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Article ; Online: Correction: Recommended standards for newborn ICU design.

Journal of perinatology : official journal of the California Perinatal Association

2024

Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Published Erratum
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-024-01908-4
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Article ; Online: Reimagining the NICU: a human-centered design approach to healthcare innovation.

Mohammed, Sabah / Savage, Troy / Smith, Judy / Shepley, Mardelle McCuskey / White, Robert D

Journal of perinatology : official journal of the California Perinatal Association

2023 Volume 43, Issue Suppl 1, Page(s) 40–44

Abstract: Design charettes have been utilized in architectural and design practice to generate innovative ideas. The Reimagining Workshop is a version that combines practical and blue-sky thinking to improve healthcare facility design. The workshop engages diverse ...

Abstract	Design charettes have been utilized in architectural and design practice to generate innovative ideas. The Reimagining Workshop is a version that combines practical and blue-sky thinking to improve healthcare facility design. The workshop engages diverse stakeholders who follow a human-centered design framework. The Reimagining the Neonatal Intensive Care Unit workshop sought to generate ideas for the future, optimal NICU without specific site or client constraints. Key themes include family-centered care, technology-enabled care, neighborhood and village design and investing in the care team. Recommendations include a supportive physical environment, celebrating milestones, complementary and alternative medicine, enhancing the transition of care, aiding the transition period, and leveraging technology. The workshop showcased the potential for transformative change in NICU design and provided a roadmap for future advancements. These findings can inform regulatory standards for NICU design and drive improvements in family-centered care, patient experiences, and outcomes within the NICU environment.
MeSH term(s)	Infant, Newborn ; Humans ; Intensive Care Units, Neonatal ; Patient-Centered Care ; Professional-Family Relations ; Delivery of Health Care ; Parents
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-023-01794-2
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Article ; Online: Recommended standards for newborn ICU design.

Journal of perinatology : official journal of the California Perinatal Association

2023 Volume 43, Issue Suppl 1, Page(s) 2–16

MeSH term(s)	Infant, Newborn ; Humans ; Intensive Care Units, Neonatal ; Intensive Care Units ; Facility Design and Construction
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-023-01784-4
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Article ; Online: The hepatic microvascular system in health and its response to toxicants.

McCuskey, Robert S

Anatomical record (Hoboken, N.J. : 2007)

2008 Volume 291, Issue 6, Page(s) 661–671

Abstract: This review briefly summarizes what is known about the dynamic morphology of the hepatic microvascular system that includes all vessels in the liver with a diameter less than 300 microm and various morphological sites within these vessels that regulate ... ...

Abstract	This review briefly summarizes what is known about the dynamic morphology of the hepatic microvascular system that includes all vessels in the liver with a diameter less than 300 microm and various morphological sites within these vessels that regulate the distribution of blood flow. The latter include the various segments of the afferent portal venules and hepatic arterioles, the sinusoids, and central and hepatic venules. Sinusoids are unique exchange vessels lined by fenestrated endothelial cells which have important endocytotic functions and phagocytic Kupffer cells which are important for host defense. These are encircled by extraluminal stellate cells that are specialized pericytes containing fat droplets that store vitamin A. The principle sites for regulating blood flow are in the sinusoidal network with stellate and endothelial cells playing a major role in regulating the diameters of sinusoids and the distribution of blood flow in individual sinusoids, lobules, or segments of lobules. The sinusoidal endothelial cells are a sensitive and early target for several toxicants. For example, as early as 30 minutes after the administration of acetaminophen, the endothelial cells become swollen and begin to lose the ability to endocytose ligands. Within 2 hr, gaps through the cytoplasm appear formed by the destruction and/or coalescence of fenestrae which permit red blood cells to penetrate into the space of Disse. Subsequently, the sinusoid may collapse or disintegrate reducing blood flow.
MeSH term(s)	Acetaminophen/toxicity ; Animals ; Corrosion Casting ; Endothelial Cells/ultrastructure ; Humans ; Kupffer Cells/ultrastructure ; Liver/anatomy & histology ; Liver/blood supply ; Liver/drug effects ; Liver/innervation ; Liver Circulation/drug effects ; Liver Circulation/physiology ; Microcirculation/anatomy & histology ; Microcirculation/drug effects ; Microcirculation/innervation ; Microcirculation/physiology ; Microscopy, Electron ; Models, Anatomic ; Models, Cardiovascular
Chemical Substances	Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.20663
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Article: 2006 A.J. Ladman AAA/Wiley Exemplary Service Award.

McCuskey, Robert S

Anatomical record. Part B, New anatomist

2006 Volume 289, Issue 3, Page(s) 88–89

MeSH term(s)	Anatomy/history ; Awards and Prizes ; History, 20th Century ; History, 21st Century ; Societies, Scientific ; United States
Language	English
Publishing date	2006-05
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	2103094-7
ISSN	1552-4906 ; 0003-276X
ISSN	1552-4906 ; 0003-276X
DOI	10.1002/ar.b.20100
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Article: Preface.

McCuskey, Robert S

Comparative hepatology

2004 Volume 3 Suppl 1, Page(s) S1

Language	English
Publishing date	2004-01-14
Publishing country	England
Document type	Journal Article
ISSN	1476-5926
ISSN	1476-5926
DOI	10.1186/1476-5926-2-S1-S1
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Article: Sinusoidal endothelial cells as an early target for hepatic toxicants.

McCuskey, Robert S

Clinical hemorheology and microcirculation

2006 Volume 34, Issue 1-2, Page(s) 5–10

Abstract: ... following a single and multiple week-end type alcoholic binge(s). SEC become swollen and begin to lose ...

Abstract	Recent studies demonstrate that the hepatic sinusoidal endothelial cells (SEC) are a sensitive direct target for early toxicity to acetaminophen (paracetamol, APAP) and this toxicity is exacerbated following a single and multiple week-end type alcoholic binge(s). SEC become swollen and begin to lose the ability to endocytose FITC-FSA, a ligand for the scavenger receptor, as early as 30 minutes after the administration of APAP. Gaps through the SEC appear to be formed by the destruction and/or coalescence of fenestrae and are seen as early as 2 hrs after the administration of APAP which is prior to any evidence of injury to parenchymal cells. The gaps permit red blood cells to penetrate into the Space of Disse. Subsequently, the sinusoid may collapse or disintegrate reducing blood flow. The gaps are larger and more frequent in ethanol binged animals subsequently treated with APAP. Similar gaps are seen in the early stages of hepatic venoocclusive disease. Administration of a NO donor or a MMP-2 and MMP-9 inhibitor minimizes endothelial injury and red blood cell penetration into the Space of Disse. The injury is exacerbated when an inhibitor of eNOS is administered and minimized when iNOS is inhibited suggesting a protective role for constitutive NO derived from SEC. Both NO and MMPs are known to affect the cytoskeleton of SEC which in turn affects the formation and maintenance of the fenestrae.
MeSH term(s)	Acetaminophen/adverse effects ; Animals ; Chemical and Drug Induced Liver Injury ; Drug-Related Side Effects and Adverse Reactions/pathology ; Endothelial Cells/drug effects ; Ethanol/adverse effects ; Humans ; Liver Diseases/drug therapy ; Liver Diseases/pathology ; Matrix Metalloproteinases/therapeutic use ; Nitric Oxide Donors/therapeutic use
Chemical Substances	Nitric Oxide Donors ; Acetaminophen (362O9ITL9D) ; Ethanol (3K9958V90M) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2006
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1381750-4
ISSN	1386-0291
ISSN	1386-0291
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Article: Anatomy of efferent hepatic nerves.

McCuskey, Robert S

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology

2004 Volume 280, Issue 1, Page(s) 821–826

Abstract: The role of neural elements in regulating blood flow through the hepatic sinusoids, solute exchange, and parenchymal function is incompletely understood. This is due in part to limited investigation in only a few species whose hepatic innervation may ... ...

Abstract	The role of neural elements in regulating blood flow through the hepatic sinusoids, solute exchange, and parenchymal function is incompletely understood. This is due in part to limited investigation in only a few species whose hepatic innervation may differ significantly from humans. For example, most experimental studies have used rats and mice having livers with little or no intralobular innervation. In contrast, most other mammals, including humans, have aminergic and peptidergic nerves extending from perivascular plexus in the portal space into the lobule, where they course in Disse's space in close relationship to stellate cells (fat storing cells of Ito) and hepatic parenchymal cells. While these fibers extend throughout the lobule, they predominate in the periportal region. Cholinergic innervation, however, appears to be restricted to structures in the portal space and immediately adjacent hepatic parenchymal cells. Neuropeptides have been colocalized with neurotransmitters in both adrenergic and cholinergic nerves. Neuropeptide Y (NPY) has been colocalized in aminergic nerves supplying all segments of the hepatic-portal venous and the hepatic arterial and biliary systems. Nerve fibers immunoreactive for substance P and somatostatin follow a similar distribution. Intralobular distribution of all of these nerve fibers is species-dependent and similar to that reported for aminergic fibers. Vasoactive intestinal peptide and calcitonin gene-related peptide (CGRP) are reported to coexist in cholinergic and sensory afferent nerves innervating portal veins and hepatic arteries and their branches, but not the other vascular segments or the bile ducts. Nitrergic nerves immunoreactive for neuronal nitric oxide (nNOS) are located in the portal tract where nNOS colocalizes with both NPY- and CGRP-containing fibers. In summary, the liver is innervated by aminergic, cholinergic, peptidergic, and nitrergic nerves. While innervation of structures in the portal tract is relatively similar between species, the extent and distribution of intralobular innervation are highly variable as well as species-dependent and may be inversely related to the density of gap junctions between contiguous hepatic parenchymal cells.
MeSH term(s)	Animals ; Cholinergic Agents/metabolism ; Humans ; Liver/anatomy & histology ; Liver/innervation ; Liver Circulation/physiology ; Neurons, Efferent/cytology ; Neurons, Efferent/metabolism ; Neuropeptides/metabolism ; Neurosecretory Systems/anatomy & histology ; Neurosecretory Systems/metabolism ; Nitric Oxide/metabolism ; Species Specificity
Chemical Substances	Cholinergic Agents ; Neuropeptides ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2004-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2103089-3
ISSN	1552-4884 ; 0003-276X
ISSN	1552-4884 ; 0003-276X
DOI	10.1002/ar.a.20087
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Article ; Online: Liver Sinusoidal Endothelial Cells.

Sørensen, Karen Kristine / Simon-Santamaria, Jaione / McCuskey, Robert S / Smedsrød, Bård

Comprehensive Physiology

2015 Volume 5, Issue 4, Page(s) 1751–1774

Abstract: The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic sinusoid and functions as a control post regulating and surveying the trafficking of molecules and cells between the liver parenchyma and the blood. The cell acts as a ...

Abstract	The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic sinusoid and functions as a control post regulating and surveying the trafficking of molecules and cells between the liver parenchyma and the blood. The cell acts as a scavenger cell responsible for removal of potential dangerous macromolecules from blood, and is increasingly acknowledged as an important player in liver immunity. This review provides an update of the major functions of the LSEC, including its role in plasma ultrafiltration and regulation of the hepatic microcirculation, scavenger functions, immune functions, and role in liver aging, as well as issues that are either undercommunicated or confusingly dealt with in the literature. These include metabolic functions, including energy metabolic interplay between the LSEC and the hepatocyte, and adequate ways of identifying and distinguishing the cells.
MeSH term(s)	Animals ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/physiology ; Humans ; Liver/blood supply ; Liver/cytology
Language	English
Publishing date	2015-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2040-4603
ISSN (online)	2040-4603
DOI	10.1002/cphy.c140078
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Article ; Online: Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation.

Ajamieh, Hussam / Farrell, Geoffrey C / McCuskey, Robert S / Yu, Jun / Chu, Eagle / Wong, Heng-Jian / Lam, Wesley / Teoh, Narci C

Liver international : official journal of the International Association for the Study of the Liver

2015 Volume 35, Issue 9, Page(s) 2174–2186

Abstract: Background & aims: Steatosis accentuates the severity of hepatic ischaemia-reperfusion injury (IRI); 'statins' (HMG-CoA reductase inhibitors) protect the heart and brain against post-ischaemic injury. We tested whether short-term administration of ... ...

Abstract	Background & aims: Steatosis accentuates the severity of hepatic ischaemia-reperfusion injury (IRI); 'statins' (HMG-CoA reductase inhibitors) protect the heart and brain against post-ischaemic injury. We tested whether short-term administration of atorvastatin protects fatty livers in obese mice against IRI. Methods: Mice with dietary or genetic simple steatosis (SS) or non-alcoholic steatohepatitis (NASH) were subjected to 60 min partial hepatic ischaemia/24 h reperfusion. Atorvastatin was injected intravenously (5 mg/kg) 1 h before IRI. Liver injury, Toll-like receptor-4 (TLR4), cytokines/chemokines, iNOS/eNOS expression, eNOS activity and thromboxane B2 (TXB2) production were determined. Results: Ischaemia-reperfusion injury was exaggerated by two- to five-fold in SS and NASH compared with lean liver. Atorvastatin pretreatment conferred 70-90% hepatic protection in all animals. Atorvastatin increased post-ischaemic eNOS mRNA/protein and strikingly enhanced eNOS activity (by phospho-eNOS). It also attenuated microparticle (MP) production, NF-κB activation, significantly dampened post-ischaemic thromboxane B2 production, induction of TNF-α, IL-6, MIP-1a, MCP-1, GM-CSF and vascular cell adhesion molecule-1 (VCAM), with a resultant reduction on macrophage and polymorphonuclear neutrophil recruitment. Up-regulation of HMGB1 and TLR4 after IRI was marked in fatty livers; 1 h pretreatment with atorvastatin reduced HMGB1 and TLR4 expression in all livers. Conclusions: Acute (1 h) atorvastatin administration is highly hepatoprotective against IRI in NASH, fatty and lean livers. Key mechanisms include suppression of inflammation by prevention of NF-κB activation, microvascular protection via eNOS activation and suppression of TXB2 and MP release. Short-term intravenous statin treatment is a readily available and effective preventive agent against hepatic IRI, irrespective of obesity and fatty liver disease, and merits clinical trials in at-risk patients.
MeSH term(s)	Animals ; Atorvastatin Calcium/administration & dosage ; Chemokines/blood ; Cytokines/blood ; HMGB1 Protein ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Liver/pathology ; Male ; Mice ; Mice, Obese ; NF-kappa B/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Non-alcoholic Fatty Liver Disease/drug therapy ; Reperfusion Injury/drug therapy ; Thromboxane B2/metabolism ; Toll-Like Receptor 4/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism
Chemical Substances	Chemokines ; Cytokines ; HMGB1 Protein ; HMGB1 protein, mouse ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; NF-kappa B ; Tlr4 protein, mouse ; Toll-Like Receptor 4 ; Vascular Cell Adhesion Molecule-1 ; Atorvastatin Calcium (48A5M73Z4Q) ; Thromboxane B2 (54397-85-2) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, mouse (EC 1.14.13.39)
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.12827
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