LIVIVO - Search results -

Search results

Result 1 - 10 of total 397

Search options

Article: Could an old brain be made young again?

Hébert, Jean M

Surgical neurology international

2022 Volume 13, Page(s) 595

Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Editorial
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_1132_2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Is Life-Extension Research on the Wrong Track?

Hébert, Jean M

Rejuvenation research

2021 Volume 24, Issue 5, Page(s) 375–376

MeSH term(s)	Life Expectancy
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2150779-X
ISSN	1557-8577 ; 1549-1684
ISSN (online)	1557-8577
ISSN	1549-1684
DOI	10.1089/rej.2021.0048
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5215: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Potential Variables for Improved Reproducibility of Neuronal Cell Grafts at Stroke Sites.

Krzyspiak, Joanna / Khodakhah, Kamran / Hébert, Jean M

Cells

2022 Volume 11, Issue 10

Abstract: Interest is growing in using cell replacements to repair the damage caused by an ischemic stroke. Yet, the usefulness of cell transplants can be limited by the variability observed in their successful engraftment. For example, we recently showed that, ... ...

Abstract	Interest is growing in using cell replacements to repair the damage caused by an ischemic stroke. Yet, the usefulness of cell transplants can be limited by the variability observed in their successful engraftment. For example, we recently showed that, although the inclusion of donor-derived vascular cells was necessary for the formation of large grafts (up to 15 mm
MeSH term(s)	Animals ; Female ; Humans ; Ischemia ; Mice ; Neurons ; Reproducibility of Results ; Stroke ; Tissue Donors
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11101656
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Executive functioning in child victims of sexual abuse: A multi-informant comparative study.

Amédée, Laetitia Mélissande / Cyr, Chantal / Jean-Thorn, Arianne / Hébert, Martine

Child abuse & neglect

2024 Volume 152, Page(s) 106737

Abstract: Background: Research examining the association between child sexual abuse and executive functions is limited. Yet, exposure to traumatic situations at a young age has been associated with changes in the prefrontal cortex, which hosts executive functions ...

Abstract	Background: Research examining the association between child sexual abuse and executive functions is limited. Yet, exposure to traumatic situations at a young age has been associated with changes in the prefrontal cortex, which hosts executive functions (Wesarg et al., 2020). These functions are crucial for social adaptation, as they make it possible to inhibit maladaptive behavior and respond flexibly to the demands of the environment. As middle childhood is a sensitive period for the development of self-regulatory abilities, exploring executive functioning in school-age children could provide potential intervention targets (Dajani & Uddin, 2015). Objective: Using multiple informants, this study compared executive functioning of sexually abused children to that of non-sexually victimized children and examined whether the differences were moderated by sex. Methods: The sample consisted of 225, 6-to-12 years old children with a history of child sexual abuse (CSA) and 97 children without a history of CSA. Children completed two executive functioning tasks measuring cognitive flexibility and inhibition. Parents and teachers completed questionnaires evaluating children's executive functioning. Results: In comparison to non-abused children, children with a history of CSA displayed greater executive functioning difficulties as assessed by both informant-reported questionnaires and self-completed tasks. Significant interaction effects were found, such as CSA predicting lower inhibition and executive functions at school in boys but not in girls. Conclusion: This study is a first step in understanding the association between CSA and executive functioning and offers a clearer picture of the differential impact of sexual trauma according to children's sex.
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	799143-5
ISSN	1873-7757 ; 0145-2134
ISSN (online)	1873-7757
ISSN	0145-2134
DOI	10.1016/j.chiabu.2024.106737
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1437: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Accurately summarizing an outbreak using epidemiological models takes time.

Case, B K M / Young, Jean-Gabriel / Hébert-Dufresne, Laurent

Royal Society open science

2023 Volume 10, Issue 9, Page(s) 230634

Abstract: Recent outbreaks of Mpox and Ebola, and worrying waves of COVID-19, influenza and respiratory syncytial virus, have all led to a sharp increase in the use of epidemiological models to estimate key epidemiological parameters. The feasibility of this ... ...

Abstract	Recent outbreaks of Mpox and Ebola, and worrying waves of COVID-19, influenza and respiratory syncytial virus, have all led to a sharp increase in the use of epidemiological models to estimate key epidemiological parameters. The feasibility of this estimation task is known as the practical identifiability (PI) problem. Here, we investigate the PI of eight commonly reported statistics of the classic susceptible-infectious-recovered model using a new measure that shows how much a researcher can expect to learn in a model-based Bayesian analysis of prevalence data. Our findings show that the basic reproductive number and final outbreak size are often poorly identified, with learning exceeding that of individual model parameters only in the early stages of an outbreak. The peak intensity, peak timing and initial growth rate are better identified, being in expectation over 20 times more probable having seen the data by the time the underlying outbreak peaks. We then test PI for a variety of true parameter combinations and find that PI is especially problematic in slow-growing or less-severe outbreaks. These results add to the growing body of literature questioning the reliability of inferences from epidemiological models when limited data are available.
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230634
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Measuring upper limb active joint position sense: Introducing a new clinical tool - The Upper Limb Proprioception Reaching Test.

Ager, Amanda L / Roy, Jean-Sébastien / Hébert, Luc J / Roos, Marianne / Borms, Dorien / Cools, Ann M

Musculoskeletal science & practice

2023 Volume 66, Page(s) 102829

Abstract: Background: Proprioception is our sense of body awareness, including the sub-category of active joint position sense (AJPS). AJPS is fundamental to joint stability and movement coordination. Despite its importance, there remain few confident ways to ... ...

Abstract	Background: Proprioception is our sense of body awareness, including the sub-category of active joint position sense (AJPS). AJPS is fundamental to joint stability and movement coordination. Despite its importance, there remain few confident ways to measure upper limb AJPS in a clinic. Objective: To assess a new AJPS clinical tool, the Upper Limb Proprioception Reaching Test (PRO-Reach; seven targets), for discriminant validity, intra-rater and absolute reliability. Design: Cross-sectional measurement study. Methods: Seventy-five healthy participants took part in a single session with 2 consecutive evaluations (E1 and E2) (within-day reliability). Twenty participants were randomly selected to perform a dominant shoulder fatigue protocol (discriminant validity), whereafter a third evaluation was repeated (E3). The PRO-Reach was analyzed with paired t tests (discriminant validity), intra-class correlation coefficients (ICCs) and minimal detectable change [MDC]) (intra-rater: within-day and between-trial relative and absolute reliability). Results: The PRO-Reach supports moderate (mostly superior targets) to excellent (mostly inferior targets) reliability. Between-trial ICCs (T1/T2/T3) varied between 0.72 and 0.90, and within-day (E1/E2) ICCs between 0.45 and 0.72, with associated MDC Conclusions: The inferior targets and overall scores demonstrate the strongest reliability. The use of the PRO-Reach tool may be suitable for clinical use upon further psychometric testing amongst pathological populations. Level of evidence: Level III cross-sectional study.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Reproducibility of Results ; Proprioception ; Movement ; Upper Extremity
Language	English
Publishing date	2023-07-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2888772-4
ISSN	2468-7812
ISSN (online)	2468-7812
DOI	10.1016/j.msksp.2023.102829
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5783: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs.

Grońska-Pęski, Marta / Gonçalves, J Tiago / Hébert, Jean M

The Journal of neuroscience : the official journal of the Society for Neuroscience

2021 Volume 41, Issue 13, Page(s) 2899–2910

Abstract: The addition of new neurons to existing neural circuits in the adult brain remains of great interest to neurobiology because of its therapeutic implications. The premier model for studying this process has been the hippocampal dentate gyrus in mice, ... ...

Abstract	The addition of new neurons to existing neural circuits in the adult brain remains of great interest to neurobiology because of its therapeutic implications. The premier model for studying this process has been the hippocampal dentate gyrus in mice, where new neurons are added to mature circuits during adulthood. Notably, external factors such as an enriched environment (EE) and exercise markedly increase hippocampal neurogenesis. Here, we demonstrate that EE acts by increasing fibroblast growth factor receptor (FGFR) function autonomously within neurogenic cells to expand their numbers in adult male and female mice. FGFRs activated by EE signal through their mediators, FGFR substrate (FRS), to induce stem cell proliferation, and through FRS and phospholipase Cγ to increase the number of adult-born neurons, providing a mechanism for how EE promotes adult neurogenesis.
MeSH term(s)	Age Factors ; Animals ; Environment ; Female ; Hippocampus/cytology ; Hippocampus/metabolism ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Neural Stem Cells/metabolism ; Neurogenesis/physiology ; Receptors, Fibroblast Growth Factor/genetics ; Receptors, Fibroblast Growth Factor/metabolism
Chemical Substances	Receptors, Fibroblast Growth Factor
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2286-20.2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Potential Variables for Improved Reproducibility of Neuronal Cell Grafts at Stroke Sites

Joanna Krzyspiak / Kamran Khodakhah / Jean M. Hébert

Cells, Vol 11, Iss 1656, p

2022 Volume 1656

Abstract	Interest is growing in using cell replacements to repair the damage caused by an ischemic stroke. Yet, the usefulness of cell transplants can be limited by the variability observed in their successful engraftment. For example, we recently showed that, although the inclusion of donor-derived vascular cells was necessary for the formation of large grafts (up to 15 mm 3 ) at stroke sites in mice, the size of the grafts overall remained highly variable. Such variability can be due to differences in the cells used for transplantation or the host environment. Here, as possible factors affecting engraftment, we test host sex, host age, the extent of ischemic damage, time of transplant after ischemia, minor differences in donor cell maturity, and cell viability at the time of transplantation. We find that graft size at stroke sites correlates with the size of ischemic damage, host sex (females having graft sizes that correlate with damage), donor cell maturity, and host age, but not with the time of transplant after stroke. A general linear model revealed that graft size is best predicted by stroke severity combined with donor cell maturity. These findings can serve as a guide to improving the reproducibility of cell-based repair therapies.
Keywords	ischemia ; neocortex ; transplantation ; vascular endothelial cells ; blood vessel ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination.

Kang, Wenfei / Nguyen, Ken C Q / Hébert, Jean M

Stem cell reports

2021 Volume 12, Issue 6, Page(s) 1223–1231

Abstract: Stimulating oligodendrocyte (OL) production from endogenous progenitor cells is an important strategy for myelin repair and functional restoration after disease or injury-induced demyelination. Subventricular zone (SVZ) stem cells are multipotential, ... ...

Abstract	Stimulating oligodendrocyte (OL) production from endogenous progenitor cells is an important strategy for myelin repair and functional restoration after disease or injury-induced demyelination. Subventricular zone (SVZ) stem cells are multipotential, generating neurons and oligodendroglia. The factors that regulate the fate of these stem cells are poorly defined. In this study, we show that genetically increasing fibroblast growth factor receptor-3 (FGFR3) activity in adult SVZ stem cells transiently and dramatically redirects their differentiation from the neuronal to the oligodendroglial lineage after pathological demyelination. The increased SVZ-derived oligodendrogenesis leads to improved OL regeneration and myelin repair, not only in the corpus callosum (a normal destination for SVZ-derived oligodendroglial cells), but also in the lower cortical layers. This study identifies FGF signaling as a potent target for improving endogenous SVZ-derived OL regeneration and remyelination.
MeSH term(s)	Adult Stem Cells/metabolism ; Adult Stem Cells/pathology ; Animals ; Corpus Callosum/metabolism ; Corpus Callosum/pathology ; Demyelinating Diseases/metabolism ; Demyelinating Diseases/pathology ; Lateral Ventricles/metabolism ; Lateral Ventricles/pathology ; Mice ; Myelin Sheath/physiology ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Oligodendroglia/metabolism ; Oligodendroglia/pathology ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; Receptor, Fibroblast Growth Factor, Type 3/metabolism ; Regeneration ; Signal Transduction
Chemical Substances	Fgfr3 protein, mouse (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2019.05.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: History of trauma and COVID-19-related psychological distress and PTSD.

Hébert, Martine / Jean-Thorn, Arianne / Fortin, Laurie

Psychiatry research communications

2022 Volume 2, Issue 4, Page(s) 100092

Abstract: The COVID-19 pandemic has a great impact on society as a whole. Yet the pandemic and associated mandatory lockdown in several countries may have increased the vulnerability of certain populations. The present study aimed to document the frequency of ... ...

Abstract	The COVID-19 pandemic has a great impact on society as a whole. Yet the pandemic and associated mandatory lockdown in several countries may have increased the vulnerability of certain populations. The present study aimed to document the frequency of clinical level of psychological distress and COVID-19 related post-traumatic stress symptoms in youth during the first wave of the pandemic. The study more specifically explored the role of prior trauma and adverse life events as a vulnerability factor for negative outcomes. A sample of 4914 adolescents and young adults from the province of Quebec, Canada was recruited online through social networks during the first wave of COVID-19. Results revealed that 26.6% of youth displayed serious psychological distress and 20.3% probable PTSD symptoms. The number of past traumas and adversity experienced showed a dose-response relation with the prevalence of psychological distress and PTSD. After controlling for socio-demographic characteristics and COVID-19 related variables (exposure, fear, suspicion of having the infection), participants with a history of five traumas and more presented a two-fold risk of serious psychological distress and probable PTSD. Emotion dysregulation was also associated with an increased risk of symptoms while resilience was linked to a reduced risk of distress.
Language	English
Publishing date	2022-11-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-5987
ISSN (online)	2772-5987
DOI	10.1016/j.psycom.2022.100092
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED