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Article ; Online: Development of Stable Liposomal Drug Delivery System of Thymoquinone and Its In Vitro Anticancer Studies Using Breast Cancer and Cervical Cancer Cell Lines.

Shariare, Mohammad Hossain / Khan, Md Asaduzzaman / Al-Masum, Abdullah / Khan, Junayet Hossain / Uddin, Jamal / Kazi, Mohsin

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: Thymoquinone, a well-known phytoconstituent derived from the seeds ... ...

Abstract	Thymoquinone, a well-known phytoconstituent derived from the seeds of
MeSH term(s)	Benzoquinones ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Delivery Systems ; Female ; Humans ; Liposomes/chemistry ; Particle Size ; Phospholipids ; Uterine Cervical Neoplasms/drug therapy
Chemical Substances	Benzoquinones ; Liposomes ; Phospholipids ; thymoquinone (O60IE26NUF)
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196744
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Article: Liposomal Drug Delivery of

Shariare, Mohammad Hossain / Pinky, Nusrat Jahan Khan / Abedin, Joynal / Kazi, Mohsin / Aldughaim, Mohammed S / Uddin, Mohammad N

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 13

Abstract: Background: Blumea lacera: Methods: B. lacera: Results: GC-MS data showed the presence of different components (e.g., phytol) in the : Conclusion: Results demonstrated ... ...

Abstract	Background: Blumea lacera Methods: B. lacera Results: GC-MS data showed the presence of different components (e.g., phytol) in the Conclusion: Results demonstrated that
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12132262
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Article ; Online: The growing complexity of COVID-19 drug and vaccine candidates: challenges and critical transitions.

Shariare, Mohammad Hossain / Parvez, Md Anowar Khasru / Karikas, George A / Kazi, Mohsin

Journal of infection and public health

2020 Volume 14, Issue 2, Page(s) 214–220

Abstract: COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting ... ...

Abstract	COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting significantly higher compared to other coronavirus, due to its constant mutation characteristics. At present although several extensive clinical trials are ongoing, neither approved drug therapy nor any vaccine are available to safely fight SARS-CoV-2. However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way. This review aims to provide an updated insight of the current research, development and trials on repurposing existing drugs and preventive intervention for COVID-19, along with the related issues, complexities and challenges, especially after the observed high transmissibility lately.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19/prevention & control ; COVID-19 Vaccines ; Clinical Trials as Topic ; Drug Repositioning ; Humans ; Pandemics ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; COVID-19 Vaccines
Language	English
Publishing date	2020-12-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2020.12.009
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Article ; Online: Preparation and Optimization of PEGylated Nano Graphene Oxide-Based Delivery System for Drugs with Different Molecular Structures Using Design of Experiment (DoE).

Shariare, Mohammad Hossain / Masum, Abdullah-Al / Alshehri, Sultan / Alanazi, Fars K / Uddin, Jamal / Kazi, Mohsin

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 5

Abstract: Graphene oxide (GO), due to its 2D planar structure and favorable physical and chemical properties, has been used in different fields including drug delivery. This study aimed to investigate the impact of different process parameters on the average size ... ...

Abstract	Graphene oxide (GO), due to its 2D planar structure and favorable physical and chemical properties, has been used in different fields including drug delivery. This study aimed to investigate the impact of different process parameters on the average size of drug-loaded PEGylated nano graphene oxide (NGO-PEG) particles using design of experiment (DoE) and the loading of drugs with different molecular structures on an NGO-PEG-based delivery system. GO was prepared from graphite, processed using a sonication method, and functionalized using PEG 6000. Acetaminophen (AMP), diclofenac (DIC), and methotrexate (MTX) were loaded onto NGO-PEG particles. Drug-loaded NGO-PEG was then characterized using dynamic light scattering (DLS), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), XRD. The DLS data showed that the drug-loaded NGO-PEG suspensions were in the size range of 200 nm-1.3 µm. The sonication time and the stirring rate were found to be the major process parameters which affected the average size of the drug-loaded NGO-PEG. FTIR, DSC, XRD, and SEM demonstrated that the functionalization or coating of the NGO occurred through physical interaction using PEG 6000. Methotrexate (MTX), with the highest number of aromatic rings, showed the highest loading efficiency of 95.6% compared to drugs with fewer aromatic rings (diclofenac (DIC) 70.5% and acetaminophen (AMP) 65.5%). This study suggests that GO-based nano delivery systems can be used to deliver drugs with multiple aromatic rings with a low water solubility and targeted delivery (e.g., cancer).
MeSH term(s)	Acetaminophen/administration & dosage ; Acetaminophen/chemistry ; Calorimetry, Differential Scanning ; Diclofenac/administration & dosage ; Diclofenac/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Graphite/chemistry ; Methotrexate/administration & dosage ; Methotrexate/chemistry ; Microscopy, Electron, Scanning ; Molecular Structure ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Particle Size ; Polyethylene Glycols/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared ; X-Ray Diffraction
Chemical Substances	Drug Carriers ; graphene oxide ; Diclofenac (144O8QL0L1) ; Polyethylene Glycol 6000 (30IQX730WE) ; Acetaminophen (362O9ITL9D) ; Polyethylene Glycols (3WJQ0SDW1A) ; Graphite (7782-42-5) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2021-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26051457
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Article ; Online: Liposomal Drug Delivery of Blumea lacera Leaf Extract

Mohammad Hossain Shariare / Nusrat Jahan Khan Pinky / Joynal Abedin / Mohsin Kazi / Mohammed S. Aldughaim / Mohammad N. Uddin

Nanomaterials, Vol 12, Iss 2262, p

In-Vivo Hepatoprotective Effects

2022 Volume 2262

Abstract: Background: Blumea lacera ( B. lacera ) is a herbaceous plant commonly found in south-east Asia. It shows significant therapeutic activities against various diseases. The objectives of this study were to evaluate hepatoprotective effects of Blumea lacera ...

Abstract	Background: Blumea lacera ( B. lacera ) is a herbaceous plant commonly found in south-east Asia. It shows significant therapeutic activities against various diseases. The objectives of this study were to evaluate hepatoprotective effects of Blumea lacera leaf extract and also to investigate the comparative effectiveness between a liposomal preparation and a suspension of B. lacera leaf extract against carbon tetrachloride (CCl 4 )-induced liver damage. Methods: B. lacera leaf extract was characterized using a GC-MS method. A liposomal preparation of B. lacera leaf extract was developed using an ethanol injection method and characterized using dynamic light scattering (DLS) and electronic microscopic systems. The hepatoprotective effects of B. lacera leaf extracts and its liposomal preparation were investigated using CCl 4 -induced liver damage in Long Evan rats. Results: GC-MS data showed the presence of different components (e.g., phytol) in the B. lacera leaf extract. DLS and microscopic data showed that a liposomal preparation of B. lacera leaf extracts was in the nano size range. In vivo study results showed that liposomal preparation and a suspension of B. lacera leaf extract normalized liver biochemical parameters, enzymes and oxidative stress markers which were elevated due to CCl 4 administration. However, a liposomal formulation of B. lacera leaf extract showed significantly better hepatoprotective effects compared to a suspension of leaf extract. In addition, histopathological evaluation showed that B. lacera leaf extract and its liposomal preparation treatments decreased the extent of CCl 4 -induced liver inflammations. Conclusion: Results demonstrated that B. lacera leaf extract was effective against CCl 4 -induced liver injury possibly due to the presence of components such as phytol. A liposomal preparation exhibited significantly better activity compared to a B. lacera suspension, probably due to improved bioavailability and stability of the leaf extract.
Keywords	liposome ; Blumea lacera ; hepatotoxicity ; particle size ; inflammations ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The growing complexity of COVID-19 drug and vaccine candidates

Mohammad Hossain Shariare / Md. Anowar Khasru Parvez / George A. Karikas / Mohsin Kazi, PhD

Journal of Infection and Public Health, Vol 14, Iss 2, Pp 214-

challenges and critical transitions

2021 Volume 220

Abstract	COVID-19 has nowadays affected almost all our societies and global health systems. The latest deadly pandemic has heavily influenced both life and livelihood worldwide. SARS-CoV-2 is the causative organism of COVID-19, that is spreading and infecting significantly higher compared to other coronavirus, due to its constant mutation characteristics. At present although several extensive clinical trials are ongoing, neither approved drug therapy nor any vaccine are available to safely fight SARS-CoV-2. However, a progressive race among numerous research groups to discover a radical cure for the COVID-19 is under way. This review aims to provide an updated insight of the current research, development and trials on repurposing existing drugs and preventive intervention for COVID-19, along with the related issues, complexities and challenges, especially after the observed high transmissibility lately.
Keywords	SARS-CoV-2 ; COVID-19 ; Drug repurposing ; Vaccine ; Computational docking ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Liposomal drug delivery of Corchorus olitorius leaf extract containing phytol using design of experiment (DoE): In-vitro anticancer and in-vivo anti-inflammatory studies.

Shariare, Mohammad Hossain / Noor, Humaira Binte / Khan, Junayet Hossain / Uddin, Jamal / Ahamad, Syed Rizwan / Altamimi, Mohammad A / Alanazi, Fars K / Kazi, Mohsin

Colloids and surfaces. B, Biointerfaces

2020 Volume 199, Page(s) 111543

Abstract: Phytol, a pharmacologically active compound present in Corchorus olitorius leaf exhibit a range of activity including anti-inflammatory, antioxidant, anticancer, hepatoprotective etc. However, phytol is poorly soluble and absorbed through the intestine ... ...

Abstract	Phytol, a pharmacologically active compound present in Corchorus olitorius leaf exhibit a range of activity including anti-inflammatory, antioxidant, anticancer, hepatoprotective etc. However, phytol is poorly soluble and absorbed through the intestine wall, therefore the aim of this study is to develop liposomal drug delivery of Corchorus olitorius leaf extract with an average particle size below 150 nm and drug loading efficiency of ≥ 85 %. The impact of different process parameters and material attributes were studied on the average particle size and polydispersity of liposomal batches using design of experiment (DoE). Corchorus olitorius leaf extraction was performed using maceration method and characterised using GC-MS. Liposomal batches of Corchorus olitorius leaf extract were characterized using Malvern zetasizer, transmission electron microscopy (TEM) and UV spectroscopy. The in-vivo anti-inflammatory study of the liposomal preparation of phytol was evaluated using a rat model and in-vitro cancer cell line study was performed on AML and Leukamia cell lines. GC-MS study data showed that phytol is present in C. olitorius leaf extract. Process parameters and material attributes perspective processing temperature, buffer pH and drug: lipid ratio is found as major parameters affecting the average particle size and PDI value of liposomes. Liposomes were prepared in the range of 80-250 nm and optimized batches of liposomes showed drug entrapment efficiency of 60-88 %. In-vivo anti-inflammatory study showed significant activity for C. olitorius leaf extract against carrageenan induced paw edema, which is significantly increased while delivered through liposomes. In-vitro cancer cell line study data suggests that liposomal delivery of phytol was more active at lower concentration compared to pure phytol, for specific cell lines.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Corchorus ; Liposomes ; Phytol ; Plant Extracts ; Rats
Chemical Substances	Anti-Inflammatory Agents ; Liposomes ; Plant Extracts ; Phytol (150-86-7)
Language	English
Publishing date	2020-12-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2020.111543
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Article ; Online: Analysis of a "3-(Naphthalen-1-ylimino) Indoline-2-one" compound and Its Antimicrobial Assessment Using Lipid-based Self-nanoemulsifying Formulations.

Ali Syed, Saeed / Bari, Ahmed / Aldughaim, Mohammed S / Rashid, Md Abdur / Shariare, Mohammad Hossain / Kazi, Mohsin

Molecules (Basel, Switzerland)

2020 Volume 26, Issue 1

Abstract: In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities-antibacterial, antiviral, and anticonvulsant. This compound is derived from naturally grown plants. Therefore, synthesis of a ... ...

Abstract	In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities-antibacterial, antiviral, and anticonvulsant. This compound is derived from naturally grown plants. Therefore, synthesis of a novel "3-(Naphthalen-1-ylimino) indoline-2-one" compound (
MeSH term(s)	Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Chromatography, High Pressure Liquid ; Drug Compounding ; Emulsifying Agents/chemistry ; Lipids/chemistry ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Molecular Structure ; Nanoparticles/chemistry ; Oxindoles/chemistry
Chemical Substances	Anti-Infective Agents ; Emulsifying Agents ; Lipids ; Oxindoles ; 2-oxindole (0S9338U62H)
Language	English
Publishing date	2020-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26010015
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Article ; Online: Analysis of a “3-(Naphthalen-1-ylimino) Indoline-2-one” compound and Its Antimicrobial Assessment Using Lipid-based Self-nanoemulsifying Formulations

Saeed Ali Syed / Ahmed Bari / Mohammed S. Aldughaim / Md Abdur Rashid / Mohammad Hossain Shariare / Mohsin Kazi

Molecules, Vol 26, Iss 15, p

2021 Volume 15

Abstract: In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities—antibacterial, antiviral, and anticonvulsant. This compound is derived from naturally grown plants. Therefore, synthesis of a ... ...

Abstract	In recent years, indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities—antibacterial, antiviral, and anticonvulsant. This compound is derived from naturally grown plants. Therefore, synthesis of a novel “3-(Naphthalen-1-ylimino) indoline-2-one” compound ( 2 ) and its analysis using UPLC systems along with antimicrobial assessment was the aim of the current study. Isatin was used as a parent drug for synthesizing compound ( 2 ). Liquid Chromatographic analysis was performed using a C18 BEH column (1.7 µm 2.1 × 50 mm) by UPLC systems. Degradation studies were carried out to see whether acid, base, thermal, and oxidizing agents had any impact on the synthesized molecule in stress conditions (100 °C). A lipid-based self-nanoemulsifying formulation was developed and selectivity, specificity, recovery, accuracy, and precision were measured as part of the UPLC system’s validation process. Antimicrobial studies were conducted using gram-positive and gram-negative bacteria. The standard samples were run with a concentration range of 5.0–100.0 µg/mL using the isocratic mobile phase comprising of methanol/water (70/30 % v / v ) at 234 nm; good linearity (R 2 = 0.9998) was found. The lower limits of detection (LOD) and quantitation (LOQ) of the method were found to be 0.81 µg/mL and 2.5 µg/mL, respectively. The coefficients of variation were found to be less than 2%. The antimicrobial study suggests that compound ( 2 ) has a substantial growth effect against gram-negative bacteria. It was successfully synthesized and applied to measure the concentrations in lipid-based dosage form, along with potent antimicrobial activities.
Keywords	UPLC systems ; molecule synthesis ; method validation ; 3-(Naphthalen-1-ylimino) indoline-2-one ; antimicrobial assessment ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Optimization of PEGylated Nano Graphene Oxide-Based Delivery System for Drugs with Different Molecular Structures Using Design of Experiment (DoE)

Mohammad Hossain Shariare / Abdullah-Al Masum / Sultan Alshehri / Fars K. Alanazi / Jamal Uddin / Mohsin Kazi

Molecules, Vol 26, Iss 5, p

2021 Volume 1457

Abstract	Graphene oxide (GO), due to its 2D planar structure and favorable physical and chemical properties, has been used in different fields including drug delivery. This study aimed to investigate the impact of different process parameters on the average size of drug-loaded PEGylated nano graphene oxide (NGO-PEG) particles using design of experiment (DoE) and the loading of drugs with different molecular structures on an NGO-PEG-based delivery system. GO was prepared from graphite, processed using a sonication method, and functionalized using PEG 6000. Acetaminophen (AMP), diclofenac (DIC), and methotrexate (MTX) were loaded onto NGO-PEG particles. Drug-loaded NGO-PEG was then characterized using dynamic light scattering (DLS), Fourier transform infrared (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), XRD. The DLS data showed that the drug-loaded NGO-PEG suspensions were in the size range of 200 nm–1.3 µm. The sonication time and the stirring rate were found to be the major process parameters which affected the average size of the drug-loaded NGO-PEG. FTIR, DSC, XRD, and SEM demonstrated that the functionalization or coating of the NGO occurred through physical interaction using PEG 6000. Methotrexate (MTX), with the highest number of aromatic rings, showed the highest loading efficiency of 95.6% compared to drugs with fewer aromatic rings (diclofenac (DIC) 70.5% and acetaminophen (AMP) 65.5%). This study suggests that GO-based nano delivery systems can be used to deliver drugs with multiple aromatic rings with a low water solubility and targeted delivery (e.g., cancer).
Keywords	graphene oxide (GO) ; nano graphene oxide (NGO) ; NGO-PEG ; aromatic ring ; loading efficiency ; methotrexate ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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