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  1. Article ; Online: Ensuring Equity in Compensation and Career Advancement for Female Physicians.

    Hostetter, Margaret K

    Mayo Clinic proceedings

    2020  Volume 95, Issue 1, Page(s) 3–5

    MeSH term(s) Female ; Humans ; Physicians ; Physicians, Women
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.11.003
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  2. Article ; Online: Academic pipeline initiatives in pediatrics.

    Gordon, Catherine M / Hostetter, Margaret K / DeBaun, Michael R

    Pediatric research

    2021  

    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01615-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Success for the physician-scientist in a resource-limited environment.

    Hostetter, Margaret K

    The Journal of pediatrics

    2012  Volume 161, Issue 1, Page(s) 1–2.e1

    MeSH term(s) Biomedical Research/economics ; Financing, Government ; Physicians ; United States
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2012.03.005
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  4. Article ; Online: Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma.

    Musser, Margaret L / Viall, Austin K / Phillips, Rachel L / Hostetter, Jesse M / Johannes, Chad M

    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire

    2021  Volume 85, Issue 1, Page(s) 68–71

    Abstract: In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to ... ...

    Abstract In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to characterize the messenger RNA (mRNA) expression of EP4R in canine osteosarcoma (OSA). Gene expression of EP4R was evaluated using RNA
    MeSH term(s) Animals ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Bone Neoplasms/veterinary ; Dog Diseases/genetics ; Dog Diseases/metabolism ; Dogs ; Gene Expression Regulation, Neoplastic ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Osteosarcoma/veterinary ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism
    Chemical Substances RNA, Messenger ; Receptors, Prostaglandin E, EP4 Subtype
    Language English
    Publishing date 2021-01-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 632814-3
    ISSN 1928-9022 ; 0830-9000
    ISSN (online) 1928-9022
    ISSN 0830-9000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gene expression of prostaglandin EP4 receptor in three canine carcinomas.

    Musser, Margaret L / Viall, Austin K / Phillips, Rachel L / Hostetter, Jesse M / Johannes, Chad M

    BMC veterinary research

    2020  Volume 16, Issue 1, Page(s) 213

    Abstract: Background: Chronic inflammation mediated by the cyclooxygenase enzymes, specifically their product prostaglandin E2 (PGE2), can result in the development of cancer. PGE2 promotes cell proliferation, apoptosis, and angiogenesis through interaction with ... ...

    Abstract Background: Chronic inflammation mediated by the cyclooxygenase enzymes, specifically their product prostaglandin E2 (PGE2), can result in the development of cancer. PGE2 promotes cell proliferation, apoptosis, and angiogenesis through interaction with its specific receptors (EP1 receptor - EP4 receptor [EP1R-EP4R]). In multiple human cancers, the expression of EP4R is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The aim of this study was to characterize the mRNA gene expression of EP4R (ptger4) in canine squamous cell carcinoma (SCC), apocrine gland anal sac adenocarcinoma (AGASACA), and transitional cell carcinoma (TCC). Archived tumor samples of canine cutaneous SCC (n = 9), AGASACA (n = 9), and TCC (n = 9), and matched archived normal tissue controls were evaluated for mRNA expression of canine EP4R using RNA in situ hybridization (RNAscope®). Quantification of RNAscope® signals in tissue sections was completed with an advanced digital pathology image analysis system (HALO). Data was expressed as copy number, H-index, and percent tumor cell expression of EP4R.
    Results: In all canine SCC, AGASACA, and TCC samples evaluated, strong universal positive expression of EP4R was identified. For SCC and AGASACA, mRNA EP4R expression was statistically higher than that of their respective normal tissues. The TCC tissues displayed significantly less mRNA EP4R expression when compared to normal bladder mucosa.
    Conclusions: These results confirm the mRNA expression of canine EP4R in all tumor types evaluated, with SCC and AGASACA displaying the highest expression, and TCC displaying the lowest expression. This study also represents the first reported veterinary evaluation of EP4R expression using the novel in situ hybridization technique, RNAscope®.
    MeSH term(s) Anal Gland Neoplasms/metabolism ; Anal Sacs ; Animals ; Apocrine Glands ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/veterinary ; Dog Diseases/genetics ; Dog Diseases/metabolism ; Dogs ; In Situ Hybridization/veterinary ; RNA, Messenger/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/genetics ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Skin Neoplasms/metabolism ; Skin Neoplasms/veterinary ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/veterinary
    Chemical Substances RNA, Messenger ; Receptors, Prostaglandin E, EP4 Subtype
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article
    ISSN 1746-6148
    ISSN (online) 1746-6148
    DOI 10.1186/s12917-020-02431-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The iC3b receptor of Candida albicans and its roles in pathogenesis.

    Hostetter, Margaret K

    Vaccine

    2009  Volume 26 Suppl 8, Page(s) I108–12

    Abstract: On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a ... ...

    Abstract On the basis of biochemical and immunologic studies, a receptor for iC3b with some activities reminiscent of the integrins CD11b and CD11c was defined on the cell wall of clinical and laboratory isolates of Candida albicans. The INT1 gene encodes a protein of 1659 amino acids; the Int1 protein participates in adhesion to epithelial cells in vitro and in vivo. Int1 is essential for hyphal morphogenesis and virulence in a murine model. Recent evidence points to the amino terminus of Int1 as the source of a peptide, Pep263, with superantigen-like activities.
    MeSH term(s) Adhesiveness ; Candida albicans/pathogenicity ; Cell Adhesion Molecules/chemistry ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/physiology ; Cloning, Molecular ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Fungal Proteins/physiology ; Heparin/pharmacology ; Receptors, Complement 3b/physiology ; Virulence
    Chemical Substances Cell Adhesion Molecules ; Fungal Proteins ; Receptors, Complement 3b ; alphaINT1 protein, Candida albicans ; Heparin (9005-49-6)
    Language English
    Publishing date 2009-04-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2008.11.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 458: Show issues

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  7. Article ; Online: Expanding the Pipeline for Pediatric Physician-Scientists.

    Dermody, Terence S / Hirsch, Raphael / Hostetter, Margaret K / Orange, Jordan S / St Geme, Joseph W

    The Journal of pediatrics

    2019  Volume 207, Page(s) 3–7.e1

    MeSH term(s) Biomedical Research/education ; Biomedical Research/organization & administration ; Career Choice ; Curriculum ; Faculty, Medical/organization & administration ; Humans ; Internship and Residency/organization & administration ; Mentoring ; Pediatrics/education ; Pediatrics/organization & administration
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2019.01.025
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  8. Article: Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma

    Musser, Margaret L / Viall, Austin K / Phillips, Rachel L / Hostetter, Jesse M / Johannes, Chad M

    Canadian journal of veterinary research. 2021 Jan., v. 85, no. 1

    2021  

    Abstract: In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to ... ...

    Abstract In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to characterize the messenger RNA (mRNA) expression of EP4R in canine osteosarcoma (OSA). Gene expression of EP4R was evaluated using RNA in-situ hybridization (RNAscope). In all canine OSA samples evaluated, strong universal positive expression of EP4R was identified. Gene expression was significantly higher in OSA tissue samples than in normal nasal turbinate bone, possibly implicating EP4R in the pathogenesis of canine OSA.
    Keywords dogs ; gene expression ; humans ; in situ hybridization ; messenger RNA ; nose ; osteosarcoma ; pathogenesis ; prognosis ; prostaglandins ; veterinary medicine
    Language English
    Dates of publication 2021-01
    Size p. 68-71.
    Publishing place Canadian Veterinary Medical Association = Association canadienne des vétérinaires
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 632814-3
    ISSN 0830-9000
    ISSN 0830-9000
    DOI 10.5304/jafscd.2020.094.021
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Addressing Gaps in Pediatric Scientist Development: The Department Chair View of 2 AMSPDC-Sponsored Programs.

    Barrett, Katherine J / Cooley, T Michelle / Schwartz, Alan L / Hostetter, Margaret K / Clapp, D Wade / Permar, Sallie R

    The Journal of pediatrics

    2020  Volume 222, Page(s) 7–12.e4

    MeSH term(s) Biomedical Research/organization & administration ; Pediatrics ; United States
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.01.054
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  10. Article ; Online: The Impact of Primary Mentors and Career Development Committees on Junior Faculty Productivity in a Pediatric Academic Health Center.

    Hackworth, Jamilah M / Meinzen-Derr, Jareen / DePalma, Mallory / Hostetter, Margaret / Klein, Melissa / O'Toole, Jennifer K / Kahn, Jessica

    The Journal of pediatrics

    2020  Volume 232, Page(s) 4–8.e1

    MeSH term(s) Academic Medical Centers ; Career Mobility ; Efficiency, Organizational ; Faculty, Medical ; Female ; Humans ; Male ; Mentoring/organization & administration ; Mentors ; Ohio ; Publishing/statistics & numerical data ; Research Support as Topic/statistics & numerical data
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.10.037
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