maxillofacial surgery

    2024  Volume 15, Issue 1, Page(s) 160–163

    Abstract: Hemangiomas are benign soft tissue tumors which are congenital and occur due to abnormal proliferations of blood vessels. Most common location of hemangiomas is subcutaneous adipose tissue, but skeletal muscle hemangiomas are very rare which make up to 0. ...

    Abstract Hemangiomas are benign soft tissue tumors which are congenital and occur due to abnormal proliferations of blood vessels. Most common location of hemangiomas is subcutaneous adipose tissue, but skeletal muscle hemangiomas are very rare which make up to 0.8% of all hemangiomas. Usually, the intramuscular lesions are common in thigh region and calf muscles and are relatively rare in the facial muscles. Long-standing lesions results in phleboliths, and this may cause some symptoms. Conventional treatment of these isolated lesions may not yield satisfactory results. Hence, surgical excision of the lesion in toto results in aesthetically pleasing results with low chances of recurrence. In this article, we report a case of a left masseter intramuscular hemangioma in 19-year-old patient which was successfully managed by complete surgical excision.
    Language English
    Publishing date 2024-03-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 2653583-X
    ISSN 2229-3418 ; 0975-5950
    ISSN (online) 2229-3418
    ISSN 0975-5950
    DOI 10.4103/njms.njms_140_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reproductive justice in post-Roe America: Impact of restricted abortion access on patients seeking permanent contraception.

    Thornton, Madeline / Arora, Kavita Shah

    Contraception

    2023  Volume 121, Page(s) 109995

    MeSH term(s) Pregnancy ; Female ; Humans ; Contraception ; Abortion, Induced ; Abortion, Spontaneous ; Social Justice ; Sterilization, Reproductive
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2023.109995
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 629: Show issues Location:
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  3. Article: Editorial: Cell signaling in cancer metastasis and lineage plasticity.

    Yang, Wei / Shah, Kavita / Yang, Rong

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1302659

    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1302659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metabolic Risk Score in Heart Failure: Fuel for Thought?

    Yoo, Edwin J / Shah, Svati H / Sharma, Kavita

    JACC. Heart failure

    2023  Volume 12, Issue 2, Page(s) 301–303

    MeSH term(s) Humans ; Heart Failure/metabolism ; Risk Factors
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.09.009
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  5. Article ; Online: CDK5: an oncogene or an anti-oncogene: location location location.

    Nikhil, Kumar / Shah, Kavita

    Molecular cancer

    2023  Volume 22, Issue 1, Page(s) 186

    Abstract: Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ... ...

    Abstract Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally linked to cancer of many origins. This review focuses on the molecular mechanisms by which CDK5 recruits diverse tissue-specific substrates to elicit distinct phenotypes in sixteen different human cancers. The emerging theme suggests that CDK5's role as an oncogene or anti-oncogene depends upon its subcellular localization. CDK5 mostly acts as an oncogene, but in gastric cancer, it is a tumor suppressor due to its unique nuclear localization. This indicates that CDK5's access to certain nuclear substrates converts it into an anti-oncogenic kinase. While acting as a bonafide oncogene, CDK5 also activates a few cancer-suppressive pathways in some cancers, presumably due to the mislocalization of nuclear substrates in the cytoplasm. Therefore, directing CDK5 to the nucleus or exporting tumor-suppressive nuclear substrates to the cytoplasm may be promising approaches to combat CDK5-induced oncogenicity, analogous to neurotoxicity triggered by nuclear CDK5. Furthermore, while p35 overexpression is oncogenic, hyperactivation of CDK5 by inducing p25 formation results in apoptosis, which could be exploited to selectively kill cancer cells by dialing up CDK5 activity, instead of inhibiting it. CDK5 thus acts as a molecular rheostat, with different activity levels eliciting distinct functional outcomes. Finally, as CDK5's role is defined by its substrates, targeting them individually or in conjunction with CDK5 should create potentially valuable new clinical opportunities.
    MeSH term(s) Humans ; Nerve Tissue Proteins/genetics ; Apoptosis ; Oncogenes ; Cytoplasm/metabolism ; Genes, Tumor Suppressor ; Cyclin-Dependent Kinase 5/genetics ; Cyclin-Dependent Kinase 5/metabolism
    Chemical Substances Nerve Tissue Proteins ; Cyclin-Dependent Kinase 5 (EC 2.7.11.1)
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091373-4
    ISSN 1476-4598 ; 1476-4598
    ISSN (online) 1476-4598
    ISSN 1476-4598
    DOI 10.1186/s12943-023-01895-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: LIMK2: A Multifaceted kinase with pleiotropic roles in human physiology and pathologies.

    Shah, Kavita / Cook, Mason

    Cancer letters

    2023  Volume 565, Page(s) 216207

    Abstract: LIMK2, a serine-specific kinase, was discovered as an actin dynamics regulating kinase. Emerging studies have shown its pivotal role in numerous human malignancies and neurodevelopmental disorder. Inducible knockdown of LIMK2 fully reverses tumorigenesis, ...

    Abstract LIMK2, a serine-specific kinase, was discovered as an actin dynamics regulating kinase. Emerging studies have shown its pivotal role in numerous human malignancies and neurodevelopmental disorder. Inducible knockdown of LIMK2 fully reverses tumorigenesis, underscoring its potential as a clinical target. However, the molecular mechanisms leading to its upregulation and its deregulated activity in various diseases largely remain unknown. Similarly, LIMK2's peptide substrate specificity has not been analyzed. This is particularly important for LIMK2, a kinase almost three decades old, as only a handful of its substrates are known to date. As a result, most of LIMK2's physiological and pathological roles have been assigned to its regulation of actin dynamics via cofilin. This review focuses on LIMK2's unique catalytic mechanism, substrate specificity and its upstream regulators at transcriptional, post-transcriptional and post-translational stages. Moreover, emerging studies have unveiled a few tumor suppressors and oncogenes as LIMK2's direct substrates, which in turn have uncovered novel molecular mechanisms by which it plays pleiotropic roles in human physiology and pathologies independent of actin dynamics.
    MeSH term(s) Humans ; Actins/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/physiology ; Actin Depolymerizing Factors/metabolism ; Protein Processing, Post-Translational ; Lim Kinases/genetics
    Chemical Substances Actins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Actin Depolymerizing Factors ; LIMK2 protein, human (EC 2.7.11.1) ; Lim Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-02
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2023.216207
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Evaluation and Immunogenicity of Combined Liposome-Based Vaccine Candidates against Hepatitis E and B Viruses in Rhesus Monkeys.

    Deshmukh, Tejaswini / Shah, Rachita / Devhare, Pradip / Lole, Kavita / Arankalle, Vidya

    Vaccines

    2024  Volume 12, Issue 1

    Abstract: The administration of vaccines using a combination approach ensures better coverage and reduces the number of injections and cost. The present study assessed liposome-complexed DNA-corresponding proteins of hepatitis E and B viruses (HEV and HBV) as ... ...

    Abstract The administration of vaccines using a combination approach ensures better coverage and reduces the number of injections and cost. The present study assessed liposome-complexed DNA-corresponding proteins of hepatitis E and B viruses (HEV and HBV) as combined vaccine candidates in rhesus monkeys. The HEV and HBV components consisted of 450 bps, neutralizing the epitope/s (NE) region, and 685 bps small (S) envelope gene-corresponding proteins, respectively. Three groups (
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12010053
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  8. Article ; Online: Correction to: Changes in Rates of Inpatient Postpartum Long‑Acting Reversible Contraception and Sterilization in the USA, 2012-2016.

    Sheyn, David / Arora, Kavita Shah

    Maternal and child health journal

    2021  Volume 25, Issue 10, Page(s) 1574

    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-021-03202-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6170: Show issues Location:
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  9. Article ; Online: Ethics of a Mandatory Waiting Period for Female Sterilization.

    Amalraj, Jessica / Arora, Kavita Shah

    The Hastings Center report

    2022  Volume 52, Issue 4, Page(s) 17–25

    Abstract: Due to a history of coerced sterilization, a federal Medicaid sterilization policy mandates that a specific consent form be signed by a patient at least thirty days prior to when the patient undergoes sterilization. However, in contemporary obstetrical ... ...

    Abstract Due to a history of coerced sterilization, a federal Medicaid sterilization policy mandates that a specific consent form be signed by a patient at least thirty days prior to when the patient undergoes sterilization. However, in contemporary obstetrical practice, the Medicaid sterilization policy serves as a policy-level barrier to autonomously desired care. We review the clinical and ethical implications of the current Medicaid sterilization policy. After discussing the utility and impact of waiting periods for other surgical procedures, we explore the psychology of time required for decision-making and consider scientific understanding of regret. We argue that the current Medicaid sterilization waiting period is clinically and ethically unjustifiable and that the policy ought to be revised in light of the goals, preferences, and concerns of the people most affected by it. While the need for continued protection against coercion remains, the current mandated waiting period does little to enforce the high-quality shared decision-making that is desired for sterilization counseling.
    MeSH term(s) Coercion ; Female ; Humans ; Medicaid ; Sterilization, Reproductive/psychology ; United States
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194940-8
    ISSN 1552-146X ; 0093-0334
    ISSN (online) 1552-146X
    ISSN 0093-0334
    DOI 10.1002/hast.1405
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    Zs.B 1672: Show issues Location:
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  10. Article: A Rare Case of Visual Hallucinations Associated With Hyponatremia.

    Sharma, Vishal / Shah, Kavita / Reddy Mallimala, Priya / Sharma, Karan

    Cureus

    2023  Volume 15, Issue 8, Page(s) e44485

    Abstract: Visual hallucinations are rare occurrences in patients presenting with hyponatremia. When they occur, the patient experiences these hallucinations with their eyes closed (vs. opened) and is insightful about the false perception. We present the case of a ... ...

    Abstract Visual hallucinations are rare occurrences in patients presenting with hyponatremia. When they occur, the patient experiences these hallucinations with their eyes closed (vs. opened) and is insightful about the false perception. We present the case of a 64-year-old male diagnosed with hyponatremia caused by a gastrointestinal illness, which led to visual hallucinations. The patient was treated with electrolyte infusion, and the hallucinations were resolved. Detailed history-taking is significant when dealing with such cases as hallucinations to differentiate it from other causes. Hallucination caused by hyponatremia can resolve with prompt correction of sodium, and the patients can be reassured.
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.44485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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