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  1. Article ; Online: Treating Geographic Atrophy-Are We Ready? A Call to Image.

    Guymer, Robyn H

    Ophthalmology. Retina

    2022  Volume 7, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Geographic Atrophy/diagnosis ; Macular Degeneration ; Fluorescein Angiography
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2022.08.022
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  2. Article ; Online: Age-Related Macular Degeneration: Who Progresses to Vision-Threatening Disease? Learning to See More in the Image.

    Guymer, Robyn H

    Ophthalmology. Retina

    2021  Volume 5, Issue 5, Page(s) 393–395

    MeSH term(s) Humans ; Macular Degeneration/diagnosis ; Vision Disorders
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2021.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatments for geographic atrophy are on our doorstep: Are we ready?

    Cohn, Amy / Guymer, Robyn H

    Clinical & experimental ophthalmology

    2023  Volume 51, Issue 8, Page(s) 761–763

    MeSH term(s) Humans ; Geographic Atrophy/diagnosis ; Geographic Atrophy/therapy ; Macular Degeneration ; Atrophy ; Fluorescein Angiography
    Language English
    Publishing date 2023-10-27
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1064: Show issues Location:
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  4. Article ; Online: Age-related macular degeneration.

    Guymer, Robyn H / Campbell, Thomas G

    Lancet (London, England)

    2023  Volume 401, Issue 10386, Page(s) 1459–1472

    Abstract: Age-related macular degeneration is an increasingly important public health issue due to ageing populations and increased longevity. Age-related macular degeneration affects individuals older than 55 years and threatens high-acuity central vision ... ...

    Abstract Age-related macular degeneration is an increasingly important public health issue due to ageing populations and increased longevity. Age-related macular degeneration affects individuals older than 55 years and threatens high-acuity central vision required for important tasks such as reading, driving, and recognising faces. Advances in retinal imaging have identified biomarkers of progression to late age-related macular degeneration. New treatments for neovascular age-related macular degeneration offer potentially longer-lasting effects, and progress is being made towards a treatment for atrophic late age-related macular degeneration. An effective intervention to slow progression in the earlier stages of disease, or to prevent late age-related macular degeneration development remains elusive, and our understanding of underlying mechanistic pathways continues to evolve.
    MeSH term(s) Humans ; Middle Aged ; Macular Degeneration/diagnosis ; Macular Degeneration/therapy ; Aging ; Visual Acuity
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)02609-5
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  5. Article ; Online: Age-Related Macular Degeneration: Not So Wet and Dry.

    Guymer, Robyn H

    Ophthalmology. Retina

    2020  Volume 4, Issue 3, Page(s) 249

    MeSH term(s) Atrophy ; Choroidal Neovascularization ; Geographic Atrophy ; Humans ; Macular Degeneration
    Language English
    Publishing date 2020-03-10
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-7219
    ISSN (online) 2468-7219
    DOI 10.1016/j.oret.2019.11.016
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  6. Article ; Online: Treating Neovascular Age-Related Macular Degeneration-So Much More to Learn.

    Guymer, Robyn H

    JAMA ophthalmology

    2020  Volume 138, Issue 10, Page(s) 1051–1052

    MeSH term(s) Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/drug therapy ; Humans ; Macular Degeneration/diagnosis ; Retina ; Visual Acuity
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2020.3000
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    Ul I Zs.26: Show issues Location:
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  7. Article ; Online: Choroidal signal hypertransmission on optical coherence tomography imaging: Association with development of geographic atrophy in age-related macular degeneration.

    Wu, Zhichao / Terheyden, Jan H / Hodgson, Lauren A B / Guymer, Robyn H

    Clinical & experimental ophthalmology

    2024  

    Abstract: Background: To examine the association between large choroidal signal hypertransmission ≥250 μm (LHyperT) on optical coherence tomography (OCT) with the risk of developing geographic atrophy (GA) and compare this risk with those associated with nascent ... ...

    Abstract Background: To examine the association between large choroidal signal hypertransmission ≥250 μm (LHyperT) on optical coherence tomography (OCT) with the risk of developing geographic atrophy (GA) and compare this risk with those associated with nascent geographic atrophy (nGA).
    Methods: Two hundred and eighty eyes from 140 participants with bilateral large drusen and without late age-related macular degeneration (AMD) or nGA at baseline underwent OCT imaging and colour fundus photography (CFP) at 6-monthly intervals up to 5 years. OCT scans were graded for the presence of LHyperT and nGA, and CFPs were graded for the presence of GA.
    Results: The five-year incidence of LHyperT and nGA were 37% and 27% respectively (p = 0.003), and the two-year probability of their progression to GA were 17% and 40%, respectively (p = 0.002). LHyperT and nGA explained 81% and 91% of the variance in the time to develop GA, respectively (p = 0.032), and they were both associated with a significantly higher rate of GA development compared to eyes without these lesions (adjusted hazard ratio = 110.8 and 183.2, respectively; p < 0.001 for both).
    Conclusions: LHyperT and nGA were both high-risk features for GA development, but the latter showed a higher rate of GA progression and explained a significantly greater proportion of the variance in the time to develop GA. As such, nGA may be a more robust surrogate endpoint than LHyperT for the conventional clinical endpoint of CFP-defined GA for intervention trials in the early stages of AMD.
    Language English
    Publishing date 2024-01-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14356
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    Zs.A 1064: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Complete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: A Longitudinal Evaluation.

    Wu, Zhichao / Hodgson, Lauren A B / Goh, Kai Lyn / Guymer, Robyn H

    Retina (Philadelphia, Pa.)

    2024  

    Abstract: Purpose: There is a need for robust earlier biomarkers of atrophic age-related macular degeneration (AMD) that could act as surrogate endpoints for the geographic atrophy (GA) in early interventional trials. This study sought to examine the risk of ... ...

    Abstract Purpose: There is a need for robust earlier biomarkers of atrophic age-related macular degeneration (AMD) that could act as surrogate endpoints for the geographic atrophy (GA) in early interventional trials. This study sought to examine the risk of progression of complete retinal pigment epithelium and outer retinal atrophy (cRORA) to the traditional atrophic endpoint of GA on color fundus photography (CFP). This study also compared the risk of progression for cRORA to that associated with the specific OCT features that define nascent GA (nGA), a strong predictor for GA development.
    Methods: One-hundred and forty participants with bilateral large drusen at baseline underwent OCT imaging and CFP at 6-monthly intervals for up to 36 months. OCT volume scans were graded for the presence of cRORA and nGA, and CFPs were graded for the presence of GA. The association and rate of progression to GA for cRORA and nGA were examined.
    Results: Both cRORA and nGA were significantly associated with GA development (adjusted hazard ratio [HR], 65.7 and 76.8 respectively; both P<0.001). The probability of progression of cRORA to GA over 24-months (26%) was significantly lower than the probability for progression of nGA (38%; P=0.039).
    Conclusions: This study confirmed that cRORA was a significant risk factor for developing GA, although its rate of progression was slightly lower compared to nGA. Whilst requiring replication in future studies, these findings suggest that the specific features of photoreceptor degeneration used to define nGA appear important when assessing risk of progression.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000004080
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    Zs.A 1724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Geographic Atrophy Trials: Turning the Ship around May Not Be That Easy.

    Guymer, Robyn H

    Ophthalmology. Retina

    2018  Volume 2, Issue 6, Page(s) 515–517

    Language English
    Publishing date 2018-04-11
    Publishing country United States
    Document type Editorial
    ISSN 2468-7219
    ISSN (online) 2468-7219
    DOI 10.1016/j.oret.2018.03.004
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  10. Article: Performance of a Smart Device over 12-Months for Home Monitoring of Patients with Intermediate Age-Related Macular Degeneration.

    Prea, Selwyn / Guymer, Robyn / Kong, George / Vingrys, Algis

    Journal of clinical medicine

    2023  Volume 12, Issue 7

    Abstract: Background: To determine the 12-month compliance with and retention of home monitoring (HM) with Melbourne Rapid Fields (MRFh) for patients with intermediate age-related macular degeneration (iAMD) and compare visual acuity (VA) and retinal sensitivity ( ...

    Abstract Background: To determine the 12-month compliance with and retention of home monitoring (HM) with Melbourne Rapid Fields (MRFh) for patients with intermediate age-related macular degeneration (iAMD) and compare visual acuity (VA) and retinal sensitivity (RS) results to clinical measures.
    Methods: Participants were recruited to a 12-month HM study with weekly testing of vision with MRFh. Inclusion criteria were a diagnosis of iAMD, understand English instructions, VA ≥ 20/40, and access to an iPad. Supervised in-clinic testing of high contrast VA (HVA, ETDRS), low-luminance VA (LLVA, ETDRS with ND2 filter), and RS (Macular Integrity Assessment, MAIA, and MRF in-clinic, MRFc) was conducted every 6-months.
    Results: A total of 54 participants (67 ± 6.8 years) were enrolled. Compliance to weekly HM was 61% and study retention at 12-months was 50% of those with uptake (
    Conclusions: Over 12-months, MRFh yields a moderate level of compliance with (61%) and retention (50%) of weekly testing. Further studies are required to assess the ability of MRFh to detect early progression to nAMD.
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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