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Article ; Online: Trauma-focused therapy retention among military sexual trauma survivors: relationship with veterans' sexual or gender minority identification.

Sexton, Minden B / Cochran, Heather M / Schubert, Jessica R / Gorin, Hillary M / Paulson, Julia L / Boyd, Meredith R / Porter, Katherine E / Smith, Erin R

Cognitive behaviour therapy

2024 , Page(s) 1–13

Abstract: Military servicemembers identifying as sexual and gender minorities (SGM) are at increased risk for military sexual trauma (MST) exposure and Post-traumatic Stress Disorder (PTSD). Although evidence-based treatments can reduce symptoms of PTSD, treatment ...

Abstract	Military servicemembers identifying as sexual and gender minorities (SGM) are at increased risk for military sexual trauma (MST) exposure and Post-traumatic Stress Disorder (PTSD). Although evidence-based treatments can reduce symptoms of PTSD, treatment attrition is concerning. Unfortunately, evaluations of such approaches with veterans identifying as SGM are currently restricted to case studies offering limited information regarding treatment completion. Both historic and current contextual factors related to military and mental health practices may uniquely influence minority veterans' treatment engagement in veteran healthcare settings. We explored associations between SGM identification and treatment of MST-focused therapy completion patterns (finishing the full protocol [FP] or receiving minimally adequate care [MAC; defined as attending eight or more sessions]). Veterans (
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2076060-7
ISSN	1651-2316 ; 1650-6073
ISSN (online)	1651-2316
ISSN	1650-6073
DOI	10.1080/16506073.2024.2313740
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Article: Posleoperatsionnyi pankreatit kak oslozhnenie pankreatoduodenal'noi rezektsii.

Gorin, D S / Kriger, A G / Galkin, G V / Raevskaya, M B

Khirurgiia

2022 , Issue 2, Page(s) 11–16

Abstract: Objective: Retrospective assessment of the influence of postoperative pancreatitis in development of pancreatic fistula.: Material and methods: The study included 173 patients after pancreatoduodenectomy performed between 2016 and 2019. Postoperative ...

Title translation	Postoperative pancreatitis after pancreatoduodenectomy.
Abstract	Objective: Retrospective assessment of the influence of postoperative pancreatitis in development of pancreatic fistula. Material and methods: The study included 173 patients after pancreatoduodenectomy performed between 2016 and 2019. Postoperative pancreatitis within the 1 Results: Postoperative pancreatitis occurred in 36 (20.8%) out of 173 patients after pancreatoduodenectomy. Pancreatic fistula occurred in 18 (50%) cases. Among 137 patients without postoperative pancreatitis, only 18 (13.1%) patients developed severe pancreatic fistula. Relative risk was 3.8 (95% CI 2.22-6.51, Conclusion: Postoperative pancreatitis significantly influences development of severe pancreatic fistula.
MeSH term(s)	Humans ; Pancreas/surgery ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreaticoduodenectomy/adverse effects ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/etiology ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors
Language	Russian
Publishing date	2022-02-10
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
DOI	10.17116/hirurgia202202111
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Article ; Online: Validation of a Zero-shot Learning Natural Language Processing Tool to Facilitate Data Abstraction for Urologic Research.

Kaufmann, Basil / Busby, Dallin / Das, Chandan Krushna / Tillu, Neeraja / Menon, Mani / Tewari, Ashutosh K / Gorin, Michael A

European urology focus

2024

Abstract: Background: Urologic research often requires data abstraction from unstructured text contained within the electronic health record. A number of natural language processing (NLP) tools have been developed to aid with this time-consuming task; however, ... ...

Abstract	Background: Urologic research often requires data abstraction from unstructured text contained within the electronic health record. A number of natural language processing (NLP) tools have been developed to aid with this time-consuming task; however, the generalizability of these tools is typically limited by the need for task-specific training. Objective: To describe the development and validation of a zero-shot learning NLP tool to facilitate data abstraction from unstructured text for use in downstream urologic research. Design, setting, and participants: An NLP tool based on the GPT-3.5 model from OpenAI was developed and compared with three physicians for time to task completion and accuracy for abstracting 14 unique variables from a set of 199 deidentified radical prostatectomy pathology reports. The reports were processed in vectorized and scanned formats to establish the impact of optical character recognition on data abstraction. Intervention: A zero-shot learning NLP tool for data abstraction. Outcome measurements and statistical analysis: The tool was compared with the human abstractors in terms of superiority for data abstraction speed and noninferiority for accuracy. Results and limitations: The human abstractors required a median (interquartile range) of 93 s (72-122 s) per report for data abstraction, whereas the software required a median of 12 s (10-15 s) for the vectorized reports and 15 s (13-17 s) for the scanned reports (p < 0.001 for all paired comparisons). The accuracies of the three human abstractors were 94.7% (95% confidence interval [CI], 93.8-95.5%), 97.8% (95% CI, 97.2-98.3%), and 96.4% (95% CI, 95.6-97%) for the combined set of 2786 data points. The tool had accuracy of 94.2% (95% CI, 93.3-94.9%) for the vectorized reports and was noninferior to the human abstractors at a margin of -10% (α = 0.025). The tool had slightly lower accuracy of 88.7% (95% CI 87.5-89.9%) for the scanned reports, making it noninferior to two of three human abstractors. Conclusions: The developed zero-shot learning NLP tool offers urologic researchers a highly generalizable and accurate method for data abstraction from unstructured text. An open access version of the tool is available for immediate use by the urologic community. Patient summary: In this report, we describe the design and validation of an artificial intelligence tool for abstracting discrete data from unstructured notes contained within the electronic medical record. This freely available tool, which is based on the GPT-3.5 technology from OpenAI, is intended to facilitate research and scientific discovery by the urologic community.
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2405-4569
ISSN (online)	2405-4569
DOI	10.1016/j.euf.2024.01.009
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Article ; Online: Interassay Variability and Clinical Implications of Five Different Prostate-specific Antigen Assays.

Kaufmann, Basil / Pellegrino, Paloma / Zuluaga, Laura / Ben-David, Reuben / Müntener, Michael / Keller, Etienne X / Spanaus, Katharina / von Eckardstein, Arnold / Gorin, Michael A / Poyet, Cédric

European urology open science

2024 Volume 63, Page(s) 4–12

Abstract: Background and objective: Prostate-specific antigen (PSA) remains a critical marker for prostate cancer (PCa) detection and monitoring. Recognising historical variability in PSA assays and the evolution of assay technology and calibration, this study ... ...

Abstract	Background and objective: Prostate-specific antigen (PSA) remains a critical marker for prostate cancer (PCa) detection and monitoring. Recognising historical variability in PSA assays and the evolution of assay technology and calibration, this study aims to reassess interassay variability using the latest generation of five assays in a contemporary cohort of men undergoing prostate biopsy. Methods: Five different commercially available PSA assays were tested in a blood sample of 76 men before undergoing a prostate biopsy. Total PSA (tPSA) and free-to-total PSA ratio (%fPSA) were compared across assays, using Roche (Basel, Switzerland) as the benchmark, and correlated with biopsy outcome to analyse the impact on PCa diagnosis. The statistical analysis included Passing-Bablok regression and Bland-Altman plots, with a Key findings and limitations: Among the 76 men, 28 (36.8%) were diagnosed with significant PCa (defined as International Society of Urological Pathology grade ≥2). A high correlation was observed between tPSA and %fPSA values among the different PSA assays tested ( Conclusions and clinical implications: Despite the use of the latest PSA assays, relevant variability of tPSA and %fPSA results can be observed among different assays. There is an urgent need for standardised calibration methods and greater awareness among practitioners concerning interassay variability. Clinicians should acknowledge that clinically relevant thresholds may depend on the specific PSA assay and that ideally the same assay is applied over time for better clinical decision-making. Patient summary: Prostate-specific antigen (PSA) is a critical marker for prostate cancer (PCa) detection and monitoring. However, significant variations were observed in the results of the latest PSA assays. Thus, standardised calibration methods and greater awareness among practitioners concerning interassay variability are needed.
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2024.03.008
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Article ; Online: Regionally specific cortical lateralization of abstract and concrete verb processing: Magnetic mismatch negativity study.

Ulanov, Maxim / Kopytin, Grigory / Bermúdez-Margaretto, Beatriz / Ntoumanis, Ioannis / Gorin, Aleksei / Moiseenko, Olesya / Blagovechtchenski, Evgeny / Moiseeva, Victoria / Shestakova, Anna / Jääskeläinen, Iiro / Shtyrov, Yury

Neuropsychologia

2024 Volume 195, Page(s) 108800

Abstract: The neural underpinnings of processing concrete and abstract semantics remain poorly understood. Previous fMRI studies have shown that multimodal and amodal neural networks respond differentially to different semantic types; importantly, abstract ... ...

Abstract	The neural underpinnings of processing concrete and abstract semantics remain poorly understood. Previous fMRI studies have shown that multimodal and amodal neural networks respond differentially to different semantic types; importantly, abstract semantics activates more left-lateralized networks, as opposed to more bilateral activity for concrete words. Due to the lack of temporal resolution, these fMRI results do not allow to easily separate language- and task-specific brain responses and to disentangle early processing stages from later post-comprehension phenomena. To tackle this, we used magnetoencephalography (MEG), a time-resolved neuroimaging technique, in combination with a task-free oddball mismatch negativity (MMN) paradigm, an established approach to tracking early automatic activation of word-specific memory traces in the brain. We recorded the magnetic MMN responses in 30 healthy adults to auditorily presented abstract and concrete action verbs to assess lateralization of word-specific lexico-semantic processing in a set of neocortical areas. We found that MMN responses to these stimuli showed different lateralization patterns of activity in the upper limb motor area (BA4) and parts of Broca's area (BA45/BA47) within ∼100-350 ms after the word disambiguation point. Importantly, the greater leftward response lateralization for abstract semantics was due to the lesser involvement of the right-hemispheric homologues, not increased left-hemispheric activity. These findings suggest differential region-specific involvement of bilateral sensorimotor systems already in the early automatic stages of processing abstract and concrete action semantics.
MeSH term(s)	Adult ; Humans ; Brain/diagnostic imaging ; Brain/physiology ; Semantics ; Language ; Magnetoencephalography ; Magnetic Resonance Imaging/methods ; Magnetic Phenomena ; Brain Mapping
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	207151-4
ISSN	1873-3514 ; 0028-3932
ISSN (online)	1873-3514
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2024.108800
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Article ; Online: Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen-Targeted

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2024 Volume 65, Issue 1, Page(s) 87–93

Abstract: This study aimed to assess the accuracy of intraprostatic tumor volume measurements on prostate-specific membrane antigen- ... ...

Abstract	This study aimed to assess the accuracy of intraprostatic tumor volume measurements on prostate-specific membrane antigen-targeted
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Prostatectomy ; Algorithms
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.266005
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Assessing the Clinical Utility of Expanded Macular OCTs Using Machine Learning.

Lin, Andrew C / Lee, Cecilia S / Blazes, Marian / Lee, Aaron Y / Gorin, Michael B

Translational vision science & technology

2021 Volume 10, Issue 6, Page(s) 32

Abstract: ... from expanding macular OCT B-scans compared with foveal-only OCT B-scans for these conditions.: Methods ... Electronic medical records were extracted to obtain 61 B-scans per eye from patients with AMD ... OCT images, we achieved improved AUROC and AUPR curves when comparing the central image (one B-scan ...

Abstract	Purpose: Optical coherence tomography (OCT) is widely used in the management of retinal pathologies, including age-related macular degeneration (AMD), diabetic macular edema (DME), and primary open-angle glaucoma (POAG). We used machine learning techniques to understand diagnostic performance gains from expanding macular OCT B-scans compared with foveal-only OCT B-scans for these conditions. Methods: Electronic medical records were extracted to obtain 61 B-scans per eye from patients with AMD, diabetic retinopathy, or POAG. We constructed deep neural networks and random forest ensembles and generated area under the receiver operating characteristic (AUROC) and area under the precision recall (AUPR) curves. Results: After extracting 630,000 OCT images, we achieved improved AUROC and AUPR curves when comparing the central image (one B-scan) to all images (61 B-scans). The AUROC and AUPR points of diminishing return for diagnostic accuracy for macular OCT coverage were found to be within 2.75 to 4.00 mm (14-19 B-scans), 4.25 to 4.50 mm (20-21 B-scans), and 4.50 to 6.25 mm (21-28 B-scans) for AMD, DME, and POAG, respectively. All models with >0.25 mm of coverage had statistically significantly improved AUROC/AUPR curves for all diseases (P < 0.05). Conclusions: Systematically expanded macular coverage models demonstrated significant differences in total macular coverage required for improved diagnostic accuracy, with the largest macular area being relevant in POAG followed by DME and then AMD. These findings support our hypothesis that the extent of macular coverage by OCT imaging in the clinical setting, for any of the three major disorders, has a measurable impact on the functionality of artificial intelligence decision support. Translational relevance: We used machine learning techniques to improve OCT imaging standards for common retinal disease diagnoses.
MeSH term(s)	Artificial Intelligence ; Diabetic Retinopathy/diagnosis ; Glaucoma, Open-Angle ; Humans ; Machine Learning ; Macular Edema/diagnosis
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.10.6.32
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Article ; Online: Four North American glaciers advanced past their modern positions thousands of years apart in the Holocene

A. G. Jones / S. A. Marcott / A. L. Gorin / T. M. Kennedy / J. D. Shakun / B. M. Goehring / B. Menounos / D. H. Clark / M. Romero / M. W. Caffee

The Cryosphere, Vol 17, Pp 5459-

2023 Volume 5475

Abstract: There is unambiguous evidence that glaciers have retreated from their 19th century positions, but it is less clear how far glaciers have retreated relative to their long-term Holocene fluctuations. Glaciers in western North America are thought to have ... ...

Abstract	There is unambiguous evidence that glaciers have retreated from their 19th century positions, but it is less clear how far glaciers have retreated relative to their long-term Holocene fluctuations. Glaciers in western North America are thought to have advanced from minimum positions in the Early Holocene to maximum positions in the Late Holocene. We assess when four North American glaciers, located between 38–60 ∘ N, were larger or smaller than their modern (2018–2020 CE) positions during the Holocene. We measured 26 paired cosmogenic in situ 14 C and 10 Be concentrations in recently exposed proglacial bedrock and applied a Monte Carlo forward model to reconstruct plausible bedrock exposure–burial histories. We find that these glaciers advanced past their modern positions thousands of years apart in the Holocene: a glacier in the Juneau Icefield (BC, Canada) at ∼2 ka, Kokanee Glacier (BC, Canada) at ∼6 ka, and Mammoth Glacier (WY, USA) at ∼1 ka; the fourth glacier, Conness Glacier (CA, USA), was likely larger than its modern position for the duration of the Holocene until present. The disparate Holocene exposure–burial histories are at odds with expectations of similar glacier histories given the presumed shared climate forcings of decreasing Northern Hemisphere summer insolation through the Holocene followed by global greenhouse gas forcing in the industrial era. We hypothesize that the range in histories is the result of unequal amounts of modern retreat relative to each glacier's Holocene maximum position, rather than asynchronous Holocene advance histories. We explore the influence of glacier hypsometry and response time on glacier retreat in the industrial era as a potential cause of the non-uniform burial durations. We also report mean abrasion rates at three of the four glaciers: Juneau Icefield Glacier ( 0.3±0.3 mm yr −1 ), Kokanee Glacier ( 0.04±0.03 mm yr −1 ), and Mammoth Glacier ( 0.2±0.2 mm yr −1 ).
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Genetically determined trehalase deficiency in various population groups of Russia and neighboring countries].

Kozlov, A I / Balanovsky, O P / Vershubskaya, G G / Gorin, I O / Balanovska, E V / Lavryashina, M B

Voprosy pitaniia

2021 Volume 90, Issue 5, Page(s) 96–103

Abstract: Due to the low specificity and sensitivity of non-invasive clinical tests trehalose malabsorption remained out of sight of gastroenterologists. Therefore, the specialists regard this disorder as rare. Trehalose became widely used in the food industry as ... ...

Abstract	Due to the low specificity and sensitivity of non-invasive clinical tests trehalose malabsorption remained out of sight of gastroenterologists. Therefore, the specialists regard this disorder as rare. Trehalose became widely used in the food industry as a harmless sucrose substitute, sweetener and stabilizer. After the discovery of the trehalase gene (rs2276064 TREH), it was found that the ATREH allele is the determinant of the disaccharide absorption disorders, and the allele's carriership may be high in some groups. There is not enough information on the ATREH frequency in the population of Russia.
MeSH term(s)	Alleles ; Carbohydrate Metabolism, Inborn Errors/epidemiology ; Diarrhea/epidemiology ; Humans ; Population Groups ; Russia/epidemiology ; Trehalase/deficiency ; Trehalase/genetics ; Trehalose
Chemical Substances	Trehalose (B8WCK70T7I) ; Trehalase (EC 3.2.1.28)
Language	Russian
Publishing date	2021-09-01
Publishing country	Russia (Federation)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	414734-0
ISSN	0042-8833
ISSN	0042-8833
DOI	10.33029/0042-8833-2021-90-5-96-103
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Article ; Online: Measurement of the Inner Macular Layers for Monitoring of Glaucoma: Confounding Effects of Age-Related Macular Degeneration.

Chew, Leila / Mohammadzadeh, Vahid / Mohammadi, Massood / Toriz, Veronica / Rosa, Nancy / Gorin, Michael B / Amini, Navid / Nouri-Mahdavi, Kouros

Ophthalmology. Glaucoma

2022 Volume 6, Issue 1, Page(s) 68–77

Abstract: ... on macular OCT B-scans with a publicly available and validated deep learning approach. Automated segmentation ...

Abstract	Objective: To investigate the confounding effect of nonexudative age-related macular degeneration (AMD), specifically drusen and outer retinal atrophy, on the architecture and automated segmentation of the inner retinal layers as measured with OCT. Design: Observational cross-sectional study. Subjects: Two hundred sixty-three consecutive eyes with nonexudative AMD were identified through a retrospective chart review. Exclusion criteria were a diagnosis of glaucoma or glaucoma suspect, other retinal pathology affecting the macula, axial length > 26.5 mm or spherical equivalent less than -6 diopters, any other optic nerve or neurologic disorders, or poor image quality. Methods: Drusen were automatically segmented on macular OCT B-scans with a publicly available and validated deep learning approach. Automated segmentation of the inner plexiform layer (IPL)/inner nuclear layer (INL) boundary was carried out with the device's proprietary software. Main outcome measures: Quality of segmentation of the IPL/INL boundary as a function of drusen size and presence of inner retinal layer displacement in the area of macular pathology (drusen or atrophy). Results: One hundred twenty-five eyes (65 patients) met the inclusion criteria. Drusen size varied between 16 and 272 μm (mean, 118 μm). Automated segmentation had a 22% chance of failure if the drusen height was between 145 and 185 μm and was most likely to fail with drusen heights above 185 μm. When drusen height was normalized by total retinal thickness, segmentation failed 36% of the time when the drusen to total retinal thickness ratio was 0.45 or above. Images were likely to show displacement of inner retinal layers with drusen heights above 176 μm and a normalized drusen height ratio of 0.5 or higher. Eighty-seven percent of images with outer retinal atrophy displayed incorrect segmentation. Conclusions: Outer retinal diseases can alter the retinal topography and affect the segmentation accuracy of the inner retinal layers. Large drusen may cause segmentation error and compression of the inner macular layers. Geographic atrophy confounds automated segmentation in a high proportion of eyes. Clinicians should be cognizant of the effects of outer retinal disease on the inner retinal layer measurements when interpreting the results of macular OCT imaging in patients with glaucoma.
MeSH term(s)	Humans ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Macular Degeneration/diagnosis ; Glaucoma/diagnosis ; Glaucoma/pathology ; Macula Lutea/pathology ; Retinal Diseases
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Observational Study ; Journal Article
ISSN	2589-4196
ISSN (online)	2589-4196
DOI	10.1016/j.ogla.2022.06.006
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