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Article ; Online: Cuarteto Artemis o de una historia sobre resiliencia colectiva

Oscar Bottasso

Revista de Medicina y Cine / Journal of Medicine and Movies, Vol 17, Iss 4, Pp 257-

2021 Volume 261

Abstract: El artículo hace una reseña acerca del célebre Cuarteto Artemis en sus 3 décadas de recorrido, y gran capacidad para adaptarse a las peripecias experimentadas a lo largo de este período, preservando la calidad interpretativa como objetivo primordial. El ... ...

Abstract	El artículo hace una reseña acerca del célebre Cuarteto Artemis en sus 3 décadas de recorrido, y gran capacidad para adaptarse a las peripecias experimentadas a lo largo de este período, preservando la calidad interpretativa como objetivo primordial. El conjunto había sufrido el tropiezo ocasionado por la partida de Friedemann Weigle quien aquejado de un trastorno bipolar y cuadro depresivo mayor pone fin a su vida el 6 de julio de 2015. Las vivencias de la agrupación aparecen bien reflejadas en el documental Artemis, The Neverending Quartet estrenado el año 2019 en Hamburgo, y posteriormente nominado al Golden Calf Film Award en la categoría de «Mejor Cortometraje Documental 2020». En sus 53 minutos la directora Hester Overmars nos brinda una pincelada a grandes rasgos de la agrupación, quien gracias a la posibilidad de asistir a los ensayos consigue registrar las experiencias detrás de bambalinas, a la par de permitirnos entrever aquellos esfuerzos reparadores, cual suerte de firme resiliencia colectiva. Teniendo a la música como principal protagonista, la película trasluce los avatares derivados de la dolorosa pérdida de un compañero de tantos años, y el empeño para no quedar atrapados en la encerrona de la desesperanza.
Keywords	cuarteto artemis ; friedemann weigle ; viola ; the neverending quartet ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Ediciones Universidad de Salamanca
Document type	Article ; Online
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Article ; Online: The potential implication of decreased DHEA levels in the pathophysiology of chronic Chagas cardiomyopathy.

Bottasso, Oscar

International journal of cardiology

2022 Volume 350, Page(s) 92–93

MeSH term(s)	Cardiomyopathies ; Chagas Cardiomyopathy ; Chagas Disease ; Dehydroepiandrosterone ; Humans
Chemical Substances	Dehydroepiandrosterone (459AG36T1B)
Language	English
Publishing date	2022-01-07
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.01.012
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Article ; Online: Chagas disease in children from the Gran Chaco region: A bibliographic appraisal.

Mendicino, Diego / Bottasso, Oscar

Tropical doctor

2022 Volume 52, Issue 4, Page(s) 560–562

Abstract: In the Gran Chaco region, the Pan American Health Organization (PAHO) declared the interruption of vector transmission of Chagas Disease in Paraguay and some district of Argentina.After a bibliographic search, by using the words "Chagas, prevalence, ... ...

Abstract	In the Gran Chaco region, the Pan American Health Organization (PAHO) declared the interruption of vector transmission of Chagas Disease in Paraguay and some district of Argentina.After a bibliographic search, by using the words "Chagas, prevalence, children, Chaco", on scientiphic articles indexed in Pubmed and Lilacs during the 2010-2021 period, we found nine studies which dealt with entomological data seroprevalence surveys of Chagas Disease in Argentine children and three studies in Bolivian children.More field studies need to be published to better understand the epidemiological situation in children from the region. Due to its social and ecological characteristics, the Gran Chaco region remains a hotspot for Chagas Disease affecting disproportionally rural communities and certain vulnerable ethnics groups.
MeSH term(s)	Chagas Disease/diagnosis ; Chagas Disease/epidemiology ; Child ; Humans ; Prevalence ; Rural Population ; Seroepidemiologic Studies ; Trypanosoma cruzi
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	193169-6
ISSN	1758-1133 ; 0049-4755
ISSN (online)	1758-1133
ISSN	0049-4755
DOI	10.1177/00494755221103002
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Book ; Online: El requiem, un romanzo y una plaga. Alessandro Manzoni, Giuseppe Verdi y las historias de antiguas epidemias

Bottasso, Oscar

2020

Abstract: ... geografía. ... Fil: Bottasso, Oscar. Universidad Nacional de Rosario. CONICET-UNR. Rosario; Argentina ...

Abstract	La historia de la Medicina, tan abundante en padecimientos que han convulsionado a la humanidad desde tiempos inmemoriales, escribe hoy una nueva página de alcance planetario y que de alguna manera nos enrostra esa otra faceta burda de la globalización. Al son del COVID19 danzamos y su coreografía nos retrotrae, entre tantas anécdotas, a sucesos no menos dolorosos como los ocurridos en la península itálica a comienzos del siglo XVII, que fueran palmariamente retratados por uno de los literatos más eximios de lengua del Dante, Alessandro Manzoni. Sin lugar a duda, un fiel representante del risorgimento que reunía a actores claves de la sociedad italiana, entre los cuales se destacaban él mismo, Giuseppe Verdi y por supuesto su gran artífice Giuseppe Mazzini. La meta era lograr una Italia unida e independiente fiel a su historia y geografía. Fil: Bottasso, Oscar. Universidad Nacional de Rosario. CONICET-UNR. Rosario; Argentina
Keywords	COVID-19 ; Pandemia ; Epidemias ; Historia ; Arte ; Alessandro Manzoni ; Giuseppe Verdi ; covid19
Language	Spanish
Publishing date	2020-04-20
Publishing country	ar
Document type	Book ; Online
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Conference proceedings ; Online: Hechos salientes en la inmunopatología de la infección por SARSCoV2

Bottasso, Oscar

2020

Abstract: ... y disponible en YouTube https://youtu.be/GvUSxHHY1nA ... Fil: Bottasso, Oscar. Universidad Nacional ...

Abstract	Charla sobre "Hechos salientes en la inmunopatología de la infección por SARSCoV2" organizada por la Facultad de Ciencias Médicas de la UNR en el Día Internacional de la Inmunología realizada el día 29/04/20 y disponible en YouTube https://youtu.be/GvUSxHHY1nA Fil: Bottasso, Oscar. Universidad Nacional de Rosario. CONICET-UNR. Rosario; Argentina
Keywords	COVID-19 ; Inmunopatología ; Respuesta inmunológica ; Inmunología ; Pandemia ; covid19
Language	Spanish
Publishing date	2020-04-29
Publisher	Facultad de Ciencias Médicas. Universidad Nacional de Rosario
Publishing country	ar
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: La pandemia COVID-19. Sus rasgos más distintivos

Bottasso, Oscar

2020

Abstract: ... cuarentena. ... Fil: Bottasso, Oscar. Universidad Nacional de Rosario. Consejo de Investigaciones de la UNR ...

Abstract	Hacia fines de noviembre de 2019, comenzó a detectarse una serie de casos de neumonía sin diagnóstico etiológico preciso en Wuhan, China. Poco tiempo después, concretamente a principios de enero de 2020 fue posible determinar que su agente causal era un nuevo coronavirus, inicialmente denominado 2019-nCoV y luego coronavirus-2 del síndrome respiratorio agudo severo (SARS-CoV-2), aunque también se lo suele identificar como COVID-19. La enfermedad que afecta particularmente las vías respiratorias se generalizó rápidamente dado la transmisión entre personas, habiendo ocasionado brotes significativos a nivel planetario con un variado espectro de morbilidad y una tasa de mortalidad que en líneas generales oscila entre un 3 y 4%. El 11 de marzo de 2020, la OMS declaró la pandemia COVID-19; la cual ha puesto en jaque a los sistemas de salud y la economía global, atento a los desafíos que plantean las pautas de prevención, la atención clínica y las cuestiones socioeconómicas vinculadas a las medidas de aislamiento y la consabida cuarentena. Fil: Bottasso, Oscar. Universidad Nacional de Rosario. Consejo de Investigaciones de la UNR. CONICET-UNR. Rosario; Argentina
Keywords	COVID-19 ; SARS-CoV-2 ; https://purl.org/becyt/ford/3.1 ; covid19
Language	Spanish
Publisher	Universidad Nacional de Rosario. Consejo de Investigaciones
Publishing country	ar
Document type	Article ; Online
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Article ; Online: Antibodies to SARS-CoV2 induced by vaccination and infection correlate with protection against the infection.

Flor, Noelia / García, María Inés / Molineri, Ana / Bottasso, Oscar / Diez, Cristina / Veaute, Carolina

Vaccine

2023 Volume 41, Issue 48, Page(s) 7206–7211

Abstract: The COVID-19 pandemic remained worldwide for almost three years, but little is known about the dynamics of humoral immune response to the third dose over time and its protection from infection. Our aim was to assess the humoral immune response after the ... ...

Abstract	The COVID-19 pandemic remained worldwide for almost three years, but little is known about the dynamics of humoral immune response to the third dose over time and its protection from infection. Our aim was to assess the humoral immune response after the third dose of the different vaccines administered to SARS-CoV-2 naive and previously infected individuals, and its correlation with protection in an academic community. For each person studied (185), three blood samples were taken between December 2021 and July 2022, one month apart. Anti-S antibodies were quantified by ELISA, while anti-N antibody levels were determined by ECLIA. Most of the participants had received two doses of viral vector-based, mRNA-based and virus-inactivated vaccines. Although anti-N antibody levels revealed that 80% of the individuals had been exposed to the virus before or during the study, only 42% reported having been diagnosed. When anti-S IgG levels were measured 3-5 months after the second dose of any vaccine, they were higher in those previously infected individuals. The same results were observed for anti-N IgG levels in those who received 2 doses of the virus-inactivated vaccine. When analyzing the dynamics of anti-S antibodies we observed that, although positive IgG antibody levels were detected 5-6 months after the second dose administration, those observed 30-60 days after the third dose were significantly higher and remained so for at least 8 months. Higher levels of anti-S IgG antibodies at the first sampling were associated with a lower incidence of subsequent infection. The same association was seen in people who received the booster compared with those who received two doses. This study provides further evidence that anti-S IgG antibodies remained at high levels over time, and both anti-S levels and the third dose of anti-SARS-CoV-2 vaccine correlate with protection against the infection. It also shows that infection acts as a booster of immunization, increasing levels of both anti-N and anti-S IgG.
MeSH term(s)	Humans ; RNA, Viral ; Pandemics ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Immunoglobulin G ; COVID-19 Vaccines ; Antibodies, Viral
Chemical Substances	RNA, Viral ; Immunoglobulin G ; COVID-19 Vaccines ; Antibodies, Viral
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.10.038
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Zs.MO 458: Show issues

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Article ; Online: Bioinformática y bioética. El desafío de complementarlas.

Bottasso, Oscar / Mendicino, Diego / Perez, Ana Rosa / Moretti, Edgardo

Medicina

2021 Volume 81, Issue 6, Page(s) 1091–1092

Title translation	Bioinformatics and bioethics. The challenge of complementing them.
MeSH term(s)	Bioethics ; Computational Biology ; Humans
Language	Spanish
Publishing date	2021-12-07
Publishing country	Argentina
Document type	Letter
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: Factors associated with mortality among hospitalized patients with COVID-19 disease treated with convalescent plasma.

Perichon, Armando M / Acosta, Andrea / Di Tulio, Liliana / Munuce, Maria José / Pezzotto, Stella / Bottasso, Oscar / Nannini, Esteban C

mBio

2023 , Page(s) e0177723

Abstract: The use of convalescent plasma (CP) for hospitalized patients with SARS-CoV-2 infection might be a useful option in certain settings. Soon after the outbreak of COVID-19, the National Ministry of Health of Argentina recommended the use of CP transfusion ... ...

Abstract	The use of convalescent plasma (CP) for hospitalized patients with SARS-CoV-2 infection might be a useful option in certain settings. Soon after the outbreak of COVID-19, the National Ministry of Health of Argentina recommended the use of CP transfusion for hospitalized patients with COVID-19 disease. Between 1 June and 3 October 2020, 480 patients, excluding those on invasive mechanical ventilation (IMV), received at least one CP infusion in the province of Santa Fe. We aimed to find factors associated with mortality among this cohort of patients. The median age was 60 years (interquartile range: 49-69 years) and 320 (66.7%) were males. Most of these patients (93.75%) received a single CP infusion, 82.1% and 95.6% before day 4 and day 7 of hospitalization, respectively. Anti-SARS-CoV-2 titers were determined in the CP units administered using Elecsys Anti-SARS-CoV-2 S assay. At 28 days of follow-up, 250 patients were discharged (52.1%), 131 (27.3%) remained hospitalized without and 16 (3.3%) with oxygen requirement, 27 (5.6%) were on IMV, and 56 (11.7%) had died. In the multivariate logistic regression analysis, the factors significantly associated with 28-day mortality were (i) requirement of IMV, (ii) the administration of CP after the third day of hospitalization, (iii) age, and (iv) number of comorbidities. The qualitative and quantitative analyses of antibodies against SARS-CoV-2 in the infused CP were not associated with mortality. Our findings may imply a seemingly favorable effect of CP administration among patients with severe COVID-19 disease when infused sooner after hospitalization.IMPORTANCEThe use of convalescent plasma (CP) could be an option for patients with severe COVID-19, especially in poor-resource countries where direct antiviral drugs are not commercially available. Currently, the U.S. Food and Drug Administration limits the CP administration for outpatients and inpatients with COVID-19 who are immunocompromised and only if high levels of anti-SARS-CoV-2 antibodies are confirmed in the CP unit. Although most of the randomized clinical trials failed to show a clear-cut benefit of CP in hospitalized patients with severe COVID-19, other studies have shown that if given early in the course of the disease, it might be a useful therapeutic option. In this retrospective study, we demonstrated that early treatment (within 3 days of hospitalization) was significantly associated with reduced 28-day mortality compared with those patients treated beyond day 3. The results from our study add up to the scientific evidence on the use of CP as a relatively safe, cheap, and possibly effective therapy in certain patients suffering from severe SARS-CoV-2 infection.
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01777-23
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Article ; Conference proceedings: Human tuberculosis: a clear case of disturbed neuroimmunoregulation

Bottasso, O

Experimental and Clinical Endocrinology & Diabetes

2010

Abstract: The hypothalamic-pituitary-adrenal (HPA) axis and the immune system have evolved in simultaneous and communicate each other, by a series common mediators, hormones and cytokines. As endogenous peptides primarily released from immune cells cytokines ... ...

Event/congress	14th Annual Meeting of the Neuroendocrinology Section of the German Society of Endocrinology (DGE) and 20th Anniversary of an Argentine-German Collaboration, Max Planck Institute, Munich, Germany, 2010
Abstract	The hypothalamic-pituitary-adrenal (HPA) axis and the immune system have evolved in simultaneous and communicate each other, by a series common mediators, hormones and cytokines. As endogenous peptides primarily released from immune cells cytokines coordinate the immune response and also lead to the HPA activation, particularly those with inflammatory effects. A major effector mechanism of the HPA axis deals with the production of adrenal steroids, glucocorticoids (GCs) and dehydroepiandrosterone (DHEA). GCs and DHEA influence innate and adaptive mechanisms of the immune response downregulating inflammatory responses, but displaying differenzial effects on the development of Th2 and Th1 responses, respectively. Tuberculosis (TB) is a disease in which tissue pathology has an immune-mediated component encompassing an excessive and/or protracted cytokine production liable to affect the immunoendocrine communication. We have shown that TB patients present increased IFN-γ, IL-10, and IL-6 plasma levels, in presence of modest increases in cortisol, prolactin, and thyroid hormones and highly augmented concentrations of growth hormone. In contrast, testosterone, leptin and DHEA levels were markedly decreased. In vitro studies demonstrate that culture supernatants from M. tuberculosis-stimulated PBMC of TB patients inhibited DHEA secretion by a human adrenal cell line. Treatment of peripheral blood mononuclear cells (PBMC) from TB patients with physiological concentrations of cortisol inhibits mycobacterial antigen-driven lymphoproliferation and IFN-γ production, whereas DHEA suppresses TGF-β production by PBMC from patients with progressive disease. Supporting the role of immune and endocrine mediators in energy expenditure and metabolism, results also show that the consumption state of TB patients is linked to the immuno-endocrine disturbances. It was found that the body mass index of active TB patients is negatively associated with circulating IL-6 levels, which in turn correlate positively with cortisol concentrations Most immunomodulating effects of GCs are achieved through the interaction with GC receptors (GR), in particular the GR-α isoform since the GR-β lacks the ability to bind GC and seems to function as an inhibitor of GR-α-mediated transcriptional activation. Current studies reveal a reduced mRNA GRα/β ratio in PBMC of severe TB patients with hormone and cytokine environment influencing the expression of GR isoforms. Taken together, its is clear that the bidirectional communication between the neuroendocrine and immune systems in TB, results in an abnormal immuno-endocrine relation taking part in the consumption state, disturbed anti-infective immune response and pathological hormonal profile.
Language	English
Publishing date	2010-09-03
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	1225416-2
ISSN	1439-3646 ; 0947-7349
ISSN (online)	1439-3646
ISSN	0947-7349
DOI	10.1055/s-0030-1266991
Database	Thieme publisher's database

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