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  1. Book ; Thesis: A terminal view at the epithelial Ca 2+ channel TRPV5

    Groot, Theun de

    2012  

    Author's details Theun de Groot
    Language English ; Dutch
    Size 165 S. : Ill., graph. Darst.
    Publishing country Netherlands
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Nijmegen, Univ., Diss., 2012
    Note Zsfassung in niederländ. Sprache
    HBZ-ID HT017214452
    ISBN 978-90-8570-688-5 ; 90-8570-688-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 E 735 order for loan Magazin

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  2. Article ; Online: An Autochthonous Susceptible

    Ahmadi, Bahram / Naeimi, Behrouz / Ahmadipour, Mohammad Javad / Morovati, Hamid / de Groot, Theun / Spruijtenburg, Bram / Badali, Hamid / Meis, Jacques F

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 11

    Abstract: ... Candida ... ...

    Abstract Candida auris
    Language English
    Publishing date 2023-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9111101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy: a retrospective cohort study using a multifactorial protocol including DHEA.

    Boyle, Phil / Andralojc, Karolina / van der Velden, Susanne / Najmabadi, Shahpar / de Groot, Theun / Turczynski, Craig / Stanford, Joseph B

    Frontiers in reproductive health

    2024  Volume 5, Page(s) 1321284

    Abstract: Background: Low serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the ... ...

    Abstract Background: Low serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the risk of miscarriage as part of a multifactorial symptom-based treatment protocol.
    Methods: This retrospective cohort study included women with low serum estradiol levels in early pregnancy, defined as ≤50% of reference levels by gestational age. Estradiol or DHEA were administered orally, and the primary outcome measure was serum estradiol level, in reference to gestational age. The secondary outcome measures included miscarriage, birth weight, and gestational age at birth.
    Results: We found no significant effect of estradiol supplementation on serum estradiol levels referenced to gestational age, while DHEA supplementation strongly increased estradiol levels. For pregnancies with low estradiol, the miscarriage rate in the non-supplemented group was 45.5%, while miscarriage rate in the estradiol and DHEA supplemented groups were 21.2% (
    Conclusions: In conclusion, DHEA supplementation restored serum estradiol levels, and when included in the treatment protocol, there was a statistically significant reduction in miscarriage.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1321284
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  4. Article ; Online: Development and Application of a Short Tandem Repeat Multiplex Typing Assay for Candida tropicalis.

    Spruijtenburg, Bram / van Haren, Merlijn H I / Chowdhary, Anuradha / Meis, Jacques F / de Groot, Theun

    Microbiology spectrum

    2023  , Page(s) e0461822

    Abstract: Candida tropicalis is a clinically important yeast that causes candidemia in humans with a high mortality rate. The yeast primarily infects immunocompromised patients, and causes outbreaks in health care facilities. Antifungal resistant isolates have ... ...

    Abstract Candida tropicalis is a clinically important yeast that causes candidemia in humans with a high mortality rate. The yeast primarily infects immunocompromised patients, and causes outbreaks in health care facilities. Antifungal resistant isolates have been reported. We developed a short tandem repeat (STR) typing scheme for C. tropicalis to enable fast, cost-effective, and high-resolution genotyping. For the development of the typing scheme, 6 novel STR markers were selected, combined into 2 multiplex PCRs. In total, 117 C. tropicalis isolates were typed, resulting in the identification of 104 different genotypes. Subsequently, the outcome of STR typing of 10 isolates was compared to single nucleotide polymorphism (SNP) calling from whole-genome sequencing (WGS). Isolates with more than 111 SNPs were differentiated by the typing assay. Two isolates, which were identical according to SNP analysis, were separated by STR typing in 1 marker. To test specificity, the STR typing was applied to 15 related yeast species, and we found no amplification of these targets. For reproducibility testing, 2 isolates were independently typed five times, which showed identical results in each experiment. In summary, we developed a reliable and multiplex STR genotyping for C. tropicalis, which was found to correlate well to SNP calling by WGS. WGS analysis from and extensive collection of isolates is required to establish the precise resolution of this STR assay.
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04618-22
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  5. Article ; Online: Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy

    Phil Boyle / Karolina Andralojc / Susanne van der Velden / Shahpar Najmabadi / Theun de Groot / Craig Turczynski / Joseph B. Stanford

    Frontiers in Reproductive Health, Vol

    a retrospective cohort study using a multifactorial protocol including DHEA

    2024  Volume 5

    Abstract: BackgroundLow serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the ... ...

    Abstract BackgroundLow serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the risk of miscarriage as part of a multifactorial symptom-based treatment protocol.MethodsThis retrospective cohort study included women with low serum estradiol levels in early pregnancy, defined as ≤50% of reference levels by gestational age. Estradiol or DHEA were administered orally, and the primary outcome measure was serum estradiol level, in reference to gestational age. The secondary outcome measures included miscarriage, birth weight, and gestational age at birth.ResultsWe found no significant effect of estradiol supplementation on serum estradiol levels referenced to gestational age, while DHEA supplementation strongly increased estradiol levels. For pregnancies with low estradiol, the miscarriage rate in the non-supplemented group was 45.5%, while miscarriage rate in the estradiol and DHEA supplemented groups were 21.2% (p = 0.067) and 17.5% (p = 0.038), respectively. Birth weight, size, gestational age, and preterm deliveries were not significantly different. No sexual abnormalities were reported in children (n = 29) of DHEA-supplemented patients after 5–7 years follow-up.ConclusionsIn conclusion, DHEA supplementation restored serum estradiol levels, and when included in the treatment protocol, there was a statistically significant reduction in miscarriage.
    Keywords pregnancy ; miscarriage ; estradiol ; dehydroepiandrosterone ; restorative reproductive medicine ; Reproduction ; QH471-489 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Application of Novel Short Tandem Repeat Typing for

    Spruijtenburg, Bram / Rudramurthy, Shivaprakash M / Meijer, Eelco F J / van Haren, Merlijn H I / Kaur, Harsimran / Chakrabarti, Arunaloke / Meis, Jacques F / de Groot, Theun

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: Wickerhamomyces anomalus, ...

    Abstract Wickerhamomyces anomalus,
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sporothrix brasiliensis genotyping reveals numerous independent zoonotic introductions in Brazil.

    Spruijtenburg, Bram / Bombassaro, Amanda / Meijer, Eelco F J / Rodrigues, Anderson Messias / Grisolia, Maria Eduarda / Vicente, Vânia Aparecida / de Queiroz-Telles, Flavio / Meis, Jacques F / de Groot, Theun

    The Journal of infection

    2023  Volume 86, Issue 6, Page(s) 610–613

    MeSH term(s) Humans ; Genotype ; Brazil/epidemiology ; Sporothrix/genetics ; Disease Outbreaks ; Sporotrichosis/epidemiology ; Antifungal Agents
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.034
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 48: Show issues

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  8. Article ; Online: Microsatellite Stability in STR Analysis

    de Groot, Theun / Meis, Jacques F

    Frontiers in cellular and infection microbiology

    2019  Volume 9, Page(s) 82

    Abstract: More than a decade ago a short tandem repeat-based typing method was developed for the ... ...

    Abstract More than a decade ago a short tandem repeat-based typing method was developed for the fungus
    MeSH term(s) Aspergillus fumigatus/classification ; Aspergillus fumigatus/genetics ; Genomic Instability ; Genotyping Techniques/methods ; Microsatellite Repeats ; Mycological Typing Techniques/methods ; Tandem Repeat Sequences
    Language English
    Publishing date 2019-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2019.00082
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  9. Article ; Online: Molecular typing and antifungal susceptibility profile of Candida krusei bloodstream isolates from Türkiye.

    Karakoyun, Ayşe Sultan / Spruijtenburg, Bram / Unal, Nevzat / Meijer, Eelco F J / Sucu, Mete / Hilmioğlu-Polat, Süleyha / Meis, Jacques F / de Groot, Theun / Ilkit, Macit

    Medical mycology

    2024  Volume 62, Issue 2

    Abstract: Candida krusei also known as Pichia kudriavzevii is a potentially multidrug-resistant yeast because it is intrinsically resistant to fluconazole and develops acquired resistance to echinocandins and polyenes. Here, we aim to provide a better ... ...

    Abstract Candida krusei also known as Pichia kudriavzevii is a potentially multidrug-resistant yeast because it is intrinsically resistant to fluconazole and develops acquired resistance to echinocandins and polyenes. Here, we aim to provide a better understanding of the epidemiology and transmission modes of C. krusei infections by comparing invasive bloodstream (n = 35) and non-invasive vaginal (n = 20) C. krusei isolates. The genetic relatedness of the isolates was assessed using a newly described short tandem repeat (STR) analysis and their sensitivity to eight antifungal compounds was evaluated by antifungal susceptibility testing using the CLSI microbroth dilution method. All C. krusei isolates revealed unique STR genotypes, indicating the absence of clonal transmission in the study group. Furthermore, no drug-resistant or non-wild-type isolates were identified. Our findings demonstrated high resolution of STR genotyping for the detection and simultaneous genetic analysis of multiple C. krusei strains in clinical samples and excellent in vitro activity of common antifungal agents against invasive strains.
    MeSH term(s) Female ; Animals ; Antifungal Agents/pharmacology ; Turkey ; Candida ; Drug Resistance, Fungal/genetics ; Molecular Typing/veterinary ; Microbial Sensitivity Tests/veterinary ; Pichia
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1421796-x
    ISSN 1460-2709 ; 1369-3786
    ISSN (online) 1460-2709
    ISSN 1369-3786
    DOI 10.1093/mmy/myae005
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    Zs.A 520: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Genotyping and susceptibility testing uncovers large azole-resistant Candida tropicalis clade in Alexandria, Egypt.

    Spruijtenburg, Bram / Meijer, Eelco F J / Xiao, Meng / Shawky, Sherine M / Meis, Jacques F / de Groot, Theun / El-Kholy, Mohammed A

    Journal of global antimicrobial resistance

    2023  Volume 34, Page(s) 99–105

    Abstract: Objectives: Candida tropicalis is an emerging medically relevant Candida species. The yeast primarily causes opportunistic infections in intensive care units and is highly prevalent in tropical countries. The genetic diversity within this species is ... ...

    Abstract Objectives: Candida tropicalis is an emerging medically relevant Candida species. The yeast primarily causes opportunistic infections in intensive care units and is highly prevalent in tropical countries. The genetic diversity within this species is high, and nosocomial transmission has been reported. C. tropicalis genotyping of isolates from low- and middle-income countries is underrepresented when compared with that from high-income countries. Also, in Egypt, only limited genotyping has been conducted for C. tropicalis isolates, while antifungal resistance seems to increase, especially against azoles.
    Methods: Antifungal susceptibility testing was performed on 64 C. tropicalis isolates from ICU patients collected from multiple hospitals in Alexandria, Egypt. Genotyping by means of short tandem repeat (STR) and whole genome sequencing (WGS) single nucleotide polymorphism (SNP) analysis was performed.
    Results: Using antifungal susceptibility testing, fluconazole resistance was observed in 24 isolates (38%), of which 23 harboured an ERG11 G464S substitution, previously shown to cause resistance in Candida albicans. STR genotyping showed that these 23 isolates were related, forming a distinct resistant clade. WGS SNP analysis subsequently confirmed this genetic relationship, although isolates within this clade differed in at least 429 SNPs, suggesting that these were independently introduced.
    Conclusion: Overall, STR and WGS SNP analysis of this collection indicates limited C. tropicalis nosocomial transmission in Alexandria, while the presence of this large azole-resistant C. tropicalis clade within this city hampers the treatment of intensive care unit patients.
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Azoles/pharmacology ; Candida tropicalis/genetics ; Egypt ; Genotype ; Cross Infection
    Chemical Substances Antifungal Agents ; Azoles
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2023.06.012
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