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Article: Biologicals in severe chronic rhinosinusitis with nasal polyps: translation to clinical practice while waiting for head-to-head studies.

Boechat, J L / Sousa-Pinto, B / Delgado, L / Silva, D

2023 Volume 61, Issue 3, Page(s) 283–286

Abstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) affects 1.0-2.6% of the population (1) and results in relevant direct and indirect costs. Recently, several randomized controlled trials (RCTs) with Type 2-targeting biologicals (anti-IL4RÎ±, anti-IL5R, ... ...

Abstract	Chronic rhinosinusitis with nasal polyps (CRSwNP) affects 1.0-2.6% of the population (1) and results in relevant direct and indirect costs. Recently, several randomized controlled trials (RCTs) with Type 2-targeting biologicals (anti-IL4RÎ±, anti-IL5R, anti-IL5 and anti-IgE) opened a new treatment field for patients refractory to first-line treatments (2,3).
MeSH term(s)	Humans ; Rhinitis/drug therapy ; Biological Products/therapeutic use ; Nasal Polyps/drug therapy ; Sinusitis/drug therapy ; Chronic Disease
Chemical Substances	Biological Products
Language	English
Publishing date	2023-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80336-4
ISSN	0300-0729
ISSN	0300-0729
DOI	10.4193/Rhin22.436
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Article ; Online: The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives.

Boechat, J L / Chora, I / Morais, A / Delgado, L

Pulmonology

2021 Volume 27, Issue 5, Page(s) 423–437

Abstract: SARS-CoV-2 is a new beta coronavirus, similar to SARS-CoV-1, that emerged at the end of 2019 in the Hubei province of China. It is responsible for coronavirus disease 2019 (COVID-19), which was declared a pandemic by the World Health Organization on ... ...

Abstract	SARS-CoV-2 is a new beta coronavirus, similar to SARS-CoV-1, that emerged at the end of 2019 in the Hubei province of China. It is responsible for coronavirus disease 2019 (COVID-19), which was declared a pandemic by the World Health Organization on March 11, 2020. The ability to gain quick control of the pandemic has been hampered by a lack of detailed knowledge about SARS-CoV-2-host interactions, mainly in relation to viral biology and host immune response. The rapid clinical course seen in COVID-19 indicates that infection control in asymptomatic patients or patients with mild disease is probably due to the innate immune response, as, considering that SARS-CoV-2 is new to humans, an effective adaptive response would not be expected to occur until approximately 2-3 weeks after contact with the virus. Antiviral innate immunity has humoral components (complement and coagulation-fibrinolysis systems, soluble proteins that recognize glycans on cell surface, interferons, chemokines, and naturally occurring antibodies) and cellular components (natural killer cells and other innate lymphocytes). Failure of this system would pave the way for uncontrolled viral replication in the airways and the mounting of an adaptive immune response, potentially amplified by an inflammatory cascade. Severe COVID-19 appears to be due not only to viral infection but also to a dysregulated immune and inflammatory response. In this paper, the authors review the most recent publications on the immunobiology of SARS-CoV-2, virus interactions with target cells, and host immune responses, and highlight possible associations between deficient innate and acquired immune responses and disease progression and mortality. Immunotherapeutic strategies targeting both the virus and dysfunctional immune responses are also addressed.
MeSH term(s)	Adaptive Immunity/immunology ; Adult ; Aged ; Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/pathology ; Disease Progression ; Humans ; Immunity, Innate/immunology ; Immunotherapy/methods ; Inflammation/immunology ; Inflammation/physiopathology ; Inflammation/virology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/pathology ; Lung Diseases, Interstitial/virology ; Middle Aged ; Respiration, Artificial/methods ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Severity of Illness Index
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-04-09
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	3009651-0
ISSN	2531-0437 ; 2531-0429
ISSN (online)	2531-0437
ISSN	2531-0429
DOI	10.1016/j.pulmoe.2021.03.008
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Article: Nasal Bacteriomes of Patients with Asthma and Allergic Rhinitis Show Unique Composition, Structure, Function and Interactions.

Pérez-Losada, Marcos / Castro-Nallar, Eduardo / Laerte Boechat, José / Delgado, Luis / Azenha Rama, Tiago / Berrios-Farías, Valentín / Oliveira, Manuela

Microorganisms

2023 Volume 11, Issue 3

Abstract: Allergic rhinitis and asthma are major public health concerns and economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with asthma comorbidity. To address this knowledge gap ... ...

Abstract	Allergic rhinitis and asthma are major public health concerns and economic burdens worldwide. However, little is known about nasal bacteriome dysbiosis during allergic rhinitis, alone or associated with asthma comorbidity. To address this knowledge gap we applied 16S rRNA high-throughput sequencing to 347 nasal samples from participants with asthma (AS = 12), allergic rhinitis (AR = 53), allergic rhinitis with asthma (ARAS = 183) and healthy controls (CT = 99). One to three of the most abundant phyla, and five to seven of the dominant genera differed significantly (
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11030683
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Article: The oral bacteriomes of patients with allergic rhinitis and asthma differ from that of healthy controls.

Pérez-Losada, Marcos / Castro-Nallar, Eduardo / Laerte Boechat, José / Delgado, Luís / Azenha Rama, Tiago / Berrios-Farías, Valentín / Oliveira, Manuela

Frontiers in microbiology

2023 Volume 14, Page(s) 1197135

Abstract: Allergic rhinitis and asthma are two of the most common chronic respiratory diseases in developed countries and have become a major public health concern. Substantial evidence has suggested a strong link between respiratory allergy and upper airway ... ...

Abstract	Allergic rhinitis and asthma are two of the most common chronic respiratory diseases in developed countries and have become a major public health concern. Substantial evidence has suggested a strong link between respiratory allergy and upper airway dysbacteriosis, but the role of the oral bacteriota is still poorly understood. Here we used 16S rRNA massive parallel sequencing to characterize the oral bacteriome of 344 individuals with allergic rhinitis (AR), allergic rhinitis with asthma (ARAS), asthma (AS) and healthy controls (CT). Four of the most abundant (>2%) phyla (Actinobacteriota, Firmicutes, Fusobacteriota, and Proteobacteria) and 10 of the dominant genera (
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1197135
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Article ; Online: New Imatinib Derivatives with Antiproliferative Activity against A549 and K562 Cancer Cells.

Oliveira, Andressa / Moura, Stefany / Pimentel, Luiz / Neto, João / Dantas, Rafael / Silva-Jr, Floriano / Bastos, Monica / Boechat, Nubia

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 3

Abstract: Tyrosine kinase enzymes are among the primary molecular targets for the treatment of some human neoplasms, such as those in lung cancer and chronic myeloid leukemia. Mutations in the enzyme domain can cause resistance and new inhibitors capable of ... ...

Abstract	Tyrosine kinase enzymes are among the primary molecular targets for the treatment of some human neoplasms, such as those in lung cancer and chronic myeloid leukemia. Mutations in the enzyme domain can cause resistance and new inhibitors capable of circumventing these mutations are highly desired. The objective of this work was to synthesize and evaluate the antiproliferative ability of ten new analogs that contain isatins and the phenylamino-pyrimidine pyridine (PAPP) skeleton, the main pharmacophore group of imatinib. The 1,2,3-triazole core was used as a spacer in the derivatives through a click chemistry reaction and gave good yields. All the analogs were tested against A549 and K562 cells, lung cancer and chronic myeloid leukemia (CML) cell lines, respectively. In A549 cells, the 3,3-difluorinated compound (
MeSH term(s)	A549 Cells ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Imatinib Mesylate/analogs & derivatives ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; K562 Cells ; Neoplasms/drug therapy ; Neoplasms/pathology ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2022-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27030750
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Article ; Online: Clinical Utility of a Reaction-Time Attention Task in the Evaluation of Cognitive Impairment in Elderly with High Educational Disparity.

Schmidt, Sergio L / Boechat, Yolanda Eliza Moreira / Schmidt, Guilherme J / Nicaretta, Denise / van Duinkerken, Eelco / Schmidt, Juliana J

Journal of Alzheimer's disease : JAD

2021 Volume 81, Issue 2, Page(s) 691–697

Abstract: Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) ...

Abstract	Background: The Clinical Dementia Rating (CDR) scale is commonly used to stage cognitive impairment, despite having educational limitations. In elderly with low education, a previous study has shown that intraindividual variability of reaction time (CV) and commission errors (CE), measured using a culture-free Go/No-Go task, can reliably distinguish early Alzheimer's disease (AD) from mild cognitive impairment (MCI) and healthy controls. Objective: We aimed to extend the clinical utility of this culture-free Go/No-Go task in a sample with high educational disparity. Methods: One hundred and ten participants with a wide range of years of formal education (0-14 years) were randomly selected from a geriatric unit and divided based on their CDR scores into cognitively unimpaired (CDR = 0), MCI (CDR = 0.5), and early AD (CDR = 1). All underwent a 90-s reaction-time test that measured the variables previously found to predict CDR in low educated elderly. Here we added years of formal education (educational level) to the model. Multivariate analyses compared differences in group means using educational level as confounding factor. A confirmatory discriminant analyses was performed, to assess if CDR scores could be predicted by the two Go/No-Go variables in a sample with high educational disparity. Results: Over all three groups, differences in both CE and CV reached statistical significance (p < 0.05). The discriminant analysis demonstrated that CV and CE discriminated cognitively impaired from cognitively normal elderly. These results remained similar when discriminating MCI from cognitively unimpaired elderly. Conclusion: The Go/No-Go task reliably discriminates elderly with MCI from elderly without cognitive impairment independent of educational disparity.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/physiopathology ; Attention/physiology ; Cognition/physiology ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/physiopathology ; Disease Progression ; Educational Status ; Female ; Humans ; Male ; Mental Status and Dementia Tests ; Severity of Illness Index ; Task Performance and Analysis
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-210151
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Zs.A 6084: Show issues

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Article ; Online: Detection of Cognitive Dysfunction in Elderly with a Low Educational Level Using a Reaction-Time Attention Task.

Schmidt, Guilherme J / Boechat, Yolanda Eliza Moreira / van Duinkerken, Eelco / Schmidt, Juliana J / Moreira, Tayssa B / Nicaretta, Denise H / Schmidt, Sergio L

Journal of Alzheimer's disease : JAD

2021 Volume 78, Issue 3, Page(s) 1197–1205

Abstract: Background: Scales for cognitive deterioration usually depend on education level.: Objective: We aimed to study the clinical utility of a culture-free Go/No-Go task in a multi-ethnic cohort with low education level.: Methods: Sixty-four ... ...

Abstract	Background: Scales for cognitive deterioration usually depend on education level. Objective: We aimed to study the clinical utility of a culture-free Go/No-Go task in a multi-ethnic cohort with low education level. Methods: Sixty-four participants with less than 4 years of formal education were included and divided on the basis of their Clinical-Dementia-Rate scores (CDR) into cognitively unimpaired (CDR = 0), mild cognitive impairment (MCI; CDR = 0.5), and early Alzheimer's disease (AD, CDR = 1). All underwent a 90-s Continuous Visual Attention Test. This test consisted of a 90-s Go/No-go task with 72 (80%) targets and 18 (20%) non-targets. For each participant, reaction times and intraindividual variability of reaction times of all correct target responses, as well as the number of omission and commission errors were evaluated. Coefficient of variability was calculated for each participant by dividing the standard deviation of the reaction times by the mean reaction time. A MANCOVA was performed to examine between-group differences using age and sex as covariates. Discriminate analysis was performed to find the most reliable test-variable to discriminate the three groups. Results: Commission error, intraindividual variability of reaction time, and coefficient of variability progressively worsened with increasing CDR level. Discriminant analysis demonstrated that coefficient of variability was the best discriminant factor, followed by intraindividual variability of reaction time and commission error. Conclusion: The Go/No-Go task was able to discriminate people with MCI or early AD from controls in the setting of illiteracy.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/physiopathology ; Attention ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/physiopathology ; Educational Status ; Female ; Humans ; Literacy ; Male ; Middle Aged ; Neuropsychological Tests ; Reaction Time
Language	English
Publishing date	2021-01-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-200881
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Article ; Online: Investigation of oral atopic diseases: Correlation between geographic tongue and fungiform papillary glossitis.

Núñez Amin Dick, T / Rocha Santos, L / Carneiro, S / Moore, D / Pestana, S / Laerte Boechat, J / Lavinas Sayed Picciani, B

Journal of stomatology, oral and maxillofacial surgery

2020 Volume 122, Issue 3, Page(s) 283–288

Abstract: Introduction: The correlation between oral lesions and atopy is not new, but few studies have investigated the prevalence of mucosal changes in diseases within the atopic spectrum, leading to conflicting data. Some studies found a possible relationship ... ...

Abstract	Introduction: The correlation between oral lesions and atopy is not new, but few studies have investigated the prevalence of mucosal changes in diseases within the atopic spectrum, leading to conflicting data. Some studies found a possible relationship between geographic tongue, transient lingual papillitis and atopic diseases. Aim: To investigate the frequency of geographic tongue and fungiform papillary glossitis in patients with atopic diseases, and its correlation with serum IgE levels and skin test results. Material and methods: The sample was comprised of participants with atopic diseases paired with participants who received negative puncture skin tests. All were submitted to stomatological and medical evaluations, prick test and oral cytopathological. Results: The female sex was more numerous in both groups. Mean age was 21 years. A total of 60 diagnoses of atopic diseases were obtained, with allergic rhinitis being the most prevalent. Fungiform papillary glossitis was the most frequent oral lesion in both groups, while geographic tongue was present in 2 cases (2%) in the test group and 2 (2%) in the control group. Atopic patients with fungiform papillary glossitis presented high serum IgE levels. In atopic patients with geographic tongue, the prick test positively identified extracts of Dermatophagoides pteronyssinus (100%) and Dermatophagoides farinae (100%). Conclusion: Due to the low frequency of geographic tongue lesions found in the study, it is no possible to conclude if that could be an oral manifestation of atopy. However fungiform papillary glossitis is a common alteration in atopic and non-atopic patients and has a relationship with high IgE serum levels. However, the consolidation of this result requires a larger sample size.
MeSH term(s)	Adult ; Female ; Glossitis/diagnosis ; Glossitis/epidemiology ; Glossitis/etiology ; Glossitis, Benign Migratory/complications ; Glossitis, Benign Migratory/diagnosis ; Glossitis, Benign Migratory/epidemiology ; Humans ; Prevalence ; Skin Tests ; Young Adult
Language	English
Publishing date	2020-06-12
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2020.05.025
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Article: ConectAR: Collaborative network of patients with asthma and carers actively involved in health research: a protocol for patient and public involvement.

Sá-Sousa, A / Rodrigues, T / Fernandes, S / Santos, A M / Garcia-Lema, I / Costa, E D / Chaves Loureiro, C / Boechat, J L / Baía Reis, A / Figueiredo, D / Fonseca, J A / Neves, A L / Jácome, C

European annals of allergy and clinical immunology

2022 Volume 55, Issue 4, Page(s) 180–188

Abstract: Summary: Background. ...

Abstract	Summary: Background.
MeSH term(s)	Humans ; Caregivers ; Focus Groups ; Asthma ; Portugal
Language	English
Publishing date	2022-03-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2105540-3
ISSN	1764-1489 ; 0397-9148
ISSN	1764-1489 ; 0397-9148
DOI	10.23822/EurAnnACI.1764-1489.249
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Zs.A 2037: Show issues

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Article ; Online: Quantum fidelity approach to the ground-state properties of the one-dimensional axial next-nearest-neighbor Ising model in a transverse field.

Bonfim, O F de Alcantara / Boechat, B / Florencio, J

Physical review. E

2017 Volume 96, Issue 4-1, Page(s) 42140

Abstract: ... neighbor interaction J_{2}, for systems of up to 24 spins. We also examine the ground-state vector ... L→∞). Paramagnetism only occurs for larger magnetic fields. The transition lines separating ...

Abstract	In this work we analyze the ground-state properties of the s=1/2 one-dimensional axial next-nearest-neighbor Ising model in a transverse field using the quantum fidelity approach. We numerically determined the fidelity susceptibility as a function of the transverse field B_{x} and the strength of the next-nearest-neighbor interaction J_{2}, for systems of up to 24 spins. We also examine the ground-state vector with respect to the spatial ordering of the spins. The ground-state phase diagram shows ferromagnetic, floating, and 〈2,2〉 phases, and we predict an infinite number of modulated phases in the thermodynamic limit (L→∞). Paramagnetism only occurs for larger magnetic fields. The transition lines separating the modulated phases seem to be of second order, whereas the line between the floating and the 〈2,2〉 phases is possibly of first order.
Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.96.042140
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