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Article ; Online: Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry.

Homer, Joshua A / Sun, Shoujun / Koelln, Rebecca A / Moses, John E

STAR protocols

2024 Volume 5, Issue 1, Page(s) 102824

Abstract: Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P-F bonds with alcohol and amine nucleophiles, reliably yielding P-O- and P-N-linked compounds. Here, we describe steps for preparing a ... ...

Abstract	Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P-F bonds with alcohol and amine nucleophiles, reliably yielding P-O- and P-N-linked compounds. Here, we describe steps for preparing a phosphoramidic difluoride and performing two sequential PFEx reactions to yield a phosphoramidate through careful catalyst selection. We then detail procedures for handling and quenching potentially toxic P-F-containing compounds to ensure user safety when conducting PFEx reactions. For complete details on the use and execution of this protocol, please refer to Sun et al.
MeSH term(s)	Fluorides ; Click Chemistry ; Phosphoric Acids ; Phosphorus ; Amides
Chemical Substances	Fluorides (Q80VPU408O) ; phosphoramidic acid (9Q189608GB) ; Phosphoric Acids ; Phosphorus (27YLU75U4W) ; Amides
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2023.102824
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ethene-1,1-disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1,1-Bissulfonylfluoride Substituted Cyclobutene Hubs.

Smedley, Christopher J / Giel, Marie-Claire / Fallon, Thomas / Moses, John E

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 30, Page(s) e202303916

Abstract: We present the synthesis of 1,1-bis(fluorosulfonyl)-2-(pyridin-1-ium-1-yl)ethan-1-ide, a bench-stable precursor to ethene-1,1-disulfonyl difluoride (EDSF). The novel SuFEx reagent, EDSF, is demonstrated in the preparation of 26 unique 1,1- ... ...

Abstract	We present the synthesis of 1,1-bis(fluorosulfonyl)-2-(pyridin-1-ium-1-yl)ethan-1-ide, a bench-stable precursor to ethene-1,1-disulfonyl difluoride (EDSF). The novel SuFEx reagent, EDSF, is demonstrated in the preparation of 26 unique 1,1-bissulfonylfluoride substituted cyclobutenes via a cycloaddition reaction. The regioselective click cycloaddition reaction is rapid, straightforward, and highly efficient, enabling the generation of highly functionalized 4-membered ring (4MR) carbocycles. These carbocycles are valuable structural motifs found in numerous bioactive natural products and pharmaceutically relevant small molecules. Additionally, we showcase diversification of the novel cyclobutene cores through selective Cs
Language	English
Publishing date	2023-06-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202303916
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Article ; Online: Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry

Joshua A. Homer / Shoujun Sun / Rebecca A. Koelln / John E. Moses

STAR Protocols, Vol 5, Iss 1, Pp 102824- (2024)

2024

Abstract: Summary: Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P–F bonds with alcohol and amine nucleophiles, reliably yielding P–O- and P–N-linked compounds. Here, we describe steps for preparing ...

Abstract	Summary: Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P–F bonds with alcohol and amine nucleophiles, reliably yielding P–O- and P–N-linked compounds. Here, we describe steps for preparing a phosphoramidic difluoride and performing two sequential PFEx reactions to yield a phosphoramidate through careful catalyst selection. We then detail procedures for handling and quenching potentially toxic P–F-containing compounds to ensure user safety when conducting PFEx reactions.For complete details on the use and execution of this protocol, please refer to Sun et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Keywords	Molecular/Chemical Probes ; Chemistry ; Material sciences ; Science (General) ; Q1-390
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Benign Intradural and Paraspinal Nerve Sheath Tumors: Advanced Surgical Techniques.

Moses, Ziev B / Barzilai, Ori / O'Toole, John E

Neurosurgery clinics of North America

2020 Volume 31, Issue 2, Page(s) 221–229

Abstract: Traditional surgical techniques for benign intradural and paraspinal nerve sheath tumors often consisted of open posterior approaches. However, these were limited by the morbidity of open surgery. In addition, iatrogenic instability is often required for ...

Abstract	Traditional surgical techniques for benign intradural and paraspinal nerve sheath tumors often consisted of open posterior approaches. However, these were limited by the morbidity of open surgery. In addition, iatrogenic instability is often required for total resection of larger or laterally located tumors, thus necessitating the use of additional hardware for spinal fusion. Advances in surgical techniques and technologies have allowed for a plethora of minimally invasive approaches throughout the cervical, thoracic, and lumbar regions. These approaches and their particular applications for the resection of benign peripheral nerve sheath tumors are described, with special attention to modern surgical strategies.
MeSH term(s)	Humans ; Lumbosacral Region/surgery ; Nerve Sheath Neoplasms/pathology ; Nerve Sheath Neoplasms/surgery ; Neurilemmoma/surgery ; Neurosurgical Procedures/methods ; Spinal Cord Neoplasms/surgery ; Thoracic Vertebrae/surgery
Language	English
Publishing date	2020-01-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196855-2
ISSN	1558-1349 ; 1042-3680
ISSN (online)	1558-1349
ISSN	1042-3680
DOI	10.1016/j.nec.2019.11.002
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Article ; Online: Correction: The growing applications of click chemistry.

Moses, John E / Moorhouse, Adam D

Chemical Society reviews

2016 Volume 45, Issue 24, Page(s) 6888

Abstract: Correction for 'The growing applications of click chemistry' by John E. Moses et al., Chem. Soc ...

Abstract	Correction for 'The growing applications of click chemistry' by John E. Moses et al., Chem. Soc. Rev., 2007, 36, 1249-1262.
Language	English
Publishing date	2016-11-03
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/c6cs90108e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells.

Gialelis, Timothy L / Wang, Zifei / Homer, Joshua A / Yang, Wen-Hsuan / Chung, Taemoon / Hu, Qingting / Smedley, Christopher J / Pawar, Nitin J / Upadhyay, Nitinkumar S / Tuveson, David A / Lyons, Scott K / Lukey, Michael J / Moses, John E

RSC medicinal chemistry

2023 Volume 14, Issue 4, Page(s) 710–714

Abstract: A concise semi-synthesis of ... ...

Abstract	A concise semi-synthesis of the
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00049d
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Article ; Online: Apparatus to measure density and viscosity of high-pressure carbon dioxide-alcohol mixtures.

Dinh, Hy / Moses, John / Hannon, John / Wilson, Veronica / Karamanis, Georgios / Krishnamachari, Vikram / Hodes, Marc

The Review of scientific instruments

2024 Volume 95, Issue 2

Abstract: ... measurements, i.e., a variable-volume method with an uncertainty of 1% of reading and a Coriolis density meter ...

Abstract	Thermophysical properties of (single phase) binary CO2-alcohol mixtures under high pressure and moderate temperature conditions are important in supercritical fluid processes. An apparatus to measure mixture density as a function of temperature (up to 80 °C) and pressure (up to 15.9 MPa) over the full range of CO2 mass fractions was designed and commissioned. The fluid delivery system enables precise control and rapid variation of the CO2 mass fraction to within 0.2% of the desired value. Our apparatus advances the state-of-the-art by assuring a uniform mixture and assuring accuracy through redundant measurements, i.e., a variable-volume method with an uncertainty of 1% of reading and a Coriolis density meter with an uncertainty of 7 kg/m3. The results for a representative CO2-ethanol mixture are provided. Moreover, a third independent "bomb" experiment was used to measure density under selected conditions to further verify our measurements and, when present, discrepancies between them and the published data for the representative system. It is shown that, when the discrepancies were present, it was due to insufficient mixing in the other apparatus. Our apparatus also measures the viscosities of the mixtures using a viscometer accurate to 0.02 cP.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0168450
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing the nature of asthma in African epidemiological studies: a scoping review protocol.

Ndlovu, Vuyelwa / Chimbari, Moses John / Sibanda, Elopy

Systematic reviews

2020 Volume 9, Issue 1, Page(s) 230

Abstract: ... We will search PubMed/MEDLINE, African Journals Online (AJOL) and relevant grey literature (e.g. Google Scholar ... EBSCOhost) from January 1990 onwards. Only primary epidemiological studies of asthma (e.g. frequency ...

Abstract	Background: Asthma is one of the most common chronic respiratory conditions in the world and is increasing in prevalence, particularly in Africa and other low-income countries. The disproportionately high numbers of premature deaths and severe or uncontrolled cases in many African countries are indicative of their inability to cope with a costly disease like asthma. Progress has, however, been made in understanding the complex and heterogeneous nature of the disease. The objective of this study will be to summarise the epidemiological literature on the nature of asthma in African countries. Methods: We registered a study protocol for a scoping review. The review was designed following the Arksey and O'Malley framework. We will search PubMed/MEDLINE, African Journals Online (AJOL) and relevant grey literature (e.g. Google Scholar, EBSCOhost) from January 1990 onwards. Only primary epidemiological studies of asthma (e.g. frequency, disease mechanisms, associated risk factors and comorbidities) written in English and conducted in Africa will be included. Two reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Findings will be reported using narrative synthesis and tabulation of the summaries. Discussion: This scoping review will capture the state of the current epidemiological literature on asthma in African countries. Results will be published in a peer-reviewed journal. We anticipate this review will identify gaps and make recommendations for future areas of study. Scoping review registration: Open Science Framework http://osf.io/n2p87/.
MeSH term(s)	Africa/epidemiology ; Asthma/epidemiology ; Delivery of Health Care ; Epidemiologic Studies ; Humans ; Poverty ; Review Literature as Topic
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-020-01491-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Leveraging implementation science to improve implementation outcomes in precision medicine.

Mogaka, John J O / James, San E / Chimbari, Moses J

American journal of translational research

2020 Volume 12, Issue 9, Page(s) 4853–4872

Abstract: Background and purpose: Introduction of omics technologies in clinical practice means increased use of validated biomarkers, through precision medicine (PM). Although implementation science (IS) affords an array of theoretical approaches that can ... ...

Abstract	Background and purpose: Introduction of omics technologies in clinical practice means increased use of validated biomarkers, through precision medicine (PM). Although implementation science (IS) affords an array of theoretical approaches that can potentially explain PM intervention uptake, their relevance and applicability in PM implementation has not been empirically tested. This article identifies and examines existing implementation frameworks for their applicability in PM, demonstrating how different IS theories can be used to generate testable implementation hypotheses in PM. Methods: A three-step methodology was employed to search and select implementation models: a scoping search in Google Scholar produced 15 commonly used models in healthcare; a systematic search in PUBMED and Web of Science using the names of each model as keywords in search strings produced 290 publications for screening and abstraction; finally, a citation frequency search in the 3 databases produced most cited models that were included in the narrative synthesis. Results: Main concepts and constructs associated with each of the 15 models were identified. Four most cited frameworks in healthcare were: REAIM, CFIR, PRISM and PARiHS. Corresponding constructs were mapped and examined for potential congruence to PM. A generalized PM implementation conceptual framework was developed showing how omics biomarker uptake relates to their evidence base, patient and provider engagement and Big data capabilities of involved organizations. Conclusion: We demonstrated how implementation complexities in PM can be addressed by explicit use of implementation theories. The work here may provide a reference for further research of empirically testing and refining the identified implementation constructs.
Language	English
Publishing date	2020-09-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Plain Language Summary of Publication of the safety and efficacy of ARRY-371797 in people with dilated cardiomyopathy and a faulty

MacRae, Calum A / Taylor, Matthew Rg / Mestroni, Luisa / Moses, John / Ashley, Euan A / Wheeler, Matthew T / Lakdawala, Neal K / Hershberger, Ray E / Sandor, Victor / Saunders, Michael E / Oliver, Colleen / Lee, Patrice A / Judge, Daniel P

Future cardiology

2023 Volume 19, Issue 2, Page(s) 55–63

Abstract: What is this plain language summary about?: This plain language summary describes the results of a study looking at the effects of a medicine called ARRY-371797 (also known as PF-07265803) in people with dilated cardiomyopathy (DCM for short) caused by ... ...

Abstract	What is this plain language summary about?: This plain language summary describes the results of a study looking at the effects of a medicine called ARRY-371797 (also known as PF-07265803) in people with dilated cardiomyopathy (DCM for short) caused by a faulty What were the results?: 12 American people (average age 50 years) with LMNA-related DCM took part in the study and received 400 mg or 100 mg of ARRY-371797 twice daily for 48 weeks. People knew which dose of ARRY-371797 they were taking. People were checked after 4, 12, 24, 36 and 48 weeks of taking ARRY-371797 to see how far they could walk in the 6-minute walk test (6MWT for short). The level of NT-proBNP in their blood was also measured. NT-proBNP is a biomarker used to measure the severity of heart failure. A biomarker is something found in the body that can be measured to indicate the extent of a disease. -After taking ARRY-371797 for 12 weeks, people were able to walk further in the 6MWT and had lower levels of NT-proBNP in their blood. This suggests improvement in functional capacity (exercise tolerance) and heart function. Researchers also asked people about their quality of life using the Kansas City Cardiomyopathy Questionnaire (KCCQ for short), and looked for any side effects. -Researchers saw some improvement in KCCQ scores. -Researchers saw no major side effects that they considered to be related to ARRY-371797 treatment. A side effect is something that people feel was caused by a medicine or treatment. Overall, this study showed that people with LMNA-related DCM who took ARRY-371797 had improved functional capacity (exercise tolerance), improved heart function, and improved quality of life. Phase 2 study (NCT02057341) Phase 2 long-term extension study (NCT02351856) Phase 3 REALM-DCM study (NCT03439514).
MeSH term(s)	Humans ; Middle Aged ; Cardiomyopathy, Dilated/drug therapy ; Cardiomyopathy, Dilated/genetics ; Quality of Life ; Lamin Type A/genetics ; Mutation ; Heart Failure/drug therapy ; Heart Failure/complications ; Biomarkers/blood
Chemical Substances	ARRY-371797 ; Lamin Type A ; Biomarkers ; LMNA protein, human
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article ; Review ; Comment
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2022-0099
Database	MEDical Literature Analysis and Retrieval System OnLINE

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