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Article ; Online: Eliminating cystic echinococcosis in the 21st century.

Flisser, Ana

2018 Volume 18, Issue 7, Page(s) 703–704

MeSH term(s)	Animals ; Bulgaria ; Cross-Sectional Studies ; Echinococcosis/epidemiology ; Prevalence ; Romania ; Turkey
Language	English
Publishing date	2018-05-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(18)30299-8
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Zs.A 5743: Show issues

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Article ; Online: The many faces of parasite calreticulin.

Esperante, Diego / Flisser, Ana / Mendlovic, Fela

Frontiers in immunology

2023 Volume 14, Page(s) 1101390

Abstract: Calreticulin from parasites and its vertebrate hosts share ~50% identity and many of its functions are equally conserved. However, the existing amino acid differences can affect its biological performance. Calreticulin plays an important role in ... ...

Abstract	Calreticulin from parasites and its vertebrate hosts share ~50% identity and many of its functions are equally conserved. However, the existing amino acid differences can affect its biological performance. Calreticulin plays an important role in Ca
MeSH term(s)	Animals ; Parasites/metabolism ; Calreticulin ; Vertebrates/metabolism ; Neoplasms/pathology ; Phagocytosis
Chemical Substances	Calreticulin
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1101390
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Article ; Online: State of the art of Taenia solium as compared to Taenia asiatica.

Flisser, Ana

The Korean journal of parasitology

2013 Volume 51, Issue 1, Page(s) 43–49

Abstract: Three species of tapeworms infect humans in their adult stage (Taenia solium, Taenia saginata and Taenia asiatica). The 3 are flat, opaque white or yellowish, and exceptional long segmented parasites, measuring 1 to 12 m in their adult stage. In this ... ...

Abstract	Three species of tapeworms infect humans in their adult stage (Taenia solium, Taenia saginata and Taenia asiatica). The 3 are flat, opaque white or yellowish, and exceptional long segmented parasites, measuring 1 to 12 m in their adult stage. In this review, the development of the knowledge regarding the first species, mainly focused on understanding how the larval stage or cysticercus is transmitted to humans, is described. The second species is a cosmopolitan parasite that only causes taeniosis and not cysticercosis; therefore, it will not be included. Information on the third species, which is presently being produced, since this species was recognized as such only at the end of the 20th century, will be discussed at the end of this review.
MeSH term(s)	Animals ; Biomedical Research/trends ; Humans ; Life Cycle Stages ; Taenia/pathogenicity ; Taenia/physiology ; Taeniasis/parasitology ; Taeniasis/transmission
Language	English
Publishing date	2013-02-18
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2013.51.1.43
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Zs.A 3476: Show issues

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Article ; Online: Measuring student satisfaction as the first assessment of the Program of Combined Studies in Medicine, an MD/PhD-like program of the Faculty of Medicine, National Autonomous University of Mexico.

Martínez-Flisser, Gina / Flisser, Ana / Castro-Guerrero, Mario Alberto / Plett-Torres, Tanya

BMC medical education

2020 Volume 20, Issue 1, Page(s) 446

Abstract: Background: The Program of Combined Studies in Medicine (PECEM, by its acronym in Spanish) is a program for simultaneous bachelor and doctorate studies (MD/PhD) that enrolls students who show academic excellence and interest in scientific research. The ... ...

Abstract	Background: The Program of Combined Studies in Medicine (PECEM, by its acronym in Spanish) is a program for simultaneous bachelor and doctorate studies (MD/PhD) that enrolls students who show academic excellence and interest in scientific research. The initial doctoral training comprises seven six-month research stays in different laboratories or clinical or computer areas with different high-quality scientific advisors who provide students with a unique experience for their scientific training. Therefore, satisfaction in this stage is decisive for students' performance and physical and psychological health. The aim of the present study was to administer a questionnaire to measure students' satisfaction with their research experience as a service-product bundle. Methods: Students answered an online questionnaire that evaluated three dimensions: perceived quality of the advisor, skills development, and infrastructure and support. Several satisfiers were also evaluated: recommendation of the advisor to peers, fulfillment of student expectations and satisfaction with the program. Correlations were calculated using Fisher's exact test. The significance was set at p < 0.05. Results: The high quality of the advisor, skills development and guidance during the stay were satisfiers correlated to the students' recommendation of their advisors to their peers and to the fulfillment of the students' scientific expectations. Conversely, skills development and infrastructure and support were satisfiers for a good to excellent experience as a PECEM student. A lack of direct interaction with the advisor's workgroup was related to dissatisfaction. Conclusions: The nontangible products of the service, such as a positive interaction between the student, the advisor and the advisor's workgroup as well as support obtained during the research stay, were satisfiers. These data indicate that promoting a fruitful bond between the student and advisor is a priority to ensure the quality of our innovative MD/PhD program.
MeSH term(s)	Faculty, Medical ; Humans ; Medicine ; Personal Satisfaction ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2020-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-020-02357-1
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Article ; Online: Zoonotic Taenia infections with focus on cysticercosis due to Taenia solium in swine and humans.

Mendlovic, Fela / Fleury, Agnes / Flisser, Ana

Research in veterinary science

2020 Volume 134, Page(s) 69–77

Abstract: Zoonotic taeniasis caused by the adult stage of Taenia solium, Taenia saginata or Taenia asiatica are considered neglected tropical diseases by the World Health Organization. The life cycle of these 3 metazoan species is very similar and includes an ... ...

Abstract	Zoonotic taeniasis caused by the adult stage of Taenia solium, Taenia saginata or Taenia asiatica are considered neglected tropical diseases by the World Health Organization. The life cycle of these 3 metazoan species is very similar and includes an intermediate host: pigs in the case of T. solium and T. asiatica, and cattle in the case of T. saginata. By eating meat (pork/T. solium, T. asiatica; beef/T. saginata) containing live cysticerci, humans develop taeniasis, which is practically asymptomatic but is the main risk factor for intermediate hosts to become infected. T. saginata causes bovine cysticercosis, while T. solium and T. asiatica cause swine cysticercosis, of veterinary and economic importance. T. solium cysticerci cause neurological disease in humans: neurocysticercosis. Cysticerci develop after ingesting microscopic eggs released from a human tapeworm carrier. Here we describe the life stages of the parasites, diagnosis, pathogenesis, symptomatology of neurocysticercosis, and prevention and control measures. Highlighting the need to validate diagnostic tools, treatments and vaccination in endemic areas, with the challenge of addressing the most vulnerable populations that lack resources. If people understand the transmission route, avoid eating uncooked or insufficiently cooked meat and have adequate hygienic habits, the life cycle of the 3 zoonotic Taenia species may be interrupted. In addition, we describe the growing field of immune response and immunomodulation elicited by the parasites, which may provide essential tools for diagnosis, treatment, control of taeniasis/cysticercosis, as well as for identification of parasite-derived immunomodulators that could aid in the treatment of emerging inflammatory diseases worldwide.
MeSH term(s)	Animals ; Humans ; Neurocysticercosis/diagnosis ; Neurocysticercosis/parasitology ; Neurocysticercosis/veterinary ; Swine ; Swine Diseases/parasitology ; Swine Diseases/prevention & control ; Swine Diseases/transmission ; Taenia ; Taenia saginata ; Taenia solium ; Zoonoses/diagnosis ; Zoonoses/parasitology
Language	English
Publishing date	2020-11-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2020.11.015
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Zs.B 673: Show issues

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Article ; Online: Why are tapeworm carriers so difficult to find? A methodological proposal for their search and recovery.

Villalobos, Nelly / Martínez-Maya, José J / Martínez-Núñez, Guadalupe / Figueroa-Delgado, Alfredo / Flisser, Ana / Sciutto, Edda

Experimental parasitology

2023 Volume 250, Page(s) 108529

Abstract: Neurocysticercosis, caused by the larval stage of Taenia solium, is a life-threatening condition and the most severe form of the disease. Yet, despite being a required link in the parasite life cycle, tapeworm carriers are rarely reported. This study is ... ...

Abstract	Neurocysticercosis, caused by the larval stage of Taenia solium, is a life-threatening condition and the most severe form of the disease. Yet, despite being a required link in the parasite life cycle, tapeworm carriers are rarely reported. This study is aimed to find and evaluate T. solium carriers, describing some characteristics of these patients and the treatment. Taeniasis cases were searched for in various Mexican states from 1983 to 2016. Previous informed consent, tapeworm-carrier patients were administered with niclosamide and a saline purge. Parasite specimens were recovered and identified, both morphologically and by PCR. From 117 treated patients, Taenia sp. specimens were obtained from 46 subjects (47.8%). From these, complete parasites were recovered from 42 (90.5%), and only detached proglottids from 4 patients. Cases were more frequent in Morelos, Chiapas, and Guerrero. More than one adult cestode was recovered from 4 patients (9.5%). To improve treatment efficacy and adherence, the drug was administered in late afternoon, resulting a high recovery yield of complete parasites (90.5%). The success rate of deworming campaigns in areas of Mexico and the world that are endemic for Taenia sp. could be improved by administering the treatment at times that do not interfere with the patients' daily activities, and national health authorities could apply this simple strategy to help eradication efforts in endemic areas. The detection of carriers will only be possible through the coordinated efforts of public and private health services, a better education of the general population to improve self-detection, and adequate, personalized diagnostic procedures for suspect cases.
MeSH term(s)	Adult ; Animals ; Humans ; Feces/parasitology ; Taeniasis/diagnosis ; Taeniasis/drug therapy ; Taeniasis/epidemiology ; Cestode Infections ; Neurocysticercosis/diagnosis ; Neurocysticercosis/drug therapy ; Neurocysticercosis/epidemiology ; Taenia solium/genetics ; Cysticercosis/diagnosis
Language	English
Publishing date	2023-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2023.108529
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Ud II Zs.159: Show issues

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Article: Fc-gamma receptor expression and cytokine responses to intravenous human immunoglobulin in whole blood from non-pregnant and pregnant women and newborns.

Vázquez-Rodríguez, Stephania / Arriaga-Pizano, Lourdes A / Mancilla-Herrera, Ismael / Prieto-Chávez, Jessica / Arizmendi-Villanueva, Roberto / Torres-Rosas, Rafael / Flisser, Ana / García-Latorre, Ethel / Cérbulo-Vázquez, Arturo

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2024

Abstract: Background: Intravenous immunoglobulin (IVIG) can suppress the inflammatory response in adults, but its role in pregnant women and newborns is poorly studied. While the adult immune system is considered mature, it is immature in neonates and suppressed ... ...

Abstract	Background: Intravenous immunoglobulin (IVIG) can suppress the inflammatory response in adults, but its role in pregnant women and newborns is poorly studied. While the adult immune system is considered mature, it is immature in neonates and suppressed in pregnancy. Since the immune response differs in these 3 groups, the use of IVIG could differentially modulate the immune response. Objectives: We aimed to explore the effect of IVIG on myeloid blood cells from non-pregnant women, pregnant women and newborns. Material and methods: Whole blood from healthy donors was incubated with lipopolysaccharide (LPS) and/or IVIG. After 0 h, 24 h and 48 h of culture, Fc-gamma receptor (CD16, CD32 and CD64) expression, monocyte and neutrophil bacterial phagocytosis, and cytokine and chemokine concentrations were determined in the supernatant. Results: The baseline expression of monocyte CD16 was higher in newborns than in adult women, but the expression of CD32 and CD64 was similar between groups. Furthermore, LPS and IVIG stimulation, together or separately, did not change Fc-gamma receptor expression in monocytes or neutrophils and did not modify their phagocytosis capacity. On the other hand, IVIG did not downregulate the proinflammatory cytokine response induced by LPS in any group. Interestingly, IVIG induced a strong interleukin 8 (IL-8) response in neonates but not in non-pregnant or pregnant women. Conclusions: Our results show that IVIG did not induce changes in Fc-gamma receptor expression, phagocytic ability, or the cytokine response to LPS in blood cells from neonates, non-pregnant or pregnant women. However, IVIG induced a strong IL-8 response in neonates that could improve immunity.
Language	English
Publishing date	2024-01-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/174566
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Article: La medicina en México hacia el siglo XX.

Flisser, Ana

Gaceta medica de Mexico

2009 Volume 145, Issue 4, Page(s) 353–356

Abstract: The end of the 19th and the beginning of the 20th century constitute a breakthrough in medicine. The Industrial Revolution was soon followed by a revolution in medicine characterized by a similar pattern where novel technology was produced. This ... ...

Title translation	The medicine in Mexico in the XX century.
Abstract	The end of the 19th and the beginning of the 20th century constitute a breakthrough in medicine. The Industrial Revolution was soon followed by a revolution in medicine characterized by a similar pattern where novel technology was produced. This initiated the transformation of medicine as a science and the establishment of medical specialties as we know them to date. Mexicans physicians must be commended for quickly adapting to this new way of thinking and practicing medicine. Important changes in clinical practice and in the medical community took place and were associated with the creation of several medical institutions. The field of public health grew as a medical concept focused on the individual and the population.
MeSH term(s)	History of Medicine ; History, 20th Century ; Mexico ; Public Health/history
Language	Spanish
Publishing date	2009-07
Publishing country	Mexico
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
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Article ; Online: The Impact of the Coronavirus Disease 19 Pandemic on Early Pregnancy Outcomes Among Patients Undergoing

Aharon, Devora / Gounko, Dmitry / Lee, Joseph A / Copperman, Alan B / Flisser, Eric

Women's health reports (New Rochelle, N.Y.)

2021 Volume 2, Issue 1, Page(s) 473–478

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-10-04
Publishing country	United States
Document type	Journal Article
ISSN	2688-4844
ISSN (online)	2688-4844
DOI	10.1089/whr.2021.0054
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Article: Where are the tapeworms?

Flisser, Ana

Parasitology international

2006 Volume 55 Suppl, Page(s) S117–20

Abstract: This review analyzes the literature in search of an answer to the fact that, in general, tapeworms are very difficult to recover. The results and comments of the authors that have searched for Taenia solium, either to define the local prevalence in ... ...

Abstract	This review analyzes the literature in search of an answer to the fact that, in general, tapeworms are very difficult to recover. The results and comments of the authors that have searched for Taenia solium, either to define the local prevalence in different countries of Latin America, to assess the efficacy of cestocidal treatment or to evaluate alternatives for controlling cysticercosis, are presented. The difficulties in tapeworm recovery and the possible explanations for this phenomenon are discussed.
MeSH term(s)	Animals ; Antigens, Helminth/isolation & purification ; Cysticercosis/drug therapy ; Cysticercosis/epidemiology ; Cysticercosis/parasitology ; Cysticercus/immunology ; Cysticercus/isolation & purification ; Enzyme-Linked Immunosorbent Assay ; Feces/parasitology ; Humans ; Latin America/epidemiology ; Taenia solium/immunology ; Taenia solium/isolation & purification
Chemical Substances	Antigens, Helminth
Language	English
Publishing date	2006
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2005.11.018
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