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  1. Article: Matrix Metalloproteases 8 Polymorphism as Risk Factor for Rotator Cuff Tear.

    Cavascan, Nathali Nunes / Assunção, Jorge Henrique / Godoy-Santos, Alexandre Leme / Neto, Arnaldo Amado Ferreira / Godoy Dos Santos, Maria Cristina Leme

    The archives of bone and joint surgery

    2023  Volume 11, Issue 9, Page(s) 565–569

    Abstract: Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-8 is a protein that degrades type I collagen, and it is known that MMP-8 has a ... ...

    Abstract Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-8 is a protein that degrades type I collagen, and it is known that MMP-8 has a polymorphism in which a T allele in the gene promoter region increases its transcription activity. This study aims to investigate the association between MMP-8 polymorphism g.-799 C>T (rs11225394) and RCT.
    Methods: To do that, we collected DNA samples from buccal epithelial cells of 128 patients (separated into RCT group and control group in a proportion 1:1) and genotyped the DNA using PCR. The statistical analyses were done using the ARLEQUIN Version 2.0, and the data normality was tested with the Shapiro-Wilk test.
    Results: The results showed a significantly higher frequency of T/T genotype in the test group (29% in the control group and 39% in the test group, p=0.0417), and that would represent a risk factor for increased collagen degradation.
    Conclusion: The MMP-8 g.-799 C>T (rs11225394) SNP was associated with RCT. With the description of a new risk factor, future research can be done to analyze how to prevent RCT or develop new treatment strategies since the disease's failure index is currently high.
    Language English
    Publishing date 2023-10-11
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2782053-1
    ISSN 2345-461X ; 2345-4644
    ISSN (online) 2345-461X
    ISSN 2345-4644
    DOI 10.22038/ABJS.2023.55108.2743
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  2. Article ; Online: Comparison of sinusitis rate after sinus lift procedure and zygomatic implant surgery: a meta-analysis.

    Rocha, Roberta Schroder / Vianna, Camila Pereira / Trojan, Larissa Carvalho / Padovan, Luis Eduardo Marques / Dos Santos, Maria Cristina Godoy Leme

    Oral and maxillofacial surgery

    2023  Volume 28, Issue 1, Page(s) 63–77

    Abstract: Purpose: To evaluate and compare the reported sinusitis occurrence after the sinus lift procedure and zygomatic implant placement.: Methods: This meta-analysis has been registered at PROSPERO. Studies were searched on six databases. Two authors ... ...

    Abstract Purpose: To evaluate and compare the reported sinusitis occurrence after the sinus lift procedure and zygomatic implant placement.
    Methods: This meta-analysis has been registered at PROSPERO. Studies were searched on six databases. Two authors screened titles and abstracts and fully analyzed the studies against the inclusion and exclusion criteria. The RoB 2.0 and the ROBINS-I tools were used to assess the quality and risk of bias of the included studies. The random-effects model was used for the meta-analysis. The prevalence of sinusitis was calculated based on the total of patients. Subgroup analysis was performed by sinus lift or zygomatic implant surgery technique.
    Results: The search identified 2419 references. After applying the inclusion criteria, 18 sinus lift and 9 zygomatic implant placement studies were considered eligible. The pooled prevalence of sinusitis after sinus lift procedure was 1.11% (95% CI 0.30-2.28). The prevalence after zygomatic implant placement was 3.76% (95% CI 0.12-10.29). In the subgroup analysis, the lateral window approach showed a prevalence of sinusitis of 1.35% (95% CI 0.34-2.8), the transcrestal technique of 0.00% (95% CI 0.00-3.18), and the SALSA technique of 1.20% (95% CI 0.00-5.10). Regarding the techniques for zygomatic implant placement, the sinus slot technique showed a prevalence of 21.62% (95% CI 9.62-36.52) and the intrasinus technique of 4.36% (95% CI 0.33-11.08), and the prevalence after the extrasinus technique was 0.00% (95% CI 0.00-1.22).
    Conclusion: The sinusitis occurrence rate was higher after zygomatic implant placement than after sinus lift procedure and this occurrence was different depending on the used technique.
    MeSH term(s) Humans ; Dental Implantation, Endosseous/methods ; Dental Implants/adverse effects ; Maxillary Sinus/surgery ; Sinus Floor Augmentation/adverse effects ; Sinus Floor Augmentation/methods ; Sinusitis/epidemiology ; Sinusitis/surgery ; Maxilla/surgery
    Chemical Substances Dental Implants
    Language English
    Publishing date 2023-06-02
    Publishing country Germany
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 2406731-3
    ISSN 1865-1569 ; 1865-1550
    ISSN (online) 1865-1569
    ISSN 1865-1550
    DOI 10.1007/s10006-023-01159-1
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    Zs.A 4767: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: THE POLYMORPHISM OF METALLOPROTEINASES 1 AND 13 AND POSTTRAUMATIC ELBOW STIFFNESS.

    Pinto, Gustavo DE Mello Ribeiro / Assunção, Jorge Henrique / Santos, Maria Cristina Leme Godoy Dos / Godoy-Santos, Alexandre Leme / Gracitelli, Mauro Emilio Conforto / Malavolta, Eduardo Angeli / Silva, Fernando Brandão DE Andrade E / Neto, Arnaldo Amado Ferreira

    Acta ortopedica brasileira

    2022  Volume 30, Issue 1, Page(s) e253503

    Abstract: Introduction: To evaluate the relationship between the genetic polymorphism of matrix metalloproteinases 1 and 13 and posttraumatic elbow stiffness, as well as the association of other risk factors with this condition.: Materials and methods: We ... ...

    Abstract Introduction: To evaluate the relationship between the genetic polymorphism of matrix metalloproteinases 1 and 13 and posttraumatic elbow stiffness, as well as the association of other risk factors with this condition.
    Materials and methods: We evaluated 20 patients with posttraumatic elbow stiffness and 12 controls with traumatic elbow disorders without contracture. Deoxyribonucleic acid (DNA) was obtained from buccal mucosa epithelial cells of the volunteers. The MMP-1 and MMP-13 genotypes were determined using PCR-restriction fragment length polymorphism assays.
    Results: We did not find any significant differences in the frequency of genotypes and alleles between the test and control groups for the polymorphism of metalloproteinases 1 and 13. We observed that genotypes 1G/2G and 2G/2G of MMP-1 were present in 65% (13/20) of patients with articular stiffness and 50% (6/12) of controls (p = 0.599). Genotypes A/A and A/G of MMP-13 were obtained in 95% (19/20) of patients and 91.6% (11/12) of controls (p = 0.491). Among the prognostic factors for elbow stiffness, only immobilization time correlated positively. The mean immobilization time for cases and controls were 16 ± 10 days and 7 ± 7 days, respectively (p = 0.017).
    Conclusion: The genetic polymorphism of MMP-1 at position -1607 and MMP-13 at position -77 was not associated with post-traumatic elbow stiffness.
    Language English
    Publishing date 2022-01-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105206-2
    ISSN 1809-4406 ; 1413-7852
    ISSN (online) 1809-4406
    ISSN 1413-7852
    DOI 10.1590/1413-785220223001e253503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: THE POLYMORPHISM OF METALLOPROTEINASES 1 AND 13 AND POSTTRAUMATIC ELBOW STIFFNESS

    GUSTAVO DE MELLO RIBEIRO PINTO / JORGE HENRIQUE ASSUNÇÃO / MARIA CRISTINA LEME GODOY DOS SANTOS / ALEXANDRE LEME GODOY-SANTOS / MAURO EMILIO CONFORTO GRACITELLI / EDUARDO ANGELI MALAVOLTA / FERNANDO BRANDÃO DE ANDRADE E SILVA / ARNALDO AMADO FERREIRA NETO

    Acta Ortopédica Brasileira, Vol 30, Iss

    2022  Volume 1

    Abstract: ABSTRACT Introduction To evaluate the relationship between the genetic polymorphism of matrix metalloproteinases 1 and 13 and posttraumatic elbow stiffness, as well as the association of other risk factors with this condition. Materials and methods We ... ...

    Abstract ABSTRACT Introduction To evaluate the relationship between the genetic polymorphism of matrix metalloproteinases 1 and 13 and posttraumatic elbow stiffness, as well as the association of other risk factors with this condition. Materials and methods We evaluated 20 patients with posttraumatic elbow stiffness and 12 controls with traumatic elbow disorders without contracture. Deoxyribonucleic acid (DNA) was obtained from buccal mucosa epithelial cells of the volunteers. The MMP-1 and MMP-13 genotypes were determined using PCR-restriction fragment length polymorphism assays. Results We did not find any significant differences in the frequency of genotypes and alleles between the test and control groups for the polymorphism of metalloproteinases 1 and 13. We observed that genotypes 1G/2G and 2G/2G of MMP-1 were present in 65% (13/20) of patients with articular stiffness and 50% (6/12) of controls (p = 0.599). Genotypes A/A and A/G of MMP-13 were obtained in 95% (19/20) of patients and 91.6% (11/12) of controls (p = 0.491). Among the prognostic factors for elbow stiffness, only immobilization time correlated positively. The mean immobilization time for cases and controls were 16 ± 10 days and 7 ± 7 days, respectively (p = 0.017). Conclusion The genetic polymorphism of MMP-1 at position -1607 and MMP-13 at position -77 was not associated with post-traumatic elbow stiffness. Level of Evidence III; Prognosis Study; Case-Control Study.
    Keywords Articular rigidity ; Elbow ; Capsule contracture ; Trauma ; Metalloproteinases ; Genetic polymorphism ; Medicine ; R ; Orthopedic surgery ; RD701-811
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Ortopedia e Traumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case-control study.

    de Araujo Munhoz, Francielle Boçon / Branco, Filipe Polese / Souza, Ricardo Lehtonen Rodrigues / Dos Santos, Maria Cristina Leme Godoy

    Clinical implant dentistry and related research

    2018  Volume 20, Issue 6, Page(s) 1003–1008

    Abstract: Background: Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases ( ...

    Abstract Background: Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix.
    Purpose: This case-control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss.
    Materials and methods: Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR-RFLP.
    Results: A significant association of rs1799750 (MMP-1) and rs11225395 (MMP-8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P < 0.0001). Haplotype T-A-GG-5A-C had a statistically significant risk effect, while haplotype C-A-G-6A-C andT-G-2G-5A-C had a protective effect in implant loss.
    Conclusions: The results of this study showed that MMPs haplotype are a risk factor to early implant loss.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil ; Case-Control Studies ; Dental Implants ; Dental Restoration Failure ; Female ; Haplotypes ; Humans ; Logistic Models ; Male ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 3/genetics ; Matrix Metalloproteinase 8/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors ; Young Adult
    Chemical Substances Dental Implants ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Matrix Metalloproteinase 8 (EC 3.4.24.34) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language English
    Publishing date 2018-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2094300-3
    ISSN 1708-8208 ; 1523-0899
    ISSN (online) 1708-8208
    ISSN 1523-0899
    DOI 10.1111/cid.12671
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5945: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The genetics of amelogenesis imperfecta: a review of the literature.

    Santos, Maria Cristina Leme Godoy Dos / Line, Sergio Roberto Peres

    Journal of applied oral science : revista FOB

    2010  Volume 13, Issue 3, Page(s) 212–217

    Abstract: A melogenesis imperfecta (AI) is a group of inherited defects of dental enamel formation that show both clinical and genetic heterogeneity. Enamel findings in AI are highly variable, ranging from deficient enamel formation to defects in the mineral and ... ...

    Abstract A melogenesis imperfecta (AI) is a group of inherited defects of dental enamel formation that show both clinical and genetic heterogeneity. Enamel findings in AI are highly variable, ranging from deficient enamel formation to defects in the mineral and protein content. Enamel formation requires the expression of multiple genes that transcribes matrix proteins and proteinases needed to control the complex process of crystal growth and mineralization. The AI phenotypes depend on the specific gene involved, the location and type of mutation, and the corresponding putative change at the protein level. Different inheritance patterns such as X-linked, autosomal dominant and autosomal recessive types have been reported. Mutations in the amelogenin, enamelin, and kallikrein-4 genes have been demonstrated to result in different types of AI and a number of other genes critical to enamel formation have been identified and proposed as candidates for AI. The aim of this article was to present an evaluation of the literature regarding role of proteins and proteinases important to enamel formation and mutation associated with AI.
    Language English
    Publishing date 2010-09-15
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2152066-5
    ISSN 1678-7765 ; 1678-7757
    ISSN (online) 1678-7765
    ISSN 1678-7757
    DOI 10.1590/s1678-77572005000300002
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  7. Article ; Online: Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype.

    de Araujo Munhoz, Francielle Boçon / Baroneza, José Eduardo / Godoy-Santos, Alexandre / Fernandes, Túlio Diniz / Branco, Filipe Polese / Alle, Lupe Furtado / de Souza, Ricardo Lehtonen / Dos Santos, Maria Cristina Leme Godoy

    The journal of gene medicine

    2016  Volume 18, Issue 11-12, Page(s) 325–330

    Abstract: Background: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flat foot. Some patients have a predisposition without a clinically recognized cause, suggesting that individual ...

    Abstract Background: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flat foot. Some patients have a predisposition without a clinically recognized cause, suggesting that individual characteristics play an important role in tendinopathy. The present study investigated whether genetic variants in matrix metalloproteinases (MMPs) are associated with PTT dysfunction.
    Methods: One hundred women who presented PTT dysfunction, with histopathological examination of the tendon and magnetic resonance imaging (MRI) confirming tendinopathy, as well as 100 asymptomatic women who presented intact PPT as assessed by MRI and constituting the control group, were evaluated for MMP-13 g.-77 A > G (rs2252070) polymorphism, individually and in haplotypes, as well as in combination with MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395) polymorphisms with PTT dysfunction. Genomic DNA was extracted from the saliva and genotypes were obtained by polymerase chain reaction-restriction fragment length polymorphism. Statistical analysis of the results included a Mann-Whitney U-test, Fisher's exact test, multiple logistic regression, chi-squared and SNPstats software (http://bioinfo. iconcologia.net/snpstats/start.htm). p < 0.05 was considered statistically significant.
    Results: The A allele frequency (MMP-13 g.-77 A > G (rs2252070) polymorphism) was significantly higher in the case group (76% and 61%, respectively; p = 0.010, odds ratio = 2.02; 95% confidence interval = 1.32-3.12). The genotype distribution was also significantly different between groups (p = 0.001, odds ratio = 2.82; 95% confidence interval = 1.58-5.02). Global haplotype analysis indicated a significant difference between both groups.
    Conclusions: In conclusion, these findings indicate that MMP-13 g.-77 A > G (rs2252070) polymorphism individually, as well as its haplotypes MMP-1 g.-519 A > G (rs1144393), MMP-1 g.-1607 G > GG (rs1799750) and MMP-8 g.-799 C > T (rs11225395), may contribute to PTT dysfunction.
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.2934
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: MMP-1 promoter genotype and haplotype association with posterior tibial tendinopathy.

    Baroneza, José Eduardo / Godoy-Santos, Alexandre / Ferreira Massa, Bruno / Boçon de Araujo Munhoz, Francielle / Diniz Fernandes, Túlio / Leme Godoy dos Santos, Maria Cristina

    Gene

    2014  Volume 547, Issue 2, Page(s) 334–337

    Abstract: Purpose: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flatfoot. Some patients have a predisposition without clinically recognized cause, suggesting that individual ... ...

    Abstract Purpose: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flatfoot. Some patients have a predisposition without clinically recognized cause, suggesting that individual characteristics play an important role in tendinopathy. The objective of the present study is to investigate the association of -519 (rs1144393) matrix metalloproteinase-1 (MMP-1) polymorphism and the -1607 (rs1799750) and -519 MMP-1 haplotypes and risk of PTT dysfunction.
    Methods: The test group included 50 females who presented PTT dysfunction Grade 2 or 3, and who were submitted to surgical treatment, with histopathological examination of the tendon and magnetic resonance image (MRI) confirming tendinopathy, while the control group was 100 asymptomatic women who present intact PTT at MRI. We analyzed functional polymorphisms MMP-1 and their haplotypes using polymerase chain reaction and restriction fragment length analysis.
    Results: There was a significant difference in the presence of the different alleles and genotypes between the control group and test group for the MMP-1 gene (p≤0.01). The G allele of the -519 MMP-1 polymorphism increased susceptibility to degeneration in the PTT tendon and seems to be a genetic risk factor. Global haplotype analysis indicated a significant difference between both groups (p<0.0001). Haplotypes G-2G and A-2G had statistically significant risk effect on PTT insufficiency. G-2G, p<0.001; OR=5.72 (CI, 2.84-11.52) and A-2G p=0.002, OR=3.95 (CI, 1.65-9.44).
    Conclusion: According to our results, -519 MMP-1 isolated and -1607/-519 MMP-1 haplotypes are associated to tendinopathy in posterior tibial tendon.
    MeSH term(s) Case-Control Studies ; Female ; Genetic Association Studies ; Haplotypes ; Humans ; Matrix Metalloproteinase 1/genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Posterior Tibial Tendon Dysfunction/genetics ; Promoter Regions, Genetic
    Chemical Substances MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language English
    Publishing date 2014-09-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2014.07.001
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    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Association of MMP-8 polymorphisms with tendinopathy of the primary posterior tibial tendon

    Alexandre Leme Godoy-Santos / Rafael Trevisan / Túlio Diniz Fernandes / Maria Cristina L. G. dos Santos

    Clinics, Vol 66, Iss 9, Pp 1641-

    a pilot study

    2011  Volume 1643

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: MMP-1 promoter genotype and haplotype association with posterior tibial tendinopathy

    Baroneza, José Eduardo / Alexandre Godoy-Santos / Bruno Ferreira Massa / Francielle Boçon de Araujo Munhoz / Maria Cristina Leme Godoy dos Santos / Túlio Diniz Fernandes

    Gene. 2014 Sept. 01, v. 547

    2014  

    Abstract: Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flatfoot. Some patients have a predisposition without clinically recognized cause, suggesting that individual characteristics ...

    Abstract Posterior tibial tendon (PTT) is particularly vulnerable and its insufficiency is recognized as the main cause of adult acquired flatfoot. Some patients have a predisposition without clinically recognized cause, suggesting that individual characteristics play an important role in tendinopathy. The objective of the present study is to investigate the association of −519 (rs1144393) matrix metalloproteinase-1 (MMP-1) polymorphism and the −1607 (rs1799750) and −519 MMP-1 haplotypes and risk of PTT dysfunction.The test group included 50 females who presented PTT dysfunction Grade 2 or 3, and who were submitted to surgical treatment, with histopathological examination of the tendon and magnetic resonance image (MRI) confirming tendinopathy, while the control group was 100 asymptomatic women who present intact PTT at MRI. We analyzed functional polymorphisms MMP-1 and their haplotypes using polymerase chain reaction and restriction fragment length analysis.There was a significant difference in the presence of the different alleles and genotypes between the control group and test group for the MMP-1 gene (p≤0.01). The G allele of the −519 MMP-1 polymorphism increased susceptibility to degeneration in the PTT tendon and seems to be a genetic risk factor. Global haplotype analysis indicated a significant difference between both groups (p<0.0001). Haplotypes G–2G and A–2G had statistically significant risk effect on PTT insufficiency. G–2G, p<0.001; OR=5.72 (CI, 2.84–11.52) and A–2G p=0.002, OR=3.95 (CI, 1.65–9.44).According to our results, −519 MMP-1 isolated and −1607/−519 MMP-1 haplotypes are associated to tendinopathy in posterior tibial tendon.
    Keywords adults ; alleles ; females ; haplotypes ; histopathology ; interstitial collagenase ; magnetic resonance imaging ; patients ; polymerase chain reaction ; risk factors ; surgery ; tibia ; women
    Language English
    Dates of publication 2014-0901
    Size p. 334-337.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2014.07.001
    Database NAL-Catalogue (AGRICOLA)

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    Z 79/715: Show issues

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