LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 4899

Search options

  1. Article ; Online: Real-time joint ocean acoustics and circulation modeling in the 2021 New England Shelf Break Acoustics experiment (L).

    DeCourcy, Brendan J / Lin, Ying-Tsong / Zhang, Weifeng Gordon / Ozanich, Emma Reeves / Kukshtel, Natalie / Siderius, Martin / Gawarkiewicz, Glen / Forsyth, Jacob

    The Journal of the Acoustical Society of America

    2022  Volume 152, Issue 5, Page(s) 2859

    Abstract: During the spring of 2021, a coordinated multi-vessel effort was organized to study physical oceanography, marine geology and biology, and acoustics on the northeast United States continental shelf, as part of the New England Shelf Break Acoustics (NESBA) ...

    Abstract During the spring of 2021, a coordinated multi-vessel effort was organized to study physical oceanography, marine geology and biology, and acoustics on the northeast United States continental shelf, as part of the New England Shelf Break Acoustics (NESBA) experiment. One scientific goal was to establish a real-time numerical model aboard the research vessel with high spatial and temporal resolution to predict the oceanography and sound propagation within the NESBA study area. The real-time forecast model performance and challenges are reported in this letter without adjustment or re-simulation after the cruise. Future research directions for post-experiment studies are also suggested.
    MeSH term(s) Acoustics ; Sound ; Geology ; New England ; Oceans and Seas
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0015139
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Genome-wide superior alleles, haplotypes and candidate genes associated with tolerance on sodic-dispersive soils in wheat (Triticum aestivum L.).

    Sharma, Darshan Lal / Bhoite, Roopali / Reeves, Karyn / Forrest, Kerrie / Smith, Rosemary / Dowla, Mirza A N N U

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

    2022  Volume 135, Issue 3, Page(s) 1113–1128

    Abstract: Key message: The pleiotropic SNPs/haplotypes, overlapping genes (metal ion binding, photosynthesis), and homozygous/biallelic SNPs and transcription factors (HTH myb-type and BHLH) hold great potential for improving wheat yield potential on sodic- ... ...

    Abstract Key message: The pleiotropic SNPs/haplotypes, overlapping genes (metal ion binding, photosynthesis), and homozygous/biallelic SNPs and transcription factors (HTH myb-type and BHLH) hold great potential for improving wheat yield potential on sodic-dispersive soils. Sodic-dispersive soils have multiple subsoil constraints including poor soil structure, alkaline pH and subsoil toxic elemental ion concentration, affecting growth and development in wheat. Tolerance is required at all developmental stages to enhance wheat yield potential on such soils. An in-depth investigation of genome-wide associations was conducted using a field phenotypic data of 206 diverse Focused Identification of Germplasm Strategy (FIGS) wheat lines for two consecutive years from different sodic and non-sodic plots and the exome targeted genotyping by sequencing (tGBS) assay. A total of 39 quantitative trait SNPs (QTSs), including 18 haplotypes were identified on chromosome 1A, 1B, 1D, 2A, 2B, 2D, 3A, 3B, 5A, 5D, 6B, 7A, 7B, 7D for yield and yield-components tolerance. Among these, three QTSs had common associations for multiple traits, indicating pleiotropism and four QTSs had close associations for multiple traits, within 32.38 Mb. The overlapping metal ion binding (Mn, Ca, Zn and Al) and photosynthesis genes and transcription factors (PHD-, Dof-, HTH myb-, BHLH-, PDZ_6-domain) identified are known to be highly regulated during germination, maximum stem elongation, anthesis, and grain development stages. The homozygous/biallelic SNPs having allele frequency above 30% were identified for yield and crop establishment/plants m
    MeSH term(s) Alleles ; Haplotypes ; Phenotype ; Plant Breeding ; Polymorphism, Single Nucleotide ; Soil ; Triticum/genetics
    Chemical Substances Soil
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2170-2
    ISSN 1432-2242 ; 0040-5752
    ISSN (online) 1432-2242
    ISSN 0040-5752
    DOI 10.1007/s00122-021-04021-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1692: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.

    Kim, Se-Ho / Tangallapally, Rajendra / Kim, In Chul / Trovato, Richard / Parker, Daniel / Patton, J Scott / Reeves, Leslie / Bradford, Chad / Wettstein, Daniel / Baichwal, Vijay / Papac, Damon / Bajji, Ashok / Carlson, Robert / Yager, Kraig M

    Bioorganic & medicinal chemistry letters

    2015  Volume 25, Issue 22, Page(s) 5254–5257

    Abstract: ... in identification of L-alanine ester mesylate, 2i (MPC-0767), which exhibited improved aqueous solubility, adequate ...

    Abstract Various types of Hsp90 inhibitors have been and continue to undergo clinical investigation. One development candidate is the purine-based, synthetic Hsp90 inhibitor 1 (MPC-3100), which successfully completed a phase I clinical study. However, further clinical development of 1 was hindered by poor solubility and consequent formulation issues and promoted development of a more water soluble prodrug. Towards this end, numerous pro-moieties were explored in vitro and in vivo. These studies resulted in identification of L-alanine ester mesylate, 2i (MPC-0767), which exhibited improved aqueous solubility, adequate chemical stability, and rapid bioconversion without the need for solubilizing excipients. Based on improved physical characteristics and favorable PK and PD profiles, 2i mesylate was selected for further development. A convergent, scalable, chromatography-free synthesis for 2i mesylate was developed to support further clinical evaluation.
    MeSH term(s) Adenine/analogs & derivatives ; Adenine/chemistry ; Adenine/pharmacology ; Alanine/analogs & derivatives ; Alanine/chemical synthesis ; Alanine/metabolism ; Alanine/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Benzodioxoles/chemistry ; Benzodioxoles/pharmacology ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Haplorhini ; Humans ; Mesylates/chemical synthesis ; Mesylates/pharmacokinetics ; Mesylates/pharmacology ; Mice ; Microsomes, Liver/metabolism ; Prodrugs/chemical synthesis ; Prodrugs/pharmacokinetics ; Prodrugs/pharmacology ; Solubility ; Water
    Chemical Substances 1-(4-(2-(6-amino-8-((6-bromo-1,3-benzodioxol-5-yl)sulfanyl)-9H-purin-9-yl)ethyl)piperidin-1-yl)-2-hydroxypropan-1-one ; Antineoplastic Agents ; Benzodioxoles ; HSP90 Heat-Shock Proteins ; Mesylates ; Prodrugs ; Water (059QF0KO0R) ; MPC-0767 (0K6G1O9YKM) ; Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2015-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2015.09.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: 3-Hydroxyisobutyric acid dehydrogenase deficiency: Expanding the clinical spectrum and quantitation of D- and L-3-Hydroxyisobutyric acid by an LC-MS/MS method.

    Sasarman, Florin / Ferdinandusse, Sacha / Sinasac, David S / Fung, Ernest / Sparkes, Rebecca / Reeves, Melanie / Rombough, Catherine / Sass, Jörn Oliver / Voit, Renate / Ruiter, Jos P N / Koster, Janet / Waterham, Hans R / Pasquini, Elisabetta / Donati, Maria A / Marquardt, Thorsten / Wanders, Ronald J A / Al-Hertani, Walla

    Journal of inherited metabolic disease

    2022  Volume 45, Issue 3, Page(s) 445–455

    Abstract: ... of urine L-3-hydroxyisobutyric acid (L-3HIBA) and a range of clinical findings. Molecular genetic analyses ... Additionally, we describe a quantitative method for the measurement of D- and L-3HIBA in plasma and urine and ...

    Abstract A deficiency of 3-hydroxyisobutyric acid dehydrogenase (HIBADH) has been recently identified as a cause of primary 3-hydroxyisobutyric aciduria in two siblings; the only previously recognized primary cause had been a deficiency of methylmalonic semialdehyde dehydrogenase, the enzyme that is immediately downstream of HIBADH in the valine catabolic pathway and is encoded by the ALDH6A1 gene. Here we report on three additional patients from two unrelated families who present with marked and persistent elevations of urine L-3-hydroxyisobutyric acid (L-3HIBA) and a range of clinical findings. Molecular genetic analyses revealed novel, homozygous variants in the HIBADH gene that are private within each family. Evidence for pathogenicity of the identified variants is presented, including enzymatic deficiency of HIBADH in patient fibroblasts. This report describes new variants in HIBADH as an underlying cause of primary 3-hydroxyisobutyric aciduria and expands the clinical spectrum of this recently identified inborn error of valine metabolism. Additionally, we describe a quantitative method for the measurement of D- and L-3HIBA in plasma and urine and present the results of a valine restriction therapy in one of the patients.
    MeSH term(s) Amino Acid Metabolism, Inborn Errors/metabolism ; Chromatography, Liquid ; Humans ; Hydroxybutyrates/urine ; Oxidoreductases ; Tandem Mass Spectrometry ; Valine
    Chemical Substances Hydroxybutyrates ; Oxidoreductases (EC 1.-) ; Valine (HG18B9YRS7) ; 3-hydroxyisobutyric acid (K75C8JDF5W)
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 438341-2
    ISSN 1573-2665 ; 0141-8955
    ISSN (online) 1573-2665
    ISSN 0141-8955
    DOI 10.1002/jimd.12486
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Observations and Fokker?Planck Simulations of the L?Shell, Energy, and Pitch Angle Structure of Earth's Electron Radiation Belts During Quiet Times

    J.?F.?Ripoll / V.?Loridan / M. H.?Denton / G.?Cunningham / G.?Reeves / O.?Santol?k / J.?Fennell / D. L.?Turner / A.?Drozdov / Juan Sebastian?Cervantes Villa / Yuri?Shprits / S. A.?Thaller / W. S.?Kurth / C. A.?Kletzing / M. G.?Henderson / A. Y.?Ukhorskiy

    Journal of Geophysical Research

    2019  

    Publishing country de
    Document type Article ; Online
    DOI 10.1029/2018JA026111
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Genome-wide superior alleles, haplotypes and candidate genes associated with tolerance on sodic-dispersive soils in wheat (Triticum aestivum L.)

    Sharma, Darshan Lal / Bhoite, Roopali / Reeves, Karyn / Forrest, Kerrie / Smith, Rosemary / Dowla, Mirza A. N. N. U.

    Theoretical and applied genetics. 2022 Mar., v. 135, no. 3

    2022  

    Abstract: KEY MESSAGE: The pleiotropic SNPs/haplotypes, overlapping genes (metal ion binding, photosynthesis), and homozygous/biallelic SNPs and transcription factors (HTH myb-type and BHLH) hold great potential for improving wheat yield potential on sodic- ... ...

    Abstract KEY MESSAGE: The pleiotropic SNPs/haplotypes, overlapping genes (metal ion binding, photosynthesis), and homozygous/biallelic SNPs and transcription factors (HTH myb-type and BHLH) hold great potential for improving wheat yield potential on sodic-dispersive soils. Sodic-dispersive soils have multiple subsoil constraints including poor soil structure, alkaline pH and subsoil toxic elemental ion concentration, affecting growth and development in wheat. Tolerance is required at all developmental stages to enhance wheat yield potential on such soils. An in-depth investigation of genome-wide associations was conducted using a field phenotypic data of 206 diverse Focused Identification of Germplasm Strategy (FIGS) wheat lines for two consecutive years from different sodic and non-sodic plots and the exome targeted genotyping by sequencing (tGBS) assay. A total of 39 quantitative trait SNPs (QTSs), including 18 haplotypes were identified on chromosome 1A, 1B, 1D, 2A, 2B, 2D, 3A, 3B, 5A, 5D, 6B, 7A, 7B, 7D for yield and yield-components tolerance. Among these, three QTSs had common associations for multiple traits, indicating pleiotropism and four QTSs had close associations for multiple traits, within 32.38 Mb. The overlapping metal ion binding (Mn, Ca, Zn and Al) and photosynthesis genes and transcription factors (PHD-, Dof-, HTH myb-, BHLH-, PDZ_6-domain) identified are known to be highly regulated during germination, maximum stem elongation, anthesis, and grain development stages. The homozygous/biallelic SNPs having allele frequency above 30% were identified for yield and crop establishment/plants m⁻². These SNPs correspond to HTH myb-type and BHLH transcription factors, brassinosteroid signalling pathway, kinase activity, ATP and chitin binding activity. These resources are valuable in haplotype-based breeding and genome editing to improve yield potential on sodic-dispersive soils.
    Keywords Triticum aestivum ; brassinosteroids ; chitin ; chromosomes ; flowering ; gene frequency ; germination ; germplasm ; haplotypes ; homozygosity ; pH ; phenotype ; photosynthesis ; plant establishment ; quantitative traits ; seed development ; soil structure ; stem elongation ; subsoil ; toxicity ; wheat ; yield components
    Language English
    Dates of publication 2022-03
    Size p. 1113-1128.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 2170-2
    ISSN 1432-2242 ; 0040-5752
    ISSN (online) 1432-2242
    ISSN 0040-5752
    DOI 10.1007/s00122-021-04021-8
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 584: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Aortic Translocation for Repair of Transposition of the Great Arteries (S,D,L) With Ventricular Septal Defect and Pulmonic Stenosis.

    Reeves, Justin G / Montesa, Christine / Fonseca, Brian / Mitchell, Max B

    The Annals of thoracic surgery

    2016  Volume 101, Issue 1, Page(s) 357–359

    Abstract: Biventricular repair for (S,D,L) transposition with ventricular septal defect, pulmonary stenosis ...

    Abstract Biventricular repair for (S,D,L) transposition with ventricular septal defect, pulmonary stenosis, and superior-inferior ventricular malposition has not been described, to our knowledge. Herein we report biventricular repair of this complex lesion by aortic translocation.
    MeSH term(s) Abnormalities, Multiple/surgery ; Aorta, Thoracic/surgery ; Cardiac Surgical Procedures/methods ; Heart Septal Defects, Ventricular/surgery ; Humans ; Infant, Newborn ; Male ; Pulmonary Valve Stenosis/surgery ; Transposition of Great Vessels/surgery ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2016-01
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2015.02.102
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Free and glycosidically bound aroma compounds in cherry (Prunus avium L.).

    Wen, Ya-Qin / He, Fei / Zhu, Bao-Qing / Lan, Yi-Bin / Pan, Qiu-Hong / Li, Chun-You / Reeves, Malcolm J / Wang, Jun

    Food chemistry

    2014  Volume 152, Page(s) 29–36

    Abstract: This paper reports the occurrence of both free and glycosidically bound aroma compounds in three sweet cherry cultivars ('Hongdeng', 'Hongyan' and 'Rainier'), with 97 compounds being identified in the three cultivars. The major free volatile compounds ... ...

    Abstract This paper reports the occurrence of both free and glycosidically bound aroma compounds in three sweet cherry cultivars ('Hongdeng', 'Hongyan' and 'Rainier'), with 97 compounds being identified in the three cultivars. The major free volatile compounds found were hexanal, (E)-2-hexenal, (E)-2-hexen-1-ol, benzyl alcohol and benzaldehyde. The major bound volatile compounds found were benzyl alcohol, geraniol, 2-phenylethanol. Also 4-vinylphenol was found in cherry fruit for the first time, and has a relatively high concentration of the glycosidically-bound form in 'Rainier'. Odour activity values (OAVs) were determined for both free and bound volatiles, with 18 compounds having an OAV above 1. The highest OAVs for three cultivars were (E)-β-ionone, hexanal, decanal and (E)-2-hexenal with the highest being over 800 for (E)-β-ionone in 'Honyang'. From these results, it was concluded that the aroma compounds present were similar in all three cultivars, but there was significant variation found in their levels and hence contribution to the aroma of these cultivars.
    MeSH term(s) Fruit/chemistry ; Gas Chromatography-Mass Spectrometry ; Odorants/analysis ; Prunus/chemistry ; Volatile Organic Compounds/chemistry
    Chemical Substances Volatile Organic Compounds
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2013.11.092
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book: Tendon reconstruction and transfers of the foot and ankle

    Reeves, Christopher L.

    (Clinics in podiatric medicine and surgery ; volume 33, number 1 (January 2016))

    2016  

    Author's details editor Christopher L. Reeves
    Series title Clinics in podiatric medicine and surgery ; volume 33, number 1 (January 2016)
    Collection
    Language English
    Size xviii, 184 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT018851050
    ISBN 978-0-323-41466-1 ; 0-323-41466-4
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 931 -33,1- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Puerperal Eclampsia.

    Reeves, L H

    Texas medical journal (Austin, Tex.)

    2023  Volume 27, Issue 2, Page(s) 55–59

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8495
    ISSN 0892-8495
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top