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Article ; Online: Iris color as a predictive factor for intraoperative floppy iris syndrome.

Safir, Margarita / Greenbaum, Eran / Vardi, Maya Atar / Friehman, Assaf / Pras, Eran / Assia, Ehud I / Sharon, Tal

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2023 Volume 261, Issue 12, Page(s) 3503–3510

Abstract: ... p < 0.01). Light-colored irises tended to exhibit a more severe IFIS compared to the brown iris ... for fellow eye IFIS in the green iris group compared to eyes with brown irises (OR = 10.43, 95% CI: 3.35-32 ... Purpose: To assess the influence of iris color on the predisposition for intraoperative floppy ...

Abstract	Purpose: To assess the influence of iris color on the predisposition for intraoperative floppy iris syndrome (IFIS) during cataract surgery. Methods: Medical records of patients who underwent cataract surgery in two medical centers between July 2019 and February 2020 were reviewed. Patients younger than 50 years, with preexisting ocular conditions affecting pupillary size or anterior chamber depth (ACD), and combined procedures were excluded. The remaining patients were questioned via telephone regarding their iris color. The association of IFIS occurrence and severity with iris color was tested using univariant and multivariant analyses. Results: Overall, 155 eyes of 155 patients were included, 74 with documented IFIS and 81 without. The mean age was 74.03 ± 7.09 years, and 35.5% were female. The most common iris color among study eyes was brown (110/155, 70.97%), followed by blue (25/155, 16.13%) and green (20/155, 12.90%). Compared to brown-colored eyes, blue irises exhibited a 4.50-fold risk for IFIS (OR = 4.50, 95% CI: 1.73-11.70, p = 0.002), and green irises 7.00-fold risk (OR = 7.00, 95% CI: 2.19-22.39, p = 0.001). After adjusting for possible confounders, the results remained statistically significant (p < 0.01). Light-colored irises tended to exhibit a more severe IFIS compared to the brown iris group (p < 0.001). IFIS bilaterality was also affected by iris color (p < 0.001), with a 10.43-fold risk for fellow eye IFIS in the green iris group compared to eyes with brown irises (OR = 10.43, 95% CI: 3.35-32.54, p < 0.001). Conclusions: Light iris color was associated with a significantly increased risk of IFIS occurrence, severity, and bilaterality on univariate and multivariate analysis in this study.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Cataract ; Intraoperative Complications/diagnosis ; Intraoperative Complications/epidemiology ; Iris ; Iris Diseases/diagnosis ; Syndrome ; Color
Language	English
Publishing date	2023-06-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-023-06110-4
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Article ; Online: Valve-in-Valve Transcatheter Aortic Valve Replacement During Second Trimester of Pregnancy.

Sajja, Aparna / Dassanayake, Maya / Morales, Iris Abrahantes / Wenger, Nanette K / Smith, Clayton / Xie, Joe / Gleason, Patrick / Greenbaum, Adam B / Ogunniyi, Modele O

JACC. Case reports

2023 Volume 27, Page(s) 102074

Abstract: Critical bioprosthetic aortic valve stenosis is a rare finding in the second trimester of pregnancy. We present the case of a successful valve-in-valve transcatheter aortic valve replacement in a 16-weeks-pregnant patient. We describe the significant ... ...

Abstract	Critical bioprosthetic aortic valve stenosis is a rare finding in the second trimester of pregnancy. We present the case of a successful valve-in-valve transcatheter aortic valve replacement in a 16-weeks-pregnant patient. We describe the significant role of the multidisciplinary heart team during preconception and pregnancy.
Language	English
Publishing date	2023-12-06
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2023.102074
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Article: The genetic basis of malignant hyperthermia.

Greenbaum, Iris / Weigl, Yuval / Pras, Elon

The Israel Medical Association journal : IMAJ

2007 Volume 9, Issue 1, Page(s) 39–41

MeSH term(s)	Genetic Predisposition to Disease ; Humans ; Malignant Hyperthermia/diagnosis ; Malignant Hyperthermia/genetics
Language	English
Publishing date	2007-01
Publishing country	Israel
Document type	Journal Article ; Review
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article ; Online: Post-refractive surgery of Israeli Defense Forces recruits in 2005-2018-prevalence, combat unit drop-out rates and utilization of eye-care services.

Greenbaum, Eran / Barayev, Edward / Shpitzer, Sagi / Heller, Dan / Nahum, Yoav / Livny, Eitan / Gershoni, Assaf / Bahar, Irit

Eye (London, England)

2022 Volume 37, Issue 7, Page(s) 1484–1488

Abstract: Purpose: To assess the number of recruits for military service in the Israeli Defense Force (IDF) who underwent refractive surgery prior to enlistment and examine whether the procedure affected their ability to accomplish combat training.: Setting: ... ...

Abstract	Purpose: To assess the number of recruits for military service in the Israeli Defense Force (IDF) who underwent refractive surgery prior to enlistment and examine whether the procedure affected their ability to accomplish combat training. Setting: Medical records of IDF recruits. Design: Retrospective analysis of medical records of recruits with ametropia who underwent or did not undergo refractive surgery prior to enlistment. Methods: Recruits were categorized into ametropes and recruits who underwent refractive surgery. Fitness and assignment to combat units and completion status of combat training were compared between the two groups. Results: The study included 334,688 (182,969 males, 151,719 females) ametropes of which 5231 (4753 males, 478 females) underwent refractive surgery prior to recruitment. Refractive surgery prevalence increased from 9/1000 ametropes in 2005 to 18.5/1000 ametropes in 2018 (r = 0.912, p < 0.001); 2643 of the operated recruits (50.5%) had their surgery at the age of 17-18. Dropout rates from combat training were significantly lower in the refractive surgery group during the study period (1.68% vs. 6.14%, respectively, p < 0.001). Soldiers in the operated group were more frequently referred to ophthalmologists than those in the ametropes group and less frequently referred to optometrists. Conclusions: The prevalence of refractive surgery in IDF recruits has increased substantially during the last decade with more of them applying to combat units. Refractive surgery opened new possibilities for recruits who were unfit for combat duty prior to surgery and did not appear to impair the chances of successfully completing combat training.
MeSH term(s)	Male ; Female ; Humans ; Prevalence ; Israel/epidemiology ; Retrospective Studies ; Refractive Errors/epidemiology ; Refractive Surgical Procedures ; Military Personnel
Language	English
Publishing date	2022-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-022-02164-6
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Zs.B 3010: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reply.

Nahum, Yoav / Gal-Or, Orly / Dadon, Judith / Greenbaum, Aharon / Israeli, David / Melles, Gerrit R J / Bahar, Irit / Livny, Eitan

Cornea

2021 Volume 41, Issue 4, Page(s) e7

MeSH term(s)	Descemet Membrane ; Humans ; Keratoplasty, Penetrating
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000002817
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Article ; Online: Kinetics of pre-myelodysplastic syndromes blood values correlate with disease risk and survival.

Joffe, Erel / Greenbaum, Uri / Man-El, Gili / Filanovsky, Kalman / Oster, Howard S / Levi, Itai / Raanani, Pia / Avivi, Irit / Mittelman, Moshe

Hematological oncology

2020 Volume 38, Issue 5, Page(s) 782–791

Abstract: We reviewed pre-diagnosis clinical data of 420 patients with pathologically confirmed myelodysplastic syndromes (MDSs) presenting with anemia. In 232 patients with yearly pre-diagnosis complete blood counts (CBCs), we also analyzed CBC kinetics in ... ...

Abstract	We reviewed pre-diagnosis clinical data of 420 patients with pathologically confirmed myelodysplastic syndromes (MDSs) presenting with anemia. In 232 patients with yearly pre-diagnosis complete blood counts (CBCs), we also analyzed CBC kinetics in respects to a standardized timepoint in which all patients had similar levels of hemoglobin (Hgb). At the standardized timepoint (last documented 12 > Hgb ≥ 11 g/dL), occurring months-years before diagnosis, median CBC values were Hgb 11.4 g/dL, absolute neutrophil count (ANC) 2.7 × 10
MeSH term(s)	Aged ; Aged, 80 and over ; Anemia/diagnosis ; Anemia/etiology ; Biomarkers/blood ; Disease Management ; Disease Susceptibility ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Myelodysplastic Syndromes/blood ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Patient Outcome Assessment ; Prognosis ; Risk Assessment ; Risk Factors ; Severity of Illness Index
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.2777
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Article ; Online: Spontaneous Descemet Membrane Detachment After Penetrating Keratoplasty-Clinical Presentation and Outcome of Air/Gas Descemetopexy.

Nahum, Yoav / Gal-Or, Orly / Dadon, Judith / Greenbaum, Aharon / Israeli, David / Melles, Gerrit R J / Bahar, Irit / Livny, Eitan

Cornea

2020 Volume 39, Issue 12, Page(s) 1499–1502

Abstract: Purpose: To describe the clinical characteristics and treatment of spontaneous Descemet membrane (DM) detachment occurring decades after penetrating keratoplasty (PK).: Methods: A multicenter interventional case series design was used. We reviewed ... ...

Abstract	Purpose: To describe the clinical characteristics and treatment of spontaneous Descemet membrane (DM) detachment occurring decades after penetrating keratoplasty (PK). Methods: A multicenter interventional case series design was used. We reviewed the medical records of 4 patients with a history of PK presenting with spontaneous DM detachment at 3 university hospitals in Israel and an ocular surgery institute in The Netherlands in 2016 to 2019. Patient demographic and clinical data, postoperative best corrected visual acuity, findings on preoperative and postoperative anterior segment optical coherence tomography (AS-OCT), and graft survival were recorded. Results: Patients were aged 46 to 50 years. All had undergone PK for keratoconus 20 to 26 years previously. Patients presented within 18 to 180 days of onset of visual disturbance. Symptoms included sudden painless visual loss (2 patients), gradual visual loss and foreign body sensation (1 patients), and visual loss not otherwise specified (1 patient). Slit-lamp examination showed corneal edema, and AS-OCT showed DM detachment of variable extent. In 2 patients, the initial diagnosis was graft rejection and failure. Treatment consisted of anterior chamber injection of air (n = 3) or 20% SF6 (n = 1). In 3 patients, the DM reattached and the cornea regained its clarity. The fourth patient had persistent DM detachment that required repeated PK. Conclusions: Spontaneous DM detachment can mimic late graft failure in patients after PK. If diagnosed early, DM reattachment may be performed by air/gas injection, avoiding repeated keratoplasty. Eyes with presumed late penetrating graft rejection or failure should be examined by AS-OCT to exclude DM detachment.
MeSH term(s)	Air ; Anterior Chamber/diagnostic imaging ; Anterior Chamber/surgery ; Corneal Diseases/etiology ; Corneal Diseases/physiopathology ; Corneal Diseases/surgery ; Descemet Membrane/pathology ; Descemet Membrane/physiopathology ; Descemet Membrane/surgery ; Endotamponade ; Female ; Graft Survival/physiology ; Humans ; Keratoconus/surgery ; Keratoplasty, Penetrating/adverse effects ; Male ; Middle Aged ; Rupture, Spontaneous ; Slit Lamp Microscopy ; Sulfur Hexafluoride/administration & dosage ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity/physiology
Chemical Substances	Sulfur Hexafluoride (WS7LR3I1D6)
Language	English
Publishing date	2020-05-23
Publishing country	United States
Document type	Case Reports ; Journal Article ; Multicenter Study
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000002369
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Article ; Online: Response rates of extra-nodal diffuse large B cell lymphoma to anti-CD19-CAR T cells: A real word retrospective multicenter study.

European journal of haematology

2023 Volume 111, Issue 1, Page(s) 63–71

Abstract: Chimeric antigen receptor T-cells (CAR-T) are widely used for the treatment of relapsed/refractory diffuse large B cell lymphoma (DLBCL). The data for CAR-T cell therapy in patients with extra-nodal (EN) lymphoma is restricted. We included 126 ... ...

Abstract	Chimeric antigen receptor T-cells (CAR-T) are widely used for the treatment of relapsed/refractory diffuse large B cell lymphoma (DLBCL). The data for CAR-T cell therapy in patients with extra-nodal (EN) lymphoma is restricted. We included 126 consecutive patients with DLBCL treated with commercially available CAR-T cells (tisagenlecleucel, n = 100, 79.4% and axicabtagene ciloleucel, n = 26, 20.6%). At lymphodepletion, 72 of 126 (57%) patients had EN disease, 42 of 126 (33%) patients had nodal disease (ND)-only and 12 of 126 (10%) showed no disease assessed by PET-CT. There were no significant differences in CAR-T related toxicities and in the median Progression free survival (PFS) between EN patients and ND (10.76 [95% CI: 7.8-13.6] vs. 14.1 [95% CI: 10-18.1] months, p = .126). Similarly, median overall survival (OS) was not significantly different (15.36 [95% CI 12.5-18.2] vs. 18.4 [95% CI 14.8-22.1] months, p = .100). Subgroup analysis according to the number of EN involved sites showed that median PFS and OS were significantly higher in patients with <3 EN sites (12.3 months [95% CI 9-15.5] vs. 4.28 months [95% CI 0.6-7.9], p = .010) compared to patients with >2 EN sites, respectively (16.5 months [95% CI 13.4-19.6] vs. 8.7 months [95% CI 4.6-12.8], p = .05). In multivariate cox regression analysis, increased number sites of EN disease and high lactate dehydrogenase (LDH) at lymphodepletion negatively impacted PFS (p = .021 and <.001, respectively), while sex, type of product administered, age and performance status did not predict PFS and OS. Of note, all the patients with involvement of gastrointestinal tract (n = 9), urinary tract (n = 9), or pharynx (n = 3) at lymphodepletion, progressed or had an early relapse. In conclusions, patients with >2 EN sites at lymphodepletion have significantly worse clinical outcomes compared to patients with <3 EN sites. Patients with specific sites of EN disease may demonstrate grim prognosis.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen ; Positron Emission Tomography Computed Tomography ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Non-Hodgkin/drug therapy ; Immunotherapy, Adoptive/adverse effects ; Lymphoma, Follicular/drug therapy ; T-Lymphocytes ; Retrospective Studies ; Antigens, CD19
Chemical Substances	Receptors, Chimeric Antigen ; Antigens, CD19
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13968
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Article ; Online: Is bone marrow examination always necessary to establish the diagnosis of myelodysplastic syndromes? A proposed non-invasive diagnostic model.

Oster, Howard S / Carmi, Gal / Kolomansky, Alex / Joffe, Erel / Kaye, Irit / Kirgner, Ilya / Greenbaum, Uri / Comaneshter, Doron / Mittelman, Moshe

Leukemia & lymphoma

2018 Volume 59, Issue 9, Page(s) 2227–2232

Abstract: A non-invasive myelodysplastic syndromes (MDS) diagnostic model would allow for care while avoiding invasive bone marrow examinations (BME). BME-established MDS patients were compared to non-MDS (BME-excluded) patients. Variables (gender, age, hemoglobin ...

Abstract	A non-invasive myelodysplastic syndromes (MDS) diagnostic model would allow for care while avoiding invasive bone marrow examinations (BME). BME-established MDS patients were compared to non-MDS (BME-excluded) patients. Variables (gender, age, hemoglobin (Hb), mean red blood cell corpuscular volume (MCV), platelet (PLT), and white blood cell (WBC)) were combined with multivariate logistic regression; a probability score (Y) was calculated. MDS (n = 48) and non-MDS (n = 63) patients were used to establish the model. The ROC was drawn, giving an AUC of 0.748 (95% CI: 0.656-0.84). Two cutoff values were used for Y. Y ≥ 0.633: high likelihood (positive predictive value (PPV) = 85%); Y ≤ 0.288: low likelihood (negative predictive value (NPV) = 81%) of MDS. The first group is defined as probable MDS (pMDS); the second, probably not MDS (pnMDS). The model was validated with 40 additional patients (20 with and 20 without MDS). Using clinical and lab data, we could diagnose or exclude MDS in about half of the patients, avoiding BME. Future work will use larger cohorts of patients to improve and further validate the model.
MeSH term(s)	Aged ; Aged, 80 and over ; Algorithms ; Bone Marrow Examination/methods ; Erythrocyte Indices ; Female ; Humans ; Leukocyte Count ; Logistic Models ; Male ; Multivariate Analysis ; Myelodysplastic Syndromes/blood ; Myelodysplastic Syndromes/diagnosis ; Platelet Count ; ROC Curve
Language	English
Publishing date	2018-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2017.1416363
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Article ; Online: Potential contribution of the Alzheimer's disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly.

Greenbaum, Lior / Ravona-Springer, Ramit / Lubitz, Irit / Schmeidler, James / Cooper, Itzik / Sano, Mary / Silverman, Jeremy M / Heymann, Anthony / Beeri, Michal Schnaider

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

2016 Volume 26, Issue 4, Page(s) 787–795

Abstract: In recent years, several promising susceptibility loci for late-onset Alzheimer's disease (AD) were discovered, by implementing genome-wide association studies (GWAS) approach. Recent GWAS meta-analysis has demonstrated the association of 19 loci (in ... ...

Abstract	In recent years, several promising susceptibility loci for late-onset Alzheimer's disease (AD) were discovered, by implementing genome-wide association studies (GWAS) approach. Recent GWAS meta-analysis has demonstrated the association of 19 loci (in addition to the APOE locus) with AD in the European ancestry population at genome-wide significance level. Since Type 2 Diabetes (T2D) is a substantial risk factor for cognitive decline and dementia, the 19 single nucleotide polymorphisms (SNPs) that represent the 19 AD loci were studied for association with performance in episodic memory, a primary cognitive domain affected by AD, in a sample of 848 cognitively normal elderly Israeli Jewish T2D patients. We found a suggestive association of SNP rs6733839, located near the bridging integrator 1 (BIN1) gene, with this phenotype. Controlling for demographic (age, sex, education, disease duration and ancestry) covariates, carriers of two copies of the AD risk allele T (TT genotype) performed significantly worse (p=0.00576; p=0.00127 among Ashkenazi origin sub-sample) in episodic memory compared to carriers of the C allele (CT+CC genotypes). When including additional potential covariates (clinical and APOE genotype), results remained significant (p=0.00769; p=0.00148 among Ashkenazi). Interestingly, as validated in multiple large studies, BIN1 is one of the most established AD risk loci, with a high odds ratio. Although preliminary and require further replications, our findings support a contribution of BIN1 to individual differences in episodic memory performance among T2D patients.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease/genetics ; Cognition/physiology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/psychology ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Memory, Episodic ; Nuclear Proteins/genetics ; Polymorphism, Single Nucleotide/genetics ; Risk ; Tumor Suppressor Proteins/genetics
Chemical Substances	Adaptor Proteins, Signal Transducing ; BIN1 protein, human ; Nuclear Proteins ; Tumor Suppressor Proteins
Language	English
Publishing date	2016-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1082947-7
ISSN	1873-7862 ; 0924-977X
ISSN (online)	1873-7862
ISSN	0924-977X
DOI	10.1016/j.euroneuro.2015.11.004
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