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  1. Article ; Online: Impact of 2100-Projected Air Temperature, Carbon Dioxide, and Water Scarcity on Grape Primary and Secondary Metabolites of Different

    Arrizabalaga-Arriazu, Marta / Gomès, Eric / Morales, Fermín / Irigoyen, Juan José / Pascual, Inmaculada / Hilbert, Ghislaine

    Journal of agricultural and food chemistry

    2021  Volume 69, Issue 22, Page(s) 6172–6185

    Abstract: The exploration of the grapevine ( ...

    Abstract The exploration of the grapevine (
    MeSH term(s) Anthocyanins ; Carbon Dioxide ; Clone Cells ; Fruit ; Temperature ; Vitis ; Water Insecurity
    Chemical Substances Anthocyanins ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c01412
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Psychiatric Emergencies and Suicide Attempts Before and During COVID-19 Lockdown in Spain.

    Irigoyen-Otiñano, María / Porras-Segovia, Alejandro / Vega-Sánchez, Diego de la / Arenas-Pijoan, Laura / Agraz-Bota, Marc / Torterolo, Giovanni / Sánchez-Cazalilla, Marta / Fuentes-Casany, Deborah / Adrados-Pérez, Marina / Puigdevall-Ruestes, Margarita

    Crisis

    2023  Volume 45, Issue 1, Page(s) 8–17

    MeSH term(s) Humans ; Suicide, Attempted/psychology ; Spain/epidemiology ; Emergencies ; Pandemics ; COVID-19/epidemiology ; Communicable Disease Control ; Suicidal Ideation
    Language English
    Publishing date 2023-01-13
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 801380-9
    ISSN 2151-2396 ; 0227-5910
    ISSN (online) 2151-2396
    ISSN 0227-5910
    DOI 10.1027/0227-5910/a000896
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1614: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Alteration in the Cerebrospinal Fluid Lipidome in Parkinson's Disease: A Post-Mortem Pilot Study.

    Fernández-Irigoyen, Joaquín / Cartas-Cejudo, Paz / Iruarrizaga-Lejarreta, Marta / Santamaría, Enrique

    Biomedicines

    2021  Volume 9, Issue 5

    Abstract: Lipid metabolism is clearly associated to Parkinson's disease (PD). Although lipid homeostasis has been widely studied in multiple animal and cellular models, as well as in blood derived from PD individuals, the cerebrospinal fluid (CSF) lipidomic ... ...

    Abstract Lipid metabolism is clearly associated to Parkinson's disease (PD). Although lipid homeostasis has been widely studied in multiple animal and cellular models, as well as in blood derived from PD individuals, the cerebrospinal fluid (CSF) lipidomic profile in PD remains largely unexplored. In this study, we characterized the post-mortem CSF lipidomic imbalance between neurologically intact controls (
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9050491
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  4. Article ; Online: PRPH2

    Fernández-Caballero, Lidia / Martín-Merida, Inmaculada / Blanco-Kelly, Fiona / Avila-Fernandez, Almudena / Carreño, Ester / Fernandez-San Jose, Patricia / Irigoyen, Cristina / Jimenez-Rolando, Belen / Lopez-Grondona, Fermina / Mahillo, Ignacio / Martin-Gutierrez, María Pilar / Minguez, Pablo / Perea-Romero, Irene / Del Pozo-Valero, Marta / Riveiro-Alvarez, Rosa / Rodilla, Cristina / Rodriguez-Peña, Lidya / Sánchez-Barbero, Ana Isabel / Swafiri, Saoud T /
    Trujillo-Tiebas, María José / Zurita, Olga / García-Sandoval, Blanca / Corton, Marta / Ayuso, Carmen

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: ... ...

    Abstract PRPH2
    MeSH term(s) Humans ; DNA Mutational Analysis ; Mutation ; Mutation, Missense ; Phenotype ; Retinal Dystrophies/genetics ; Retinitis Pigmentosa/genetics
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052913
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  5. Article: High Temperature and Elevated Carbon Dioxide Modify Berry Composition of Different Clones of Grapevine (

    Arrizabalaga-Arriazu, Marta / Gomès, Eric / Morales, Fermín / Irigoyen, Juan José / Pascual, Inmaculada / Hilbert, Ghislaine

    Frontiers in plant science

    2020  Volume 11, Page(s) 603687

    Abstract: Tempranillo is a grapevine ( ...

    Abstract Tempranillo is a grapevine (
    Language English
    Publishing date 2020-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.603687
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  6. Article: Application of adipose-derived mesenchymal stem cells in an

    González-Cubero, Elsa / González-Fernández, María Luisa / Rodríguez-Díaz, María / Palomo-Irigoyen, Marta / Woodhoo, Ashwin / Villar-Suárez, Vega

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 992221

    Abstract: Background: Neuropathic pain is one of the most difficult to treat chronic pain syndromes. It has significant effects on patients' quality of life and substantially adds to the burden of direct and indirect medical costs. There is a critical need to ... ...

    Abstract Background: Neuropathic pain is one of the most difficult to treat chronic pain syndromes. It has significant effects on patients' quality of life and substantially adds to the burden of direct and indirect medical costs. There is a critical need to improve therapies for peripheral nerve regeneration. The aim of this study is to address this issue by performing a detailed analysis of the therapeutic benefits of two treatment options: adipose tissue derived-mesenchymal stem cells (ASCs) and ASC-conditioned medium (CM).
    Methods: To this end, we used an
    Results: Our data suggests that both ASCs and CM are potentially beneficial treatments for promoting myelination and axonal regeneration. After TNF-induced nerve damage we observed an upregulation of c-Jun along with a downregulation of Krox-20 myelin-associated transcription factor. However, when CM was added to TNF-treated nerves the opposite effect occurred and also resulted in increased expression of myelin-related genes and their corresponding proteins.
    Conclusion: Findings from our
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.992221
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  7. Article ; Online: Sequestosome 1/p62 enhances chronic skin inflammation.

    Sukseree, Supawadee / Bakiri, Latifa / Palomo-Irigoyen, Marta / Uluçkan, Özge / Petzelbauer, Peter / Wagner, Erwin F

    The Journal of allergy and clinical immunology

    2021  Volume 147, Issue 6, Page(s) 2386–2393.e4

    Abstract: Background: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of ... ...

    Abstract Background: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling.
    Objective: We sought to determine whether p62 plays a role in the cutaneous and systemic manifestations of an AD-like mouse model.
    Methods: AD-like skin lesions were induced by deletion of JunB/AP-1, specifically in epidermal keratinocytes (JunB
    Results: Expression of p62 was elevated in skin lesions of JunB
    Conclusions: Our results provide the first in vivo evidence for a proinflammatory role of p62 in skin and suggest that p62-dependent signaling pathways may be promising therapeutic targets to ameliorate the skin manifestations of AD and possibly psoriasis.
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Disease Models, Animal ; Disease Susceptibility ; Mice ; Mice, Knockout ; Phenotype ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Skin/immunology ; Skin/metabolism ; Skin/pathology
    Chemical Substances Biomarkers ; Sequestosome-1 Protein
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.02.028
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.92: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Growth performance and carbon partitioning of grapevine Tempranillo clones under simulated climate change scenarios: Elevated CO

    Arrizabalaga-Arriazu, Marta / Morales, Fermín / Irigoyen, Juan José / Hilbert, Ghislaine / Pascual, Inmaculada

    Journal of plant physiology

    2020  Volume 252, Page(s) 153226

    Abstract: Atmospheric ... ...

    Abstract Atmospheric CO
    MeSH term(s) Carbon/metabolism ; Carbon Dioxide/metabolism ; Climate Change ; Global Warming ; Hot Temperature ; Vitis/growth & development ; Vitis/metabolism ; Vitis/physiology
    Chemical Substances Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
    Language English
    Publishing date 2020-07-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2020.153226
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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: Patient’s new role

    Isabel Rodrigo / Isabel Irigoyen / Belén Tirapu / Marta Martin

    International Journal of Integrated Care, Vol 19, Iss

    healthcare safety assessor. Profile and willingness

    2019  Volume 4

    Abstract: Introduction: Patient safety is a global priority. About 10% of people who receive health care in industrialized countries will suffer because of preventable harm and adverse events. One of the areas where competencies of patients can improve the quality ...

    Abstract Introduction: Patient safety is a global priority. About 10% of people who receive health care in industrialized countries will suffer because of preventable harm and adverse events. One of the areas where competencies of patients can improve the quality of Health Care Organizations is Patient Safety. Nevertheless, the role of patient as assessor of safe practices in health care remains almost unexplored. Theory/methods: The role of patient as assessor involves voluntarily and anonymously tracking health care safe practice adherence. It is different from others which goal is that the patient reports adverse events. We conducted a research work to assess if patients or companions (P&C) are willing and able to engage in the assessment of professionals’ adherence to safe practices based on scientific evidence. 101 patients undergoing oncological treatment and/or their companions have been recruited and trained in 4 safe practices during 2018. 5 focus groups (patients and healthcare professionals) have been conducted to identify the challenges and requirements of the role of P&C as assessors of safe practices. Results: After the training programme, P&C willingness to participate as safety assessors varied according to the safe practice evaluated, from 76% for hand hygiene to 83% for patient identification or matching the drug with the patient. The % of P&C willing to challenge the professionals in case they detected a violation in a safe practice ranged from 49% for hand hygiene to 86% for matching drug to patient. Nevertheless, the % ranged from 3% for hand hygiene to 32% for patient identification when asked if they had actually challenged a health professional when they saw a non-compliance of the protocol. 90% of P&C said that the willingness to challenge a professional depended on the perceived risk of suffering an adverse event. Age, gender and education level were similar between the group who would be safety assessors and the group who would not. 240 codes have been identified in the focus groups. Discussion: The P&C engagement as safety assessors is an innovative way of patient empowerment and it has been seldom explored. We think that it can provide invaluable help to assess safety practices within health care organizations, which in turn, improves the quality of care provided to the patients. Conclusions: 3 out of 4 P&C were willing to enrol as safety assessors. On the other hand, patients found it difficult to adopt a challenging attitude towards the professionals, which depended on the perceived risk of suffering an adverse event. The characteristics of the patients do not predict their willingness to engage in this new role. The feedback from the focus groups is absolutely necessary. Lessons learned: The complexity of carrying out a project of these characteristics and the ethical issues emerged. Limitations: We have recruited oncological patients in a Tertiary Hospital in Spain. Suggestions for future research: Different types of P&C and safe practices could be assessed. Cultural, geographic and health care context can affect the patient willingness to become a safety assessor.
    Keywords patient empowerment ; safety assessment ; patient safety ; safety assessor ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: In vitro study to assess modulation of

    Díaz-Navarro, Marta / Irigoyen Von-Sierakowski, Álvaro / Palomo, María / Escribano, Pilar / Guinea, Jesús / Burillo, Almudena / Galar, Alicia / Muñoz, Patricia / Guembe, María

    Biofilm

    2023  Volume 5, Page(s) 100116

    Abstract: Background: Vulvovaginal candidiasis (VVC) is caused by biofilm formation and epithelial invasion. In addition, : Methods: We prospectively collected CA and EC isolates from vaginal swabs over 6 months. We selected positive cultures with both CA and ... ...

    Abstract Background: Vulvovaginal candidiasis (VVC) is caused by biofilm formation and epithelial invasion. In addition,
    Methods: We prospectively collected CA and EC isolates from vaginal swabs over 6 months. We selected positive cultures with both CA and EC (cases) and a comparator group with either CA or EC (controls). We analyzed overall biomass production and metabolic activity in single cultures and in co-cultures based on staining assays, confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) to assess biofilm occupation. We also analyzed clinical manifestations.
    Results: We cultured 455 samples, 16 (3.5%) of which had CA and EC (cases); only CA or EC (controls) was detected, respectively, in 72 (15.8%) and 98 (21.5%). Biomass production and metabolic activity were significantly more pronounced in co-cultures in both groups. CLSM and SEM, on the other hand, showed the biofilm of each species to be significantly reduced when they were cultured together, with higher values in CA (percentage biofilm reduction: CA, 95.8% vs. EC, 36.2%, p < 0.001). There were no clinically significant differences between co-infected patients and patients infected only by
    Conclusion: Ours is the first study assessing co-cultures of CA and EC in a large collection of samples. We observed that coinfection of CA and EC was unusual (3.5%) and promoted high biomass, whereas microscopy enabled us to detect a reduction in biofilm production when microorganisms were co-cultured. No differences in symptoms were observed.
    Language English
    Publishing date 2023-04-02
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2023.100116
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