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Article ; Online: Adding a piece to the puzzle of Latin American blood donors and the potential risk of <i>Trypanosoma cruzi</i> transmission in Germany.

Ullrich, Julian / Guertler, Lutz / Quenzel, Ernst / Weinauer, Franz / Rößler, Dieter / Kalus, Ulrich / Pruß, Axel / Albajar-Viñas, Pedro / Pritsch, Michael

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 1014134

Abstract: Introduction: Chagas disease (CD) is caused by the ... Trypanosoma cruzi ... ( ... T. cruzi ... ) infection and has become a global health concern due to population mobility, as well as non-vectorial transmission routes. Several countries outside Latin ... ...

Abstract	Introduction: Chagas disease (CD) is caused by the Trypanosoma cruzi (T. cruzi) infection and has become a global health concern due to population mobility, as well as non-vectorial transmission routes. Several countries outside Latin America (LA) have reported transfusion-associated transmission, but equivalent studies in Germany are lacking. This study aims to collect first data on the risk of transfusion associated transmission as well as LA blood donors originating from CD endemic countries in Germany. Materials and methods: A total of 305 blood donors who were assumed to be at risk for T. cruzi infection were retrospectively (267) as well as prospectively (38) selected at German blood donation sites in Bavaria and Berlin, and all retrospectively as well as 27 prospectively selected were serologically screened. Prospective study subjects additionally filled out a questionnaire. Results: All samples tested seronegative for T. cuzi specific antibodies. Prospectively enrolled study subjects all had high socio-economic status including good education. Knowledge regarding CD was limited but willingness to donate frequently was high. Blood donation rates from donors born in LA countries seem to increase from 2015. Discussion: Although no transfusion associated T. cruzi infection has been documented in Germany, it has likely already happened unnoticed, or will do in the near future. Performing risk-adapted serology-based blood donor screenings in Germany could avoid transfusion-associated transmission events as well as contribute to active case detection. Moreover, larger, and ongoing studies are needed to increase the evidence base as well as end the neglect of CD in Germany.
MeSH term(s)	Humans ; Trypanosoma cruzi ; Blood Donors ; Latin America/epidemiology ; Retrospective Studies ; Prospective Studies ; Antibodies, Protozoan ; Chagas Disease ; Germany/epidemiology
Chemical Substances	Antibodies, Protozoan
Language	English
Publishing date	2022-10-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.1014134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The multidimensional comprehension of Chagas disease. Contributions, approaches, challenges and opportunities from and beyond the Information, Education and Communication field.

Sanmartino, Mariana / Forsyth, Colin J / Avaria, Andrea / Velarde-Rodriguez, Mar / Gómez I Prat, Jordi / Albajar-Viñas, Pedro

Memorias do Instituto Oswaldo Cruz

2022 Volume 117, Page(s) e200460

Abstract: Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as ... ...

Abstract	Chagas is a complex, multidimensional phenomenon in which political, economic, environmental, biomedical, epidemiological, psychological, and sociocultural factors intersect. Nonetheless, the hegemonic conceptualisation has long envisioned Chagas as primarily a biomedical question, while ignoring or downplaying the other dimensions, and this limited view has reinforced the disease's long neglect. Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness, increased case detection and follow-up, improved adherence to care, and integrated participation of various actors from multiple action levels. Information, Education, and Communication (IEC) initiatives have great potential for impact in the implementation of multidimensional programs of prevention and control successfully customised to the diverse and complex contexts where Chagas disease persists.
MeSH term(s)	Chagas Disease/prevention & control ; Communication ; Comprehension ; Humans
Language	English
Publishing date	2022-06-01
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760200460
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Article ; Online: Chagas and health promotion: dialogue inspired by the Curitiba Statement.

Sanmartino, Mariana / Avaria Saavedra, Andrea / Gómez I Prat, Jordi / Albajar-Viñas, Pedro

Health promotion international

2019 Volume 34, Issue Supplement_1, Page(s) i82–i91

Abstract: With the objective of providing an insightful analysis of Chagas disease in the world, the authors share their collective reflections about the current situation of this public health problem in: rural environments of Latin America; urban environments of ...

Abstract	With the objective of providing an insightful analysis of Chagas disease in the world, the authors share their collective reflections about the current situation of this public health problem in: rural environments of Latin America; urban environments of endemic and non-endemic areas everywhere; and, at a global level. A perspective based on the 'Democracy and Health Promotion' axis allowed the development of an innovative update about Chagas disease as a model of a complex socio-environmental health problem, with a key set of elements that goes beyond biomedical aspects. The authors created a dialogue between the fundamental elements of the Curitiba Statement on Health Promotion and Equity and crucial aspects of a reflection on the reality of Chagas disease today that at the same time challenges the different actors involved. With that reference, the call to promote a 'critical analysis of viabilities and opportunities for action, considering the potentialities and barriers imposed by the complexity of social movements in the present context of recedes and the loss of rights' was emphasized repeatedly. Finally, on the occasion of the recent creation of the Technical Group on Information, Education and Communication to control Chagas disease, WHO Department of Control of Neglected Tropical Diseases, the authors share reflections to propose an inclusive and transformative approach of health promotion-what we hope is a new horizon for people affected, directly and indirectly, by Chagas disease.
MeSH term(s)	Chagas Disease/prevention & control ; Female ; Health Promotion/methods ; Health Promotion/organization & administration ; Human Rights ; Humans ; Male ; Neglected Diseases/prevention & control ; Politics ; Socioeconomic Factors ; Trypanosoma cruzi
Language	English
Publishing date	2019-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1027448-0
ISSN	1460-2245 ; 0957-4824
ISSN (online)	1460-2245
ISSN	0957-4824
DOI	10.1093/heapro/day105
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Article ; Online: Advancing the treatment for Chagas' disease.

Albajar-Viñas, Pedro / Dias, João Carlos P

The New England journal of medicine

2014 Volume 370, Issue 20, Page(s) 1942–1943

MeSH term(s)	Chagas Disease/drug therapy ; Female ; Humans ; Male ; Nitroimidazoles/administration & dosage ; Triazoles/administration & dosage ; Trypanocidal Agents/therapeutic use
Chemical Substances	Nitroimidazoles ; Triazoles ; Trypanocidal Agents ; posaconazole (6TK1G07BHZ) ; benzonidazole (YC42NRJ1ZD)
Language	English
Publishing date	2014-06-19
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMe1403689
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Article ; Online: Community-based actions in consulates: a new paradigm for opportunities for systematic integration in Chagas disease detection.

Gómez I Prat, Jordi / Gregori, Maria Serrano / Guiu, Isabel Claveria / Choque, Estefa / Flores-Chavez, Maria Delmans / Molina, Israel / Zarzuela, Francesc / Sulleiro, Elena / Dehousse, Aurore / Albajar-Vinas, Pedro / Ouaarab, Hakima

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 847

Abstract: Research has shown that multidimensional approaches to Chagas disease (CD), integrating its biomedical and psycho-socio-cultural components, are successful in enhancing early access to diagnosis, treatment and sustainable follow-up.For the first time, a ... ...

Abstract	Research has shown that multidimensional approaches to Chagas disease (CD), integrating its biomedical and psycho-socio-cultural components, are successful in enhancing early access to diagnosis, treatment and sustainable follow-up.For the first time, a consulate was selected for a community-based CD detection campaign. Two different strategies were designed, implemented and compared between 2021 and 2022 at the Consulate General of Bolivia and a reference health facility in Barcelona open to all Bolivians in Catalonia.Strategy 1 consisted in CD awareness-raising activities before referring those interested to the reference facility for infectious disease screening. Strategy 2 offered additional in-situ serological CD screening. Most of the 307 participants were Bolivian women residents in Barcelona. In strategy 1, 73 people (35.8% of those who were offered the test) were screened and 19.2% of them were diagnosed with CD. Additionally, 53,4% completed their vaccination schedules and 28.8% were treated for other parasitic infections (strongyloidiasis, giardiasis, eosinophilia, syphilis). In strategy 2, 103 people were screened in-situ (100% of those who were offered the test) and 13.5% received a CD diagnosis. 21,4% completed their vaccination schedule at the reference health facility and 2,9% were referred for iron deficiency anemia, strongyloidiasis or chronic hepatitis C.The fact that the screening took place in an official workplace of representatives of their own country, together with the presence of community-based participants fueled trust and increased CD understanding. Each of the strategies assessed had different benefits. Opportunities for systematic integration for CD based on community action in consulates may enhance early access to diagnosis, care and disease prevention.
MeSH term(s)	Humans ; Female ; Strongyloidiasis ; Chagas Disease/diagnosis ; Chagas Disease/epidemiology ; Mass Screening ; Eosinophilia ; Community Participation
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08844-2
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Article ; Online: How people affected by Chagas disease have struggled with their negligence: history, associative movement and World Chagas Disease Day.

de Oliveira Junior, Wilson Alves / Gómez I Prat, Jordi / Albajar-Viñas, Pedro / Carrazzone, Cristina / Kropf, Simone Petraglia / Dehousse, Aurore / Camargo, Ana Maria de Arruda / Anselmi, Mariella / Barba, Maria Cristina Parada / Guiu, Isabel Claveria / Barros, Maria das Neves Dantas Silveira / Cavalvanti, Maria da Glória Melo / Correia, Cassandra Barros / Martins, Silvia Marinho

Memorias do Instituto Oswaldo Cruz

2022 Volume 117, Page(s) e220066

Abstract: It is well documented that Chagas disease (CD) can pose a public health problem to countries. As one of the World Health Organization Neglected Tropical Diseases undoubtedly calls for comprehensive healthcare, transcending a restricted biomedical ... ...

Abstract	It is well documented that Chagas disease (CD) can pose a public health problem to countries. As one of the World Health Organization Neglected Tropical Diseases undoubtedly calls for comprehensive healthcare, transcending a restricted biomedical approach. After more than a century since their discovery, in 1909, people affected by CD are still frequently marginalised and/or neglected. The aim of this article is to tell the story of their activism, highlighting key historical experiences and successful initiatives, from 1909 to 2019. The first association was created in 1987, in the city of Recife, Brazil. So far, thirty associations have been reported on five continents. They were created as independent non-profit civil society organisations and run democratically by affected people. Among the common associations' objectives, we notably find: increase the visibility of the affected; make their voice heard; build bridges between patients, health system professionals, public health officials, policy makers and the academic and scientific communities. The International Federation of Associations of People Affected by CD - FINDECHAGAS, created in 2010 with the input of the Americas, Europe and the Western Pacific, counts as one of the main responses to the globalisation of CD. Despite all the obstacles and difficulties encountered, the Federation has thrived, grown, and matured. As a result of this mobilisation along with the support of many national and international partners, in May 2019 the 72nd World Health Assembly decided to establish World Chagas Disease Day, on 14 April. The associative movement has increased the understanding of the challenges related to the disease and breaks the silence around Chagas disease, improving surveillance, and sustaining engagement towards the United Nations 2030 agenda.
MeSH term(s)	Anniversaries and Special Events ; Chagas Disease/epidemiology ; Chagas Disease/history ; Chagas Disease/prevention & control ; Global Health/history ; Global Health/statistics & numerical data ; History, 20th Century ; History, 21st Century ; Humans ; World Health Organization
Language	English
Publishing date	2022-07-13
Publishing country	Brazil
Document type	Historical Article ; Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760220066
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Article ; Online: The hidden Chagas disease burden in Europe.

Albajar-Vinas, P / Jannin, J

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2011 Volume 16, Issue 38

MeSH term(s)	Chagas Disease/prevention & control ; Chagas Disease/transmission ; Communicable Diseases, Emerging ; Cost of Illness ; Emigrants and Immigrants ; Europe/epidemiology ; Humans ; Sickness Impact Profile ; Trypanosoma cruzi/isolation & purification
Language	English
Publishing date	2011-09-22
Publishing country	Sweden
Document type	Editorial
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/ese.16.38.19975-en
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Article ; Online: Community-based approaches for malaria case management in remote communities in the Brazilian Amazon.

Prat, Jordi Gómez I / Morais, Paulo / Claret, Mercè / Badia, Pere / Fialho, Romeo R / Albajar-Vinas, Pedro / Villegas, Leopoldo / Ascaso, Carlos

Revista da Sociedade Brasileira de Medicina Tropical

2020 Volume 53, Page(s) e20200048

Abstract: Introduction: Malaria case management is a pivotal intervention in malaria elimination. However, many remote areas in Brazil still lack access to basic health services. This study describes a community-based approach (CBA) for malaria case management in ...

Abstract	Introduction: Malaria case management is a pivotal intervention in malaria elimination. However, many remote areas in Brazil still lack access to basic health services. This study describes a community-based approach (CBA) for malaria case management in the large remote area of the Jaú National Park (JNP), Amazonas, Brazil. Methods: In 2001, a general health CBA was initiated with a motor group (MG); a participative community health diagnosis (PCHD) was subsequently implemented between 2001 and 2005. In 2006, a CBA for malaria case management started with an expanded MG including all sectors with a stake in malaria control, from the local residents to the federal government. In 2008, community microscopists were selected and trained to diagnose hemoparasites. A full malaria strategy was implemented in 2009 with subsequent quality control follow-up. Results: Two educational materials were co-created with local communities. The MG identified malaria as a major health problem and the malaria MG planned the control activities. Ten communities selected a resident to become malaria microscopists, and ten solar-operated health centers were built. The number of slide readings increased from 923 in 2006 to 1,900 in 2009, while malaria infections decreased from 354 cases in 2005 to 20 cases in 2015. The excess time (≥ 48 hours) between first symptoms and diagnosis/treatment decreased from 68.9% of cases in 2005 to 14.3% in 2010. Conclusions: While many factors were likely involved in the reduction of malaria transmission in the JNP, the CBA played an important role in the sustained success of the initiative.
MeSH term(s)	Brazil ; Case Management ; Community Health Services/organization & administration ; Community-Based Participatory Research ; Humans ; Malaria/diagnosis ; Malaria/drug therapy ; Public Health ; Rural Population
Language	English
Publishing date	2020-09-23
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0048-2020
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Book ; Online: Advancing the treatment for Chagas' disease

Dias, João Carlos P / Albajar-Viñas, Pedro

2014

Abstract: Editorial ... ...

Abstract	Editorial Comment
Language	English
Publishing date	2014-05-01
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Quality Control in Screening for Infectious Diseases at Blood Banks. Rationale and Methodology.

Sáez-Alquezar, Amadeo / Albajar-Viñas, Pedro / Guimarães, André Valpassos / Corrêa, José Abol

EJIFCC

2015 Volume 26, Issue 4, Page(s) 278–285

Abstract: Quality control procedures are indispensable to ensure the reliability of the results provided by laboratories responsible for serological screening in blood banks. International recommendations on systems of quality management classify as a top ... ...

Abstract	Quality control procedures are indispensable to ensure the reliability of the results provided by laboratories responsible for serological screening in blood banks. International recommendations on systems of quality management classify as a top component the inclusion of two types of control: (a) internal quality control (IQC) and (b) external quality control (EQC). In EQC it is essential to have, at least, a monthly frequency of laboratory assessment. On the other hand, IQC involves the daily use of low-reactivity control sera, which should be systematically added in all run, carried out in the laboratory for each parameter. Through the IQC analysis some variations in the criteria of run acceptance and rejection may be revealed, but it is of paramount importance to ensure the previous definition of these criteria and even more importantly, the adherence to them; and that corresponds to the validation of analytical runs of each test. Since 2010 this has been, for instance, the experience of the PNCQ, developing external quality control programmes on serology for blood banks. These programmes use samples of lyophilized sera well-characterized for the reactivity related to the parameters used for the serological screening of blood donors. The programmes have used blind panels of six samples for monthly assessments. In the last 50 assessments, which involved 68 blood banks in Brazil, a significant number of instances of non-compliance were observed in all monthly assessments. These results provide strong support to the recommendation of systematic monthly assessments. () National Quality Control Programme (PNCQ).
Language	English
Publishing date	2015-11-27
Publishing country	Italy
Document type	Journal Article
ISSN	1650-3414
ISSN	1650-3414
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