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Article ; Online: Genomic mechanisms controlling renal vitamin D metabolism.

Meyer, Mark B / Pike, J Wesley

The Journal of steroid biochemistry and molecular biology

2023 Volume 228, Page(s) 106252

Abstract: Vitamin D metabolism centers on regulation in the kidney of CYP27B1 induction by PTH, suppression by FGF23 and 1,25(OH) ...

Abstract	Vitamin D metabolism centers on regulation in the kidney of CYP27B1 induction by PTH, suppression by FGF23 and 1,25(OH)
MeSH term(s)	Mice ; Animals ; Calcitriol/pharmacology ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism ; Kidney/metabolism ; Genomics ; Receptors, Calcitriol/metabolism ; Vitamin D/metabolism
Chemical Substances	Calcitriol (FXC9231JVH) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Receptors, Calcitriol ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106252
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Article: Molecular insights into mineralotropic hormone inter-regulation.

Pike, J Wesley / Lee, Seong Min / Meyer, Mark B

Frontiers in endocrinology

2023 Volume 14, Page(s) 1213361

Abstract: The regulation of mineral homeostasis involves the three mineralotropic hormones PTH, FGF23 and 1,25-dihydroxyvitamin ... ...

Abstract	The regulation of mineral homeostasis involves the three mineralotropic hormones PTH, FGF23 and 1,25-dihydroxyvitamin D
MeSH term(s)	Humans ; Calcitriol/metabolism ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; Parathyroid Hormone/metabolism ; Kidney/metabolism ; Calcium/metabolism
Chemical Substances	Calcitriol (FXC9231JVH) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Parathyroid Hormone ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1213361
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Article ; Online: New Approaches to Assess Mechanisms of Action of Selective Vitamin D Analogues.

Pike, John Wesley / Meyer, Mark B

International journal of molecular sciences

2021 Volume 22, Issue 22

Abstract: Recent studies of transcription have revealed an advanced set of overarching principles that govern vitamin D action on a genome-wide scale. These tenets of vitamin D transcription have emerged as a result of the application of now well-established ... ...

Abstract	Recent studies of transcription have revealed an advanced set of overarching principles that govern vitamin D action on a genome-wide scale. These tenets of vitamin D transcription have emerged as a result of the application of now well-established techniques of chromatin immunoprecipitation coupled to next-generation DNA sequencing that have now been linked directly to CRISPR-Cas9 genomic editing in culture cells and in mouse tissues in vivo. Accordingly, these techniques have established that the vitamin D hormone modulates sets of cell-type specific genes via an initial action that involves rapid binding of the VDR-ligand complex to multiple enhancer elements at open chromatin sites that drive the expression of individual genes. Importantly, a sequential set of downstream events follows this initial binding that results in rapid histone acetylation at these sites, the recruitment of additional histone modifiers across the gene locus, and in many cases, the appearance of H3K36me3 and RNA polymerase II across gene bodies. The measured recruitment of these factors and/or activities and their presence at specific regions in the gene locus correlate with the emerging presence of cognate transcripts, thereby highlighting sequential molecular events that occur during activation of most genes both in vitro and in vivo. These features provide a novel approach to the study of vitamin D analogs and their actions in vivo and suggest that they can be used for synthetic compound evaluation and to select for novel tissue- and gene-specific features. This may be particularly useful for ligand activation of nuclear receptors given the targeting of these factors directly to genetic sites in the nucleus.
MeSH term(s)	Acetylation ; Animals ; Chromatin/chemistry ; Chromatin/metabolism ; Enhancer Elements, Genetic ; Epigenesis, Genetic ; Histones/genetics ; Histones/metabolism ; Humans ; Mice ; Protein Binding ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Signal Transduction ; Transcription, Genetic ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism ; Vitamin D/pharmacology
Chemical Substances	Chromatin ; Histones ; RNA, Messenger ; Receptors, Calcitriol ; VDR protein, human ; Vitamin D (1406-16-2) ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2021-11-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222212352
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Article ; Online: Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D

Lee, Seong Min / Meyer, Mark B / Benkusky, Nancy A / Pike, J Wesley

The Journal of steroid biochemistry and molecular biology

2023 Volume 232, Page(s) 106335

Abstract: Phosphate (P) is an essential element involved in various biological actions, such as bone integrity, energy production, cell signaling and molecular component. P homeostasis is modulated by 4 main tissues; intestine, kidney, bone, and parathyroid gland, ...

Abstract	Phosphate (P) is an essential element involved in various biological actions, such as bone integrity, energy production, cell signaling and molecular component. P homeostasis is modulated by 4 main tissues; intestine, kidney, bone, and parathyroid gland, where 1,25-dihydroxyvitamin D
MeSH term(s)	Mice ; Animals ; Calcitriol/pharmacology ; Calcitriol/metabolism ; Phosphates ; Transcriptome ; Genome-Wide Association Study ; Vitamin D/pharmacology ; Vitamin D/metabolism ; 24,25-Dihydroxyvitamin D 3 ; Calcium/metabolism
Chemical Substances	1,25-dihydroxyvitamin D (66772-14-3) ; Calcitriol (FXC9231JVH) ; Phosphates ; Vitamin D (1406-16-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-05-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106335
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Article ; Online: The unsettled science of nonrenal calcitriol production and its clinical relevance.

Pike, J Wesley / Meyer, Mark B

The Journal of clinical investigation

2020 Volume 130, Issue 9, Page(s) 4519–4521

MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Animals ; Calcitriol/metabolism ; Cholestanetriol 26-Monooxygenase/metabolism ; Cytochrome P450 Family 2/metabolism ; Humans ; Kidney/metabolism ; Liver/metabolism
Chemical Substances	Cytochrome P450 Family 2 (EC 1.14.14.1) ; CYP2R1 protein, human (EC 1.14.14.24) ; Cholestanetriol 26-Monooxygenase (EC 1.14.15.15) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; CYP27B1 protein, human (EC 1.14.15.18) ; Calcitriol (FXC9231JVH)
Keywords	covid19
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI141334
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Article ; Online: MRI Findings after Recent Image-Guided Lumbar Puncture: The Rate of Dural Enhancement and Subdural Collections.

Mark, I T / Dillon, W P / Richie, M B / Villanueva-Meyer, J E

AJNR. American journal of neuroradiology

2022 Volume 43, Issue 5, Page(s) 784–788

Abstract: Background and purpose: The rate of abnormal intracranial MR imaging findings including subdural collections and dural enhancement after recent lumbar puncture is not known. The purpose of our study was to examine the intracranial MR imaging findings ... ...

Abstract	Background and purpose: The rate of abnormal intracranial MR imaging findings including subdural collections and dural enhancement after recent lumbar puncture is not known. The purpose of our study was to examine the intracranial MR imaging findings after recent image-guided lumbar puncture. Materials and methods: Patients who underwent contrast-enhanced MR imaging of the brain within 7 days of a CT-guided lumbar puncture between January 2014 and April 2021 were included. Contrast-enhanced MR images were reviewed for diffuse dural enhancement, morphologic findings of brain sag, dural venous sinus distension, and subdural collections. Results: Of the 160 patients who met the inclusion criteria, only 6 patients (3.9%) had new diffuse dural enhancement, though none had dural enhancement when the MR imaging was within 2 days of lumbar puncture. All 6 patients with dural enhancement had small, concurrent subdural collections. Two additional patients had subdural collections, for a total of 5.2% of our population. Conclusions: Our study is the first to examine intracranial MR imaging after recent lumbar puncture and has 2 key findings: First, 5.2% of patients had small, bilateral subdural collections after recent lumbar puncture, suggesting that asymptomatic subdural collections after recent lumbar puncture are not atypical and do not require further work-up. Additionally, when MR imaging was performed within 2 days of lumbar puncture, none of our patients had diffuse dural enhancement. This argues against the commonly held practice of performing MR imaging before lumbar puncture to avoid findings of dural enhancement, and should not delay diagnostic work-up.
MeSH term(s)	Brain ; Humans ; Magnetic Resonance Imaging/methods ; Spinal Puncture/adverse effects ; Subdural Space/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7496
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Article ; Online: Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression.

Meyer, Mark B / Pike, J Wesley

The Journal of steroid biochemistry and molecular biology

2019 Volume 196, Page(s) 105500

Abstract: Cyp27b1 and Cyp24a1 are reciprocally regulated in the kidney by the key hormones PTH, FGF23, and 1,25(OH) ...

Abstract	Cyp27b1 and Cyp24a1 are reciprocally regulated in the kidney by the key hormones PTH, FGF23, and 1,25(OH)
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism ; Animals ; Calcitriol/pharmacology ; Calcium/metabolism ; Calcium/pharmacology ; Fibroblast Growth Factors/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Kidney/drug effects ; Kidney/metabolism ; Parathyroid Hormone/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Vitamin D/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.15.18) ; Calcitriol (FXC9231JVH) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-10-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2019.105500
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Article ; Online: New Approaches to Assess Mechanisms of Action of Selective Vitamin D Analogues

John Wesley Pike / Mark B. Meyer

International Journal of Molecular Sciences, Vol 22, Iss 12352, p

2021 Volume 12352

Abstract	Recent studies of transcription have revealed an advanced set of overarching principles that govern vitamin D action on a genome-wide scale. These tenets of vitamin D transcription have emerged as a result of the application of now well-established techniques of chromatin immunoprecipitation coupled to next-generation DNA sequencing that have now been linked directly to CRISPR-Cas9 genomic editing in culture cells and in mouse tissues in vivo. Accordingly, these techniques have established that the vitamin D hormone modulates sets of cell-type specific genes via an initial action that involves rapid binding of the VDR–ligand complex to multiple enhancer elements at open chromatin sites that drive the expression of individual genes. Importantly, a sequential set of downstream events follows this initial binding that results in rapid histone acetylation at these sites, the recruitment of additional histone modifiers across the gene locus, and in many cases, the appearance of H3K36me3 and RNA polymerase II across gene bodies. The measured recruitment of these factors and/or activities and their presence at specific regions in the gene locus correlate with the emerging presence of cognate transcripts, thereby highlighting sequential molecular events that occur during activation of most genes both in vitro and in vivo. These features provide a novel approach to the study of vitamin D analogs and their actions in vivo and suggest that they can be used for synthetic compound evaluation and to select for novel tissue- and gene-specific features. This may be particularly useful for ligand activation of nuclear receptors given the targeting of these factors directly to genetic sites in the nucleus.
Keywords	vitamin D biology and action ; transcription ; ChIP-chip analysis ; distal enhancers ; histone H3 acetylation ; RNA polymerase II ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.

Oda, Yuko / Wong, Christian T / Oh, Dennis H / Meyer, Mark B / Pike, J Wesley / Bikle, Daniel D

The Journal of steroid biochemistry and molecular biology

2023 Volume 232, Page(s) 106352

Abstract: The vitamin D receptor with its ligand 1,25 dihydroxy vitamin ... ...

Abstract	The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D
MeSH term(s)	Animals ; Mice ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Receptor Cross-Talk ; Epidermis/metabolism ; Keratinocytes/metabolism ; Epidermal Cells/metabolism ; Cell Differentiation/genetics ; Transcription Factors/metabolism ; Vitamin D/metabolism
Chemical Substances	Receptors, Calcitriol ; Transcription Factors ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106352
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Article: Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice.

Verlinden, Lieve / Doms, Stefanie / Janssens, Iris / Meyer, Mark B / Pike, J Wesley / Carmeliet, Geert / Verstuyf, Annemieke

Frontiers in endocrinology

2023 Volume 14, Page(s) 1223021

Abstract: Introduction: Neuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone ... ...

Abstract	Introduction: Neuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone homeostasis. Indeed, osteoblasts and osteoclasts express NRP2 and male and female global Methods: We first examined the Results and discussion: We show that
MeSH term(s)	Animals ; Female ; Male ; Mice ; Cancellous Bone ; Cholecalciferol ; Cross-Sectional Studies ; Neuropilin-2/genetics ; Osteoblasts ; Vascular Endothelial Growth Factor A ; Calcitriol
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Neuropilin-2 ; Vascular Endothelial Growth Factor A ; Nrp2 protein, mouse ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1223021
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