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  1. Book: Principles of clinical cancer genetics

    Chung, Daniel C. / Haber, Daniel A.

    a handbook from the Massachusetts General Hospital

    2010  

    Author's details Daniel C. Chung ; Daniel A. Haber ed
    Keywords Neoplasms / genetics
    Language English
    Size XI, 227 S. : Ill., graph. Darst., 279 mm x 216 mm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017032031
    ISBN 978-0-387-93844-8 ; 9780387938462 ; 0-387-93844-3 ; 038793846X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2011 A 4687 order for loan Magazin

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  2. Article ; Online: Neurotrophic Factors in the Treatment of Inherited Retinal Diseases.

    Blouin, Laure / Sahel, José-Alain / Chung, Daniel C

    Cold Spring Harbor perspectives in medicine

    2023  

    Abstract: Inherited retinal diseases (IRDs) are the leading cause of blindness in working-age individuals worldwide. Their genetic etiology is especially heterogenous, so the development of gene-specific therapies is unlikely to meet the medical needs of the ... ...

    Abstract Inherited retinal diseases (IRDs) are the leading cause of blindness in working-age individuals worldwide. Their genetic etiology is especially heterogenous, so the development of gene-specific therapies is unlikely to meet the medical needs of the entire patient community. Considering these challenges, a complementary strategy could be to develop therapies independent of the underlying gene variant causing retinal degeneration. As the retina is a neural tissue, it is in theory amenable to neuroprotective therapies that could help prolong cell survival or promote retinal function. Many neurotrophic factors have shown favorable results in preclinical animal models of neurodegenerative diseases, but unfortunately these findings have not yet translated into successful human clinical trials. The clinical development of these new therapies is mostly impeded by selection of pertinent clinical end points and time-to-readout, as the majority of IRDs show a relatively slow disease progression rate. Despite these challenges, several strategies have moved forward into clinical development.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a041665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genetic Testing and Early Onset Colon Cancer.

    Chung, Daniel C

    Gastroenterology

    2018  Volume 154, Issue 4, Page(s) 788–789

    MeSH term(s) Age of Onset ; Colonic Neoplasms/genetics ; Genetic Testing ; Humans
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2018.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply.

    Friedman, Madeline / Chung, Daniel C

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 18, Issue 7, Page(s) 1648

    MeSH term(s) Endoscopy ; Humans ; Stomach Neoplasms
    Language English
    Publishing date 2020-01-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Case 33-2023: An 86-Year-Old Man with Shortness of Breath.

    Luis, Sushil Allen / Chung, Ryan / Stefanescu Schmidt, Ada C / Clark, Jeffrey W / Pearson, Daniel S

    The New England journal of medicine

    2023  Volume 389, Issue 17, Page(s) 1602–1613

    MeSH term(s) Aged, 80 and over ; Humans ; Male ; Dyspnea/etiology
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2300908
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  6. Article ; Online: Education Scholarship Assessment Reconsidered: Expansion of Glassick's Criteria to Incorporate Health Equity.

    Bockrath, Robyn / Osman, Cynthia / Trainor, Jennifer / Wang, Helen C / Phatak, Uma Padhye / Richards, Daniel G / Keeley, Meg / Chung, Esther K

    Academic medicine : journal of the Association of American Medical Colleges

    2024  Volume 99, Issue 5, Page(s) 487–492

    Abstract: Abstract: Recent events have ignited widespread attention to structural racism and implicit bias throughout the U.S. health care system and medical institutions, resulting in a call for antiracism approaches to advance health equity. Medical education ... ...

    Abstract Abstract: Recent events have ignited widespread attention to structural racism and implicit bias throughout the U.S. health care system and medical institutions, resulting in a call for antiracism approaches to advance health equity. Medical education leaders are well positioned to advance health equity, not only through their training of fellows, residents, and medical students, but also in their approach to scholarship. Education scholarship drives innovation and critical evaluation of current practices; it impacts and intersects with multiple factors that have the potential to reduce health inequities. Thus, it is critical to prioritize the assessment of education scholarship through a health equity lens. Medical education scholarly dissemination has markedly expanded over the past 2 to 3 decades, yet medical educators have continued to embrace Boyer's and Glassick and colleagues' definitions of scholarship. The authors propose an approach to medical education scholarship assessment that expands each of Glassick's 6 existing criteria to address health inequities and adds health equity as a seventh criterion. With this, medical educators, researchers, reviewers, and others can consider how education scholarship affects diverse populations and settings, direct educational products and scholarship to address health inequities, and raise the importance of advancing health equity in medical education scholarship. By expanding and standardizing the assessment of scholarship to incorporate health equity, the medical education community can foster a cultural shift that brings health equity to the forefront of education scholarship.
    MeSH term(s) Humans ; Health Equity ; Education, Medical/standards ; United States ; Fellowships and Scholarships/standards ; Racism/prevention & control
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000005654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diagnostic and treatment recommendations for recurrent or persistent symptoms after trapeziectomy: a Delphi study.

    Herren, Daniel B / Boeckstyns, Michel / Chung, Kevin C / Farnebo, Simon / Hagert, Elisabet / Tang, Jin Bo / Verstreken, Frederik / Marks, Miriam

    The Journal of hand surgery, European volume

    2024  , Page(s) 17531934241227386

    Abstract: The aim of this Delphi study was to provide a diagnostic and treatment algorithm for patients with persistent or recurrent symptoms after trapeziometacarpal joint resection arthroplasty. Three Delphi rounds were conducted in which surveys were sent to ... ...

    Abstract The aim of this Delphi study was to provide a diagnostic and treatment algorithm for patients with persistent or recurrent symptoms after trapeziometacarpal joint resection arthroplasty. Three Delphi rounds were conducted in which surveys were sent to 182 experienced hand surgeons worldwide. Responses were received from 140 participants. A consensus threshold was set at 67% agreement. Diagnostic tools and treatment approaches for six common revision scenarios achieved consensus. Radiographs are appropriate as primary (97%) and CT scans as secondary (76%) diagnostic tools. For scaphometacarpal impingement, 67% of respondents agreed that revision interposition is appropriate, with 93% recommending autologous tendon for the interposition. Additional suspension was considered appropriate by 68% of the participants. The diagnostic and treatment algorithm can help the surgeon to identify the reason for persistent symptoms after trapeziometacarpal joint resection arthroplasty and to choose an appropriate treatment strategy.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/17531934241227386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Revisions after trapeziometacarpal joint resection arthroplasty: A systematic literature review.

    Neumeister, Sara / Hagert, Elisabet / Chung, Kevin C / Farnebo, Simon / Boeckstyns, Michel / Herren, Daniel B / Marks, Miriam

    Plastic and reconstructive surgery

    2024  

    Abstract: Background: The aim of this systematic literature review was to describe current indications and interventions for revisions after trapeziometacarpal joint (TMJ) resection arthroplasty.: Methods: The literature search was conducted by an experienced ... ...

    Abstract Background: The aim of this systematic literature review was to describe current indications and interventions for revisions after trapeziometacarpal joint (TMJ) resection arthroplasty.
    Methods: The literature search was conducted by an experienced librarian in the Medline, EMBASE, Cochrane Library, Web of Science and Scopus databases. We included all articles that investigated any TMJ arthroplasty procedure in which the trapezium was completely resected and if any subsequent revision procedure including joint-related and soft-tissue surgeries was mentioned. Two independent reviewers selected the articles and were involved in data extraction.
    Results: Sixty-two articles reporting on 5,284 operated thumbs and 434 revision surgeries were included. We extracted 24 indications for revision and 31 revision techniques. Most revisions were performed because of subsidence/impingement of the first metacarpal bone (n=194 thumbs) followed by unspecified pain (n=53), metacarpophalangeal joint problems (n=28) and scaphotrapezoidal osteoarthritis (n=17). Eleven treatment strategies were found for subsidence/impingement of the first metacarpal, the most frequent being revision of the existing interposition using autologous tendon (n=46) and soft tissue interposition with distraction pinning (n=28).
    Conclusions: There are a wide variety of indications and even more surgical techniques described in the literature to treat persisting or recurrent pain after TMJ resection arthroplasty. Currently, there is no uniform treatment guideline available how to diagnose and treat such cases. Therefore, the results of this literature review will form the basis for a Delphi study aiming to develop recommendations for the diagnosis and treatment of persistent / recurrent pain after TMJ resection arthroplasty.
    Level of evidence: IV.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000011323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ultraviolet vision in anemonefish improves colour discrimination.

    Mitchell, Laurie J / Phelan, Amelia / Cortesi, Fabio / Marshall, N Justin / Chung, Wen-Sung / Osorio, Daniel C / Cheney, Karen L

    The Journal of experimental biology

    2024  Volume 227, Issue 7

    Abstract: In many animals, ultraviolet (UV) vision guides navigation, foraging, and communication, but few studies have addressed the contribution of UV signals to colour vision, or measured UV discrimination thresholds using behavioural experiments. Here, we ... ...

    Abstract In many animals, ultraviolet (UV) vision guides navigation, foraging, and communication, but few studies have addressed the contribution of UV signals to colour vision, or measured UV discrimination thresholds using behavioural experiments. Here, we tested UV colour vision in an anemonefish (Amphiprion ocellaris) using a five-channel (RGB-V-UV) LED display. We first determined that the maximal sensitivity of the A. ocellaris UV cone was ∼386 nm using microspectrophotometry. Three additional cone spectral sensitivities had maxima at ∼497, 515 and ∼535 nm. We then behaviourally measured colour discrimination thresholds by training anemonefish to distinguish a coloured target pixel from grey distractor pixels of varying intensity. Thresholds were calculated for nine sets of colours with and without UV signals. Using a tetrachromatic vision model, we found that anemonefish were better (i.e. discrimination thresholds were lower) at discriminating colours when target pixels had higher UV chromatic contrast. These colours caused a greater stimulation of the UV cone relative to other cone types. These findings imply that a UV component of colour signals and cues improves their detectability, which likely increases the prominence of anemonefish body patterns for communication and the silhouette of zooplankton prey.
    MeSH term(s) Animals ; Color ; Color Vision ; Retinal Cone Photoreceptor Cells/physiology ; Color Perception/physiology ; Perciformes ; Ultraviolet Rays
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.247425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Enigma of Carcinoids.

    Chung, Daniel C

    Gastroenterology

    2015  Volume 149, Issue 1, Page(s) 14–15

    MeSH term(s) Carcinoid Tumor/genetics ; Female ; Germ-Line Mutation ; Humans ; Intestinal Neoplasms/genetics ; Male ; Phosphotransferases (Alcohol Group Acceptor)/genetics
    Chemical Substances Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2015.05.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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