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  1. Article ; Online: Reply to Zeynep G. Gul, Alberto Martini, and Carl A. Olsson's Letter to the Editor re: Jacob A. Burns, Adam B. Weiner, William J. Catalona, et al. Inflammatory Bowel Disease and the Risk of Prostate Cancer. Eur Urol 2019;75:846-52.

    Burns, Jacob A / Weiner, Adam B / Kundu, Shilajit

    European urology

    2019  Volume 76, Issue 4, Page(s) e99–e100

    MeSH term(s) Humans ; Inflammatory Bowel Diseases ; Male ; Prostatectomy ; Prostatic Neoplasms/surgery
    Language English
    Publishing date 2019-05-28
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2019.05.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  2. Article ; Online: Re: Lum S, Hoo AF, Hulskamp G, Wade A, Stocks J. Potential misinterpretation of infant lung function unless prospective healthy controls are studied. Pediatr pulmonol 2010;45:906-913.

    Weiner, Daniel J

    Pediatric pulmonology

    2011  Volume 46, Issue 5, Page(s) 517–518

    MeSH term(s) Cystic Fibrosis/diagnosis ; Female ; Forced Expiratory Flow Rates ; Forced Expiratory Volume ; Humans ; Lung Diseases/diagnosis ; Male
    Language English
    Publishing date 2011-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.21373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
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  3. Article ; Online: Agroecological genetics of biomass allocation in wheat uncovers genotype interactions with canopy shade and plant size.

    Golan, Guy / Weiner, Jacob / Zhao, Yusheng / Schnurbusch, Thorsten

    The New phytologist

    2024  Volume 242, Issue 1, Page(s) 107–120

    Abstract: How plants distribute biomass among organs influences resource acquisition, reproduction and plant-plant interactions, and is essential in understanding plant ecology, evolution, and yield production in agriculture. However, the genetic mechanisms ... ...

    Abstract How plants distribute biomass among organs influences resource acquisition, reproduction and plant-plant interactions, and is essential in understanding plant ecology, evolution, and yield production in agriculture. However, the genetic mechanisms regulating allocation responses to the environment are largely unknown. We studied recombinant lines of wheat (Triticum spp.) grown as single plants under sunlight and simulated canopy shade to investigate genotype-by-environment interactions in biomass allocation to the leaves, stems, spikes, and grains. Size-corrected mass fractions and allometric slopes were employed to dissect allocation responses to light limitation and plant size. Size adjustments revealed light-responsive alleles associated with adaptation to the crop environment. Combined with an allometric approach, we demonstrated that polymorphism in the DELLA protein is associated with the response to shade and size. While a gibberellin-sensitive allelic effect on stem allocation was amplified when plants were shaded, size-dependent effects of this allele drive allocation to reproduction, suggesting that the ontogenetic trajectory of the plant affects the consequences of shade responses for allocation. Our approach provides a basis for exploring the genetic determinants underlying investment strategies in the face of different resource constraints and will be useful in predicting social behaviours of individuals in a crop community.
    MeSH term(s) Humans ; Biomass ; Triticum/genetics ; Plants ; Sunlight ; Genotype ; Plant Leaves/genetics
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19576
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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  4. Article ; Conference proceedings: Klinische Unterscheidung von Cpc- und Ipc-PH und Wechsel der Verteilung durch den neuen PVR-Grenzwert

    Pfeuffer-Jovic, E / Weiner, S / Hübner, G / Walthelm-Hösel, J / Held, M

    Pneumologie

    2024  Volume 78, Issue S 01

    Event/congress 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0044-1778860
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.142: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 54: Show issues

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  5. Article ; Online: Prevalence, stability, and clinical significance of an isolated low FEV

    Wyatt, MacKenzie L / Sokolow, Andrew G / Brown, Rebekah F / Kaslow, Jacob A / Tolle, James J / Weiner, Daniel J / Rosas-Salazar, Christian

    Pediatric pulmonology

    2024  

    Abstract: Objectives: In adults, an isolated low FEV: Methods: We conducted a retrospective study of spirometries from children ages 6-21 years and categorized tests into spirometry patterns according to published guidelines and recent literature. In a ... ...

    Abstract Objectives: In adults, an isolated low FEV
    Methods: We conducted a retrospective study of spirometries from children ages 6-21 years and categorized tests into spirometry patterns according to published guidelines and recent literature. In a subgroup of tests with an isolated low FEV
    Results: The isolated low FEV
    Conclusions: The isolated low FEV
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26987
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
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  6. Article ; Online: Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation.

    Meyer, Kirstin / Lammers, Nicholas C / Bugaj, Lukasz J / Garcia, Hernan G / Weiner, Orion D

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6929

    Abstract: YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How cells ensure the selective activation of YAP effector genes is unknown. This knowledge is essential to rationally control cellular decision-making. Here we ... ...

    Abstract YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How cells ensure the selective activation of YAP effector genes is unknown. This knowledge is essential to rationally control cellular decision-making. Here we leverage optogenetics, live-imaging of transcription, and cell fate analysis to understand and control gene activation and cell behavior. We reveal that cells decode the steady-state concentrations and timing of YAP activation to control proliferation, cell fate, and expression of the pluripotency regulators Oct4 and Nanog. While oscillatory YAP inputs induce Oct4 expression and proliferation optimally at frequencies that mimic native dynamics, cellular differentiation requires persistently low YAP levels. We identify the molecular logic of the Oct4 dynamic decoder, which acts through an adaptive change sensor. Our work reveals how YAP levels and dynamics enable multiplexing of information transmission for the regulation of developmental decision-making and establishes a platform for the rational control of these behaviors.
    MeSH term(s) Cell Differentiation/genetics ; Cell Proliferation/genetics ; Optogenetics ; Stem Cells ; Cell Communication
    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42643-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Designing a public access naloxone program for public transportation stations.

    Kohli, Sajeev / Garg, Jay / Velasquez, David E / Weiner, Scott G

    Healthcare (Amsterdam, Netherlands)

    2023  Volume 11, Issue 2, Page(s) 100694

    Abstract: The opioid overdose epidemic has caused over 600,000 deaths in the U.S. since 1999. Public access naloxone programs show great potential as a strategy for reducing opioid overdose-related deaths. However, their implementation within public transit ... ...

    Abstract The opioid overdose epidemic has caused over 600,000 deaths in the U.S. since 1999. Public access naloxone programs show great potential as a strategy for reducing opioid overdose-related deaths. However, their implementation within public transit stations, often characterized as opioid overdose hotspots, has been limited, partly because of a lack of understanding in how to structure such programs. Here, we propose a comprehensive framework for implementing public access naloxone programs at public transit stations to curb opioid overdose-related deaths. The framework, tailored to local contexts, relies on coordination between local public health organizations to provide naloxone at public access points and bystander training, local academic institutions to oversee program evaluation, and public transit organizations to manage naloxone maintenance. We use the city of Cambridge, Massachusetts as a case study to demonstrate how it and other municipalities may implement such an initiative.
    MeSH term(s) Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders ; Opiate Overdose/drug therapy ; Analgesics, Opioid/therapeutic use ; Drug Overdose/drug therapy ; Drug Overdose/epidemiology
    Chemical Substances Naloxone (36B82AMQ7N) ; Narcotic Antagonists ; Analgesics, Opioid
    Language English
    Publishing date 2023-05-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2724773-9
    ISSN 2213-0772 ; 2213-0764 ; 2213-0772
    ISSN (online) 2213-0772 ; 2213-0764
    ISSN 2213-0772
    DOI 10.1016/j.hjdsi.2023.100694
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  8. Article ; Online: LDmat: efficiently queryable compression of linkage disequilibrium matrices.

    Weiner, Rockwell J / Lakhani, Chirag / Knowles, David A / Gürsoy, Gamze

    Bioinformatics (Oxford, England)

    2023  Volume 39, Issue 2

    Abstract: Motivation: Linkage disequilibrium (LD) matrices derived from large populations are widely used in population genetics in fine-mapping, LD score regression, and linear mixed models for Genome-wide Association Studies (GWAS). However, these matrices can ... ...

    Abstract Motivation: Linkage disequilibrium (LD) matrices derived from large populations are widely used in population genetics in fine-mapping, LD score regression, and linear mixed models for Genome-wide Association Studies (GWAS). However, these matrices can reach large sizes when they are derived from millions of individuals; hence, moving, sharing and extracting granular information from this large amount of data can be cumbersome.
    Results: We sought to address the need for compressing and easily querying large LD matrices by developing LDmat. LDmat is a standalone tool to compress large LD matrices in an HDF5 file format and query these compressed matrices. It can extract submatrices corresponding to a sub-region of the genome, a list of select loci, and loci within a minor allele frequency range. LDmat can also rebuild the original file formats from the compressed files.
    Availability and implementation: LDmat is implemented in python, and can be installed on Unix systems with the command 'pip install ldmat'. It can also be accessed through https://github.com/G2Lab/ldmat and https://pypi.org/project/ldmat/.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) Humans ; Linkage Disequilibrium ; Software ; Genome-Wide Association Study ; Data Compression ; Genome
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Book ; Online: Neurology for the non-neurologist

    Weiner, William J. / Goetz, Christopher G.

    2004  

    Author's details edited by William J. Weiner, Christopher G. Goetz
    Keywords Nervous system diseases ; Diagnostic techniques, neurological ; Diagnosis, differential
    Language English
    Size 1 Online-Ressource (xiv, 610 Seiten), Illustrationen
    Edition 5th ed.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-4631-1 ; 0-7817-4631-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  10. Article ; Online: Cardiac Xenotransplantation: Clinical Impact of Science and Discovery.

    Garry, Daniel J / Weiner, Joshua I / Greising, Sarah M / Garry, Mary G / Sachs, David H

    Circulation

    2022  Volume 146, Issue 13, Page(s) 961–963

    MeSH term(s) Heart ; Heart Transplantation ; Humans ; Transplantation, Heterologous
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.059191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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