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  1. Article ; Online: Performance of van der Waals Corrected Functionals for Guest Adsorption in the M

    Vlaisavljevich, Bess / Huck, Johanna / Hulvey, Zeric / Lee, Kyuho / Mason, Jarad A / Neaton, Jeffrey B / Long, Jeffrey R / Brown, Craig M / Alfè, Dario / Michaelides, Angelos / Smit, Berend

    The journal of physical chemistry. A

    2017  Volume 121, Issue 21, Page(s) 4139–4151

    Abstract: ... different functionals for the M ...

    Abstract Small-molecule binding in metal-organic frameworks (MOFs) can be accurately studied both experimentally and computationally, provided the proper tools are employed. Herein, we compare and contrast properties associated with guest binding by means of density functional theory (DFT) calculations using nine different functionals for the M
    Language English
    Publishing date 2017-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.7b00076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene.

    McClements, Michelle / Davies, Wayne I L / Michaelides, Michel / Carroll, Joseph / Rha, Jungtae / Mollon, John D / Neitz, Maureen / MacLaren, Robert E / Moore, Anthony T / Hunt, David M

    Vision research

    2013  Volume 80, Page(s) 41–50

    Abstract: ... L/M opsin gene. Spectral analysis shows that the mutant opsin fails to form a pigment in vitro and ... quantitative PCR analysis identifies this mutant gene as the only gene present in the affected subject's L/M ...

    Abstract In this report, we describe a male subject who presents with a complex phenotype of myopia associated with cone dysfunction and a protan vision deficiency. Retinal imaging demonstrates extensive cone disruption, including the presence of non-waveguiding cones, an overall thinning of the retina, and an irregular mottled appearance of the hyper-reflective band associated with the inner segment ellipsoid portion of the photoreceptor. Mutation screening revealed a novel p.Glu41Lys missense mutation in a hybrid L/M opsin gene. Spectral analysis shows that the mutant opsin fails to form a pigment in vitro and fails to be trafficked to the cell membrane in transfected Neuro2a cells. Extensive sequence and quantitative PCR analysis identifies this mutant gene as the only gene present in the affected subject's L/M opsin gene array, yet the presence of protanopia indicates that the mutant opsin must retain some activity in vivo. To account for this apparent contradiction, we propose that a limited amount of functional pigment is formed within the normal cellular environment of the intact photoreceptor, and that this requires the presence of chaperone proteins that promote stability and normal folding of the mutant protein.
    MeSH term(s) Adolescent ; Color Vision Defects/genetics ; Cone Opsins/genetics ; Cone Opsins/metabolism ; Genetic Diseases, X-Linked/genetics ; Humans ; Male ; Mutation, Missense ; Myopia/genetics ; Retinitis Pigmentosa/genetics
    Chemical Substances Cone Opsins
    Language English
    Publishing date 2013-01-18
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2012.12.012
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    Zs.A 521: Show issues Location:
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  3. Article ; Online: Seasonal Variation and the Effect of the Transition Period on Physical Fitness Parameters in Youth Female Soccer Players.

    Parpa, Koulla / Katanic, Borko / Michaelides, Marcos

    Sports (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: ... jump and 30 m sprint test (all ...

    Abstract This study examined seasonal variation and the effect of the transition period on physical fitness parameters in female youth soccer players. Twenty-four players (13-17 years old) were assessed through field and laboratory testing. They completed laboratory testing three times: (1) at the beginning of the season (post-preseason), (2) at the end of the regular season (postseason), and (3) following the transition period (preseason). Field testing was conducted post-preseason and postseason. Results indicated that weight and body fat significantly increased from post-preseason to postseason and following the transition period. A paired samples T-test revealed that the players performed significantly better in the vertical jump and 30 m sprint test (all
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704239-X
    ISSN 2075-4663 ; 2075-4663
    ISSN (online) 2075-4663
    ISSN 2075-4663
    DOI 10.3390/sports12030084
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  4. Article ; Online: Bioenvironmental Predictors of Childhood Reading and Speech Difficulties.

    Michaelides, Orestis / Luciano, Michelle

    Journal of speech, language, and hearing research : JSLHR

    2023  Volume 66, Issue 5, Page(s) 1740–1754

    Abstract: Purpose: Reading and speech difficulties are common in childhood, yet it is not fully understood how much of their etiology is shared. This partly derives from methodological issues related to overlooking the potential co-occurrence between the two sets ...

    Abstract Purpose: Reading and speech difficulties are common in childhood, yet it is not fully understood how much of their etiology is shared. This partly derives from methodological issues related to overlooking the potential co-occurrence between the two sets of difficulties. This study investigated the effects of five bioenvironmental predictors in a sample assessed for such co-occurrence.
    Method: A combination of exploratory and confirmatory analyses was performed on longitudinal data from the National Child Development Study. Exploratory latent class analysis was performed on children's reading, speech, and language outcomes at ages 7 and 11 years. Membership in the obtained classes was modeled using a regression with sex and four early-life predictors: gestation period, socioeconomic status, maternal education, and the home reading environment.
    Results: The model yielded four latent classes that broadly reflected (1) average reading and speech, (2) excellent reading, (3) reading difficulties, and (4) speech difficulties. Early-life factors significantly predicted class membership. Male sex and preterm birth emerged as risk factors for both reading and speech difficulties. Protective effects against reading difficulties were identified for maternal education, and lower (but not higher) levels of socioeconomic status and the home reading environment.
    Conclusions: Co-occurrence of reading and speech difficulties in the sample was low, and differential patterns of effect of the social environment were supported. Reading outcomes were under stronger malleable influence than speech outcomes.
    MeSH term(s) Infant, Newborn ; Child ; Female ; Humans ; Male ; Reading ; Speech ; Premature Birth/epidemiology ; Speech Disorders ; Dyslexia/epidemiology ; Dyslexia/etiology
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1364086-0
    ISSN 1558-9102 ; 1092-4388
    ISSN (online) 1558-9102
    ISSN 1092-4388
    DOI 10.1044/2023_JSLHR-22-00476
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    Zs.A 606: Show issues Location:
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  5. Article ; Online: Exploring the role of mu opioid receptors in the therapeutic potential and abuse liability of (S)-ketamine.

    Levinstein, Marjorie R / Michaelides, Michael

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2023  Volume 49, Issue 1, Page(s) 315–316

    MeSH term(s) Humans ; Ketamine/therapeutic use ; Ketamine/pharmacology ; Receptors, Opioid, mu ; Pain/drug therapy ; Analgesics, Opioid/pharmacology
    Chemical Substances Ketamine (690G0D6V8H) ; Receptors, Opioid, mu ; Analgesics, Opioid
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type News
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-023-01652-x
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    Zs.A 2379: Show issues Location:
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  6. Article ; Online: Ten-electron count rule for the binding of adsorbates on single-atom alloy catalysts.

    Schumann, Julia / Stamatakis, Michail / Michaelides, Angelos / Réocreux, Romain

    Nature chemistry

    2024  

    Abstract: Single-atom alloys have recently emerged as highly active and selective alloy catalysts. Unlike pure metals, single-atom alloys escape the well-established conceptual framework developed nearly three decades ago for predicting catalytic performance. ... ...

    Abstract Single-atom alloys have recently emerged as highly active and selective alloy catalysts. Unlike pure metals, single-atom alloys escape the well-established conceptual framework developed nearly three decades ago for predicting catalytic performance. Although this offers the opportunity to explore so far unattainable chemistries, this leaves us without a simple guide for the design of single-atom alloys able to catalyse targeted reactions. Here, based on thousands of density functional theory calculations, we reveal a 10-electron count rule for the binding of adsorbates on the dopant atoms, usually the active sites, of single-atom alloy surfaces. A simple molecular orbital approach rationalizes this rule and the nature of the adsorbate-dopant interaction. In addition, our intuitive model can accelerate the rational design of single-atom alloy catalysts. Indeed, we illustrate how the unique insights provided by the electron count rule help identify the most promising dopant for an industrially relevant hydrogenation reaction, thereby reducing the number of potential materials by more than one order of magnitude.
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-023-01424-6
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  7. Article ; Online: RDH12 retinopathy: clinical features, biology, genetics and future directions.

    Daich Varela, Malena / Michaelides, Michel

    Ophthalmic genetics

    2022  , Page(s) 1–6

    Abstract: Retinol dehydrogenase 12 (RDH12) is a small gene located on chromosome 14, encoding an enzyme capable of metabolizing retinoids. It is primarily located in photoreceptor inner segments and thereby is believed to have an important role in clearing ... ...

    Abstract Retinol dehydrogenase 12 (RDH12) is a small gene located on chromosome 14, encoding an enzyme capable of metabolizing retinoids. It is primarily located in photoreceptor inner segments and thereby is believed to have an important role in clearing excessive retinal and other toxic aldehydes produced by light exposure. Clinical features: RDH12-associated retinopathy has wide phenotypic variability; including early-onset severe retinal dystrophy/Leber Congenital Amaurosis (EOSRD/LCA; most frequent presentation), retinitis pigmentosa, cone-rod dystrophy, and macular dystrophy. It can be inherited in an autosomal recessive and dominant fashion. RDH12-EOSRD/LCA's key features are early visual impairment, petal-shaped, coloboma-like macular atrophy with variegated watercolour-like pattern, peripapillary sparing, and often dense bone spicule pigmentation. Future directions: There is currently no treatment available for RDH12-retinopathy. However, extensive preclinical investigations and an ongoing prospective natural history study are preparing the necessary foundation to design and establish forthcoming clinical trials. Herein, we will concisely review pathophysiology, molecular genetics, clinical features, and discuss therapeutic approaches.
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2022.2062392
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    Zs.A 1708: Show issues Location:
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  8. Article ; Online: Adaptive Optics Retinal Imaging in RDH12-Associated Early Onset Severe Retinal Dystrophy.

    Daich Varela, Malena / Dixit, Mira / Kalitzeos, Angelos / Michaelides, Michel

    Investigative ophthalmology & visual science

    2024  Volume 65, Issue 3, Page(s) 9

    Abstract: Purpose: RDH12 is among the most common genes found in individuals with early-onset severe retinal (EOSRD). Adaptive optics scanning light ophthalmoscopy (AOSLO) enables resolution of individual rod and cone photoreceptors in the retina. This study ... ...

    Abstract Purpose: RDH12 is among the most common genes found in individuals with early-onset severe retinal (EOSRD). Adaptive optics scanning light ophthalmoscopy (AOSLO) enables resolution of individual rod and cone photoreceptors in the retina. This study presents the first AOSLO imaging of individuals with RDH12-associated EOSRD.
    Methods: Case series of patients who attended Moorfields Eye Hospital (London, UK). Spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and blue autofluorescence imaging were analyzed. En face image sequences of photoreceptors were recorded using either of two AOSLO modalities. Cross-sectional analysis was undertaken for seven patients and longitudinal analysis for one patient.
    Results: Nine eyes from eight patients are presented in this case series. The mean age at the time of the assessment was 11.2 ± 6.5 years of age (range 7-29). A subfoveal continuous ellipsoid zone (EZ) line was present in eight eyes. Posterior pole AOSLO revealed patches of cone mosaics. Average cone densities at regions of interest 0.5° to the fovea ranged from 12,620 to 23,660 cells/mm2, whereas intercell spacing ranged from 7.0 to 9.7 µm.
    Conclusions: This study demonstrates that AOSLO can provide useful high-quality images in patients with EOSRD, even during childhood, with nystagmus, and early macular atrophy. Cones at the posterior pole can appear as scattered islands or, possibly later in life, as a single subfoveal conglomerate. Detailed image analysis suggests that retinal pigment epithelial stress and dysfunction may be the initial step toward degeneration, with NIR being a useful tool to assess retinal well-being in RDH12-associated EOSRD.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; Cross-Sectional Studies ; Retina/diagnostic imaging ; Retinal Dystrophies/diagnostic imaging ; Retinal Dystrophies/genetics ; Tomography, Optical Coherence ; Alcohol Oxidoreductases/genetics ; Eye Diseases, Hereditary
    Chemical Substances RDH12 protein, human (EC 1.1.1.105) ; Alcohol Oxidoreductases (EC 1.1.-)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.65.3.9
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    Zs.A 45: Show issues Location:
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  9. Article ; Online: Aerobic capacity of professional soccer players before and after COVID-19 infection.

    Parpa, Koulla / Michaelides, Marcos

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 11850

    Abstract: This investigation aimed to assess the aerobic capacity of professional soccer players pre-and post-COVID-19 infection. Twenty-one division-1 elite soccer players (age 24.24 ± 5.75 years, height 178.21 ± 5.44 cm, weight 74.12 ± 5.21 kg) participated in ... ...

    Abstract This investigation aimed to assess the aerobic capacity of professional soccer players pre-and post-COVID-19 infection. Twenty-one division-1 elite soccer players (age 24.24 ± 5.75 years, height 178.21 ± 5.44 cm, weight 74.12 ± 5.21 kg) participated in this study. This observational study compared the same players' aerobic capacity pre-, and 60-days post COVID-19 recovery. The statistical analysis demonstrated that the infected players had significantly lower VO
    MeSH term(s) Adolescent ; Adult ; Athletic Performance/physiology ; COVID-19 ; Exercise Test ; Humans ; Oxygen Consumption/physiology ; Running/physiology ; Soccer/physiology ; Young Adult
    Language English
    Publishing date 2022-07-13
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-16031-7
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  10. Article ; Online: Anterior-Posterior and Inter-Limb Lower Body Strength Asymmetry in Soccer, Basketball, Futsal, and Volleyball Players.

    Parpa, Koulla / Michaelides, Marcos

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 8

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Adolescent ; Adult ; Athletes ; Basketball ; Female ; Humans ; Male ; Range of Motion, Articular ; Soccer ; Volleyball
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58081080
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