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  1. Article: The genetic diversity of Plasmodium vivax--a review.

    de Souza-Neiras, Wanessa Christina / de Melo, Luciane Moreno Storti / Machado, Ricardo Luiz Dantas

    Memorias do Instituto Oswaldo Cruz

    2007  Volume 102, Issue 3, Page(s) 245–254

    Abstract: The genetic diversity of Plasmodium vivax has been investigated in several malaria-endemic areas, including the Brazilian Amazon region, where this is currently the most prevalent species causing malaria in humans. This review summarizes current views on ...

    Abstract The genetic diversity of Plasmodium vivax has been investigated in several malaria-endemic areas, including the Brazilian Amazon region, where this is currently the most prevalent species causing malaria in humans. This review summarizes current views on the use of molecular markers to examine P. vivax populations, with a focus on studies performed in Brazilian research laboratories. We emphasize the importance of phylogenetic studies on this parasite and discuss the perspectives created by our increasing understanding of genetic diversity and population structure of this parasite for the development of new control strategies, including vaccines, and more effective drugs for the treatment of P. vivax malaria.
    MeSH term(s) Animals ; Antigens, Protozoan/genetics ; Brazil ; Evolution, Molecular ; Genetic Markers/genetics ; Genetic Variation ; Humans ; Malaria, Vivax/parasitology ; Malaria, Vivax/prevention & control ; Phylogeny ; Plasmodium vivax/genetics ; Plasmodium vivax/immunology ; Polymorphism, Genetic ; Protozoan Proteins/genetics
    Chemical Substances Antigens, Protozoan ; Genetic Markers ; Protozoan Proteins
    Language English
    Publishing date 2007-06-03
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 953293-6
    ISSN 1678-8060 ; 0074-0276
    ISSN (online) 1678-8060
    ISSN 0074-0276
    DOI 10.1590/s0074-02762007000300002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The genetic diversity of Plasmodium vivax

    Wanessa Christina de Souza-Neiras / Luciane Moreno Storti de Melo / Ricardo Luiz Dantas Machado

    Memórias do Instituto Oswaldo Cruz., Vol 102, Iss 3, Pp 245-

    a review

    2007  Volume 254

    Abstract: The genetic diversity of Plasmodium vivax has been investigated in several malaria-endemic areas, including the Brazilian Amazon region, where this is currently the most prevalent species causing malaria in humans. This review summarizes current views on ...

    Abstract The genetic diversity of Plasmodium vivax has been investigated in several malaria-endemic areas, including the Brazilian Amazon region, where this is currently the most prevalent species causing malaria in humans. This review summarizes current views on the use of molecular markers to examine P. vivax populations, with a focus on studies performed in Brazilian research laboratories. We emphasize the importance of phylogenetic studies on this parasite and discuss the perspectives created by our increasing understanding of genetic diversity and population structure of this parasite for the development of new control strategies, including vaccines, and more effective drugs for the treatment of P. vivax malaria.
    Keywords malaria ; Plasmodium vivax ; genetic diversity ; molecular markers ; phylogeny ; evolution ; Arctic medicine. Tropical medicine ; RC955-962 ; Microbiology ; QR1-502
    Language English
    Publishing date 2007-06-01T00:00:00Z
    Publisher Instituto Oswaldo Cruz, Ministério da Saúde
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax.

    Storti-Melo, Luciane Moreno / da Costa, Daniela Reis / Souza-Neiras, Wanessa Christina / Cassiano, Gustavo Capatti / Couto, Vanja Suely Calvosa D'Almeida / Póvoa, Marinete Marins / Soares, Irene da Silva / de Carvalho, Luzia Helena / Arevalo-Herrera, Myrian / Herrera, Sócrates / Rossit, Andrea Regina Baptista / Cordeiro, José Antonio / de Mattos, Luiz Carlos / Machado, Ricardo Luiz Dantas

    Acta tropica

    2012  Volume 121, Issue 2, Page(s) 152–155

    Abstract: We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of ... ...

    Abstract We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alleles ; Antibodies, Protozoan/blood ; Antigens, Protozoan/immunology ; Brazil ; Enzyme-Linked Immunosorbent Assay ; Gene Frequency ; HLA-DRB1 Chains/genetics ; HLA-DRB1 Chains/immunology ; Humans ; Immunoglobulin G/blood ; Malaria, Vivax/immunology ; Middle Aged ; Plasmodium vivax/immunology
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; HLA-DRB1 Chains ; Immunoglobulin G
    Language English
    Publishing date 2012-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2011.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

    Storti-Melo, Luciane Moreno / da Costa, Daniela Reis / Souza-Neiras, Wanessa Christina / Cassiano, Gustavo Capatti / Couto, Vanja Suely Calvosa D’Almeida / Póvoa, Marinete Marins / Soares, Irene da Silva / de Carvalho, Luzia Helena / Arevalo-Herrera, Myrian / Herrera, Sócrates / Rossit, Andrea Regina Baptista / Cordeiro, José Antonio / de Mattos, Luiz Carlos / Machado, Ricardo Luiz Dantas

    Acta tropica. 2012 Feb., v. 121, no. 2 p.152-155

    2012  

    Abstract: We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of ... ...

    Abstract We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
    Keywords Plasmodium vivax ; alleles ; antibodies ; antibody formation ; antigens ; at-risk population ; enzyme-linked immunosorbent assay ; gene frequency ; humans ; immunoglobulin G ; malaria ; merozoites ; patients ; peptides ; surface proteins ; Brazil
    Language English
    Dates of publication 2012-02
    Size p. 152-155.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2011.10.009
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  5. Article: Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?

    Cavasini, Carlos Eugênio / Mattos, Luiz Carlos de / Couto, Alvaro Augusto D'Almeida / Bonini-Domingos, Cláudia Regina / Valencia, Socrates Herrera / Neiras, Wanessa Christina de Souza / Alves, Renata Tomé / Rossit, Andréa Regina Baptista / Castilho, Lilian / Machado, Ricardo Luiz Dantas

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2007  Volume 101, Issue 10, Page(s) 1042–1044

    Abstract: We present evidence for Plasmodium vivax infection among Duffy blood group-negative inhabitants of Brazil. The P. vivax identification was determined by both genotypic and non-genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP and ...

    Abstract We present evidence for Plasmodium vivax infection among Duffy blood group-negative inhabitants of Brazil. The P. vivax identification was determined by both genotypic and non-genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP and phenotyped using a microtyping kit. We detected two homozygous FY*B-33 carriers infected by P. vivax, whose circumsporozoite protein genotypes were VK210 and/or P. vivax-like. Additional efforts are necessary in order to clarify the evidence that P. vivax is being transmitted among Duffy blood group-negative patients from the Brazilian Amazon region.
    MeSH term(s) Brazil/epidemiology ; Duffy Blood-Group System/genetics ; Duffy Blood-Group System/immunology ; Female ; Humans ; Malaria, Vivax/blood ; Malaria, Vivax/epidemiology ; Malaria, Vivax/immunology ; Male
    Chemical Substances Duffy Blood-Group System
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1016/j.trstmh.2007.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

    Storti-Melo, Luciane Moreno / da Costa, Daniela Reis / Souza-Neiras, Wanessa Christina / Cassiano, Gustavo Capatti / Couto, Vanja Suely Calvosa D’Almeida / Póvoa, Marinete Marins / Soares, Irene da Silva / de Carvalho, Luzia Helena / Arevalo-Herrera, Myrian / Herrera, Sócrates / Rossit, Andrea Regina Baptista / Cordeiro, José Antonio / de Mattos, Luiz Carlos / Machado, Ricardo Luiz Dantas

    Acta tropica

    Volume v. 121,, Issue no. 2

    Abstract: We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of ... ...

    Abstract We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
    Keywords merozoites ; surface proteins ; alleles ; antibodies ; immunoglobulin G ; Plasmodium vivax ; humans ; antibody formation ; at-risk population ; enzyme-linked immunosorbent assay ; patients ; malaria ; peptides ; antigens ; gene frequency
    Language English
    Document type Article
    ISSN 0001-706X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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