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Article ; Online: Awake Total Neuromuscular Blockade as Experienced by Anesthesiologist Volunteers.

Schuller, Peter J / Voss, Logan J / Barry, John J

2024 Volume 140, Issue 2, Page(s) 336–338

MeSH term(s)	Humans ; Neuromuscular Blockade ; Anesthesiologists ; Wakefulness ; Anesthetics
Chemical Substances	Anesthetics
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004808
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Uk I Zs.133: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 199: Show issues

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Article ; Online: The general anaesthetic propofol prevents cerebrocortical potentiation in neocortical mouse brain slices.

Voss, Logan J

Brain research

2022 Volume 1792, Page(s) 148018

Abstract: Propofol is well known to cause amnesia independent of its sedative effect. Memory consolidation processes in the hippocampus have been proposed as a target - however the neural substrates for propofol's amnesic actions remain understudied and poorly ... ...

Abstract	Propofol is well known to cause amnesia independent of its sedative effect. Memory consolidation processes in the hippocampus have been proposed as a target - however the neural substrates for propofol's amnesic actions remain understudied and poorly described. In particular, the potential role of the cerebral cortex has not been investigated. As an in vitro experimental model of cortical memory consolidation, potentiated cerebral cortex evoked responses were generated in mouse neocortical slices using high frequency (20 Hz) stimulation to layer IV cortical grey matter or subcortical white matter. In separate experiments, slices were pretreated with propofol at two concentrations, 2 µg/mL and 4 µg/mL, to determine the effect of clinically relevant propofol levels on the potentiation response. Only grey matter stimulation induced a significant and lasting increase in cortical evoked potential amplitude in the drug-free condition. Propofol at 2 µg/mL completely inhibited cortical evoked response potentiation, while the 4 µg/mL concentration caused a small but significant depressant effect consequent to the high frequency stimulation. These findings support the hypothesis that propofol disrupts memory consolidation and actively facilitates memory decay in the cerebral cortex. The results further highlight the importance of the cerebral cortex in the early phase of long term memory consolidation.
MeSH term(s)	Anesthetics, General/pharmacology ; Anesthetics, Intravenous/pharmacology ; Animals ; Hippocampus ; Mice ; Neocortex ; Propofol/pharmacology
Chemical Substances	Anesthetics, General ; Anesthetics, Intravenous ; Propofol (YI7VU623SF)
Language	English
Publishing date	2022-07-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2022.148018
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Article ; Online: A systematic exploration of local network state space in neocortical mouse brain slices.

Voss, Logan J

Brain research

2022 Volume 1779, Page(s) 147784

Abstract: The ex vivo cortical slice is an extremely versatile preparation, but its utility ultimately depends on understanding its limitations and functional constraints. A question for experimentalists new to the field of cortical slice electrophysiology might ... ...

Abstract	The ex vivo cortical slice is an extremely versatile preparation, but its utility ultimately depends on understanding its limitations and functional constraints. A question for experimentalists new to the field of cortical slice electrophysiology might be - what are the different network dynamical states available to a cortical slice as a function of excitatory drive? The purpose of this study is to provide a coherent answer to this question, within the context of extracellularly recorded population field potentials. Cortical slices (400 µm) were prepared from adult male or female C57 mice. Evoked responses were recorded within cortical layer III/IV using extracellularly positioned metal electrodes. In the first part of the study, slice excitatory drive was increased by reducing the concentration of magnesium ions in the artificial cerebrospinal fluid - and the evoked responses categorized during the transition. In the second part, each of the identified functional states were explored in greater detail with tissue perfusion conditions and excitatory drive optimised for the requisite response state. As expected, rodent cortical slices did not generate spontaneous, persistent EEG-like field potential activity. However, distinct response states (spontaneous and evoked) characterized by intermittent population bursts could be differentiated as a function of excitatory drive. Each state reflected different modes of neocortical activation: "monosynaptic" responses were brief, non-propagating activations, reflecting an inhibited cortex with sensory processing blocked; polysynaptic and epileptiform activity propagated intra-cortically, the latter reflecting a hyperactivated, hypersynchronous "seizing" cortex. Polysynaptic activity most closely resembled sensory "up states" associated with intracortical sensory processing. Understanding the functional distinction between the different cortical slice response states is the starting point for designing experiments that maximise the utility of this ex vivo model. The results and descriptions in this study should help slice experimentalists less experienced in the nuances of cortical slice neurophysiology to make informed choices about how to tailor the parameters of the model to suit the specific aims of their research.
MeSH term(s)	Animals ; Electrophysiological Phenomena/physiology ; Evoked Potentials/physiology ; Female ; In Vitro Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Neocortex/physiology
Language	English
Publishing date	2022-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2022.147784
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Zs.A 161: Show issues

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Article ; Online: Relationship between artificial cerebrospinal fluid oxygenation, slice depth and tissue performance in submerged brain slice experiments.

Voss, Logan J

Neuroscience letters

2020 Volume 736, Page(s) 135275

Abstract: One of the challenges for slice experimentalists is achieving optimal tissue oxygenation. One area that has not been addressed in submerged slices is the relationship between oxygenation of the artificial cerebrospinal fluid, slice depth and tissue ... ...

Abstract	One of the challenges for slice experimentalists is achieving optimal tissue oxygenation. One area that has not been addressed in submerged slices is the relationship between oxygenation of the artificial cerebrospinal fluid, slice depth and tissue performance. In this study we varied the depth of slice submersion, measured the oxygen profile in the solution and related these to slice activity in the form of spontaneous population events. While the oxygen profile curves were qualitatively similar (peaking approximately 1.7 mm below the solution surface), the average oxygen content was highly variable and correlated strongly with slice depth (R
MeSH term(s)	Animals ; Brain ; Cerebrospinal Fluid/chemistry ; In Vitro Techniques ; Mice ; Oxygen/analysis
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-07-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2020.135275
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Zs.A 1166: Show issues

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Article ; Online: Tissue oxygen partial pressure as a viability metric for ex vivo brain tissue slices.

Voss, Logan J / Steyn-Ross, D Alistair

Journal of neuroscience methods

2023 Volume 396, Page(s) 109932

Abstract: Background: Despite the prevalent use of the ex vivo brain slice preparation in neurophysiology research, a reliable method for judging tissue viability - and thus suitability of a slice for inclusion in an experiment - is lacking. The utility of ... ...

Abstract	Background: Despite the prevalent use of the ex vivo brain slice preparation in neurophysiology research, a reliable method for judging tissue viability - and thus suitability of a slice for inclusion in an experiment - is lacking. The utility of indirect electrophysiological measures of tissue health is model-specific and needs to be used cautiously. In this study, we verify a more direct test of slice viability, based on tissue oxygen consumption rate. New method: We hypothesised that the minimum intra-slice partial pressure of oxygen (pO Results: Tissue pO Comparison with existing methods: While measurement of tissue oxygen levels and oxygen consumption is not new, intra-tissue pO Conclusion: The results confirm that tissue oxygen minimum pO
Language	English
Publishing date	2023-07-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282721-9
ISSN	1872-678X ; 0165-0270
ISSN (online)	1872-678X
ISSN	0165-0270
DOI	10.1016/j.jneumeth.2023.109932
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Zs.A 1486: Show issues

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Article ; Online: Electrophysiological field potential identification of an intact GABAergic system in mouse cortical slices.

Voss, Logan J / Garcia, Violet

Brain research

2021 Volume 1756, Page(s) 147295

Abstract: In brain slice experiments there's currently no validated electrophysiological method for differentiating viability between GABAergic and glutamatergic cell populations. Here we investigated the neurophysiology of high frequency field potential activity - ...

Abstract	In brain slice experiments there's currently no validated electrophysiological method for differentiating viability between GABAergic and glutamatergic cell populations. Here we investigated the neurophysiology of high frequency field potential activity - and its utility for probing the functional state of the GABAergic system in brain slices. Field potentials were recorded from mouse cortical slices exposed to 50 mM potassium ("elevated-K") and the induced high frequency (>20 Hz) response characterized pharmacologically. The elevated-K responses were also related to the high frequency activity imbedded in no-magnesium seizure-like events (SLE) from the same slices. The elevated-K response, comprising a transient burst of high frequency activity, was strongly GABA
MeSH term(s)	Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Brain/drug effects ; Brain/physiopathology ; Electrophysiological Phenomena/drug effects ; Mice, Inbred C57BL ; Neurons/drug effects ; Picrotoxin/pharmacology ; Seizures/drug therapy ; Seizures/physiopathology ; gamma-Aminobutyric Acid/pharmacology ; Mice
Chemical Substances	Picrotoxin (124-87-8) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2021-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2021.147295
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Zs.A 161: Show issues

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Article ; Online: Seeing is Believing: Chasing Sevoflurane Vapor Trails.

Termaat, Jonathan / Tighe, Rachael / Kopf, Larissa / Voss, Logan J

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2023 Volume 39, Issue 2, Page(s) 235–239

Abstract: Purpose: Sevoflurane is an inhalational general anesthetic that has been used recently to treat chronic, painful lesions, reportedly supporting analgesia and wound healing. The potential for repeated exposure to off-gassed sevoflurane vapor, especially ... ...

Abstract	Purpose: Sevoflurane is an inhalational general anesthetic that has been used recently to treat chronic, painful lesions, reportedly supporting analgesia and wound healing. The potential for repeated exposure to off-gassed sevoflurane vapor, especially outside the air-conditioned operating theatre environment, is of some concern. Design: This paper explores the qualitative and quantitative pathing of off-gassed sevoflurane from a topically applied liquid source. Methods: Using a small, unventilated test-box (total volume 0.5 m Findings: In keeping with its higher density than air, sevoflurane vapor was seen to "waterfall" from the liquid source and accumulate in the bottom of the test-box. Sevoflurane vapor concentration was minimal above the liquid source. When extrapolated to a larger (unventilated) room, we estimate that the sevoflurane concentration would be less than 10 ppm one centimetre above the liquid pool. With vacuum extraction, these levels would be even lower. Conclusions: Due to sevoflurane's tendency to accumulate on the floor, it is concluded that topical application of liquid sevoflurane posses virtually no risk to off-gas exposure in unventilated spaces.
MeSH term(s)	Sevoflurane ; Methyl Ethers/analysis ; Anesthetics, Inhalation/analysis ; Operating Rooms
Chemical Substances	Sevoflurane (38LVP0K73A) ; Methyl Ethers ; Anesthetics, Inhalation
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2023.07.019
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Zs.A 2458: Show issues

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Article ; Online: Non-NMDA Mechanisms of Analgesia in Ketamine Analogs.

Voss, Logan J / Harvey, Martyn G / Sleigh, James W

Frontiers in pain research (Lausanne, Switzerland)

2022 Volume 3, Page(s) 827372

Abstract: Despite 50 years of clinical use and experimental endeavor the anesthetic, analgesic, and psychomimetic effects of ketamine remain to be fully elucidated. While NMDA receptor antagonism has been long held as ketamine's fundamental molecular action, ... ...

Abstract	Despite 50 years of clinical use and experimental endeavor the anesthetic, analgesic, and psychomimetic effects of ketamine remain to be fully elucidated. While NMDA receptor antagonism has been long held as ketamine's fundamental molecular action, interrogation of bespoke ketamine analogs with known absent NMDA binding, yet profound anesthetic and analgesia fingerprints, suggests alternative targets are responsible for these effects. Herein we describe experimental findings utilizing such analogs as probes to explore ketamine-based analgesic molecular targets. We have focused on two-pore potassium leak channels, identifying TWIK channels as a rational target to pursue further. While the totality of ketamine's mechanistic action is yet to be fully determined, these investigations raise the intriguing prospect of separating out analgesia and anesthetic effects from ketamine's undesirable psychomimesis-and development of more specific analgesic medications.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-561X
ISSN (online)	2673-561X
DOI	10.3389/fpain.2022.827372
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Article ; Online: A Metabolic Mechanism for Anaesthetic Suppression of Cortical Synaptic Function in Mouse Brain Slices-A Pilot Investigation.

Voss, Logan J / Sleigh, Jamie W

International journal of molecular sciences

2020 Volume 21, Issue 13

Abstract: Regulation of synaptically located ionotropic receptors is thought to be the main mechanism by which anaesthetics cause unconsciousness. An alternative explanation, which has received much less attention, is that of primary anaesthetic disruption of ... ...

Abstract	Regulation of synaptically located ionotropic receptors is thought to be the main mechanism by which anaesthetics cause unconsciousness. An alternative explanation, which has received much less attention, is that of primary anaesthetic disruption of brain metabolism via suppression of mitochondrial proteins. In this pilot study in mouse cortical slices, we investigated the effect of disrupting cellular metabolism on tissue oxygen handling and cortical population seizure-like event (SLE) activity, using the mitochondrial complex I inhibitor rotenone, and compared this to the effects of the general anaesthetics sevoflurane, propofol and ketamine. Rotenone caused an increase in tissue oxygen (98 mmHg to 157 mmHg (
MeSH term(s)	Anesthetics, Inhalation/pharmacology ; Animals ; Brain/drug effects ; Electron Transport Complex I/antagonists & inhibitors ; Electron Transport Complex I/drug effects ; Electron Transport Complex I/metabolism ; Female ; Ketamine/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Oxygen/metabolism ; Pilot Projects ; Propofol/pharmacology ; Rotenone/metabolism ; Rotenone/pharmacology ; Sevoflurane/pharmacology
Chemical Substances	Anesthetics, Inhalation ; Rotenone (03L9OT429T) ; Sevoflurane (38LVP0K73A) ; Ketamine (690G0D6V8H) ; Electron Transport Complex I (EC 7.1.1.2) ; Oxygen (S88TT14065) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2020-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21134703
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Article ; Online: Determination of Krogh Coefficient for Oxygen Consumption Measurement from Thin Slices of Rodent Cortical Tissue Using a Fick's Law Model of Diffusion.

Steyn-Ross, D Alistair / Steyn-Ross, Moira L / Sleigh, Jamie W / Voss, Logan J

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: To investigate the impact of experimental interventions on living biological tissue, ex vivo rodent brain slices are often used as a more controllable alternative to a live animal model. However, for meaningful results, the biological sample must be ... ...

Abstract	To investigate the impact of experimental interventions on living biological tissue, ex vivo rodent brain slices are often used as a more controllable alternative to a live animal model. However, for meaningful results, the biological sample must be known to be healthy and viable. One of the gold-standard approaches to identifying tissue viability status is to measure the rate of tissue oxygen consumption under specific controlled conditions. Here, we work with thin (400 μm) slices of mouse cortical brain tissue which are sustained by a steady flow of oxygenated artificial cerebralspinal fluid (aCSF) at room temperature. To quantify tissue oxygen consumption (
MeSH term(s)	Animals ; Mice ; Rodentia ; Diffusion ; Oxygen ; Respiratory Function Tests ; Oxygen Consumption
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076450
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