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Article ; Online: A mean first passage time genome rearrangement distance.

Francis, Andrew R / Wynn, Henry P

2020 Volume 80, Issue 6, Page(s) 1971–1992

Abstract: This paper introduces a new way to define a genome rearrangement distance, using the concept of mean first passage time from probability theory. Crucially, this distance provides a genuine metric on genome space. We develop the theory and introduce a ... ...

Abstract	This paper introduces a new way to define a genome rearrangement distance, using the concept of mean first passage time from probability theory. Crucially, this distance provides a genuine metric on genome space. We develop the theory and introduce a link to a graph-based zeta function. The approach is very general and can be applied to a wide variety of group-theoretic models of genome evolution.
MeSH term(s)	Bacteria/genetics ; Chromosome Inversion ; Evolution, Molecular ; Gene Rearrangement ; Genome ; Genome, Bacterial ; Likelihood Functions ; Markov Chains ; Mathematical Concepts ; Models, Genetic ; Phylogeny ; Probability Theory ; Time Factors
Language	English
Publishing date	2020-04-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187101-8
ISSN	1432-1416 ; 0303-6812
ISSN (online)	1432-1416
ISSN	0303-6812
DOI	10.1007/s00285-020-01487-w
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Article ; Online: Geographic diffusion of digital mammography in the United States.

Wiese, Daniel / Stroup, Antoinette M / Islami, Farhad / Mattes, Molly / Baylor, Emma / Boscoe, Francis P / Henry, Kevin A

Cancer

2023 Volume 129, Issue 14, Page(s) 2144–2151

Abstract: Background: Examining temporal and spatial diffusion of a new technology, such as digital mammography, can provide important insights into potential disparities associated with access to new medical technologies and how quickly these technologies are ... ...

Abstract	Background: Examining temporal and spatial diffusion of a new technology, such as digital mammography, can provide important insights into potential disparities associated with access to new medical technologies and how quickly these technologies are adopted. Although digital mammography is currently a standard technology in the United States for breast cancer screening, its adoption and geographic diffusion, as medical facilities transitioned from film to digital units, has not been explored well. Methods: This study evaluated the geographic diffusion of digital mammography facilities from 2001 to 2014 in the contiguous United States (excluding Alaska and Hawaii) and estimated the geographic accessibility to this new technology for women aged ≥45 years at the census tract level within a 20-minute drivetime by population density, rural/urban residence, and race/ethnicity. The number of mammography units by technology type (film or digital) and density per 10,000 women were also summarized. Results: The adoption of digital mammography advanced first in densely populated regions and last in remote rural areas. Overall, proportion of digital mammography units increased from 1.4% in 2001 to 94.6% in 2014, but since 2008, there was a decline in density of units from 2.31 per 10,000 women aged ≥45 years to 1.97 in 2014. In 2014, approximately 87% of women aged ≥45 years in the contiguous United States had accessibility to digital mammography, but this proportion was substantially lower for Native American women (67%) and rural residents (32%). Conclusion: Understanding the diffusion of and accessibility to digital mammography may help predict future medical technology diffusion and assess its role in geographic differences in cancer diagnosis and treatment.
MeSH term(s)	United States/epidemiology ; Female ; Humans ; Mass Screening ; Mammography ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/epidemiology ; Early Detection of Cancer ; Hawaii ; Health Services Accessibility
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.34774
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Uh III Zs.146: Show issues

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Article ; Online: Remote Acute Assessment of Cardiac Patients Post-Acute Coronary Syndrome (TELE-ACS): A Randomized Controlled Trial.

Alshahrani, Nasser S / Hartley, Adam / Howard, James / Hajhosseiny, Reza / Khawaja, Saud / Seligman, Henry / Akbari, Tamim / Alharbi, Badr A / Bassett, Paul / Al-Lamee, Rasha / Francis, Darrel / Kaura, Amit / Kelshiker, Mihir A / Peters, Nicholas S / Khamis, Ramzi

Journal of the American College of Cardiology

2024

Abstract: ... rate of readmission over 6-months (hazard ratio [HR] 0.24; 95% confidence interval [CI] 0.13 to 0.44; p ...

Abstract	Background: Telemedicine programmes can provide remote diagnostic information to aid clinical decision that could optimize care and reduce unplanned re-admissions post ACS. Objectives: TELE-ACS is a randomized controlled trial which aims to compare a telemedicine-based approach versus standard care in patients following ACS. Methods: Patients were suitable for inclusion with at least one cardiovascular risk factor and presenting with ACS and were randomized (1:1) prior to discharge. The primary outcome was time to first readmission at 6-months. Secondary outcomes included emergency department (ED) visits, major adverse cardiovascular events and patient reported symptoms. The primary analysis was performed according to intention to treat. The trial was registered on ClinicalTrial.gov (NCT05015634). Results: 337 patients were randomized from January 2022 to April 2023, with a 3.6% drop-out rate. The mean age was 58.1 years. There was a reduced rate of readmission over 6-months (hazard ratio [HR] 0.24; 95% confidence interval [CI] 0.13 to 0.44; p < 0.001) and ED attendance (HR 0.59; 95% CI 0.59; 95% CI 0.40 to 0.89) in the telemedicine arm, and fewer unplanned coronary revascularizations (3% in telemedicine arm versus 9% in standard therapy arm). The occurrence of chest pain (9% versus 24%), breathlessness (21% versus 39%) and dizziness (6% versus 18%) at 6-months was lower in the telemedicine group. Conclusions: The TELE-ACS study has shown that a telemedicine-based approach for the management of patients following ACS was associated with a reduction in hospital readmission, ED visits, unplanned coronary revascularization and patient reported symptoms.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2024.03.398
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Tremor Assessment in Robot-Assisted Microlaryngeal Surgery Using Computer Vision-Based Tool Tracking.

Cho, Sue M / Joo, Henry H / Golla, Pranathi / Sahu, Manish / Shankar, Ahjeetha / Trakimas, Danielle R / Creighton, Francis / Akst, Lee / Taylor, Russell H / Galaiya, Deepa

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2024

Abstract: ... to freehand instruments (P = .012). Normalized path length significantly decreased with robot-assisted ... compared to freehand trials (P = .001). For the scissors, robot-assisted trials resulted in a significant ... decrease in absolute tremor bandpower (P = .002) and normalized path length (P < .001). For the graspers ...

Abstract	Objective: Use microscopic video-based tracking of laryngeal surgical instruments to investigate the effect of robot assistance on instrument tremor. Study design: Experimental trial. Setting: Tertiary Academic Medical Center. Methods: In this randomized cross-over trial, 36 videos were recorded from 6 surgeons performing left and right cordectomies on cadaveric pig larynges. These recordings captured 3 distinct conditions: without robotic assistance, with robot-assisted scissors, and with robot-assisted graspers. To assess tool tremor, we employed computer vision-based algorithms for tracking surgical tools. Absolute tremor bandpower and normalized path length were utilized as quantitative measures. Wilcoxon rank sum exact tests were employed for statistical analyses and comparisons between trials. Additionally, surveys were administered to assess the perceived ease of use of the robotic system. Results: Absolute tremor bandpower showed a significant decrease when using robot-assisted instruments compared to freehand instruments (P = .012). Normalized path length significantly decreased with robot-assisted compared to freehand trials (P = .001). For the scissors, robot-assisted trials resulted in a significant decrease in absolute tremor bandpower (P = .002) and normalized path length (P < .001). For the graspers, there was no significant difference in absolute tremor bandpower (P = .4), but there was a significantly lower normalized path length in the robot-assisted trials (P = .03). Conclusion: This study demonstrated that computer-vision-based approaches can be used to assess tool motion in simulated microlaryngeal procedures. The results suggest that robot assistance is capable of reducing instrument tremor.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1002/ohn.714
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Article ; Online: Identifying variation in the cost of abdominally based breast reconstruction in the UK.

Kwasnicki, Richard M / Irukulla, Meghna / Che Bakri, Nur Amalina / Whiteman, Elena / Gardiner, Matthew / Dunne, Jonathan / Henry, Francis P / Gokani, Vimal / Hunter, Judith E / Williams, Georgina / Wood, Simon H

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 88, Page(s) 466–472

Abstract: ... per case. Units with ERAS had significantly lower total costs than those without (p < 0.05).: Conclusion ...

Abstract	Aims: To understand variation in the cost of autologous breast reconstruction in the UK, including identifying key areas of cost variability, differences between and within units and the impact of enhanced recovery protocols (ERAS). Methods: A micro-costing study was designed based on the responses to a national survey of clinical preferences completed by the majority of plastic surgeons and anaesthetists involved in the UK. Detailed costs were estimated from macro elements such as ward and theatre running costs, down to that of surgical meshes, anaesthetic drugs and flap monitoring devices. Results: The largest variation in cost arose from postoperative location and length of stay, preoperative imaging and flap monitoring strategies. Plastic surgeon costs varied from £1282 to £3141, whereas anaesthetic costs were between £32 and £151 (not including salary). Estimated cost variation within units was up to £893 per case. Units with ERAS had significantly lower total costs than those without (p < 0.05). Conclusion: This study reveals significant cost variation in breast reconstruction in the UK based on clinician preferences. Many areas of practice driving this variation lack strong evidence of any clinical advantage. The total cost of a deep inferior epigastric perforator in the majority, if not all units, likely surpasses the national tariff for reimbursement, particularly when considering additional resource demand for immediate and bilateral breast reconstruction, as well as future symmetrisation procedures. Whilst units should look to streamline costs through ERAS, there should also be a realistic tariff that promotes excellent care.
MeSH term(s)	Humans ; Female ; Mammaplasty/methods ; Surgical Flaps/surgery ; United Kingdom ; Perforator Flap/surgery ; Breast Neoplasms/surgery ; Epigastric Arteries/surgery ; Retrospective Studies
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.11.025
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Article ; Online: Preserving a patent DIEP pedicle to facilitate salvage breast reconstruction with a second free flap: A case report.

Reissis, Dimitris / Butler, Daniel P / Henry, Francis P / Wood, Simon H

Microsurgery

2018 Volume 38, Issue 5, Page(s) 563–566

Abstract: Surgeons performing free flap breast reconstruction need to have a range of techniques in their armamentarium to successfully salvage cases of flap failure. We present a case of 47-year-old patient who suffered near-total right breast deep inferior ... ...

Abstract	Surgeons performing free flap breast reconstruction need to have a range of techniques in their armamentarium to successfully salvage cases of flap failure. We present a case of 47-year-old patient who suffered near-total right breast deep inferior epigastric perforator (DIEP) flap failure 3 days post-bilateral immediate breast reconstruction with DIEP flaps. At debridement, the DIEP pedicle was noted to be patent with preserved perfusion to a small segment of tissue around the origin of the pedicle. This tissue and the DIEP pedicle itself were therefore preserved to facilitate subsequent breast reconstruction using stacked transverse upper gracilis flaps anastomosed end-to-end to the original DIEP pedicle. Post-operatively, both flaps remained viable with no further complications and symmetrical aesthetic result maintained at 2 months follow-up post-salvage procedure. This case emphasizes the importance of exercising caution during initial debridement for free flap failure to preserve viable tissue in the flap and pedicle, particularly in circumstances where vascular flow in the pedicle is maintained, to facilitate successful salvage reconstruction.
MeSH term(s)	Anastomosis, Surgical/methods ; Autografts ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/surgery ; Debridement/adverse effects ; Debridement/methods ; Epigastric Arteries ; Female ; Follow-Up Studies ; Free Tissue Flaps/surgery ; Gracilis Muscle/surgery ; Graft Survival ; Humans ; Mammaplasty/methods ; Mastectomy/rehabilitation ; Middle Aged ; Perforator Flap/adverse effects ; Perforator Flap/blood supply ; Physical Appearance, Body ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Treatment Outcome
Language	English
Publishing date	2018-01-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	605524-2
ISSN	1098-2752 ; 0738-1085
ISSN (online)	1098-2752
ISSN	0738-1085
DOI	10.1002/micr.30292
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Article: Mottling as a prognosis marker in cardiogenic shock.

Merdji, Hamid / Bataille, Vincent / Curtiaud, Anais / Bonello, Laurent / Roubille, François / Levy, Bruno / Lim, Pascal / Schneider, Francis / Khachab, Hadi / Dib, Jean-Claude / Seronde, Marie-France / Schurtz, Guillaume / Harbaoui, Brahim / Vanzetto, Gerald / Marchand, Severine / Gebhard, Caroline Eva / Henry, Patrick / Combaret, Nicolas / Marchandot, Benjamin /

Lattuca, Benoit / Biendel, Caroline / Leurent, Guillaume / Gerbaud, Edouard / Puymirat, Etienne / Bonnefoy, Eric / Meziani, Ferhat / Delmas, Clément

Annals of intensive care

2023 Volume 13, Issue 1, Page(s) 80

Abstract: ... respiratory support was significantly higher in patients with mottling (50.2% vs. 30.1%, p < 0.001) and ... likewise for the need for renal replacement therapy (19.9% vs. 12.4%, p = 0.09). However, the need ... a higher length of stay (19 vs. 16 days, p = 0.033), a higher 30-day mortality rate (31% vs. 23.3%, p = 0 ...

Abstract	Aims: Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all etiologies. Methods and results: FRENSHOCK is a prospective multicenter observational registry conducted in French critical care units between April and October, 2016. Among the 772 enrolled patients (mean age 65.7 ± 14.9 years; 71.5% male), 660 had skin mottling assessed at admission (85.5%) with almost 39% of patients in cardiogenic shock presenting mottling. The need for invasive respiratory support was significantly higher in patients with mottling (50.2% vs. 30.1%, p < 0.001) and likewise for the need for renal replacement therapy (19.9% vs. 12.4%, p = 0.09). However, the need for mechanical circulatory support was similar in both groups. Patients with mottling at admission presented a higher length of stay (19 vs. 16 days, p = 0.033), a higher 30-day mortality rate (31% vs. 23.3%, p = 0.031), and also showed significantly higher mortality at 1-year (54% vs. 42%, p = 0.003). The subgroup of patients in whom mottling appeared during the first 24 h after admission had the worst prognosis at 30 days. Conclusion: Skin mottling at admission in patients with cardiogenic shock was statistically associated with prolonged length of stay and poor outcomes. As a perfusion-targeted resuscitation parameter, mottling is a simple, clinical-based approach and may thus help to improve and guide immediate goal-directed therapy to improve cardiogenic shock patients' outcomes.
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2617094-2
ISSN	2110-5820
ISSN	2110-5820
DOI	10.1186/s13613-023-01175-0
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Article: Subcutaneous sarcoidosis (Darier-Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature.

Youn, Paul / Francis, Roslyn J / Preston, Henry / Lake, Fiona

Respirology case reports

2022 Volume 10, Issue 5, Page(s) e0949

Abstract: Cutaneous manifestations of sarcoidosis are common, but subcutaneous nodules are rare, originally described in 1904 by Darier and Roussy and thought to represent isolated skin disease. We present a 61-year-old male who presented with 3 months of ... ...

Abstract	Cutaneous manifestations of sarcoidosis are common, but subcutaneous nodules are rare, originally described in 1904 by Darier and Roussy and thought to represent isolated skin disease. We present a 61-year-old male who presented with 3 months of subcutaneous nodules on the forearms and knees. Biopsy confirmed sarcoidosis. An [F-18] fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) showed confluent uptake in the skin of forearms and knees, along with thighs and buttocks, mediastinal, hilar and upper abdominal lymph nodes, and multiple bones. He was well and treated with hydroxychloroquine 400 mg/day. The nodules resolved and a repeat FDG PET/CT at 5 months showed a significant decrease in the uptake at all involved sites. Although a PET scan can demonstrate extensive disease in a patient presenting with subcutaneous nodules, the literature suggests prognosis is good and treatment should start simply with the least toxic approach, such as with hydroxychloroquine therapy.
Language	English
Publishing date	2022-04-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.949
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Article ; Online: The west Africa Ebola virus disease outbreak: 10 years on.

Kyobe Bosa, Henry / Kamara, Neema / Aragaw, Merawi / Wayengera, Misaki / Talisuna, Ambrose / Bangura, James / Mwebesa, Henry G / Katoto, Patrick D M C / Agyarko, Robert Kwame / Ihekweazu, Chikwe / Bousso, Abdoulaye / Joshua, Obasanya / Douno, Moussa / Fallah, Mosoka P / Squire, James Sylvester / Nyenswah, Tolbert Geewleh / Nelson, Thelma V / Maeda, Justin / Raji, Tajudeen /

Traoré, Mamadou Souncalo / Olu, Olushayo Oluseun / Tegegn Woldemariam, Yonas / Djoudalbaye, Benjamin / Ngongo, Ngashi / Kasolo, Francis Chisaka / Mbala, Placide / Fall, Ibrahima Socé / Ouma, Ahmed Ogwell / Kaseya, Jean / Aceng, Jane Ruth

The Lancet. Global health

2024

Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(24)00129-3
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Article ; Online: The effects of age, sex, and hot carcass weight on cooked lamb flavor and off-flavor in four muscle cuts.

Garza, Horacio / Jaborek, Jerad R / Zerby, Henry N / Moeller, Steven J / Wick, Macdonald P / Fluharty, Francis L / England, Eric M / Garcia, Lyda G

Translational animal science

2021 Volume 5, Issue 3, Page(s) txab083

Abstract: The present study used 48 lambs originating from three different locations in the Western United States (16 lambs per location; 8 ewes and 8 wethers per location). Each consisting of similar breed composition (Suffolk cross) that were selected to ... ...

Abstract	The present study used 48 lambs originating from three different locations in the Western United States (16 lambs per location; 8 ewes and 8 wethers per location). Each consisting of similar breed composition (Suffolk cross) that were selected to represent weight by age at harvest treatments: light weight carcasses at 5 mo (
Language	English
Publishing date	2021-05-10
Publishing country	England
Document type	Journal Article
ISSN	2573-2102
ISSN (online)	2573-2102
DOI	10.1093/tas/txab083
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