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Article ; Online: Indirect effect of diabatic heating on Mei-yu frontogenesis

Hu, Yang / Deng, Yi / Lin, Yanluan / Zhou, Zhimin / Cui, Chunguang / Li, Chao / Dong, Xiquan

Clim Dyn. 2022 Aug., v. 59, no. 3-4 p.851-868

2022

Abstract: Mei-yu fronts are accompanied with the formation of frontal clouds. In addition to its direct ... effect on Mei-yu fronts through the modification of atmospheric temperature, diabatic heating related ... contributions to the Mei-yu frontogenesis. The indirect effect of diabatic heating on Mei-yu frontogenesis is ...

Abstract	Mei-yu fronts are accompanied with the formation of frontal clouds. In addition to its direct effect on Mei-yu fronts through the modification of atmospheric temperature, diabatic heating related to clouds formation also influences frontogenesis indirectly by changing local atmospheric circulation. To quantify such indirect effects, piecewise potential vorticity (PV) inversion is adopted to decompose the process of deformation frontogenesis into several parts associated with distinct PV anomalies. The balanced flow associated with the interior-level diabatic PV anomaly emerges as the most stable and important contributor to the total deformation frontogenesis with the effect of local diabatic PV anomaly in the frontal zone outweighing the effect of remote diabatic PV anomaly. Lower-boundary thermal anomaly (i.e., surface cooling associated with frontal clouds formation) and mean flow provide weak negative and positive contributions to the deformation frontogenesis, respectively. The balanced flow associated with the upper-level PV perturbations is weak at lower-levels, especially in the vicinity of the front zone and thus has negligible contributions to the Mei-yu frontogenesis. The indirect effect of diabatic heating on Mei-yu frontogenesis is generally weaker in magnitude compared to the direct effect of temperature modification as well as the impact of moisture depletion that is also tied to clouds formation. The results presented here add further evidences about the importance of cloud feedback to the evolution of Mei-yu fronts and suggest the necessity of improved model representations of cloud processes in achieving a better simulation and prediction of Mei-yu rainfall.
Keywords	air temperature ; atmospheric circulation ; cooling ; deformation ; evolution ; heat ; prediction ; rain
Language	English
Dates of publication	2022-08
Size	p. 851-868.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-022-06159-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In reply of the comment "Is oral lichen planus potentially malignant: A reply to Yu-Wei Chiu et al".

Chiu, Yu-Wei / Su, Yee-Fun / Yang, Cheng-Chieh / Liu, Chung-Ji / Chen, Yi-Ju / Cheng, Han-Chieh / Wu, Cheng-Hsien / Chen, Pei-Yin / Lee, Yu-Hsien / Chen, Yen-Lin / Chen, Yi-Tzu / Peng, Chih-Yu / Lu, Ming-Yi / Yu, Chuan-Hang / Kao, Shou-Yen / Fwu, Chyng-Wen / Huang, Yu-Feng

Oral diseases

2022 Volume 29, Issue 5, Page(s) 2317–2318

MeSH term(s)	Humans ; Lichen Planus, Oral/complications ; Cell Transformation, Neoplastic ; Mouth Neoplasms
Language	English
Publishing date	2022-05-04
Publishing country	Denmark
Document type	Letter
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14214
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Zs.A 4427: Show issues

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Article ; Online: The analgesic properties of Yu-Xue-Bi tablets in the inflammatory pain mice: By the inhibition of CCL3-mediated macrophage transmigration into the spinal cord.

Zhang, Guoxin / Tian, Congmin / Liang, Tingjun / Chi, Hongyu / Wu, Anguo / Li, Jiahao / Yao, Xuemin / Wang, Qi / Zhu, Chunyan / Lin, Na

Journal of ethnopharmacology

2022 Volume 289, Page(s) 115051

Abstract: ... with central sensitization in the spinal cord, is far from effectively treated. Yu-Xue-Bi Tablets (YXB) is a patented ...

Abstract	Ethnopharmacological relevance: Until now, inflammatory pain, especially ones with central sensitization in the spinal cord, is far from effectively treated. Yu-Xue-Bi Tablets (YXB) is a patented medicine, which has been widely applied for inflammatory pain. However, its therapeutic characteristics and mechanism remain unknown. Aim of the study: This study is designed to evaluate the analgesic characteristics and explore the underlying mechanism of YXB in the inflammatory pain model induced by Complete Freund's Adjuvant (CFA). Materials and methods: The analgesic effects were measured by Von Frey test. The expression of calcitonin gene-related peptide (CGRP) was quantified by immunofluorescence. The expression of immune factors was analyzed via Luminex assay. The further quantifications of C-C Motif chemokine ligand 3 (CCL3) were verified by Enzyme-linked immunosorbent assay (ELISA). The transmigration of macrophage and activation of microglia were evaluated by immunofluorescence. Spinal injections of purified CCL3, CCR1 antagonist (J113863) and CCR5 antagonist (Maraviroc) were used to clarify roles of CCL3 assumed in the pharmacological mechanism of YXB. Results: In CFA mice, YXB ameliorated the mechanical allodynia in dose and time dependent way, suppressed the central sensitization in dose dependent way. In the L5 spinal cord, YXB downregulated the expression of macrophage M1 pro-inflammatory factors TNFRI and CCL3, inhibited the transmigration of circulating macrophage and the activation of microglia. Purified CCL3 led to the transmigration of macrophage, activation of microglia, central sensitization, and mechanical allodynia in the Sham mice. Inhibitors of CCR1 and CCR5 attenuated above symptoms in CFA mice. Purified CCL3 blocked YXB mediated down regulation of CCL3, inhibition of macrophage transmigration, but not activation of microglia. Conclusion: YXB exerts the analgesic effects by inhibiting CCL3-mediated peripheral macrophage transmigrate into spinal cord. This study provided a novel approach for inflammatory pain treatment and new insight into the pharmacological action of YXB.
MeSH term(s)	Analgesics/administration & dosage ; Analgesics/pharmacology ; Animals ; Cell Movement/drug effects ; Chemokine CCL3/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Hyperalgesia/drug therapy ; Inflammation/drug therapy ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Pain/drug therapy ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Tablets ; Time Factors
Chemical Substances	Analgesics ; Ccl3 protein, mouse ; Chemokine CCL3 ; Drugs, Chinese Herbal ; Tablets
Language	English
Publishing date	2022-01-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115051
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Zs.A 1494: Show issues

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Article ; Online: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice.

Wang, Anlu / Guan, Baoyi / Shao, Chang / Zhao, Lin / Li, Qiuyi / Hao, Haiping / Gao, Zhuye / Chen, Keji / Hou, Yuanlong / Xu, Hao

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 103, Page(s) 154220

Abstract: ... characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction ...

Abstract	Background: Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. Purpose: To investigate the protective effects of QXJYG against AS and its potential mechanisms. Methods: QXJYG was orally administered at doses of 1.664 and 4.992 g·kg Results: QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Conclusion: Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism.
MeSH term(s)	Animals ; Apolipoproteins E ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Diet, High-Fat/adverse effects ; Drugs, Chinese Herbal ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Inflammation/metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Ribosomal, 16S
Chemical Substances	Apolipoproteins E ; Drugs, Chinese Herbal ; RNA, Messenger ; RNA, Ribosomal, 16S ; qing-xin-jie-yu granules ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154220
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Zs.A 4115: Show issues

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Article ; Online: Qing-Xin-Jie-Yu Granule inhibits ferroptosis and stabilizes atherosclerotic plaques by regulating the GPX4/xCT signaling pathway.

Zhang, Jie / Wang, Xinyi / Guan, Baoyi / Wang, Xue / An, Xiaojing / Wang, Tong / Chen, Xuanye / Zhao, Lin / Jia, Jundi / Song, Luxia / Ma, Dan / Li, Qiuyi / Zhang, He / Ju, Jianqing / Xu, Hao

Journal of ethnopharmacology

2022 Volume 301, Page(s) 115852

Abstract: Ethnopharmacological relevance: Qing-Xin-Jie-Yu Granule (QXJYG) is an integrated ...

Abstract	Ethnopharmacological relevance: Qing-Xin-Jie-Yu Granule (QXJYG) is an integrated traditional Chinese medicine formula used to treat atherosclerotic (AS) cardiovascular diseases. A randomized controlled trial found that QXJYG reduced cardiovascular events and experiments also verified that QXJYG attenuated AS by remodeling the intestinal flora. Aim of the study: To determine whether QXJYG would attenuate AS and plaque vulnerability by regulating ferroptosis in high-fat diet-induced atherosclerotic ApoE Methods: AS models in ApoE Results: QXJYG attenuated AS progression and plaque vulnerability. Characteristic morphological changes of ferroptosis in the QXJYG-treated animals were rare. Total iron was significantly lower in the QXJYG group than in the model group (P < 0.05); QXJYG suppressed the lipid peroxidation (LPO) levels (malondialdehyde), enhanced the antioxidant capacity (superoxide dismutase and glutathione), and reduced inflammatory factors (interleukin [IL]-6, IL-1β, tumor necrosis factor-α) associated with ferroptosis. Expression of GPX4/xCT in aorta tissues was remarkably increased in the QXJYG group. QXJYG inhibited ferroptosis in J744A.1 macrophages disturbed using RSL3. The Fe Conclusion: QXJYG inhibits ferroptosis in vulnerable AS plaques partially via the GPX4/xCT signaling pathway.
MeSH term(s)	Animals ; Mice ; Amino Acid Transport Systems, Acidic/metabolism ; Apolipoproteins E ; Ferroptosis ; Plaque, Atherosclerotic/drug therapy ; Signal Transduction
Chemical Substances	Amino Acid Transport Systems, Acidic ; Apolipoproteins E ; glutathione peroxidase 4, mouse (EC 1.11.1.9) ; qing-xin-jie-yu granules
Language	English
Publishing date	2022-10-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115852
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Zs.A 1494: Show issues

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Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage.

Xue, Dao-Jin / Zhen, Zheng / Wang, Ke-Xin / Zhao, Jia-Lin / Gao, Yao / Chen, Yu-Peng / Shen, You-Bi / Peng, Zi-Zhuang / Guan, Dao-Gang / Huang, Tao

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 103

Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

Abstract	Background: Chinese herbal medicine (CHM) is characterized by "multi- compounds, multi-targets and multi-pathway", which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Methods: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. Results: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Conclusions: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
MeSH term(s)	Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Reproducibility of Results
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-022-03577-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long noncoding RNA transcriptome analysis reveals novel lncRNAs in Morus alba 'Yu-711' response to drought stress.

Ackah, Michael / Jin, Xin / Zhang, Qiaonan / Amoako, Frank Kwarteng / Wang, Lei / Attaribo, Thomas / Zhao, Mengdi / Yuan, Feng / Herman, Richard Ansah / Qiu, Changyu / Lin, Qiang / Yin, Zhi / Zhao, Weiguo

The plant genome

2022 Volume 17, Issue 1, Page(s) e20273

Abstract: Drought stress has been a key environmental factor affecting plant growth and development. The plant genome is capable of producing long noncoding RNAs (lncRNAs). To better understand white mulberry (Morus alba L.) drought response mechanism, we ... ...

Abstract	Drought stress has been a key environmental factor affecting plant growth and development. The plant genome is capable of producing long noncoding RNAs (lncRNAs). To better understand white mulberry (Morus alba L.) drought response mechanism, we conducted a comparative transcriptome study comparing two treatments: drought-stressed (EG) and well-watered (CK) plants. A total of 674 differentially expressed lncRNAs (DElncRNAs) were identified. In addition, 782 differentially expressed messenger RNAs (DEmRNAs) were identified. We conducted Gene Ontology (GO) and KEGG enrichment analyses focusing on the differential lncRNAs cis-target genes. The target genes of the DElncRNAs were most significantly involved in the biosynthesis of secondary metabolites. Gene regulatory networks of the target genes involving DElncRNAs-mRNAs-DEmRNAs and DElncRNA-miRNA-DEmRNA were constructed. In the DElncRNAs-DEmRNAs network, 30 DEmRNAs involved in the biosynthesis of secondary metabolites are collocated with 46 DElncRNAs. The interaction between DElncRNAs and candidate genes was identified using LncTar. In summary, quantitative real-time polymerase chain reaction (qRT-PCR) validated nine candidate genes and seven target lncRNAs including those identified by LncTar. We predicted that the DElncRNAs-DEmRNAs might recruit microRNAs (miRNAs) to interact with gene regulatory networks under the drought stress response in mulberry. The findings will contribute to our understanding of the regulatory functions of lncRNAs under drought stress and will shed new light on the mulberry-drought stress interactions.
MeSH term(s)	RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Droughts ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Gene Expression Profiling ; RNA, Messenger/genetics ; Morus
Chemical Substances	RNA, Long Noncoding ; MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375444-8
ISSN	1940-3372 ; 0011-183X
ISSN (online)	1940-3372
ISSN	0011-183X
DOI	10.1002/tpg2.20273
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Z 7758: Show issues

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Article ; Online: Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang.

Wang, Zihao / Lin, Hui-Heng / Linghu, Kegang / Huang, Run-Yue / Li, Guangyao / Zuo, Huali / Yu, Hua / Chan, Ging / Hu, Yuanjia

Chemical & pharmaceutical bulletin

2019 Volume 67, Issue 8, Page(s) 778–785

Abstract: ... For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used ...

Abstract	Herbal formulae have a long history in clinical medicine in Asia. While the complexity of the formulae leads to the complex compound-target interactions and the resultant multi-target therapeutic effects, it is difficult to elucidate the molecular/therapeutic mechanism of action for the many formulae. For example, the Hua-Yu-Qiang-Shen-Tong-Bi-Fang (TBF), an herbal formula of Chinese medicine, has been used for treating rheumatoid arthritis. However, the target information of a great number of compounds from the TBF formula is missing. In this study, we predicted the targets of the compounds from the TBF formula via network analysis and in silico computing. Initially, the information of the phytochemicals contained in the plants of the herbal formula was collected, and subsequently computed to their corresponding fingerprints for the sake of structural similarity calculation. Then a compound structural similarity network infused with available target information was constructed. Five local similarity indices were used and compared for their performance on predicting the potential new targets of the compounds. Finally, the Preferential Attachment Index was selected for it having an area under curve (AUC) of 0.886, which outperforms the other four algorithms in predicting the compound-target interactions. This method could provide a promising direction for identifying the compound-target interactions of herbal formulae in silico.
MeSH term(s)	Algorithms ; Arthritis, Rheumatoid/drug therapy ; Drug Compounding ; Drug Interactions ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2019-07-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c18-00808
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Zs.A 770: Show issues

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Article: Inflorescence pruning and cincturing after full female bloom improve 'Yu Her Pau' litchi (Litchi chinensis) fruit bearing 10.17660/th2022/016

Chang, JenYu / Tang, Lisa / Lin, Mei-Li / Chang, Yu-An / Chang, Jer-Way

Fruits

2022 Volume 77, Issue 4, Page(s) –

Language	French
Document type	Article
ZDB-ID	240538-6
ISSN	0016-2299 ; 0248-1294
Database	Current Contents Nutrition, Environment, Agriculture

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Article: [Autobiography of modern acupuncturist Yu Shu-zhuang].

Li, Jia-jian' i / Guo, Jing / Yu, Zhen-zhong / Wang, Lin-peng

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2014 Volume 34, Issue 11, Page(s) 1123–1126

Abstract: Professor YU Shu-zhuang is a distinguished acupuncturist in China. He has practiced the TCM ... points. Professor YU has educated a great number of acupuncture-moxibustion talents in China and foreign ...

Abstract	Professor YU Shu-zhuang is a distinguished acupuncturist in China. He has practiced the TCM acupuncture-moxibustion clinical, educational and scientific research for 60 years in his life. In clinic, he summarized the experiences "five-ming first"; in treatment, he insisted "dredging" and "regulating", protecting the function of spleen and stomach, and needles should be less but specific. In the meanwhile, he made a deep study on the function and clinical effects of specific acupoints, and used the research results of propagated sensation along channel to guide clinical treatment, forming his special academic points. Professor YU has educated a great number of acupuncture-moxibustion talents in China and foreign countries, making great contribution to the popularization of acupuncture-moxibustion in the worldwide.
MeSH term(s)	Acupuncture/education ; Acupuncture/history ; Acupuncture Points ; Acupuncture Therapy/history ; China ; History, 20th Century ; History, 21st Century
Language	Chinese
Publishing date	2014-11
Publishing country	China
Document type	Biography ; English Abstract ; Historical Article ; Journal Article ; Portraits ; Research Support, Non-U.S. Gov't
ISSN	0255-2930
ISSN	0255-2930
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