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  1. Article ; Online: Editorial overview: Innate immunity - 2023: Just in time defense.

    Hiscott, John

    Current opinion in immunology

    2023  Volume 82, Page(s) 102302

    MeSH term(s) Humans ; Immunity, Innate
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Editorial
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102302
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
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  2. Article ; Online: Editorial: Insights in virus and host: 2021.

    Hiscott, John / Brandt, Curtis R

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1190338

    MeSH term(s) Humans ; Viruses/genetics ; Chikungunya Fever
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1190338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Paula Pitha-Rowe, PhD (1938-2015).

    Hiscott, John

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2015  Volume 35, Issue 5, Page(s) 325–326

    MeSH term(s) Famous Persons ; History, 20th Century ; History, 21st Century
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2015.1501
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    Zs.A 1748: Show issues Location:
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  4. Article ; Online: Editorial overview: The challenge to defeat dengue.

    Hiscott, John / Wilder-Smith, Annelies

    Current opinion in virology

    2020  Volume 43, Page(s) iii–v

    MeSH term(s) Animals ; Culicidae/physiology ; Culicidae/virology ; Dengue/epidemiology ; Dengue/prevention & control ; Dengue/transmission ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/physiology ; Humans ; Seasons
    Language English
    Publishing date 2020-11-07
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2020.10.004
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  5. Article ; Online: A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy.

    Muscolini, Michela / Hiscott, John / Tassone, Evelyne

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2589, Page(s) 379–399

    Abstract: Oncolytic virotherapy represents an efficient immunotherapeutic approach for cancer treatment. Oncolytic viruses (OVs) promote antitumor responses through tumor-selective cell lysis and immune system activation. However, some tumor cell lines and primary ...

    Abstract Oncolytic virotherapy represents an efficient immunotherapeutic approach for cancer treatment. Oncolytic viruses (OVs) promote antitumor responses through tumor-selective cell lysis and immune system activation. However, some tumor cell lines and primary tumors display resistance to therapy. Here we describe a protocol to identify novel host factors responsible for tumor resistance to oncolysis using an unbiased genome-wide CRISPR-Cas9 loss-of-function screening. Cas9-expressing tumor cells are transduced with a library of pooled single-guide RNA (sgRNA)-expressing lentiviruses that target all human genes to obtain a cell population where each cell is knocked out for a single gene. Upon OV infection, resistant cells survive, while sensitive cells die. The relative abundance of each genome-integrated sgRNA is measured by next-generation sequencing (NGS) in resistant and control cells. This protocol is amenable to uncover host factors involved in the resistance to different OVs in multiple tumor models.
    MeSH term(s) Humans ; CRISPR-Cas Systems/genetics ; High-Throughput Nucleotide Sequencing ; Neoplasms/genetics ; Neoplasms/therapy ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2022-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2788-4_25
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  6. Article ; Online: The Coronavirus pandemic - 2022: Viruses, variants & vaccines.

    Alexandridi, Magdalini / Mazej, Julija / Palermo, Enrico / Hiscott, John

    Cytokine & growth factor reviews

    2022  Volume 63, Page(s) 1–9

    Abstract: Since the beginning of the COVID-19 pandemic in 2019-2020, Cytokine & Growth Factor Reviews has published several Special Issues focused on the biology, pathogenesis and therapeutic options in the treatment of COVID-19 infection, including articles on ... ...

    Abstract Since the beginning of the COVID-19 pandemic in 2019-2020, Cytokine & Growth Factor Reviews has published several Special Issues focused on the biology, pathogenesis and therapeutic options in the treatment of COVID-19 infection, including articles on the involvement of the chemokine system in the cytokine storm in COVID-19, intervention in the early stages of COVID-19 pneumonia, the therapeutic value of corticosteroid treatment, early clinical intervention with type 1 interferons, progress in vaccine development, and organ specific complications of COVID-19. By 2022, multiple highly efficacious vaccines are available and are being administered in countries around the world, therapeutic options have been clinically evaluated and approved, and SARS-CoV-2 has arguably become the most thoroughly studied virus in history. But, with progress has also come unanticipated problems - misinformation, anti-vaxxers, opposition to protective masks, and politically motivated interference disguised as knowledge. With this issue of CGFR, we continue to document the global coronavirus pandemic and provide an update on the emergence of viral variants, the global effort to administer vaccines and the impediments to progress posed by misinformation and anti-vaccine sentiment.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2022.02.002
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    Zs.A 2653: Show issues Location:
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  7. Article ; Online: Introduction to innate sensing and response to pathogens (part 2).

    Hiscott, John

    Cytokine & growth factor reviews

    2014  Volume 25, Issue 6, Page(s) 629–630

    MeSH term(s) Animals ; Humans ; Immunity, Innate
    Language English
    Publishing date 2014-12
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2014.11.001
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    Zs.A 2653: Show issues Location:
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  8. Article ; Online: Introduction to innate sensing and response to pathogens.

    Hiscott, John

    Cytokine & growth factor reviews

    2014  Volume 25, Issue 5, Page(s) 489–490

    MeSH term(s) Animals ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2014.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2653: Show issues Location:
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  9. Article ; Online: Cytokines 2017 in Kanazawa: Looking beyond the horizon of integrated cytokine research from the sea of Japan.

    Olagnier, David / Hiscott, John

    Cytokine & growth factor reviews

    2018  Volume 50, Page(s) 75–82

    Abstract: At the 5th Annual meeting of the International Cytokine and Interferon Society held in Kanazawa, Japan from Oct. 29-Nov. 2 2017, new research was presented in the broad field of cytokine and interferon research. The meeting provided an outstanding ... ...

    Abstract At the 5th Annual meeting of the International Cytokine and Interferon Society held in Kanazawa, Japan from Oct. 29-Nov. 2 2017, new research was presented in the broad field of cytokine and interferon research. The meeting provided an outstanding platform for investigators in basic science and clinical research to communicate, share and discuss their recent findings in this fast moving area of research.
    MeSH term(s) Antiviral Agents ; Congresses as Topic ; Cytokines ; Humans ; Inflammation ; Interferons ; Japan ; Research/organization & administration ; Research/trends
    Chemical Substances Antiviral Agents ; Cytokines ; Interferons (9008-11-1)
    Language English
    Publishing date 2018-02-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2018.01.008
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  10. Article ; Online: Dengue virus infection and Nrf2 regulation of oxidative stress.

    Zevini, Alessandra / Ferrari, Matteo / Olagnier, David / Hiscott, John

    Current opinion in virology

    2020  Volume 43, Page(s) 35–40

    Abstract: Dengue virus is a positive sense, single-stranded RNA virus of the Flaviviridae family that causes mild to severe dengue fever in hundreds of millions of people in tropical/subtropical regions of the world each year. Like many other viruses, dengue has ... ...

    Abstract Dengue virus is a positive sense, single-stranded RNA virus of the Flaviviridae family that causes mild to severe dengue fever in hundreds of millions of people in tropical/subtropical regions of the world each year. Like many other viruses, dengue has evolved strategies to evade the innate immune response of the host to establish infection. Here we provide an overview of the major alterations provoked by dengue in infected cells, that is, oxidative stress, metabolic reprogramming, and antiviral/inflammatory responses. These biological processes are interconnected and coordinated through the anti-oxidant transcription factor Nrf2, which functions at the interface of metabolism and antiviral immunity.
    MeSH term(s) Animals ; Dengue/genetics ; Dengue/immunology ; Dengue/metabolism ; Dengue/virology ; Dengue Virus/genetics ; Dengue Virus/physiology ; Humans ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/immunology ; Oxidative Stress
    Chemical Substances NF-E2-Related Factor 2
    Language English
    Publishing date 2020-08-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2020.07.015
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